[Biodegradable screw versus a press-fit bone plug fixation for ACL reconstruction: a prospective randomized study]. / Biodegradierbare Schraube vs. einer Press-fit-Verankerung für VKB-Rekonstruktionen : Eine prospektive randomisierte Studie.

BACKGROUND: Press-fit fixation of a tendon graft has been advocated in order to achieve tendon to bone healing. HYPOTHESIS: Fixation of a tendon graft with a porous bone scaffold limits bone tunnel enlargement compared with a biodegradable interference screw fixation. METHODS: Between 2005 and 2006, 20 patients (17 men, 3 women) were enrolled in this study for primary reconstruction of the ACL. Patients were randomized to either obtain graft fixation in the tibial tunnel by means of an interference screw (I) or a press-fit fixation with a porous bone cylinder (P). Three months after surgery, a CT scan of the knee was performed and tunnel enlargement was analysed in the coronal and sagittal planes for the proximal, middle and distal thirds of the tunnel. After 6 months, 1 and 2 years, International Knee Documentation Committee (IKDC), Tegner and Lysholm scores of both groups were compared. RESULTS: The bone tunnel enlargement was 106.9±10.9% for group P and 121.9±9.0% for group I (P<0.02) in the AP plane and 102.8±15.2% vs 121.5±10.1% in the coronal plane (P<0.01). IKDC, Tegner, and Lysholm scores improved in both groups from pre- to postoperative assessment without significant differences between the two groups. There was a trend to higher knee stability in group P after 3 months (0.6±1.4 mm vs 1.81±.5 mm, P=0.08). CONCLUSIONS: Both interference screw and a press-fit fixation lead to a high number of good or very good outcomes after ACL reconstruction. Tibial press-fit fixation decreases the amount of proximal bone tunnel enlargement. Press-fit fixation decreases the amount of proximal bone tunnel enlargement and improves bone to tendon contact.

Proprioceptive elbow training reduces pain and improves function in painful lateral epicondylitis-a prospective trial.

BACKGROUND: In painful epicondylitis, previous studies reported deficiencies in elbow proprioception. In line, proprioceptive training of the lower limb has been reported substantial beneficial in a number of indications. Therefore, we have asked if a specified proprioceptive training using training devices that are capable of activating the deep musculature in the upper limb is able to reduce the symptoms of epicondylitis. MATERIALS AND METHODS: We included 71 patients with painful lateral epicondylitis > 3 months. INTERVENTIONS: Group A: Proprioceptive training intervention with a Flexibar® (9 min daily for 12 weeks). Group B: at least 40 min running or walking/week with the XCO® in addition to the proprioceptive training with the Flexibar® (9 min daily for 12 weeks), follow-up for 12 weeks. Primary end point: Pain on visual analogue scale (VAS, 0-10); secondary end points: DASH-Score (0 = very good, 100 = very poor), grip strength according to Jamar dynamometer (kg), vibration sensation measured with a 128 Hz tuning fork. RESULTS: The pain on VAS in group A was reduced significantly. 3.6 ± 2.0 to 2.4 ± 2.1 (-33%, p = 0.013), and from 3.7 ± 2.4 to 2.2 ± 1.9 (-41%, p = 0.004) in group B after 12 weeks. There was no significant difference between A and B (p = 0.899). In both groups, there was a significant improvement of the DASH-Score (A: 32 ± 15 to 14 ± 12, -56%, p < 0.001; B: 27 ± 12 to 12 ± 11, -55%, p = 0.001) without any difference between groups A and B (p = 0.339). Grip strength improvement in group A from 24 ± 12 to 33 ± 11 kg (+38%, p < 0.001), and from 29 ± 14 to 34 ± 11 kg (+15%, p < 0.001) in group B. In line, vibration sensation improved in both groups (A: 6.3 ± 0.6 to 6.5 ± 0.5, p = 0.0001; B: 6.3 ± 0.7 to 6.6 ± 0.5, p = 0.003). CONCLUSION: A 12-week proprioceptive training with the Flexibar® improves pain, quality of life, grip strength and vibration sensation in patients with painful lateral epicondylitis. LEVEL OF EVIDENCE: Ib, randomised clinical trial TRIAL REGISTRATION: German Clinical Trials Register, DRKS00024857 , registered on 25 March 2021-retrospectively registered, http://apps.who.int/trialsearch/.

