Utility of MRI for Patients 45 Years Old and Older With Hip or Knee Pain: A Systematic Review.

BACKGROUND. MRI utility for patients 45 years old and older with hip or knee pain is not well established. OBJECTIVE. We performed this systematic review to assess whether MRI-diagnosed hip or knee pathology in patients 45 years old and older correlates with symptoms or benefits from arthroscopic surgery. EVIDENCE ACQUISITION. A literature search (PubMed, Web of Science, Embase) of articles published before October 3, 2022, was performed to identify original research pertaining to the study question. Publication information, study design, cohort size, osteoarthritis severity, age (range, mean), measured outcomes, minimum follow-up length, and MRI field strength were extracted. Study methods were appraised with NIH's study quality assessment tools. EVIDENCE SYNTHESIS. The search yielded 1125 potential studies, of which 31 met the inclusion criteria (18 knee, 13 hip). Knee studies (10 prospective, eight retrospective) included 5907 patients (age range, 45-90 years). Bone marrow edema-like lesions, joint effusions, and synovitis on MRI were associated with symptoms. In patients with osteoarthritis, meniscal tears were less likely to be symptom generators and were less likely to respond to arthroscopic surgery with osteoarthritis progression. Hip studies (11 retrospective, two prospective) included 6385 patients (age range, 50 to ≥ 85 years). Patients with Tönnis grade 2 osteoarthritis and lower with and without femoroacetabular impingement (FAI) showed improved outcomes after arthroscopy, suggesting a role for MRI in the diagnosis of labral tears, chondral lesions, and FAI. Although this group benefited from arthroscopic surgery, outcomes were inferior to those in younger patients. Variability in study characteristics, follow-up, and outcome measures precluded a meta-analysis. CONCLUSION. In patients 45 years old and older, several knee structural lesions on MRI correlated with symptoms, representing potential imaging biomarkers. Meniscal tear identification on MRI likely has diminished clinical value as osteoarthritis progresses. For the hip, MRI can play a role in the diagnosis of labral tears, chondral lesions, and FAI in patients without advanced osteoarthritis. CLINICAL IMPACT. Several structural lesions on knee MRI correlating with symptoms may represent imaging biomarkers used as treatment targets. Osteoarthritis, not age, may play the greatest role in determining the utility of MRI for patients 45 years old and older with hip or knee pain.

Compressed Sensing SEMAC MRI of Hip, Knee, and Ankle Arthroplasty Implants: A 1.5-T and 3-T Intrapatient Performance Comparison for Diagnosing Periprosthetic Abnormalities.

BACKGROUND. The utility of 3-T MRI for diagnosing joint disorders is established, but its performance for diagnosing abnormalities around arthroplasty implants is unclear. OBJECTIVE. The purpose of this study was to compare 1.5-T and 3-T compressed sensing slice encoding for metal artifact correction (SEMAC) MRI for diagnosing peri-prosthetic abnormalities around hip, knee, and ankle arthroplasty implants. METHODS. Forty-five participants (26 women, 19 men; mean age ± SD, 71 ± 14 years) with symptomatic lower extremity arthroplasty (hip, knee, and ankle, 15 each) prospectively underwent consecutive 1.5- and 3-T MRI examinations with intermediate-weighted (IW) and STIR compressed sensing SEMAC sequences. Using a Likert scale, three radiologists evaluated the presence or absence of periprosthetic abnormalities, including bone marrow edema-like signal, osteolysis, stress reaction/fracture, synovitis, and tendon abnormalities and collections; image quality; and visibility of anatomic structures. Statistical analysis included nonparametric comparison and interchangeability testing. RESULTS. For diagnosing periprosthetic abnormalities, 1.5-T and 3-T compressed sensing SEMAC MRI were interchangeable. Across all three joints, 3-T MRI had lower noise than 1.5-T MRI (median IW and STIR scores at 3 T vs 1.5 T, 4 and 4 [range, 2-5 and 3-5] vs 3 and 3 [range, 2-5 and 2-4]; p < .01 for both), sharper edges (median IW and STIR scores at 3 T vs 1.5 T, 4 and 4 [both ranges, 2-5] vs 3 and 3 [range, 2-4 and 2-5]; p < .02 and p < .05), and more effective metal artifact reduction (median IW and STIR scores at 3 T vs 1.5 T, 4 and 4 [range, 3-5 and 2-5] vs 4 and 4 [both ranges, 3-5]; p < .02 and p = .72). Agreement was moderate to substantial for image contrast (IW and STIR, 0.66 and 0.54 [95% CI, 0.41-0.91 and 0.29-0.80]; p = .58 and p = .16) and joint capsule visualization (IW and STIR, 0.57 and 0.70 [range, 0.32-0.81 and 0.51-0.89]; p = .16 and p = .19). The bone-implant interface was more visible at 1.5 T (median IW and STIR scores, 4 and 4 [both ranges, 2-5] at 1.5 T vs 3 and 3 [both ranges, 2-5] at 3 T; p = .08 and p = .58), but periprosthetic tissues had superior visibility at 3 T (IW and STIR, 4 and 4 [both ranges, 3-5] at 3 T vs 4 and 4 [ranges, 2-5 and 3-5] at 1.5 T; p = .07 and p = .19). CONCLUSION. Optimized 1.5-T and 3-T compressed sensing SEMAC MRI are interchangeable for diagnosing periprosthetic abnormalities, although metallic artifacts are larger at 3 T. CLINICAL IMPACT. With compressed sensing SEMAC MRI, lower extremity arthroplasty implants can be imaged at 3 T rather than 1.5 T.

