Osteosarcoma of the jaw: an analysis of a series of 74 cases.

AIMS: To analyse a series of cases of osteosarcoma of the jaw. METHODS AND RESULTS: The study included 74 cases of osteosarcoma of the jaw. Their clinical, radiographic and histopathological features were analysed, and their frequency with respect to aggressive and malignant pathologies of the jaw was determined. Survival was assessed in 17 cases with available follow-up. Osteosarcoma of the jaw accounted for 10% of primary malignant and aggressive tumours of the jaw, and for 8% of all malignant lesions of the jaw, including metastatic and lymphoproliferative tumours. The mean age was 43 ± 18 years. Radiographic features varied greatly and were non-specific, with a predominance of mixed images. The dominant histological pattern was osteoblastic (48.4%), followed by chondroblastic (37.1%). The survival rate at 5 years was 68%. Females and patients with a predominantly chondroblastic pattern had lower survival rates. CONCLUSIONS: Osteosarcoma of the jaw was the most frequent primary malignant tumour of the jaw. Female gender and a predominantly chondroblastic pattern may be associated with a worse prognosis.

Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjögren's syndrome among 1,726 registry participants.

OBJECTIVE: To examine associations between labial salivary gland (LSG) histopathology and other phenotypic features of Sjögren's syndrome (SS). METHODS: The database of the Sjögren's International Collaborative Clinical Alliance (SICCA), a registry of patients with symptoms of possible SS as well as those with obvious disease, was used for the present study. LSG biopsy specimens from SICCA participants were subjected to protocol-directed histopathologic assessments. Among the 1,726 LSG specimens exhibiting any pattern of sialadenitis, we compared biopsy diagnoses against concurrent salivary, ocular, and serologic features. RESULTS: LSG specimens included 61% with focal lymphocytic sialadenitis (FLS; 69% of which had focus scores of ≥1 per 4 mm²) and 37% with nonspecific or sclerosing chronic sialadenitis (NS/SCS). Focus scores of ≥1 were strongly associated with serum anti-SSA/SSB positivity, rheumatoid factor, and the ocular component of SS, but not with symptoms of dry mouth or dry eyes. Those with positive anti-SSA/SSB were 9 times (95% confidence interval [95% CI] 7.4-11.9) more likely to have a focus score of ≥1 than were those without anti-SSA/SSB, and those with an unstimulated whole salivary flow rate of <0.1 ml/minute were 2 times (95% CI 1.7-2.8) more likely to have a focus score of ≥1 than were those with a higher flow rate, after controlling for other phenotypic features of SS. CONCLUSION: Distinguishing FLS from NS/SCS is essential in assessing LSG biopsies, before determining focus score. A diagnosis of FLS with a focus score of ≥1 per 4 mm², as compared to FLS with a focus score of <1 or NS/SCS, is strongly associated with the ocular and serologic components of SS and reflects SS autoimmunity.

Malignant oral-maxillary neoplasm in children and adolescents. A retrospective analysis from the biopsy service at a school of dentistry in Argentina.

There are few studies on oral-maxillary lesions in children and adolescents, and reports on malignant neoplasms are scarce. Comparison of available data is difficult due to the different criteria and racial-ethnic origin of the populations in each study. The aim of this work was to perform a retrospective study of malignant oral neoplasms in patients aged up to 20 years diagnosed at a center specialized in histopathological diagnosis of oral diseases between 1990 and 2005. The 24 retrieved cases accounted for 0.9% (n: 2434) of total biopsies in this age group during that period, and for 8.4% (n: 236) of the tumors. Mean age of the whole population was 9.2 years with even distribution according to sex. The most frequent tumor types were extranodal non-Hodgkin lymphoma (7 cases), osteosarcoma (4 cases) and Ewing sarcoma (3 cases). These data can be considered representative of our population of children and adolescents and serve as a basis for recognition and presumptive diagnosis in clinical practice.

Extranodal oral non-Hodgkin's lymphomas. A retrospective study of 40 cases in Argentina.

