ABSTRACT
Irisin was identified as a myokine secreted by contracting skeletal muscle, possibly mediating some exercise health benefits via 'browning' of white adipose tissue. However, a controversy exists concerning irisin origin, regulation and function in humans. Thus, we have explored Fndc5 gene and irisin protein in two clinical studies: (i) a cross-sectional study (effects of type 2 diabetes (T2D) in drug-naive men) and (ii) an intervention study (exercise effects in sedentary, overweight/obese individuals). Glucose tolerance and insulin sensitivity were assessed. Maximal aerobic capacity and muscle strength were measured before and after training. Body composition (magnetic resonance imaging), muscle and liver fat content (1H-magnetic resonance spectroscopy (MRS)) and in vivo muscle metabolism (32P-MRS) were determined. Skeletal muscle and subcutaneous abdominal adipose tissue samples were taken in the fasted state and during euglycaemic hyperinsulinaemia (adipose tissue) and before/after exercise training (muscle). We found that muscle Fndc5 mRNA was increased in prediabetes but not T2D. Fndc5 in adipose tissue and irisin in plasma were reduced in T2D by 40% and 50%, respectively. In contrast, T2D-derived myotubes expressed/secreted the highest levels of Fndc5/irisin. Neither hyperinsulinaemia (adipose tissue/plasma) nor exercise (muscle/plasma) affected Fndc5/irisin in vivo. Circulating irisin was positively associated with muscle mass, strength and metabolism and negatively with fasting glycaemia. Glucose and palmitate decreased Fndc5 mRNA in myotubes in vitro. We conclude that distinct patterns of Fndc5/irisin in muscle, adipose tissue and circulation, and concordant in vivo down-regulation in T2D, indicate that irisin might distinguish metabolic health and disease. Moreover, Fndc5/irisin was discordantly regulated in diabetic muscle and myotubes in vitro, suggesting that whole body factors, such as glucose and fatty acids, might be important for irisin regulation. Exercise did not affect Fndc5/irisin. However, irisin was positively linked to muscle mass, strength and metabolism, pointing to common regulatory factors and/or the potential for irisin to modify muscle phenotype.
Subject(s)
Adipose Tissue/physiopathology , Diabetes Mellitus, Type 2/physiopathology , Exercise Therapy , Fibronectins/metabolism , Muscle, Skeletal/physiopathology , Obesity/physiopathology , Adult , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/rehabilitation , Female , Humans , Male , Obesity/complications , Obesity/rehabilitationABSTRACT
This study investigates individual performance adaptations on 2 years of training between European Aerobics Championships. An elite, 22-year-old aerobic gymnast performed postural coordination test, Y-Balance test, squat and countermovement jumps, 60 s test of repeated jumps, an isokinetic leg muscle strength test, and the Wingate test. Postural stability and flexibility improved in terms of increased distance achieved in the Y-Balance test in the anterior (by 6.3%), posteromedial (by 2%), and posterolateral (by 4.8%) directions. Lower limb muscular endurance also increased, which can be corroborated by a reduced fatigue index in the 60 s test of repeated jumps (from 42% to 27% after the 1st and to 22% after the 2nd year of training). In addition, mean power increased during dominant (by 23.2% at 60°/s and by 18.5% at 180°/s) and non-dominant leg extension (by 4.9% at 180°/s and by 15.5% at 300°/s), plus dominant leg flexion (by 2.0% at 60°/s and by 6.9% at 300°/s). Similarly, peak torque/body weight ratio increased during dominant (by 24.9% at 60°/s, by 11.5% at 180°/s, and by 2.1% at 300°/s) and non-dominant leg extension (by 0.5% at 60°/s and by 6.4% at 300°/s), plus dominant leg flexion (by 1.7% at 60°/s and by 5.4% at 300°/s). However, 2 years of training failed to show any significant improvements in the explosive power of lower limbs and anaerobic performance. These findings indicate that general aerobic gymnastics training without any specific inputs leads to performance adaptation, namely, in abilities closely related to competition routine (dynamic balance and strength endurance of lower limbs).