MRI-based breast volumetry-evaluation of three different software solutions.

As lipofilling of the female breast is becoming more popular in plastic surgery, the use of MRI to assess breast volume has been employed to control postoperative results. Therefore, we sought to evaluate the accuracy of magnetic resonance imaging (MRI)-based breast volumetry software tools by comparing the measurements of silicone implant augmented breasts with the actual implant volume specified by the manufacturer. MRI-based volume analysis was performed in eight bilaterally augmented patients (46 ± 9 years) with three different software programs (Brainlab© I plan 2.6 neuronavigation software; mass analysis, version 5.3, Medis©; and OsiriX© v.3.0.2. 32-bit). The implant volumes analysed by the BrainLab© software had a mean deviation of 2.2 ± 1.7% (r = 0.99) relative to the implanted prosthesis. OsiriX© software analysis resulted in a mean deviation of 2.8 ± 3.0% (r = 0.99) and the Medis© software had a mean deviation of 3.1 ± 3.0% (r = 0.99). Overall, the volumes of all analysed breast implants correlated very well with the real implant volumes. Processing time was 10 min per breast with each system and 30 s (OsiriX©) to 5 min (BrainLab© and Medis©) per silicone implant. MRI-based volumetry is a powerful tool to calculate both native breast and silicone implant volume in situ. All software solutions performed well and the measurements were close to the actual implant sizes. The use of MRI breast volumetry may be helpful in: (1) planning reconstructive and aesthetic surgery of asymmetric breasts, (2) calculating implant size in patients with missing documentation of a previously implanted device and (3) assessing post-operative results objectively.

[Conservative treatment of Achilles tendinopathy]. / Konservative Behandlung der Achillestendinopathie.

Hind foot tendinopathies mainly involve the Achilles tendon. Color and Power-Doppler ultrasound visualizes pathological neovessels in painful tendons, which are associated with pain mediating nerve fibres. These neovessels are characterized by an increased capillary blood flow at the point of pain. Painful eccentric training can significantly reduce pain and improve function in Achilles tendinopathy (evidence level Ib). Shock wave therapy in combination with eccentric training is superior to eccentric training alone (evidence level Ib). Long-term results suggest a collagen induction and reduced pain following topical application of glyceryl trinitrate (NO) (evidence level Ib). Color and Power-Doppler-guided sclerosing therapy using polidocanol reduces pain, improves function and may lead to tendon remodeling (evidence level Ib). Pain-restricted sport up to a visual analogue scale (VAS) score 5/10 during therapy is recommended (evidence level Ib). Cryotherapy sessions of 3-times 10 min of reduce pain and capillary blood flow (evidence level Ib). The role of proprioceptive training in tendinopathy has to be determined in future trials (evidence level II). Anecdotical treatment of hindfoot tendinopathies has been replaced by evidence-based recommendations.

[Organ transplantation, composite tissue allotransplantation, and plastic surgery]. / Organtransplantation, Gewebetransplantation und plastische Chirurgie.

Transplantations play an increasing role for plastic reconstructive surgeons. The increasing number of solid organ transplantations and the improved long-term survival rates lead to increased numbers of these patients also undergoing plastic and reconstructive procedures. Free flap transfer in solid organ transplant patients is feasible with no higher risk to both transplant function and postoperative complications than for nontransplant patients, even during immune suppression. Composite tissue allotransplantation (CTA) is an evolving field in plastic reconstructive surgery with hands, arms, partial faces, abdominal walls, and knee joints being transferred in clinical settings. However only an interdisciplinary approach using all available resources in highly selected patients after exhausting all other plastic reconstructive procedures is able to achieve reasonable results. The potential complications of long-term immune suppression and patient compliance have to be balanced with the expected and achieved functional result of CTA, whose procedures must be discussed as a potential tissue or organ transplantation, given the legal and logistic implications. The interdisciplinary cooperation of transplant surgeons, microsurgeons, psychologists, and ergo- and physiotherapists is mandatory to achieve successful CTA results.