Common Skeletal Neoplasms and Nonneoplastic Lesions at 18F-FDG PET/CT.

Numerous primary and metastatic osseous lesions and incidental osseous findings are encountered at fluorine 18 (18F) fluorodeoxyglucose (FDG) PET/CT. These lesions show varying degrees of FDG uptake. Malignancies are generally more FDG avid than are benign lesions, but many exceptions exist. Although aggressive lesions tend to be more FDG avid than nonaggressive lesions, this concept holds true particularly for lesions of the same histologic subtype. In addition, some benign osseous processes such as Paget disease have variable degrees of FDG avidity on the basis of disease metabolic activity. This creates a diagnostic dilemma for radiologists and clinicians, especially in patients with known malignancies, and can result in unnecessary diagnostic imaging or interventions for incidental osseous lesions. Evaluation of morphologic CT characteristics of osseous lesions at FDG PET/CT can be a valuable adjunct to metabolic analysis to further characterize lesions, enhance diagnostic and staging accuracy, and avoid unnecessary invasive biopsy procedures. The authors review the common primary and metastatic bone lesions at FDG PET/CT, with an emphasis on morphologic CT assessment of lesions to help narrow the differential diagnosis. Imaging manifestations of common incidental nonneoplastic bone lesions at FDG PET/CT are discussed to provide information on differentiation of these lesions from osseous neoplasms. The guidelines of the National Comprehensive Cancer Network (NCCN) for common primary osseous malignancies are also summarized. Online supplemental material is available for this article. ©RSNA, 2021.

Postoperative Musculoskeletal Imaging and Interventions Following Hip Preservation Surgery, Deformity Correction, and Hip Arthroplasty.

Total hip arthroplasty and hip preservation surgeries have substantially increased over the past few decades. Musculoskeletal imaging and interventions are cornerstones of comprehensive postoperative care and surveillance in patients undergoing established and more recently introduced hip surgeries. Hence the radiologist's role continues to evolve and expand. A strong understanding of hip joint anatomy and biomechanics, surgical procedures, expected normal postoperative imaging appearances, and postoperative complications ensures accurate imaging interpretation, intervention, and optimal patient care. This article presents surgical principles and procedural details pertinent to postoperative imaging evaluation strategies after common hip surgeries, such as radiography, ultrasonography, computed tomography, and magnetic resonance imaging. We review and illustrate the expected postoperative imaging appearances and complications following chondrolabral repair, acetabuloplasty, osteochondroplasty, periacetabular osteotomy, realigning and derotational femoral osteotomies, and hip arthroplasty.