A retrospective study was conducted of extranodal oral Non-Hodgkin's Lymphomas diagnosed at the Surgical Pathology Laboratory of the School of Dentistry at Buenos Aires University, Argentina, between 1985 and 2004. The 40 cases found represent 0.2% of the oral biopsies diagnosed during that time and 4.6% of malignant neoplasias. Overall mean age of patients was 49.4 years, and frequency was greater in males. 80% affected soft tissues. Prevalent location was gingival, followed by palate. Intraosseous cases were more frequent in mandible (75%) than in upper maxilla. 100% of the cases were phenotype B, with a higher frequency of high-grade aggressiveness. The most common histological type was Diffuse Large Cell Lymphoma. 60% of the Plasmablastic Lymphomas in the series came from HIV+ patients. Evolution time prior to consultation was 1 to 3 months in 57.7% of the cases.

Odontogenic tumors in children and adolescents. A 15-year retrospective study in Argentina.

There are few studies on bucco-maxillary lesions in children and adolescents, and reports on odontogenic tumors (OT) are scanty. Comparison among the available data is difficult due to differences in the criteria used in each study. The aim of the present work was to perform a retrospective study of OT in patients aged up to 20 years diagnosed at a center specialized in histopathologic diagnosis of oral diseases. All cases diagnosed with OT between 1990 and 2004 were retrieved from the Service archives. The 153 retrieved cases accounted for 7% of total biopsies performed during that period, and to 78.4% of tumors of the jaws. Mean age of the whole population was 12.7 years and the male to female ratio was 2:1. The most frequent tumor types were Odontoma, (50.9%), Ameloblastoma (18.3%) and Myxoma (8.5%), and the most infrequent was Calcifying Epithelial Odontogenic Tumor (1.3%). According to our results, OT cannot be considered infrequent. They are the prevalent tumors of the jaws in the age group studied herein.

Human papillomavirus in oral lesions.

Growing evidence suggests a role for human papillomavirus (HPV) in oral cancer; however its involvement is still controversial. This study evaluates the frequency of HPV DNA in a variety of oral lesions in patients from Argentina. A total of 77 oral tissue samples from 66 patients were selected (cases); the clinical-histopathological diagnoses corresponded to: 11 HPV- associated benign lesions, 8 non-HPV associated benign lesions, 33 premalignant lesions and 25 cancers. Sixty exfoliated cell samples from normal oral mucosa were used as controls. HPV detection and typing were performed by polymerase chain reaction (PCR) using primers MY09, 11, combined with RFLP or alternatively PCR using primers GP5+, 6+ combined with dot blot hybridization. HPV was detected in 91.0% of HPV- associated benign lesions, 14.3% of non-HPV associated benign lesions, 51.5% of preneoplasias and 60.0% of cancers. No control sample tested HPV positive. In benign HPV- associated lesions, 30.0% of HPV positive samples harbored high-risk types, while in preneoplastic lesions the value rose to 59.9%. In cancer lesions, HPV detection in verrucous carcinoma was 88.9% and in squamous cell carcinoma 43.8%, with high-risk type rates of 75.5% and 85.6%, respectively. The high HPV frequency detected in preneoplastic and neoplastic lesions supports an HPV etiological role in at least a subset of oral cancers.

Agnor as a marker of malignant transformation in odontogenic keratocysts.

Nucleolar Organizer Region (AgNOR) counts have been reported as a useful, complementary diagnostic tool for several neoplasias. The morphometric evaluation of AgNOR has also been shown to contribute to the detection of incipient cellular alterations. The aim of the present study was to perform a morphometric analysis of AgNOR in keratocysts (KC), and in three rare cases of malignant transformation of keratocysts (KCm) to explore their use as a marker of the process of malignant transformation in this entity. We performed a study of the 3 cases of keratocysts that had suffered transformation into squamous cell carcinoma (SCC) that were available in our files and of 8 cases of solitary keratocysts (KCs). Paraffin sections were silver stained and employed to perform a morphometric analysis of 7 parameters related to number, size and shape of AgNORs. A comparative analysis of the epithelium of solitary keractocyts (KCs), the cystic epithelium adjacent to the area of transformation (KCm) and the epithelium of the SCC cords was performed. The epithelia of KCs and KCm exhibited statistically significant differences for four of the parameters analyzed: nuclear volume (VNUC), single AgNOR volume (VNOR), Total AgNOR per nucleus (TVNOR) and Contour Index of nuclei (CINUC). KCs and SCC exhibited statistically significant differences for all of the parameters. Given the ease with which this technique can be applied to routine histopathological material, we propose AgNOR evaluation as a diagnostic and prognostic aid in cystic entities that are suspected to have a neoplastic potential.

