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1.

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT_2A Serotonin Receptor.

Kim, Kuglae; Che, Tao; Panova, Ouliana; DiBerto, Jeffrey F; Lyu, Jiankun; Krumm, Brian E; Wacker, Daniel; Robertson, Michael J; Seven, Alpay B; Nichols, David E; Shoichet, Brian K; Skiniotis, Georgios; Roth, Bryan L.

Cell ; 182(6): 1574-1588.e19, 2020 09 17.

Article in English | MEDLINE | ID: mdl-32946782

2.

Bespoke library docking for 5-HT_2A receptor agonists with antidepressant activity.

Kaplan, Anat Levit; Confair, Danielle N; Kim, Kuglae; Barros-Álvarez, Ximena; Rodriguiz, Ramona M; Yang, Ying; Kweon, Oh Sang; Che, Tao; McCorvy, John D; Kamber, David N; Phelan, James P; Martins, Luan Carvalho; Pogorelov, Vladimir M; DiBerto, Jeffrey F; Slocum, Samuel T; Huang, Xi-Ping; Kumar, Jain Manish; Robertson, Michael J; Panova, Ouliana; Seven, Alpay B; Wetsel, Autumn Q; Wetsel, William C; Irwin, John J; Skiniotis, Georgios; Shoichet, Brian K; Roth, Bryan L; Ellman, Jonathan A.

Nature ; 610(7932): 582-591, 2022 10.

Article in English | MEDLINE | ID: mdl-36171289

3.

Structure, function and pharmacology of human itch GPCRs.

Cao, Can; Kang, Hye Jin; Singh, Isha; Chen, He; Zhang, Chengwei; Ye, Wenlei; Hayes, Byron W; Liu, Jing; Gumpper, Ryan H; Bender, Brian J; Slocum, Samuel T; Krumm, Brian E; Lansu, Katherine; McCorvy, John D; Kroeze, Wesley K; English, Justin G; DiBerto, Jeffrey F; Olsen, Reid H J; Huang, Xi-Ping; Zhang, Shicheng; Liu, Yongfeng; Kim, Kuglae; Karpiak, Joel; Jan, Lily Y; Abraham, Soman N; Jin, Jian; Shoichet, Brian K; Fay, Jonathan F; Roth, Bryan L.

Nature ; 600(7887): 170-175, 2021 12.

Article in English | MEDLINE | ID: mdl-34789874

4.

Constitutive activation of T cells by Î³2-herpesviral GPCR through the interaction with cellular CXCR4.

Kwon, Eun-Kyung; Min, Chan-Ki; Kim, Yuri; Lee, Jae-Won; Aigerim, Abdimadiyeva; Schmidt, Sebastian; Nam, Hyun-Jun; Han, Seong Kyu; Kim, Kuglae; Cha, Jeong Seok; Kim, Hoyoung; Kim, Sanguk; Cho, Hyun-Soo; Choi, Myung-Sik; Cho, Nam-Hyuk.

Biochim Biophys Acta Mol Cell Res ; 1864(1): 1-11, 2017 Jan.

Article in English | MEDLINE | ID: mdl-27751885

5.

Monomerization and ER Relocalization of GRASP Is a Requisite for Unconventional Secretion of CFTR.

Kim, Jiyoon; Noh, Shin Hye; Piao, He; Kim, Dong Hee; Kim, Kuglae; Cha, Jeong Seok; Chung, Woo Young; Cho, Hyun-Soo; Kim, Joo Young; Lee, Min Goo.

Traffic ; 17(7): 733-53, 2016 07.

Article in English | MEDLINE | ID: mdl-27062250

6.

Crystal structure of GSK3ß in complex with the flavonoid, morin.

Kim, Kuglae; Cha, Jeong Seok; Kim, Jin-Sik; Ahn, Jinsook; Ha, Nam-Chul; Cho, Hyun-Soo.

Biochem Biophys Res Commun ; 504(2): 519-524, 2018 10 02.

Article in English | MEDLINE | ID: mdl-30197003

7.

A missense allele of KARRIKIN-INSENSITIVE2 impairs ligand-binding and downstream signaling in Arabidopsis thaliana.