Society of Skeletal Radiology- white paper. Guidelines for the diagnostic management of incidental solitary bone lesions on CT and MRI in adults: bone reporting and data system (Bone-RADS).

The purpose of this article is to present algorithms for the diagnostic management of solitary bone lesions incidentally encountered on computed tomography (CT) and magnetic resonance (MRI) in adults. Based on review of the current literature and expert opinion, the Practice Guidelines and Technical Standards Committee of the Society of Skeletal Radiology (SSR) proposes a bone reporting and data system (Bone-RADS) for incidentally encountered solitary bone lesions on CT and MRI with four possible diagnostic management recommendations (Bone-RADS1, leave alone; Bone-RADS2, perform different imaging modality; Bone-RADS3, perform follow-up imaging; Bone-RADS4, biopsy and/or oncologic referral). Two algorithms for CT based on lesion density (lucent or sclerotic/mixed) and two for MRI allow the user to arrive at a specific Bone-RADS management recommendation. Representative cases are provided to illustrate the usability of the algorithms.

Imaging Spectrum of Calvarial Abnormalities.

Calvarial abnormalities are usually discovered incidentally on radiologic studies or less commonly manifest with symptoms. This narrative review describes the imaging spectrum of the abnormal calvaria. The extent, multiplicity, and other imaging features of calvarial abnormalities can be combined with the clinical information to establish a final diagnosis or at least narrow the differential considerations. Prior trauma (congenital depression, leptomeningeal cysts, posttraumatic osteolysis), surgical intervention (flap osteonecrosis and burr holes), infection, and inflammatory processes (sarcoidosis) can result in focal bone loss, which may also be seen with idiopathic disorders without (bilateral parietal thinning and Gorham disease) or with (Parry-Romberg syndrome) atrophy of the overlying soft tissues. Anatomic variants (arachnoid granulations, venous lakes, parietal foramina) and certain congenital lesions (epidermoid and dermoid cysts, atretic encephalocele, sinus pericranii, and aplasia cutis congenita) manifest as solitary lytic lesions. Other congenital entities (lacunar skull and dysplasia) display a diffuse pattern of skull involvement. Several benign and malignant primary bone tumors involve the calvaria and manifest as lytic, sclerotic, mixed lytic and sclerotic, or thinning lesions, whereas multifocal disease is mainly due to hematologic or secondary malignancies. Metabolic disorders such as rickets, hyperparathyroidism, renal osteodystrophy, acromegaly, and Paget disease involve the calvaria in a more diffuse pattern. Online supplemental material is available for this article. ©RSNA, 2021.

Metal artifacts of hip arthroplasty implants at 1.5-T and 3.0-T: a closer look into the B1 effects.

OBJECTIVE: To evaluate the effect of circular polarization (CP) and elliptical polarization (EP) of the B1 field on metal implant-induced artifacts of titanium (Ti) and cobalt-chromium (CoCr) hip arthroplasty implants at 1.5-T and 3.0-T field strengths. MATERIAL AND METHODS: In vitro Ti and CoCr total hip arthroplasty implants were evaluated using high transmit and receive bandwidth turbo spin echo (HBW-TSE) and slice encoding for metal artifact correction (SEMAC) metal artifact reduction techniques. Each technique was implemented at 1.5-T, which only allows for CP of B1 field as the system default, as well as 3.0-T, which permitted CP and EP. Manual segmentation quantified the size of the metal artifacts at the level of the acetabular cup, femoral neck, and femoral shaft. RESULTS: In the acetabular cup and femoral neck, 1.5-T CP achieved smaller artifact sizes than 3.0-T CP (28-29% on HBW-TSE, p = 0.002-0.005; 17-34% on SEMAC, p = 0.019-0.102) and 3.0-T EP (25-28% on HBW-TSE, p = 0.010-0.011; 14-36% on SEMAC, p = 0.058-0.135) techniques. In the femoral stem region, 3.0-T EP achieved more efficient artifact suppression than 3.0-T CP (HBW-TSE 44-45%, p < 0.001-0.022; SEMAC 76-104%, p < 0.001-0.022) and 1.5-T CP (HBW-TSE 76-96%, p < 0.001-0.003; SEMAC 138-173%, p = 0.003-0.005) techniques. CONCLUSION: Despite slightly superior metal reduction ability of the 1.5-T in the region of the acetabular cup and prosthesis neck, 3.0-T MRI of hip arthroplasty implants using elliptically polarized RF pulses may overall be more effective in reducing metal artifacts than the current standard 1.5-T MRI techniques, which by default implements circularly polarized RF pulses.