Efficacy of Core Needle Biopsy Technique for Jawbone Diseases.

Core needle biopsy (CNB) has been proven useful for diagnosing bone lesions, although it is not often used for jawbone lesions. The aim of this study was to evaluate the efficacy of the CNB method in a series of cases of intramaxillary lesions. CNB was performed on 85 patients with intraosseous lesions which were grouped according to radiographic appearance as: radiopaque lesions (RO, n=13), radiolucent lesions (RL, n=39) and mixed lesions with both radiolucent and radiopaque areas (RL-RO, n=33). The technique enabled us to obtain several tissue cylinders from each lesion (average 2.5 cylinders), which were processed following routine histopathological technique and H&E stain, plus special techniques when necessary. The histopathological analysis together with clinical data enabled accurate diagnosis (AD) in 81% of the cases and descriptive diagnosis (DD) in 14%. The material obtained in 5% of the cases was not appropriate for study (ND). The difference between successful (AD) and unsuccessful (DD+ND) CNB cases is statistically significant. The highest percentage of successful CBNs was for RO and RLRO lesions (85% and 100% respectively). RL lesions were more difficult because most of them were cystic lesions with fluid content.

La biopsia-punción ósea ( Core needle biopsy, CNB) es un procedimiento de probada utilidad en el diagnóstico de lesiones óseas. Sin embargo, no es una técnica de uso frecuente en las lesiones de los maxilares. La finalidad de este trabajo fue evaluar la eficacia del método de CNB en una serie de casos de lesiones intramaxilares. Se realizaron CNB en 85 pacientes con lesiones intraóseas, las cuales fueron agrupadas según su aspecto radiográfico en lesiones radiopacas ( RO, n=13), lesiones radiolucidas (RL, n=39) y lesiones mixtas con sectores radiolúcidos y radiopacos (RL-RO, n=33). La técnica permitió obtener varios cilindros de tejido de cada lesión ( promedio: 2.5 cilindros) los cuales fueron procesados según técnica histopatológica de rutina con tinción de H&E y técnicas especiales en los casos en que fueron necesarias. El análisis de los cuadros histopatológicos conjuntamente con los datos clínicos, permitió realizar un un diagnóstico de certeza (AD) en el 81% de los casos y un diagnostico descriptivo (DD) en el 14 % . En el 5% de los casos el material obtenido no fue adecuado para su estudio (ND) La diferencia entre los casos de CNB exitosa y no exitosa ( DD+ND) es estadisticamente significativa. El mayor porcentaje de CBN exitosas correspondió a las lesiones RO y RL-RO ( 85% y 100% respectivamente) Las lesiones RL presentaron mayor dificultad debido a que, en su mayoría, eran lesiones quísticas con contenido líquido.

Pericoronal follicles of asymptomatic impacted teeth: a radiographic, histomorphologic, and immunohistochemical study.

Objective. To associate radiographic and histopathological features of pericoronal follicles (PFs) of asymptomatic impacted teeth and evaluate cell proliferation and apoptosis in the epithelium. Study Design. Epithelium and mesenchyme of radiographically normal (NPF ≤ 2.5 mm) and hyperplastic (HPF 2.6 to 5 mm) PF (n = 140) were studied histologically. Cell proliferation (PI) and epithelial apoptosis were evaluated by Ki-67 and bcl-2 expression in 14 NPFs and 10 dentigerous cysts (DCs). Results. Radiographically, 127 were NPFs and 13 were HPFs; 87.8% of total PFs exhibited epithelium on the surface. Reduced enamel epithelium was observed in 78 (61.4%) NPFs and 6 (46.2%) HPFs, squamous metaplasia in 17 (13.4%) NPFs and 4 (30.8%) HPFs, and cystic epithelium in 15 (11.8%) NPFs and 3 (23%) HPFs. Mean PI was 1.97 ± 1.25 and 7.97 ± 1.74 in the epithelial component of NPF and DC, respectively; bcl-2 positive expression was observed in 9 (64.3%) NPFs and 7 (70%) DCs. Conclusion. The scant epithelial remnant proliferation could imply low risk for development of odontogenic pathologies in the absence of an additional stimulus.

Increased subepithelial vascularization and VEGF expression reveal potentially malignant changes in human oral mucosa lesions.

