Search details
1.
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
Nature
; 504(7480): 437-40, 2013 Dec 19.
Article
in English
| MEDLINE | ID: mdl-24226772
2.
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings.
Nat Metab
; 6(2): 290-303, 2024 Feb.
Article
in English
| MEDLINE | ID: mdl-38316982
3.
An apoA-I mimetic peptibody generates HDL-like particles and increases alpha-1 HDL subfraction in mice.
J Lipid Res
; 53(4): 643-52, 2012 Apr.
Article
in English
| MEDLINE | ID: mdl-22287724
4.
Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice.
J Pharmacol Exp Ther
; 338(1): 70-81, 2011 Jul.
Article
in English
| MEDLINE | ID: mdl-21471191
5.
GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys.
Cell Rep Med
; 2(5): 100263, 2021 05 18.
Article
in English
| MEDLINE | ID: mdl-34095876
6.
Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor.
Am J Physiol Endocrinol Metab
; 299(4): E624-32, 2010 Oct.
Article
in English
| MEDLINE | ID: mdl-20647556
7.
Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia.
J Pharmacol Exp Ther
; 331(3): 871-81, 2009 Dec.
Article
in English
| MEDLINE | ID: mdl-19720878
8.
Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys.
J Pharmacol Exp Ther
; 329(1): 102-11, 2009 Apr.
Article
in English
| MEDLINE | ID: mdl-19129372
9.
2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.
J Med Chem
; 51(10): 2933-43, 2008 May 22.
Article
in English
| MEDLINE | ID: mdl-18419108
10.
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models.
Sci Transl Med
; 10(472)2018 12 19.
Article
in English
| MEDLINE | ID: mdl-30567927
11.
2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11beta-hydroxysteriod dehydrogenase type 1.
J Med Chem
; 50(3): 429-32, 2007 Feb 08.
Article
in English
| MEDLINE | ID: mdl-17266194
12.
Enhancement of therapeutic protein in vivo activities through glycoengineering.
Nat Biotechnol
; 21(4): 414-21, 2003 Apr.
Article
in English
| MEDLINE | ID: mdl-12612588
13.
Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.
Sci Transl Med
; 9(412)2017 Oct 18.
Article
in English
| MEDLINE | ID: mdl-29046435
14.
5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties.
ACS Med Chem Lett
; 7(7): 666-70, 2016 Jul 14.
Article
in English
| MEDLINE | ID: mdl-27437074
15.
Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394.
ACS Med Chem Lett
; 7(7): 714-8, 2016 Jul 14.
Article
in English
| MEDLINE | ID: mdl-27437083
16.
Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.
Cell Metab
; 21(5): 731-8, 2015 May 05.
Article
in English
| MEDLINE | ID: mdl-25955208
17.
FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/ß-Klotho bispecific protein.
PLoS One
; 8(4): e61432, 2013.
Article
in English
| MEDLINE | ID: mdl-23630589
18.
Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase.
J Med Chem
; 56(24): 10132-41, 2013 Dec 27.
Article
in English
| MEDLINE | ID: mdl-24294923
19.
Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys.
Endocrinology
; 153(9): 4192-203, 2012 Sep.
Article
in English
| MEDLINE | ID: mdl-22798348
20.
Treating diabetes and obesity with an FGF21-mimetic antibody activating the ßKlotho/FGFR1c receptor complex.
Sci Transl Med
; 4(162): 162ra153, 2012 Nov 28.
Article
in English
| MEDLINE | ID: mdl-23197570