Heterogeneous thermal conductance of nanoparticle-fluid interfaces: An atomistic nodal approach.

The Interfacial Thermal Conductance (ITC) is a fundamental property of materials and has particular relevance at the nanoscale. The ITC quantifies the thermal resistance between materials of different compositions or between fluids in contact with materials. Furthermore, the ITC determines the rate of cooling/heating of the materials and the temperature drop across the interface. Here, we propose a method to compute local ITCs and temperature drops of nanoparticle-fluid interfaces. Our approach resolves the ITC at the atomic level using the atomic coordinates of the nanomaterial as nodes to compute local thermal transport properties. We obtain high-resolution descriptions of the interfacial thermal transport by combining the atomistic nodal approach, computational geometry techniques, and "computational farming" using non-equilibrium molecular dynamics simulations. We use our method to investigate the ITC of nanoparticle-fluid interfaces as a function of the nanoparticle size and geometry, targeting experimentally relevant structures of gold nanoparticles: capped octagonal rods, cuboctahedrons, decahedrons, rhombic dodecahedrons, cubes, icosahedrons, truncated octahedrons, octahedrons, and spheres. We show that the ITC of these very different geometries varies significantly in different regions of the nanoparticle, increasing generally in the order face < edge < vertex. We show that the ITC of these complex geometries can be accurately described in terms of the local coordination number of the atoms in the nanoparticle surface. Nanoparticle geometries with lower surface coordination numbers feature higher ITCs, and the ITC generally increases with the decreasing particle size.

Direct detection of polarization multiplexed single sideband signals with orthogonal offset carriers.

We propose a novel direct detection (DD) scheme for polarization division multiplexed (PDM) single sideband (SSB) signals with two orthogonal carriers located at the opposite sides. Polarization diversity is realized with a pair of optical filters that are used to suppress the unwanted orthogonal carrier component. A PDM-SSB DD receiver is thus constructed without polarization de-rotation. The intra-polarization signal-signal beat interference (SSBI) can be mitigated by Kramers-Kronig detection or iterative SSBI cancellation. For inter-polarization SSBI mitigation, we propose a joint iterative SSBI cancellation method. The proposed PDM-SSB DD scheme is validated with a principle experiment of 40Gbaud PDM-SSB 16-ary quadrature amplitude modulation (16-QAM) signals. After 80km standard single-mode fiber (SSMF) transmission, the bit-error rates (BERs) achieve 20% hard-decision forward error correction (HD-FEC) threshold of 1.5 × 10-2. The performance of iterative SSBI cancellation, Kramers-Kronig detection, and joint iterative SSBI cancellation are evaluated for PDM-SSB signals with different carrier-to-signal ratios (CSPRs) through numerical simulations. Moreover, a multi-input-multi-output (MIMO) equalization scheme is proposed and validated with numerical simulation, which can suppress the linear inter-polarization crosstalk and relax the sharpness requirement of optical filter edges.

Memristive Bionic Memory Circuit Implementation and Its Application in Multisensory Mutual Associative Learning Networks.

Memory is vital and indispensable for organisms and brain-inspired intelligence to gain complete sensation and cognition of the environment. In this work, a memristive bionic memory circuit inspired by human memory model is proposed, which includes 1) receptor and sensory neuron (SN), 2) short-term memory (STM) module, and 3) long-term memory (LTM) module. By leveraging the in-memory computing characteristic of memristors, various functions such as sensation, learning, forgetting, recall, consolidation, reconsolidation, retrieval, and reset are realized. Besides, a multisensory mutual associative learning network is constructed with several bionic memory units to memorize and associate sensory information of different modalities bidirectionally. Except for association establishment, enhancement, and extinction, we also mimicked multisensory integration to manifest the synthetic process of information from different sensory channels. According to the simulation results in PSPICE, the proposed circuit performs high robustness, low area overhead, and low power consumption. Combining associative memory with human memory model, this work provides a possible idea for further research in associative learning networks.

Controlling local thermal gradients at molecular scales with Janus nanoheaters.

The generation and control of heat transport with nanoparticles is an essential objective of thermoplasmonics. Janus nanoparticles consisting of dissimilar materials with contrasting interfacial Kapitza conductance provide a route to control heat transport at the nanoscale. Here we use the recently introduced Atomistic Nodal Approach to map the surface temperature and Kapitza conductance of Janus nanoparticles to individual atoms. We show that the transition in the thermal transport properties between the hydrophobic and hydrophilic interfaces is exceptionally abrupt, occurring over length scales below 1 nm. We demonstrate the generality of this result using coarse-grained and all-atom models of gold nanoparticles. Further, we show how this behaviour provides a route to sustain significant temperature differences, on the order of tens of degrees for µW heat rates, between adjacent molecular layers attached to heated gold nanoparticles. Our work provides fundamental insight into nanoscale heat transport and a principle to design heterogeneous Janus nanoparticles for thermal transport applications.

Dissecting signaling regulators driving AXL-mediated bypass resistance and associated phenotypes by phosphosite perturbations.

Receptor tyrosine kinase (RTK)-targeted therapies are often effective but invariably limited by drug resistance. A major mechanism of acquired resistance involves "bypass" switching to alternative pathways driven by non-targeted RTKs that restore proliferation. One such RTK is AXL whose overexpression, frequently observed in bypass resistant tumors, drives both cell survival and associated malignant phenotypes such as epithelial-to-mesenchymal (EMT) transition and migration. However, the signaling molecules and pathways eliciting these responses have remained elusive. To explore these coordinated effects, we generated a panel of mutant lung adenocarcinoma PC9 cell lines in which each AXL intracellular tyrosine residue was mutated to phenylalanine. By integrating measurements of phosphorylation signaling and other phenotypic changes associated with resistance through multivariate modeling, we mapped signaling perturbations to specific resistant phenotypes. Our results suggest that AXL signaling can be summarized into two clusters associated with progressive disease and poor clinical outcomes in lung cancer patients. These clusters displayed favorable Abl1 and SFK motifs and their phosphorylation was consistently decreased by dasatinib. High-throughput kinase specificity profiling showed that AXL likely activates the SFK cluster through FAK1 which is known to complex with Src. Moreover, the SFK cluster overlapped with a previously established focal adhesion kinase (FAK1) signature conferring EMT-mediated erlotinib resistance in lung cancer cells. Finally, we show that downstream of this kinase signaling, AXL and YAP form a positive feedback loop that sustains drug tolerant persister cells. Altogether, this work demonstrates an approach for dissecting signaling regulators by which AXL drives erlotinib resistance-associated phenotypic changes.

Ce(III)/Photoassisted Synthesis of Amides from Carboxylic Acids and Isocyanates.

The Ce(III)-photocatalyzed synthesis of amides from carboxylic acids and aryl isocyanates was developed. The reaction includes the formation of alkyl radicals from carboxylic acids followed by radical addition to the electron-deficient carbon of isocyanate.