OBJECTIVE: The objective of this study was to provide evidence that the magnitude of angiogenesis induced by oral mucosa epithelium with potentially malignant lesions is related to the degree of epithelial aggressiveness. METHODS AND RESULTS: We evaluated 96 biopsies that included: (1) leukoplakia with and without dysplasia, (2) nontumoral borders adjacent to squamous cell carcinomas with and without dysplasia, and (3) normal oral mucosa. Number, size, and localization of vessels labeled immunohistochemically for the antigen CD34 were assessed by image analysis using a software developed "ad hoc." All vascular sections and those localized immediately below the epithelium (sub-basal vessels) were separately evaluated in areas 30-µm deep. Vascular endothelial growth factor (VEGF) expression was labeled immunohistochemically and evaluated semiquantitatively against a standard. Leukoplakia and nontumoral borders adjacent to carcinomas exhibited an increase in VEGF expression and in subepithelial vascularization. This increase was significantly greater in leukoplakia with dysplastic changes than in leukoplakia without dysplasia. Conversely, no differences were observed between epithelia with and without dysplasia adjacent to carcinomas. CONCLUSIONS: Demonstration of expression of epithelial VEGF and sub-basal vascularization could be an additional aid for evaluation of the severity of potentially malignant lesions in oral mucosa routine biopsies.

Efficacy of core needle biopsy technique for jawbone diseases

La biopsia-punción ósea ( Core needle biopsy, CNB) es un procedimiento de probada utilidad en el diagnóstico delesiones óseas. Sin embargo, no es una técnica de uso frecuente en las lesiones de los maxilares. La finalidad de este trabajo fue evaluar la eficacia del método de CNB en una serie de casosde lesiones intramaxilares. Se realizaron CNB en 85 pacientes con lesiones intraóseas, las cuales fueron agrupadas según su aspecto radiográfico en lesiones radiopacas ( RO, n=13), lesiones radiolucidas (RL,n=39) y lesiones mixtas con sectores radiolúcidos y radiopacos (RL-RO, n=33). La técnica permitió obtener varios cilindros de tejido de cada lesión ( promedio: 2.5 cilindros) los cualesfueron procesados según técnica histopatológica de rutina con tinción de H&E y técnicas especiales en los casos en que fueron necesarias. El análisis de los cuadros histopatológicos conjuntamente con los datos clínicos, permitió realizar un un diagnóstico de certeza (AD) en el 81por ciento de los casos y un diagnostico descriptivo (DD) en el 14 por ciento. En el 5 por ciento de los casos el material obtenido no fue adecuado para su estudio (ND) Ladiferencia entre los casos de CNB exitosa y no exitosa (DD+ND) es estadisticamente significativa. El mayor porcentaje de CBN exitosas correspondió a las lesiones RO y RL-RO (85 por ciento y 100 por ciento respectivamente) Las lesiones RL presentaron mayor dificultad debido a que, en su mayoría, eran lesiones quísticas con contenido líquido...

Tumor odontogénico adenomatoide: reporte de un caso y revisión de la literatura / Adenomatoid odontogenic tumor: report of a case and review of the literature

El Tumor Odontogénico Adenomatoide (TOA) es una lesión tumoral benigna de origen odontogénico de la que se conocen 3 variantes clínicas: folicular (70.8 por ciento), extrafolicular (26.9 por ciento) y periférica (2.3 por ciento), todas ellas con un mismo patrón histopatológico. La literatura mundial acepta que la mayoría de estas lesiones se diagnostican en la segunda década de la vida, se presentan con el doble defrecuencia en el género femenino, se ubican generalmente en maxilar superior y asociadas, en su variante folicular, con un canino no erupcionado.En los estudios radiográficos el TOA puede presentar características similares a lesiones como el Quiste Dentígero, el Tumor OdontogénicoQuístico Calcificante (Quiste de Gorlin) y el Tumor Odontogénico Epitelial Calcificante (Tumor de Pindborg), entre otros, de los que debe hacerse el diagnóstico diferencial. En este trabajo se presenta un caso clínico de TOA folicular con una localización poco habitual y se realiza una extensa revisión de la literatura mundial...