Cartilage Imaging in Osteoarthritis.

Osteoarthritis (OA) is the most common joint disease in the United States. The prevalence of OA is rising due to an aging population and increasing rates of obesity. Magnetic resonance imaging (MRI) allows an incomparable noninvasive assessment of all joint structures. Irreversible and progressive degradation of the articular cartilage remains the hallmark feature of OA. To date, attempts at developing disease-modifying drugs or biomechanical interventions for treating OA have proven unsuccessful. MRI-based cartilage imaging techniques have continued to advance, however, and will likely play a central role in the development of these joint preservation methods of the future. In this narrative review, we describe clinical MR image acquisition and assessment of cartilage. We discuss the semiquantitative cartilage scoring methods used in research. Lastly, we review the quantitative MRI techniques that allow assessment of changes in the biochemical composition of cartilage, even before the morphological changes are evident.

Metal About the Hip and Artifact Reduction Techniques: From Basic Concepts to Advanced Imaging.

Promising outcomes of hip replacement interventions in this era of aging populations have led to higher demands for hip arthroplasty procedures. These require effective methods and techniques for the detection of postoperative outcomes and complications. Based on the presence or absence of radiographic findings, magnetic resonance imaging (MRI) and computed tomography (CT) may be required to detect and further characterize different causes of failing implants. Yet metal-related artifacts degrade image quality and pose significant challenges for adequate image quality. To mitigate such artifacts in MRI, a set of techniques, collectively known as metal artifact reduction sequence (MARS) MRI, were developed that optimize the framework of the conventional pulse sequences and exploit novel multispectral and multispatial imaging methods such as Slice Encoding for Metal Artifact Correction (SEMAC) and Multi-Acquisition Variable-Resonance Image Combination (MAVRIC). Metal-induced artifacts on CT can be effectively reduced with virtual monochromatic reconstruction of dual-energy CT data sets, metal artifact reduction reconstruction algorithms, and postprocessing image visualization techniques.

Partially thrombosed aneurysm of the medial marginal vein.

Lower extremity superficial venous aneurysms are occasionally encountered by clinicians and are almost always located above the knee. Very few cases of aneurysm of the medial marginal vein in the most distal part, near the origin of the great saphenous vein, have been reported. We present a case of partially thrombosed aneurysm of the medial marginal vein, and briefly review the imaging characteristics and treatment options of this entity. Being aware of the existence of superficial venous aneurysms may help clinicians in their differential diagnosis of foot masses and choice of appropriate treatment.

Reliability of distal tibio-fibular syndesmotic instability measurements using weightbearing and non-weightbearing cone-beam CT.

BACKGROUND: To investigate the reliability and reproducibility of syndesmosis measurements on weightbearing (WB) cone-beam computed tomography (CBCT) images and compare them with measurements obtained using non-weightbearing (NWB) images. METHODS: In this IRB-approved, retrospective study of 5 men and 9 women with prior ankle injuries, simultaneous WB and NWB CBCT scans were taken. A set of 21 syndesmosis measurements using WB and NWB images were performed by 3 independent observers. Pearson/Spearman correlation and intra-class correlation (ICC) were used to assess intra- and inter-observer reliability, respectively. RESULTS: We observed substantial to perfect intra-observer reliability (ICC=0.72-0.99) in 20 measurements. Moderate to perfect agreement (ICC=0.45-0.97) between observers was noted in 19 measurements. CONCLUSION: Measurements evaluating the distance between tibia and fibula in the axial plane 10mm above the plafond had high intra- and inter-observer reliability. Mean posterior tibio-fibular distance, diastasis, and angular measurement were significantly different between WB and NWB images.

Dedicated CT and MRI Techniques for the Evaluation of the Postoperative Knee.

