Subject(s)
Cell Nucleus/ultrastructure , Odontoblasts/ultrastructure , Animals , Incisor/cytology , RatsSubject(s)
Anesthetics, Local/pharmacology , Central Nervous System/drug effects , Cetylpyridinium/pharmacology , Collagen/pharmacology , Pyridinium Compounds/pharmacology , Pyrrolidines/pharmacology , Uracil/analogs & derivatives , Anesthesia, Dental , Animals , Conditioning, Classical/drug effects , Dose-Response Relationship, Drug , Drug Combinations/pharmacology , Drug Evaluation, Preclinical , Ointments , Rats , Time Factors , Uracil/pharmacologySubject(s)
Anesthetics, Local/toxicity , Cetylpyridinium/toxicity , Collagen/toxicity , Pyridinium Compounds/toxicity , Pyrrolidines/toxicity , Uracil/analogs & derivatives , Anaphylaxis/chemically induced , Anesthetics, Local/immunology , Animals , Cetylpyridinium/immunology , Collagen/immunology , Drug Combinations/immunology , Drug Combinations/toxicity , Guinea Pigs , Lethal Dose 50 , Ointment Bases , Ointments , Pyrrolidines/immunology , Rabbits , Rats , Time Factors , Uracil/immunology , Uracil/toxicitySubject(s)
Acetanilides , Anesthesia, Dental/methods , Anesthetics, Local , Collagen/pharmacology , Trimecaine , Acetanilides/administration & dosage , Anesthetics, Local/administration & dosage , Animals , Delayed-Action Preparations , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Rabbits , Solutions , Trimecaine/administration & dosageABSTRACT
This paper discusses the results of experiments conducted with a view to determining the hidden effects of epoxy composites, which cannot generally be ascertained through the use of various toxicological, biochemical, immunological, allergic, morphological, and cytological methods of examination. To discover possible hidden effects of epoxy filling materials experimental use was made of the following methods: hunger diet, ethylalcohol supply, and composite extract supply. Shifts in functions of the organism were evaluated by the following criteria: weight dynamics of animals, histamine content of the blood, and eosinopenic reaction of the blood. The data obtained by the authors shows that it is possible for functional straining to be used as a method of discovering possible hidden harmful effects of dental polymers.