Metástasis en cóndilo mandibular: presentación de un caso clínico / Mandibular condyle metastasis: report of a clinical case

Las metástasis bucales constituyen un grupo de baja frecuencia pero de gran importancia en particular por su localización. Según datos bibliográficos internacionales, representan del 1 por ciento al 8 por ciento de todas las neoplasias malignas bucales. Pueden localizarse tanto en los tejidos blandos como en los huesos maxilares (84 por ciento) prevaleciendo en la mandíbula, principalmente en el área molar, seguida del sector premolar. La localización condilar es rara. En los últimos 55 años sólo han sido reportados 48 casos. Dado que no existen patrones clínicos ni radiográficos que permitan caracterizar las lesiones, estas patologías suelen en un principio ser tratadas erróneamente como desordenes propios de la articulación temporo mandibular (ATM).Se presenta un caso clínico de a una paciente de sexo femenino de 36 años con antecedentes de adenocarcinoma de recto que presenta una metástasis en cóndilo bajo la apariencia clínica de un cuadro de disfunción de la ATM. Corresponde al tercer caso reportado en la literatura.

Oral metastases are a group of low-frequency lesions but important particularly because of its location. According to international bibliographic data represent 1% to 8% of oral malignancies. They can be located both in soft tissues and in the jaws (84%). Prevails in the mandible, mainly in the molar area, followed by the premolar region. The condylar location is extremely rare. Since the clinical and radiographic features are not characteristic, these lesions are often erroneously treated initially as temporomandibular joint (TMJ) disorders.In the last 55 years only 48 cases have been reported. We present a 36-years-old female patient with antecedents of rectal adenocarcinoma treated two years ago, having a metastasis in the mandibular condyle with clinical appearance of TMJ dysfunction.This is the third case reported in the literature.

Expresión inmunohistoquímica de p53 en individuos con liquen / Immunohistochemical expression of p53 in individuals with lichen planus

Objetivo: Estimar el riesgo del potencial de malignización del liquen plano bucal analizando la expresión de la proteína p53. Materiales y metodos: Se realizó un diseño de cohorte de sujetos con diagnostico histopatológico de liquen. El desenlace fue el desarrollo de cáncer si/no. El total de individuos que cumplió con los criterios de inclusión/exclusión fue de 58. A los 58 sujetos se les realizó la determinación de p53. Resultados: Cuarenta y nueve individuos mostraron una expresión de p53 menor al 5% con una P>0,05% intrasujeto no transformado. En los 9 individuos transformados se observaron diferencias significativas entre la determinación pre y post de la proteína p53. El Riesgo Relativo fue de 188 con una significación estadística de P< 0,01. Conclusion: La expresión de la proteína p53 en los individuos con liquen apoya la hipótesis que niveles superiores al 5%constituye un factor de incremento del riesgo en la transformación maligna de esta patología. Nuestros hallazgos deberían ser corroborados en el futuro con mayor número de individuos. La determinación de la p53 mediante IHQ en individuos con liquen plano bucal podría modificar el seguimiento clínico de estos individuos. Esto permitiría un diagnóstico precoz de cualquier alteración que pueda indicar un posible cambio hacia la malignización.

Objective: To determine the risk for potential malignant transformation of oral lichen planus by analyzing protein p53 expression. Materials and methods: Cohort study of subjects with a histopathologic diagnosis of lichen. The study analyzed whether or not subjects developed cancer. A total of 58 subjects fulfilled the inclusion/exclusion criteria, and were analyzed for p53. Results: Fortynine(49) subjects showed a p53 expression <5%, with a p>0.05 among subjects undergoing no transformation. In the 9 subjects undergoing malignant transformation, significant differences were observed between pre and post p53 expression. The relative risk was 188, with a statistical significance of p< 0.01. Conclusions: Protein p53 expression in subjects with lichen supports the hypothesis that levels >5% are associated with an increased risk of malignant transformation of this condition. Should our findings be proved in a larger series in the future, the clinical follow-up of these subjects could be modified. This would allow an early diagnosis of any disorder indicative of a potential malignant transformation.

Malignant oral-maxillary neoplasm in children and adolescents: a retrospective analysis from the biopsy service at a school of dentistry in Argentina / Neoplasias malignas bucomaxilares en niños y adolescentes: análisis retrospectivo del servicio de biopsias de una facultad de odontología en Argentina

There are few studies on oral-maxillary lesions in children and adolescents, and reports on malignant neoplasms are scarce. Comparison of available data is difficult due to the different criteriaand racial-ethnic origin of the populations in each study. The aim of this work was to perform a retrospective study of malignant oral neoplasms in patients aged up to 20 years diagnosed at a center specialized in histopathological diagnosis of oral diseases between 1990 and 2005. The 24 retrieved cases accounted for 0.9% (n: 2434) of total biopsies in this age group during that period, and for 8.4% (n: 236) of the tumors. Mean age of the wholepopulation was 9.2 years with even distribution according to sex. The most frequent tumor types were extranodal non-Hodgkin lymphoma (7 cases), osteosarcoma (4 cases) and Ewing sarcoma (3 cases). These data can be considered representative of our population of children and adolescents and serve as a basis for recognitionand presumptive diagnosis in clinical practice.