[Nicotine in plastic surgery : a review]. / Nikotinkonsum und plastische Chirurgie : Eine aktuelle Ubersicht.

BACKGROUND: The surgical complication rate is significantly increased in active smoking patients. However there are no evidence-based recommendations regarding smoking among patients seeking plastic surgical procedures. METHODS: MEDLINE analysis was performed of all relevant clinical and experimental papers from 1965 to 2008. RESULTS: In face-lift operations smokers present a 13-fold risk of skin necrosis. In mamma reduction procedures the risk among smokers is doubled for number of complications, with T-incision site necrosis (odds ratio 3.1) and infection rate (OR 3.3) significantly elevated among active smokers. Transverse rectus abdominis myocutaneous flaps for breast reconstruction are associated with significantly higher flap necrosis rates for smokers than nonsmokers (19% vs 9%, P=0.005). The smoking history can be indicative, but usually the number of cigarettes is drastically underestimated. Cotinine testing is a method of determining smoking quantitatively up to 4 days before testing. CONCLUSION: Four weeks of abstinence from smoking reduces smoking-associated complications. Despite the published evidence, smoking is no longer relevant in the German 2008 Disease-Related Group for plastic surgical procedures.

[200 - 400 m breaststroke event dominate among knee overuse injuries in elite swimming athletes]. / Die 200- bis 400 m-Brustlage dominiert bei Knieüberlastungsschäden im Schwimmsport.

HYPOTHESIS: We hypothesized that pool swimming has a low risk for acute injuries; however overuse injuries are predominant, depending on exposure time and swimming discipline. METHODS: 341 elite swimmers (19 +/- 11 years, BMI 20.3 +/- 3) were enrolled. Swimming was performed at mean since 10.1 +/- 8 years with 3.8 units every week during 43 weeks every year. RESULTS: The overall pool swimming injury rate was 0.39 / 1000 h. Overuse injuries (0.22 / 1000 h) were more frequent than acute injuries (0.17 / 1000 h). The upper extremity was involved more frequently (0.11 / 1000 h) than the trunk (0.067 / 1000 h) or the lower extremity (0.085 / 1000 h). Knee pain was predominant (0.17 / 1000 h) followed by shoulder overuse injuries (0.11 / 1000 h). Especially the 200 - 400 m breaststroke event had a fivefold higher risk for knee pain (relative risk, RR 5.1, p = 0.001). Freestyle had a reduced relative risk for knee pain (RR 0.5, p = 0.03), where shoulder overuse syndromes were predominant. Butterfly increased acute shoulder injury with RR 4.4 (p = 0.004), cervical spine injuries (RR 4.0, p = 0.03) and lower back pain (RR 2.5, p = 0.011). Swimming for more than four times a week had a higher risk for knee injuries (RR 2.1) and shoulder injuries (RR 4.0). We found that stretching was associated with a fivefold reduced risk for overuse knee injuries. CONCLUSION: Competitive swimming is a reasonable safe sport, where overuse injuries are predominant. 200 - 400 m breaststroke events increase the risk for knee overuse injuries more than other disciplines. Training for more than four times a week increases the risk twofold for knee and fourfold for shoulder overuse injuries.

[C-type scaphoid fracture in a elite power lifting]. / Scaphoidfraktur vom Typ C bei einem Elite-Kraftsportler.

