ABSTRACT
Adenomyoepithelioma (AME) is a biphasic neoplasm of epithelial and myoepithelial cells. It is most commonly found in the breast, although rare cases have been reported from the lung, salivary glands, and skin. There are 5 well-documented cases of cutaneous AME in the literature. We report a new case of cutaneous AME. Our case was commingled with apocrine hidrocystoma. This is the first report of cutaneous AME in a male patient and the first to describe SOX10 immunostaining in cutaneous AME. We review the literature on cutaneous AME and note the greater than chance colocalization with other adnexal tumors. We speculate that AME may represent localized overgrowth of myoepithelial cells within a pre-existent sweat gland tumor. Histopathologists should be aware of the potential of SOX10-positive myoepithelial neoplasms to mimic nodular melanocytic proliferations.
Subject(s)
Adenomyoepithelioma/pathology , Apocrine Glands/pathology , Hidrocystoma/pathology , Neoplasms, Complex and Mixed/pathology , Skin Neoplasms/pathology , Sweat Gland Neoplasms/pathology , Adenomyoepithelioma/chemistry , Adenomyoepithelioma/surgery , Adult , Aged, 80 and over , Apocrine Glands/chemistry , Apocrine Glands/surgery , Biomarkers, Tumor/analysis , Biopsy , Female , Hidrocystoma/chemistry , Hidrocystoma/surgery , Humans , Immunohistochemistry , Male , Middle Aged , Neoplasms, Complex and Mixed/chemistry , Neoplasms, Complex and Mixed/surgery , SOXE Transcription Factors/analysis , Skin Neoplasms/chemistry , Skin Neoplasms/surgery , Sweat Gland Neoplasms/chemistry , Sweat Gland Neoplasms/surgery , Treatment OutcomeABSTRACT
Non-melanoma skin cancer (NMSC) is the most common cancer in humans. Basal cell carcinoma accounts for 75 percent to 80 percent of NMSC. We report a primary cutaneous BCC on the upper chest in which vascular invasion was demonstrated by histopathology and the unique application of dual immunohistochemistry.