Los estudios sobre neoplasias bucomaxilares en niños y adolescentes son relativamente poco comunes y escasos los reportes sobre neoplasias malignas. Los datos disponibles son difíciles de comparar debido a diferencias en los criterios de análisis utilizados en cada estudio y origen racial-étnico de la población. El objetivo del presente trabajo fue realizar un estudio retrospectivo de neoplasias malignas bucales en pacientes de hasta 20 años de edad diagnosticados en un centro especializado en diagnóstico anatomopatológico bucal entre 1990 y 2005. Los 24 casos hallados representaron el 0.9 por ciento (n: 2434) del total de biopsias de este grupo etario en ese periodo y el 8.4 por ciento (n: 286) de los tumores. La edad media general fue de 9.2 años, con similar distribución según sexo. Los tipos tumorales más frecuentes fueronlos Linfomas No Hodgkin extraganglionares (7 casos), el Osteosarcoma (4 casos) y el Sarcoma de Ewing (3 casos). Estos datos pueden ser considerados representativos de nuestra po blación infanto juvenil y sirven de base para a su recono ci miento y diagnostico presuntivo en la práctica clínica.

Malignant oral-maxillary neoplasm in children and adolescents: a retrospective analysis from the biopsy service at a school of dentistry in Argentina / Neoplasias malignas bucomaxilares en niños y adolescentes: análisis retrospectivo del servicio de biopsias de una facultad de odontología en Argentina

There are few studies on oral-maxillary lesions in children and adolescents, and reports on malignant neoplasms are scarce. Comparison of available data is difficult due to the different criteriaand racial-ethnic origin of the populations in each study. The aim of this work was to perform a retrospective study of malignant oral neoplasms in patients aged up to 20 years diagnosed at a center specialized in histopathological diagnosis of oral diseases between 1990 and 2005. The 24 retrieved cases accounted for 0.9% (n: 2434) of total biopsies in this age group during that period, and for 8.4% (n: 236) of the tumors. Mean age of the wholepopulation was 9.2 years with even distribution according to sex. The most frequent tumor types were extranodal non-Hodgkin lymphoma (7 cases), osteosarcoma (4 cases) and Ewing sarcoma (3 cases). These data can be considered representative of our population of children and adolescents and serve as a basis for recognitionand presumptive diagnosis in clinical practice.(AU)

Los estudios sobre neoplasias bucomaxilares en niños y adolescentes son relativamente poco comunes y escasos los reportes sobre neoplasias malignas. Los datos disponibles son difíciles de comparar debido a diferencias en los criterios de análisis utilizados en cada estudio y origen racial-étnico de la población. El objetivo del presente trabajo fue realizar un estudio retrospectivo de neoplasias malignas bucales en pacientes de hasta 20 años de edad diagnosticados en un centro especializado en diagnóstico anatomopatológico bucal entre 1990 y 2005. Los 24 casos hallados representaron el 0.9 por ciento (n: 2434) del total de biopsias de este grupo etario en ese periodo y el 8.4 por ciento (n: 286) de los tumores. La edad media general fue de 9.2 años, con similar distribución según sexo. Los tipos tumorales más frecuentes fueronlos Linfomas No Hodgkin extraganglionares (7 casos), el Osteosarcoma (4 casos) y el Sarcoma de Ewing (3 casos). Estos datos pueden ser considerados representativos de nuestra po blación infanto juvenil y sirven de base para a su recono ci miento y diagnostico presuntivo en la práctica clínica.(AU)

Leiomioma intraóseo de maxilar superior: hallazgo radiográfico posterior a un traumatismo dentario / Maxillary intraosseous leiomyoma: radiographic finding after dental trauma