Power lifting injuries most often involve shoulder injuries with an injury rate of 0.57 to 0.71/1000 hours of power lifting. Wrist injuries are less common in power lifters with 0.05/1000 hours exposure vs. 0.23/1000 h in elite weight lifting men. Often, two contributing factors causing wrist injuries are encountered: a) loss of balance causing the barbell to drift back behind the head of the power lifter, which hyperextends the wrist and b) the maximal weight. We report on an elite power lifting athlete preparing for the World Masters Bench press championships suffering two months of persisting pain during bench press exercise and rest in the snuff-box area following a loss of balance of the bar-bell during bench press with 280 kg load. Following prolonged presentation 2 months after the initial injury with training in the meantime, CT-scan was performed revealing a C-type scaphoid fracture. Surgery was performed as Herbert screw fixation and bone grafting according to the technique of Matti-Russe, followed by an immobilisation of twelve weeks with a plaster. We recommended ending the athletes' power lifting career, however he further exercised with the plaster with consecutive re-operation 3months later and 2nd Matti-Russe and Herbert screw re-do. One year later he became national champion with 240 kg bench pressing. Given the limited scaphoid blood supply and the high complication rate especially among C-type scaphoid fractures, a surgical procedure with bone grafting, Herbert screw fixation and sufficient plaster immobilisation is advocated in scaphoid fractures in elite athletes.

[Innovative wound therapy and skin substitutes for burns]. / Innovative Wundtherapie und Hautersatz bei Verbrennungen.

The success of modern burn therapy is based mainly on special burn intensive care, topical treatment, early eschar excision, and wound closure by immediate skin grafting or skin substitutes. This paper describes the current state of wound care and skin substitutes in burn therapy.

[Hirudo medicinalis-leech applications in plastic and reconstructive microsurgery--a literature review]. / Hirudo medicinalis-Anwendungen in der plastischen und rekonstruktiven Mikrochirurgie--eine Literaturübersicht.

Medical leech therapy has enjoyed a renaissance in the world of reconstructive microsurgery during recent years. Especially venous congestion is decreased using hirudo medicinalis application such as following replantation of amputated fingers or congested flaps. They provide a temporary relief to venous engorgement whilst venous drainage is re-established. Living in symbiosis with Aeromonas hydrophila, who can digest the sixfold blood meal related to their body weight, and a broad number of anticoagulant agents such as the thrombin inhibitor hirudin, apyrase as well as collagenase, hyaluronidase, Factor Xa inhibitor and fibrinase I and II, leeches decrease venous congestion. Laser Doppler flowmetry could demonstrate a significant increase in superficial skin perfusion following leech application 16 mm around the biting zone. Following the initial blood meal accounting for about 2.5 ml, the anticoagulant effect of the various leeches enzymes follows within the next 5-6 hours, which both account for the beneficial effects. Infection associated with leech therapy is a documented complication of leech application, with reported incidences ranging from 2.4 to 20 % and a chinolone antibiotic is currently recommended to face the potential Aeromonas hydrophila infection. Anemia is a second adverse effect during medicinal leech application which has to be taken account with repetitive blood samples. Besides the successful applications of leeches in various applications in plastic and reconstructive microsurgery, randomized-controlled trials are pending to elucidate the value of hirudo medicinalis according to evidence-based criteria above from case series and case studies.

[Achilles tendon rupture--early functional and surgical options with special emphasis on rehabilitation issues]. / Frühfunktionell konservative und operative Behandlungsmöglichkeiten sowie Rehabilitationsoptionen bei der Achillessehnenruptur.

Achilles tendon ruptures are one end of a continuum starting with the healthy Achilles tendon via the thickened and painful tendinopathic Achilles tendon with neovascularisation to the complete tendon rupture. Often times chinolone antibiotics, cortisone therapy and valgus foot axis are associated risk factors. Incidence of Achilles tendon ruptures is estimated to be 10/100 000 per year with a mean age of 35-40 years. Physical activity is encountered in 75 % cases of Achilles tendon ruptures. Running is associated with Achilles tendinopathy as the predominant overuse injury in an analysis among 291 athletes with 10 million kilometers exposure. The Achilles tendinopathic rate was 0.016/1000 km differentiated in 0.008/1000 km mid-portion tendinopathy and 0.005/1000 km insertional tendinopathy. Achilles tendinopathy in running overuse injuries is followed by runner's knee (0.013/1000 km), shin splint (0.0104/1000 km) and plantar fasciitis (0.0054/1000 km). Dynamic ultrasound in 20 degrees plantar flexion is of utmost importance for therapeutic decision making. With an adaptation rate of 75 % or more of the ruptured tendon in 20 degrees plantar flexion and a high patient's compliance we perform an early functional conservative treatment regimen in Achilles tendon ruptures. In almost all other cases the percutaneous Achilles tendon repair is indicated, where nervus suralis lesions have to be appreciated. The vulnerable zone is 10-12 cm proximal to the calcaneus at the lateral border of the Achilles tendon with the sural nerve in close proximity with the tendon. Early functional rehabilitation is not associated with a higher risk of rerupture but with improved subjective assessments and should therefore be advocated.

