[Diagnostic algorithm in patients with cervical metastasis of malignant tumours unknown primary location].

Carcinoma of unknown primary location are heterogeneous group of metastatic tumours where primary location could not be discovered with detail anamnesis, clinical examination and diagnostic procedures. Patients with metastasis carcinoma of unknown primary location in clinical oncology are represent with about 4% of total number of patients with solid tumours. The most frequent location carcinoma of unknown primary location, discovered with autopsy, are lungs, pancreas, colon, kidney, prostate and breast. Metastasis in cervical lymph nodes carcinoma of unknown primary location are represent between 3-9% of total number of patients with head and neck carcinoma. Patients with persistent cervical lymph node should be examined through diagnostical plan "step by step" for identification carcinoma of unknown primary location.

[Postoperative morbidity and quality of live in patients after radical and modified radical neck dissection].

Useful of radical neck dissection would not be questioned if the effects would be perfect. When postoperative morbidity is associated with oncological shortage of radical neck dissection in functional and cosmetics disfunction, looking for a new therapeutics procedures are justify. In our study were 319 patients. They were treated in period from 01 January 2000 to 31 December 2002. The follow-up was 5 year. We tried to consolidate distribition of n. accesorius operative injuries in modified radical neck dissection and relationship beetwen shoulder pain and shoulder droop after modified and radical neck dissection. Injured n.accesorius in modified radical neck dissection was significantly decreased in patients with modified radical neck dissection. The frequence of patients is significantly different (chi m2=26.662; df = 1; p<0.01) in categories of complications of n.accesorius (shoulder pain, shoulder droop). Shoulder pain and shoulder droop were significantly decreased in modified radical neck dissection (p<0.01).

[Correlation between results of PCR and specific serological tests in diagnosis of Epstein-Barr virus in patients with mononucleosis syndrome].

Routine laboratory diagnosis of infectious mononucleosis is based on EBV serological testing, but due to problems in interpretation of results, molecular methods, especially PCR, are often necessary. The aim of the present study was to investigate correlation between results of PCR and specific serological tests in diagnosis of Epstein-Barr virus in patients with mononucleosis syndrome. The study comprised 68 patients with mononucleosis syndrome. Their blood samples were tested using ELISA for detection of 4 EBV specific antibodies (anti-VCA IgM and IgG, anti-EA-D IgG and anti-EBNA-1 IgG) and PCR for detection of EBV DNA. According to results of serology 42 patients had acute primary infection, 2 reactivation, 1 chronic active infection, 19 past infection, and 4 have been EBV seronegative. EBV DNA was detected in 17 patients (25%) and all of them were serologically defined as acutely infected. PCR was useful for resolving unclear serology results. Specific serology is the first step in diagnosis of IM, but PCR may serve as a useful additional diagnostic tool for clarifying serological dilemmas, reaching final diagnosis and defining status of the infection.

[Forensic importance of face, mouth, teeth, ear, throat, nose and labyrinth injuries].

Evaluation of bodily injuries and diminished general vital activity from face and facial bones injuries accompanied by scars and disfiguration ranges from 5 to 50 percent depending on the disfiguration, loss of function and degree of aesthetic marring. They are graded accordingly and they may be: mild (5 to 20%), medium (20 to 35%) and serious when the degree of bodily injury and diminished general vital activity is 35 to 50%. Percentage of bodily injuries and diminished general vital activity from jaw defects ranges from 30 to 80 percent depending on the disfiguration, loss of function and degree of aesthetic marring. Percentage of bodily injuries and diminished general vital activity from nose structure nasal pyramid defects ranges from 10 to 20 percent depending on the disfiguration, loss of function and degree of aesthetic marring. Partial loss of nose structure is estimated at 15%, whereas the complete one may go up to 30%. Diminished general vital activity and percentage of bodily injury with partial laryngectomy ranges from 20 to 40%. In case of subtotal laryngectomy, this is up to 60% and with total one, it reaches 80%.