Objetivo: informar sobre un caso inusual de leiomioma intramaxilar, sus características clínico-radiográficas y su diagnóstico diferencial. Caso clínico: se presenta a la consulta una niña de 10 años de edad con una lesión osteolítica en el maxilar superior, inicialmente considerada -según los antecedentes clínicos- una complicación periapical, producto de lesión pulpar postraumática. Luego de realizar el tratamiento endodóntico convencional, los controles radiográficos posteriores evidenciaron, a los 2 meses, falta de remisión de la lesión osteolítica y, a los 4 meses, aumento de su tamaño. Tras su extirpación quirúrgica, el estudio histopatológico correspondiente diagnosticó leiomioma. Conclusiones: el leiomioma es una neoplasia benigna del músculo liso que, habitualmente, se localiza en los tejidos blandos. Su presencia en la cavidad bucal es infrecuente y es aún más rara en los maxilares. Por su aspecto radiográfico inespecífico, puede confundirse con otras patologías, lo cual dificulta el diagnóstico precoz.(

Leiomioma intraóseo de maxilar superior: hallazgo radiográfico posterior a un traumatismo dentario / Maxillary intraosseous leiomyoma: radiographic finding after dental trauma

Objetivo: informar sobre un caso inusual de leiomioma intramaxilar, sus características clínico-radiográficas y su diagnóstico diferencial. Caso clínico: se presenta a la consulta una niña de 10 años de edad con una lesión osteolítica en el maxilar superior, inicialmente considerada -según los antecedentes clínicos- una complicación periapical, producto de lesión pulpar postraumática. Luego de realizar el tratamiento endodóntico convencional, los controles radiográficos posteriores evidenciaron, a los 2 meses, falta de remisión de la lesión osteolítica y, a los 4 meses, aumento de su tamaño. Tras su extirpación quirúrgica, el estudio histopatológico correspondiente diagnosticó leiomioma. Conclusiones: el leiomioma es una neoplasia benigna del músculo liso que, habitualmente, se localiza en los tejidos blandos. Su presencia en la cavidad bucal es infrecuente y es aún más rara en los maxilares. Por su aspecto radiográfico inespecífico, puede confundirse con otras patologías, lo cual dificulta el diagnóstico precoz.(AU))

Tumores odontogénicos en niños y adolescentes. Estudio retrospectivo de 15 años en Argentina / Odontogenic tumors in children and adolescents. A 15-year retrospective study in Argentina

Los estudios sobre lesiones buco maxilares en niños y adolescentes son relativamente poco comunes y escasos los reportes sobre tumores odontogénicos (TO) en la literatura internacional actualizada. Los datos disponibles son difíciles decomparar debido a los diferentes criterios de análisis utilizados. El objetivo del presente trabajo fue realizar un estudio retrospectivo de TO en pacientes de hasta 20 años de edad diagnosticados en un centro especializado en diagnóstico anatomopatológico bucal. Se seleccionaron de los archivos del Servicio los casos con diagnósticos de TO correspondientes al período 1990-2004. Los 153 casos hallados representaron el 7% del total de biopsias realizadas y el 78.4 % de los tumores maxilares. La edad media general fue de 12.7 años y la relación hombre-mujer 2:1. Los tipos tumorales más frecuentes fueron el Odontoma (50.9%), Ameloblastoma (18.3%) y Mixoma (8.5%). El más infrecuente fue el TumorOdontogénico Epitelial Calcificante (1.3%). Según los datos obtenidos los TO no pueden ser considerados infrecuentes. En los maxilares son los prevalentes en el grupo etario estudiado

There are few studies on bucco-maxillary lesions in children and adolescents, and reports on odontogenic tumors (OT)are scanty. Comparison among the available data is difficult due to differences in the criteria used in each study. Theaim of the present work was to perform a retrospective study of OT in patients aged up to 20 years diagnosed at a cen-ter specialized in histopathologic diagnosis of oral diseases. All cases diagnosed with OT between 1990 and 2004 wereretrieved from the Service archives. The 153 retrieved cases accounted for 7% of total biopsies performed during thatperiod, and to 78.4% of tumors of the jaws. Mean age of the whole population was 12.7 years and the male to femaleratio was 2:1. The most frequent tumor types were Odontoma, (50.9%), Ameloblastoma (18.3%) and Myxoma (8.5%),and the most infrequent was Calcifying Epithelial Odontogenic Tumor (1.3%). According to our results, OT cannot beconsidered infrequent. They are the prevalent tumors of the jaws in the age group studied herein