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1.
Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress.
J Pharmacol Exp Ther
; 363(1): 114-125, 2017 10.
Article
in English
| MEDLINE | ID: mdl-28790194
2.
Azepanone-based inhibitors of human cathepsin S: optimization of selectivity via the P2 substituent.
Bioorg Med Chem Lett
; 21(15): 4409-15, 2011 Aug 01.
Article
in English
| MEDLINE | ID: mdl-21733692
3.
3,5-Disubstituted-indole-7-carboxamides: the discovery of a novel series of potent, selective inhibitors of IKK-ß.
Bioorg Med Chem Lett
; 21(8): 2255-8, 2011 Apr 15.
Article
in English
| MEDLINE | ID: mdl-21429745
4.
Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.
J Med Chem
; 64(21): 15949-15972, 2021 11 11.
Article
in English
| MEDLINE | ID: mdl-34705450
5.
Spongipyran Synthetic Studies. Total Synthesis of (+)-Spongistatin 2.
Tetrahedron
; 65(33): 6470-6488, 2009 Aug 15.
Article
in English
| MEDLINE | ID: mdl-20161196
6.
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
J Med Chem
; 62(9): 4683-4702, 2019 05 09.
Article
in English
| MEDLINE | ID: mdl-30973731
7.
3,5-Disubstituted-indole-7-carboxamides as IKKß Inhibitors: Optimization of Oral Activity via the C3 Substituent.
ACS Med Chem Lett
; 9(12): 1164-1169, 2018 Dec 13.
Article
in English
| MEDLINE | ID: mdl-30613320
8.
Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J Med Chem
; 59(8): 3991-4006, 2016 04 28.
Article
in English
| MEDLINE | ID: mdl-27031670
9.
Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO.
PLoS One
; 9(6): e98896, 2014.
Article
in English
| MEDLINE | ID: mdl-24896564
10.
Keap calm, and carry on covalently.
J Med Chem
; 56(19): 7463-76, 2013 Oct 10.
Article
in English
| MEDLINE | ID: mdl-23837912
11.
The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2 Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, a NIH Postdoctoral Fellowship to C.S.B., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr George T. Furst, Dr. Patrick J. Carroll, and Dr. Rakesh Kohli of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra, respectively.
Angew Chem Int Ed Engl
; 40(1): 196-199, 2001 Jan 05.
Article
in English
| MEDLINE | ID: mdl-11169711
12.
The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2.
Angew Chem Int Ed Engl
; 40(1): 196-199, 2001 Jan 05.
Article
in English
| MEDLINE | ID: mdl-29711943
13.
Progress towards the development of anti-inflammatory inhibitors of IKKbeta.
Curr Top Med Chem
; 9(7): 623-39, 2009.
Article
in English
| MEDLINE | ID: mdl-19689370
14.
Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta).
J Med Chem
; 52(9): 3098-102, 2009 May 14.
Article
in English
| MEDLINE | ID: mdl-19348415
15.
3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists.
Bioorg Med Chem Lett
; 17(14): 3864-7, 2007 Jul 15.
Article
in English
| MEDLINE | ID: mdl-17524641
16.
The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases.
Bioorg Med Chem Lett
; 17(14): 3972-7, 2007 Jul 15.
Article
in English
| MEDLINE | ID: mdl-17502144
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