[Avulsion injuries of the anterior inferior iliac spine among soccer players--a differential diagnosis to neoplasm decades following the trauma]. / Avulsionsverletzungen der Spina iliaca anterior inferior bei Fussballern - eine Differenzialdiagnose zum Neoplasma Jahrzehnte nach einem Trauma.

Pelvic apophyseal injuries typically involve adolescents, ranging gradually from apophysitis as a chronic traction injury to avulsion fractures after a sudden contraction of a muscle to the immature musculo-skeleton adolescent. While avulsion fractures to the anterior superior iliac spine, the iliac crest and the pubic bone are common, injuries to the anterior inferior iliac spine (AIIS) are only rarely encountered. We report on two 42 and 43-year old male soccer players complaining of groin pain. Both had AIIS avulsion fractures diagnosed by conventional plain x-ray of the pelvis, ultrasound and magnetic resonance imaging. One patient had an acute adductor longus muscle injury with concomitant asymptomatic AIIS avulsion fracture. Conservative treatment of the muscle injury with initial RICE therapy followed by pain-restricted jogging brought him back to sport within four weeks. The other patient had local tenderness and exercise pain at AIIS with a large exostosis on imaging studies mimicking a pseudotumor. Surgical resection was applied and the rectus femoris muscle was reattached. After three months of intensive physical therapy he could be return to sport. Avulsion fractures of the AIIS may cause persistent pain syndrome and mimic a pseudotumor decades after the initial trauma, which can be treated by surgical resection and reattachment of the rectus femoris muscle with good results. Conservative treatment for minor dislocated AIIS avulsion fractures can be effective in sportsmen. Differential diagnosis often involves bony tumors, so patient's soccer history gives important information regarding past avulsion fractures of the pelvis, which often occur during kicking in the adolescence.

[Nordic pole walking injuries--nordic walking thumb as novel injury entity]. / Nordic Walking Verletzungen--Der Nordic-Walking-Daumen als neue Verletzungsentität.

BACKGROUND: Nordic pole Walking (NW) as trend sport is associated with beneficial effects on the cardiovascular system. Data regarding the injury and overload injury rates are pending. METHODS: 137 athletes (74 % females, 53 +/- 12 years, weight 73 +/- 13 kg, height 169 +/- 11 cm) were prospectively ask using a two-sided questionnaire. Mean NW experience was 212.8 weeks with 2.9 +/- 1.8 hours/week. The overall exposure was 29 160 h. RESULTS: NW injury rate was 0.926/1000 h. Falls were evident in 0.24/1000 h. The upper extremity was involved more frequently (0.549/1000 h) than the lower extremity (0.344/1000 h). The most severe injury was a concomitant shoulder dislocation and luxation of the proximal interphalangeal joint of the index finger after a fall. The most frequent injury in NW was a distorsion of the ulnar collateral ligament of the thumb (0.206/1000 h) after fall. Shoulder injuries account for 0.171/1000 h with 0.069/1000 h shoulder dislocations. Distal radius fractures were rare as ankle sprains and shinspints (0.034/1000 h). Muscle injuries were encountered only at the gastrocnemius muscle (0.137/1000 h). No knee ligament injuries were noted. In 5%, NW injuries caused interruption of the performance, with all patients returning to sport within 4 weeks on the same level as before. DISCUSSION: Nordic Walking is safe. Most frequently, a Nordic walking thumb is encountered during a fall with the athlete holding on to the NW pole until the very last moment before the hand hits the ground with the pole handle as hypomochlium that forces the thumb into abduction and extension. Modifications of the grip construction as well as information of the athlete and behaviour changes may be preventive measures.