Lee, Inhye; Kim, Kuglae; Lee, Sumin; Lee, Seungjun; Hwang, Eunjin; Shin, Kihye; Kim, Dayoung; Choi, Jungki; Choi, Hyunmo; Cha, Jeong Seok; Kim, Hoyoung; Lee, Rin-A; Jeong, Suyeong; Kim, Jeongsik; Kim, Yumi; Nam, Hong Gil; Park, Soon-Ki; Cho, Hyun-Soo; Soh, Moon-Soo.

J Exp Bot ; 69(15): 3609-3623, 2018 06 27.

Article in English | MEDLINE | ID: mdl-29722815

8.

Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation.

Jeong, Sun Ah; Kim, Kuglae; Lee, Ji Hoon; Cha, Jeong Seok; Khadka, Prabhat; Cho, Hyun-Soo; Chung, In Kwon.

J Cell Sci ; 128(12): 2287-301, 2015 Jun 15.

Article in English | MEDLINE | ID: mdl-25999477

9.

Solution structure of the transmembrane 2 domain of the human melanocortin-4 receptor in sodium dodecyl sulfate (SDS) micelles and the functional implication of the D90N mutant.

Yun, Ji-Hye; Kim, Minsup; Kim, Kuglae; Lee, Dongju; Jung, Youngjin; Oh, Daeseok; Ko, Yoon-Joo; Cho, Art E; Cho, Hyun-Soo; Lee, Weontae.

Biochim Biophys Acta ; 1848(6): 1294-302, 2015 Jun.

Article in English | MEDLINE | ID: mdl-25753114

10.

In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates.

Yang, Gyongseon; Zhu, Wei; Kim, Kuglae; Byun, Soo Young; Choi, Gahee; Wang, Ke; Cha, Jeong Seok; Cho, Hyun-Soo; Oldfield, Eric; No, Joo Hwan.

Antimicrob Agents Chemother ; 59(12): 7530-9, 2015 Dec.

Article in English | MEDLINE | ID: mdl-26392508

11.

Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.

Yun, Ji-Hye; Kim, Kuglae; Jung, Youngjin; Park, Jae-Hyun; Cho, Hyun-Soo; Lee, Weontae.

Biochem Biophys Res Commun ; 456(1): 116-21, 2015 Jan 02.

Article in English | MEDLINE | ID: mdl-25446108

12.

The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor.

Cho, Yong-Soon; Kang, Yingjin; Kim, Kuglae; Cha, Young-Je; Cho, Hyun-Soo.

Biochem Biophys Res Commun ; 447(1): 7-11, 2014 Apr 25.

Article in English | MEDLINE | ID: mdl-24657156

13.

Constitutive activation mechanism of a class C GPCR.

Shin, Jinwoo; Park, Junhyeon; Jeong, Jieun; Lam, Jordy Homing; Qiu, Xingyu; Wu, Di; Kim, Kuglae; Lee, Joo-Youn; Robinson, Carol V; Hyun, Jaekyung; Katritch, Vsevolod; Kim, Kwang Pyo; Cho, Yunje.

Nat Struct Mol Biol ; 31(4): 678-687, 2024 Apr.

Article in English | MEDLINE | ID: mdl-38332368

14.

AlphaFold2 structures template ligand discovery.

Lyu, Jiankun; Kapolka, Nicholas; Gumpper, Ryan; Alon, Assaf; Wang, Liang; Jain, Manish K; Barros-Álvarez, Ximena; Sakamoto, Kensuke; Kim, Yoojoong; DiBerto, Jeffrey; Kim, Kuglae; Tummino, Tia A; Huang, Sijie; Irwin, John J; Tarkhanova, Olga O; Moroz, Yurii; Skiniotis, Georgios; Kruse, Andrew C; Shoichet, Brian K; Roth, Bryan L.

bioRxiv ; 2024 Mar 13.

Article in English | MEDLINE | ID: mdl-38187536

15.

AlphaFold2 structures guide prospective ligand discovery.

