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1.
Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations.
Nat Cancer
; 4(9): 1345-1361, 2023 09.
Article
in English
| MEDLINE | ID: mdl-37743366
2.
CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma.
Cancer Res
; 82(6): 1110-1127, 2022 03 15.
Article
in English
| MEDLINE | ID: mdl-35074756
3.
MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung Cancer.
Mol Cancer Res
; 20(5): 722-734, 2022 05 04.
Article
in English
| MEDLINE | ID: mdl-35149545
4.
Prospective Clinical Genomic Profiling of Ewing Sarcoma: ERF and FGFR1 Mutations as Recurrent Secondary Alterations of Potential Biologic and Therapeutic Relevance.
JCO Precis Oncol
; 6: e2200048, 2022 08.
Article
in English
| MEDLINE | ID: mdl-35952322
5.
Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements.
Cancer Discov
; 12(5): 1233-1247, 2022 05 02.
Article
in English
| MEDLINE | ID: mdl-35135829
6.
Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling.
Dis Model Mech
; 15(1)2022 01 01.
Article
in English
| MEDLINE | ID: mdl-34841430
7.
Novel Preclinical Patient-Derived Lung Cancer Models Reveal Inhibition of HER3 and MTOR Signaling as Therapeutic Strategies for NRG1 Fusion-Positive Cancers.
J Thorac Oncol
; 16(7): 1149-1165, 2021 07.
Article
in English
| MEDLINE | ID: mdl-33839363
8.
The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions.
Clin Cancer Res
; 27(11): 3154-3166, 2021 06 01.
Article
in English
| MEDLINE | ID: mdl-33824166
9.
Therapeutic Potential of NTRK3 Inhibition in Desmoplastic Small Round Cell Tumor.
Clin Cancer Res
; 27(4): 1184-1194, 2021 02 15.
Article
in English
| MEDLINE | ID: mdl-33229458
10.
Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity.
Cancer Cell
; 39(7): 973-988.e9, 2021 07 12.
Article
in English
| MEDLINE | ID: mdl-34115989
11.
NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors.
Commun Biol
; 3(1): 776, 2020 12 16.
Article
in English
| MEDLINE | ID: mdl-33328556
12.
RET inhibition in novel patient-derived models of RET-fusion positive lung adenocarcinoma reveals a role for MYC upregulation.
Dis Model Mech
; 2020 Dec 14.
Article
in English
| MEDLINE | ID: mdl-33318047
13.
A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries.
Cancers (Basel)
; 12(6)2020 Jun 17.
Article
in English
| MEDLINE | ID: mdl-32560455
14.
HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers.
Cancer Discov
; 10(5): 674-687, 2020 05.
Article
in English
| MEDLINE | ID: mdl-32213539
15.
Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14-mutant Non-small Cell Lung Cancer.
Clin Cancer Res
; 25(4): 1248-1260, 2019 02 15.
Article
in English
| MEDLINE | ID: mdl-30352902
16.
Author Correction: Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations.
Nat Cancer
; 4(10): 1526, 2023 Oct.
Article
in English
| MEDLINE | ID: mdl-37814012
17.
Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis.
Cancer Cell
; 31(2): 286-299, 2017 02 13.
Article
in English
| MEDLINE | ID: mdl-28196596
18.
Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors.
Cancer Res
; 76(15): 4525-34, 2016 08 01.
Article
in English
| MEDLINE | ID: mdl-27256563
19.
Loss of BAP1 function leads to EZH2-dependent transformation.
Nat Med
; 21(11): 1344-9, 2015 Nov.
Article
in English
| MEDLINE | ID: mdl-26437366
20.
Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status".
Nat Med
; 22(6): 578-9, 2016 06 07.
Article
in English
| MEDLINE | ID: mdl-27270773