[Gymnastic school sport injuries--aspects of preventive measures]. / Turnunfälle im Schulsport -- Ansätze für präventive Massnahmen.

INTRODUCTION: Gymnastic school sport injuries account for a significant morbidity and mortality among children and adolescents. Preventive issues may be derived from a thorough in-depth analysis of the pattern and circumstances of gymnastic injuries. METHODS: During a school year among 3993 schools in 43 889 classes with 993 056 pupils 2234 school sport injuries have been reported to the Gemeinde Unfall Versicherung (GUV) Niedersachsen, Germany. RESULTS: Gymnastic sport injuries account for 18 % (403 accidents), which is second after ball sports injuries. Regarding the distribution of the gymnastic disciplines, vault was the major discipline with 34 %, followed by floor exercise (21.3 %), mini- and competition trampoline (16.8 %), and parallel bars (8.2 %). The analysis of the type of injury during vault accidents revealed contusion (31 %) as the predominant injury, followed by sprains (15.4 %), and fractures (15.4 %). Floor exercise injuries distributed among distorsions (26.7 %), contusions (18.6 %), muscle tears (14 %). Back injuries especially of the cervical and thoracic spine, accounted for 40 % of all their injuries. Minor head injuries account for 4.7 % of all floor exercise injuries. Mini-trampoline injuries distribute among contusions (30 %), fractures (22.5 %), distorsions (7.5 %). 21.8 % collisions were noted against a box in comparison to 6.8 % in case of the horse. CONCLUSION: Gymnast injuries account for a significant number of all school sport related injuries. Vault and floor exercise account for the vast majority of all injuries, with alarming high numbers of spine injuries during floor exercise and mini-trampoline. A preservation of a high level of attention during a sport lesson, safety measures including appropriate mats and landing zones are mandatory to reduce injuries. Muscle injuries and ankle sprains can be prevented by a prospective proprioceptive training intervention to be implemented in school sports.

[Prospective proprioceptive and coordinative training for injury reduction in elite female soccer]. / Prospektives Propriozeptions- und Koordinationstraining zur Verletzungsreduktion im professionellen Frauenfussballsport.

PURPOSE: Does a prospective proprioceptive-coordinative additional training intervention in elite female soccer changes frequency and pattern of injuries? MATERIALS AND METHODS: 24 female soccer players of the German first division team of FC Bayern München were thoroughly supervised during the season 2003/04 regarding injuries resulting in an absence from at least one scheduled training session or game. During the winter break an additional proprioceptive-coordinative training program was initiated, which was performed on a regular basis during the second half of the season. Furthermore, we evaluated jump&reach, throwing power, coordinative skills, and flexibility. RESULTS: All evaluated fitness results increased significantly during the season after the training intervention, such as jump&reach 44 +/- 4 cm vs. 38 +/- 10 cm (p < 0.05), coordinative power left and right leg, respectively (71 +/- 44 s vs. 45 +/- 37 s, 80 +/- 41 s vs. 50 +/- 32 s, both p < 0.05), flexibility left and right hip (89 +/- 8 degrees vs. 78 +/- 13 degrees and 88 +/- 9 degrees vs. 79 +/- 10 degrees, p < 0.05). Comparing the 1st to the 2nd half of the season, 25 vs. 26 injuries after foulplay and 69 vs. 52 without contact occur (p < 0.05). Muscle injuries resulting in game or training absence were significantly reduced by 400% (12 vs. 3, p < 0.05). In the 1st half of the season, 2 anterior cruciate ruptures (ACL) occur vs. none in the 2nd half after the training intervention. CONCLUSION: An additional proprioceptive-coordinative training intervention increases coordinative abilities, jump power, throwing power, and flexibility during a half season. After initiation of the proprioceptive-coordinative training the incidence of muscle injuries resulting in an absence of at least one game or practice session was reduced significantly by 400 %. Regarding the reduced incidence of ACL injuries after proprioceptive-coordinative training in female elite soccer players, further studies have to be performed to elucidate the value of this training intervention.