Lyu, Jiankun; Kapolka, Nicholas; Gumpper, Ryan; Alon, Assaf; Wang, Liang; Jain, Manish K; Barros-Álvarez, Ximena; Sakamoto, Kensuke; Kim, Yoojoong; DiBerto, Jeffrey; Kim, Kuglae; Glenn, Isabella S; Tummino, Tia A; Huang, Sijie; Irwin, John J; Tarkhanova, Olga O; Moroz, Yurii; Skiniotis, Georgios; Kruse, Andrew C; Shoichet, Brian K; Roth, Bryan L.

Science ; : eadn6354, 2024 May 16.

Article in English | MEDLINE | ID: mdl-38753765

16.

Structural basis for the inhibition of human lysozyme by PliC from Brucella abortus.

Um, Si-Hyeon; Kim, Jin-Sik; Kim, Kuglae; Kim, Nahee; Cho, Hyun-Soo; Ha, Nam-Chul.

Biochemistry ; 52(51): 9385-93, 2013 Dec 23.

Article in English | MEDLINE | ID: mdl-24308818

17.

Structural studies of serotonin receptor family.

Parajulee, Apeksha; Kim, Kuglae.

BMB Rep ; 56(10): 527-536, 2023 Oct.

Article in English | MEDLINE | ID: mdl-37817438

18.

Molecular mechanism of biased signaling at the kappa opioid receptor.

El Daibani, Amal; Paggi, Joseph M; Kim, Kuglae; Laloudakis, Yianni D; Popov, Petr; Bernhard, Sarah M; Krumm, Brian E; Olsen, Reid H J; Diberto, Jeffrey; Carroll, F Ivy; Katritch, Vsevolod; Wünsch, Bernhard; Dror, Ron O; Che, Tao.

Nat Commun ; 14(1): 1338, 2023 03 11.

Article in English | MEDLINE | ID: mdl-36906681

19.

Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation.

Jeong, Sun Ah; Kim, Kuglae; Lee, Ji Hoon; Cha, Jeong Seok; Khadka, Prabhat; Cho, Hyun-Soo; Chung, In Kwon.

J Cell Sci ; 128(15): 2951, 2015 Aug 01.

Article in English | MEDLINE | ID: mdl-26240165

20.

Inactive and active state structures template selective tools for the human 5-HT_5A receptor.

Zhang, Shicheng; Chen, He; Zhang, Chengwei; Yang, Ying; Popov, Petr; Liu, Jing; Krumm, Brian E; Cao, Can; Kim, Kuglae; Xiong, Yan; Katritch, Vsevolod; Shoichet, Brian K; Jin, Jian; Fay, Jonathan F; Roth, Bryan L.

Nat Struct Mol Biol ; 29(7): 677-687, 2022 07.

Article in English | MEDLINE | ID: mdl-35835867

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Structure of a Hallucinogen-Activated Gq-Coupled 5-HT_2A Serotonin Receptor.

Bespoke library docking for 5-HT_2A receptor agonists with antidepressant activity.

Structure, function and pharmacology of human itch GPCRs.

Constitutive activation of T cells by Î³2-herpesviral GPCR through the interaction with cellular CXCR4.

Monomerization and ER Relocalization of GRASP Is a Requisite for Unconventional Secretion of CFTR.

Crystal structure of GSK3ß in complex with the flavonoid, morin.

A missense allele of KARRIKIN-INSENSITIVE2 impairs ligand-binding and downstream signaling in Arabidopsis thaliana.

Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation.

Solution structure of the transmembrane 2 domain of the human melanocortin-4 receptor in sodium dodecyl sulfate (SDS) micelles and the functional implication of the D90N mutant.

In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates.

Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.

The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor.

Constitutive activation mechanism of a class C GPCR.

AlphaFold2 structures template ligand discovery.

AlphaFold2 structures guide prospective ligand discovery.

Structural basis for the inhibition of human lysozyme by PliC from Brucella abortus.

Structural studies of serotonin receptor family.

Molecular mechanism of biased signaling at the kappa opioid receptor.

Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation.

Inactive and active state structures template selective tools for the human 5-HT_5A receptor.