Advances in surgical techniques, orthopaedic implant design, and higher demands for improved functionality of the aging population have resulted in a high prevalence of patients with metallic implants about the knee. Total knee arthroplasty, knee-replacing tumor prostheses, and osteosynthesis implants create various imaging artifacts and pose special challenges for the imaging evaluation with computed tomography (CT) and magnetic resonance imaging (MRI). CT artifacts can be effectively mitigated with metal artifact reduction reconstruction algorithms, dual-energy data acquisition with virtual monoenergetic extrapolation, and three-dimensional postprocessing techniques, such as volume and cinematic rendering. Artifacts related to metal implants on MRI can be reduced via optimization of the scan parameters and using advanced techniques such as multi-acquisition variable-resonance image combination, and slice encoding for metal artifact correction.

Advanced MR Imaging after Total Hip Arthroplasty: The Clinical Impact.

Recent metal artifact reduction techniques in magnetic resonance imaging (MRI) have sparked a new aera in visualization of the peri-implant region and assessment of failing orthopaedic hardware. Modes of failure after total hip arthroplasty can be classified into four broad categories: osseous abnormalities, implant instability and dislocation, implant-associated synovitis, and soft tissue abnormalities. Although MRI is complementary to plain radiography and computed tomography to diagnose the first two categories, it is paramount to investigate the complications related to the synovium and soft tissues. We review the most common modes of failure of hip implants and the MRI characteristics of various causes of pain and dysfunction after hip arthroplasty including osseous stress reaction and fracture, implant loosening, implant instability, polyethylene wear­induced synovitis, adverse reaction to metal debris, infection, hematoma, recurrent hemarthrosis, heterotopic ossification, muscle, tendon, and nerve abnormalities, and periprosthetic neoplasms.

Leaps in Technology: Advanced MR Imaging after Total Hip Arthroplasty.

The vast majority of the metal-related artifacts in magnetic resonance imaging (MRI) arise from B0 inhomogeneity. These artifacts include failed fat suppression, signal loss, signal pileup, and image distortions. Metal artifact reduction sequence MRI has been used to mitigate these artifacts via optimization of the scan parameters and exploiting new techniques such as fully phase-encoded imaging and multispectral imaging including multi-acquisition variable-resonance image combination and slice encoding for metal artifact correction. Applicability of MRI in the vicinity of metal implants has been revolutionized by these new techniques at the expense of longer acquisition times. To reach clinically viable scan times, these novel techniques have been successfully coupled with various acceleration paradigms such as parallel imaging and compressed sensing.

Comparing velocity and fluid shear stress in a stenotic phantom with steady flow: phase-contrast MRI, particle image velocimetry and computational fluid dynamics.

OBJECT: This study aims to validate phase-contrast magnetic resonance imaging (PC-MRI) measurements of a steady flow through a severe stenotic phantom using particle image velocimetry (PIV) and computational fluid dynamics (CFD). MATERIALS AND METHODS: The study was performed in an axisymmetric 87 % area stenosis model using an inlet Reynolds number (Re) of 160, corresponding to a jet Re of 444. Velocity patterns and estimated fluid shear stresses from three modalities were analyzed and compared qualitatively and quantitatively. RESULTS: Visual analysis via contour subtraction and Bland-Altman plots showed good agreement for flow velocities and less agreement for maximum shear stress (MSS). The Pearson's coefficients of correlation between PC-MRI and PIV were 0.97 for the velocity field and 0.82 for the MSS. The corresponding parameters between PC-MRI and CFD were 0.96 and 0.84, respectively. CONCLUSION: Findings indicate that PC-MRI can be implemented to estimate velocity flow fields and MSS; however, this method is not sufficiently accurate to quantify the MSS at regions of high shear rate.

In vitro validation of flow measurement with phase contrast MRI at 3 tesla using stereoscopic particle image velocimetry and stereoscopic particle image velocimetry-based computational fluid dynamics.