[Prevention of school sport injuries--an analysis of ballsports with 2234 injuries]. / Prävention von Schulsportverletzungen -- Analyse von Ballsportarten bei 2234 Verletzungen.

PURPOSE: Ball sport school injuries account for a significant morbidity among children and adolescents. MATERIALS AND METHODS: During a school year 2234 school sport injuries have been reported to the Gemeinde Unfall Versicherung (GUV) Niedersachsen, Germany. RESULTS: Regarding the non-gender-specific distribution of the ball sport disciplines, basketball leads with 32 % (n = 431), followed by soccer (24 %, n = 316), volleyball (17 %, n = 232), handball (8.3 %, n = 110) and hockey (4.9 %, n = 65). Sprains (27 %) dominate in basketball, followed by ligament distorsions and ruptures (23 %) and fractures (21 %), with frequent finger injuries (61 %) without contact of an opponent, and injuries of the lower extremity (28 %). Soccer leads to contusions (29 %), in 52 % of the lower extremity frequently after collision with an opponent (22 %) or the ball (20 %). In volleyball upper extremity injuries (71 %) dominate with 53 % finger sprains in individual volleyball play. CONCLUSION: Ball school sport injuries account for a significant morbidity with frequent finger injuries. Proprioceptive deficits may play a role in those finger injuries in basketball, volleyball and handball. During hockey, severe dental and facial injuries were apparent. A prospective proprioceptive training program aiming on fingers and the ankle region may therefore be a preventive measure such as helmets with facial protection in hockey school sport.

Differential effects of dofetilide, amiodarone, and class lc drugs on left and right atrial refractoriness and left atrial vulnerability in pigs.

OBJECTIVES: Antiarrhythmic drugs have been shown to prolong right atrial refractoriness while data on the left atrium are not available. In pigs we have observed shorter effective refractory periods (ERP) of the left compared with the right atrium associated with a much higher left atrial vulnerability for tachyarrhythmias. Since this could suggest a different distribution of repolarizing ion channels in left and right atrium, we investigated whether antiarrhythmic drugs blocking different ion channels have a differential effect on left and right atrial ERP and left atrial vulnerability. METHODS: In pentobarbital-anesthetized pigs (n=40) we measured and compared ERPs in both atria before and after different drugs with the S1-S2 extrastimulus method at three basic cycle lengths (BCL) and assessed the inducibility of atrial fibrillation/flutter (AF/AFL) by the premature S2 stimulus. RESULTS: At the three BCL tested (240/300/400 ms) baseline ERPs were shorter in left vs. right atrium (112+/-2/124+/-2/129+/-2 ms vs. 147+/-2/163+/-2/167+/-2 ms, P<0.001). Mostly non-sustained AF/AFL induced by the S2 extrastimulus was very frequent in the left (68%) and nearly absent in the right atrium (3%). Only amiodarone, 5 mg/kg i.v., which showed a balanced increase of left and right atrial ERP (29+/-5/33+/-4/35+/-3% vs. 30+/-5/35+/-5/42+/-7%), decreased the inducibility of AF/AFL significantly (-72%, P<0.01). Dofetilide, 10 microg/kg i.v., had a stronger effect on right than left atrial ERP (36+/-4/39+/-5/46+/-10% vs. 23+/-2/22+/-7/22+/-5%, P<0.05), while flecainide, 1 mg/kg i.v., prolonged left more than right atrial ERP (58+/-15/36+/-7/40+/-7% vs. 26+/-5/24+/-5/21+/-4%, P<0.05) similar to 1 mg/ kg of propafenone (46+/-5/45+/-7/32+/-10% vs. 17+/-4/21+/-5/ 25+/-8%, P<0.05). CONCLUSION: The shorter refractoriness of the left compared with the right atrium observed in pigs was associated with a high left atrial vulnerability for tachyarrhythmias, which was reduced only by amiodarone showing a balanced increase of left and right atrial ERP. Dofetilide was stronger on right atrial ERP, flecainide and propafenone on left atrial ERP. These differences suggest a differential distribution of repolarizing ion channels between left and right atrium with possible relevance for the antiarrhythmic efficacy of drugs.