PURPOSE: To validate conventional phase-contrast MRI (PC-MRI) measurements of steady and pulsatile flows through stenotic phantoms with various degrees of narrowing at Reynolds numbers mimicking flows in the human iliac artery using stereoscopic particle image velocimetry (SPIV) as gold standard. MATERIALS AND METHODS: A series of detailed experiments are reported for validation of MR measurements of steady and pulsatile flows with SPIV and CFD on three different stenotic models with 50%, 74%, and 87% area occlusions at three sites: two diameters proximal to the stenosis, at the throat, and two diameters distal to the stenosis. RESULTS: Agreement between conventional spin-warp PC-MRI with Cartesian read-out and SPIV was demonstrated for both steady and pulsatile flows with mean Reynolds numbers of 130, 160, and 190 at the inlet by evaluating the linear regression between the two methods. The analysis revealed a correlation coefficient of > 0.99 and > 0.96 for steady and pulsatile flows, respectively. Additionally, it was found that the most accurate measures of flow by the sequence were at the throat of the stenosis (error < 5% for both steady and pulsatile mean flows). The flow rate error distal to the stenosis was primarily found to be a function of narrowing severity including dependence on proper Venc selection. CONCLUSION: SPIV and CFD provide excellent approaches to in vitro validation of new or existing PC-MRI flow measurement techniques.

Modern Low-Field MRI of the Musculoskeletal System: Practice Considerations, Opportunities, and Challenges.

ABSTRACT: Magnetic resonance imaging (MRI) provides essential information for diagnosing and treating musculoskeletal disorders. Although most musculoskeletal MRI examinations are performed at 1.5 and 3.0 T, modern low-field MRI systems offer new opportunities for affordable MRI worldwide. In 2021, a 0.55 T modern low-field, whole-body MRI system with an 80-cm-wide bore was introduced for clinical use in the United States and Europe. Compared with current higher-field-strength MRI systems, the 0.55 T MRI system has a lower total ownership cost, including purchase price, installation, and maintenance. Although signal-to-noise ratios scale with field strength, modern signal transmission and receiver chains improve signal yield compared with older low-field magnetic resonance scanner generations. Advanced radiofrequency coils permit short echo spacing and overall compacter echo trains than previously possible. Deep learning-based advanced image reconstruction algorithms provide substantial improvements in perceived signal-to-noise ratios, contrast, and spatial resolution. Musculoskeletal tissue contrast evolutions behave differently at 0.55 T, which requires careful consideration when designing pulse sequences. Similar to other field strengths, parallel imaging and simultaneous multislice acquisition techniques are vital for efficient musculoskeletal MRI acquisitions. Pliable receiver coils with a more cost-effective design offer a path to more affordable surface coils and improve image quality. Whereas fat suppression is inherently more challenging at lower field strengths, chemical shift selective fat suppression is reliable and homogeneous with modern low-field MRI technology. Dixon-based gradient echo pulse sequences provide efficient and reliable multicontrast options, including postcontrast MRI. Metal artifact reduction MRI benefits substantially from the lower field strength, including slice encoding for metal artifact correction for effective metal artifact reduction of high-susceptibility metallic implants. Wide-bore scanner designs offer exciting opportunities for interventional MRI. This review provides an overview of the economical aspects, signal and image quality considerations, technological components and coils, musculoskeletal tissue relaxation times, and image contrast of modern low-field MRI and discusses the mainstream and new applications, challenges, and opportunities of musculoskeletal MRI.

MR Imaging of the Knee Posterolateral and Posteromedial Corner Injuries.

The posteromedial and posterolateral corners of the knee are important areas to consider when assessing the patient with a possible knee injury. An understanding of the anatomy, associated biomechanics, and typical injury patterns in these regions will improve the value that the radiologist interpreting the MRIs brings to this patient population.

Postoperative MR Imaging of Joints: Technical Considerations.

Postoperative MR imaging of joints is now commonly requested, yet artifacts caused by metallic orthopedic implants remain a significant challenge during image interpretation. Effective artifact reduction is essential to identify postsurgical complications, such as prosthesis loosening, infection, adverse local tissue reaction, and periarticular soft tissue injuries. This article reviews basic and advanced metal artifact reduction MR imaging techniques applied to various clinical protocols for successful postoperative MR imaging of small and large joints.