ABSTRACT
Balance, together with other motor qualities, plays an important role in the successful execution of specific gymnastic skills. However, it is also not clear whether different demands on dynamic balance and power produced by lower limb can be observed in sport-specific differences among gymnasts of various modalities. The question also is as to what extent isokinetic leg muscle strength contributes to anterior and posterior postural stability in gymnasts. Therefore, the aim of the study was i) to compare variables of dynamic balance and isokinetic leg muscle strength in rhythmic, artistic, and aerobic gymnasts, and ii) to investigate the relationship of reach distances in anterior, posteromedial, and posterolateral directions, as well as the composite score in the Y-balance test with an isokinetic muscle strength during knee extension and flexion at different velocities in female gymnasts of various disciplines. Altogether seven aerobic, five artistic, and six rhythmic gymnasts performed the Y-balance test and isokinetic leg muscle strength test at 60°/s, 180°/s, and 300°/s. Results showed significant between-group differences in the composite score in the Y-balance test of the dominant (F = 3.536, p = .041) and non-dominant symmetry (F = 4.804, p = .015). Similarly, average power produced during knee extension and knee flexion at 60°/s, 180°/s and 300°/s differed significantly among these groups (all at pË0.05). In addition, there was a significant relationship between the composite score of the dominant limb symmetry and isokinetic dominant limb extension strength at 60°/s (r = .54), 180°/s (r = .87), and 300°/s (r = .84) in aerobic gymnasts. The composite score of the dominant limb symmetry was also associated with isokinetic dominant limb extension strength, albeit only at 60°/s in both artistic (r = .60) and rhythmic gymnasts (r = .55). Such between-group differences may be ascribed to their different demands on maintenance of balance under dynamic conditions and leg muscle power within their sport specializations. Taking into account significant association between the dominant limb symmetry and isokinetic dominant limb extension strength, it may be concluded that both muscle strength and fast speeds contribute to dynamic balance in adolescent gymnasts.
ABSTRACT
This study evaluates the effect of 3 months resistance and aerobic training on muscle strength and power in 17 male overweight and obese men. Subjects underwent either a resistance or aerobic training for a period of 3 months (three sessions per week). Peak isometric force, rate of force development, peak power and height of countermovement and squat jumps, reactive strength index, and mean power in the concentric phase of bench presses were all assessed prior to and after completing the training program. Results identified a significant increase of mean power during both countermovement bench presses at 30 kg (18.6%, p = .021), 40 kg (14.6%, p = .033), and 50 kg (13.1%, p = .042) and concentric-only bench presses at 30 kg (19.6%, p = .017) and 40 kg (13.9%, p = .037) after the resistance training. There was also a significant increase in the height of the jump (12.8%, p = .013), peak power (10.1%, p = .026), and peak velocity (9.7%, p = .037) during the countermovement jump and height of the jump (11.8%, p = .019), peak power (9.6%, p = .032), and peak velocity (9.5%, p = .040) during the squat jump. There were no significant changes in the reactive strength index, peak force, and the rate of force development after the resistance training. The aerobic group failed to show any significant improvements in these parameters. It may be concluded that 3 months of resistance training without caloric restriction enhances upper and lower body muscle power in overweight and obese men.
Subject(s)
Muscle Strength , Obesity , Resistance Training , Adult , Exercise Test/methods , Humans , Male , Physical Fitness/physiologyABSTRACT
The authors evaluated the effect of 3 months of resistance and aerobic training (3 sessions/week) on body balance in a group of 25 overweight and obese individuals. Prior to and after the training, they performed static and task-oriented balance tests under various conditions. Mean center of pressure (CoP) velocity and mean trace length of the CoP in the y-axis registered during a one-legged stance significantly decreased after the resistance training (19.1%, p = .024; 29.3%, p = .009). Mean trace length of the CoP in the y-axis decreased significantly also during a bipedal stance on a foam surface with eyes open and closed (10.9%, p = .040; 18.2%, p = .027). In addition, mean CoP distance and mean squared CoP distance in the anteroposterior direction during a visually guided center of mass (CoM) tracking task significantly improved (14.7%, p = .033; 28.2%, p = .016). However, only mean trace length of the CoP in the y-axis during a bipedal stance on a foam surface with eyes open and closed significantly decreased after the aerobic training (10.3%, p = .047; 16.5%, p = .029). It may be concluded that resistance training is more efficient for the improvement of the anteroposterior unilateral stability and the accuracy of the regulation of the CoM anteroposterior position than aerobic training in overweight and obese individuals.
Subject(s)
Feedback, Sensory/physiology , Overweight/rehabilitation , Postural Balance/physiology , Resistance Training/methods , Adult , Humans , Male , Obesity/rehabilitation , Treatment OutcomeABSTRACT
BACKGROUND: Contrary to static and dynamic balance, there is a lack of scientific evidence on the training induced changes in reactive balance control in response to unexpected perturbations in overweight and obese individuals. OBJECTIVE: This study evaluates the effect of 3 months of resistance and aerobic training programs on postural responses to unexpected perturbations under stable and unstable conditions in the overweight and obese. METHODS: A group of 17 overweight and obese subjects, divided into two groups, underwent either resistance or aerobic training for a period of 3 months (3 sessions per week). Prior to and after completing the training, they performed the load release balance test while standing on either a stable or unstable surface, with eyes open and closed. RESULTS: Peak posterior center of pressure (CoP) displacement, and the time to peak posterior CoP displacement during a bipedal stance on a foam surface with eyes open (17.3%, p = 0.019 and 15.4%, p = 0.029) and eyes closed (15.0%, p = 0.027 and 13.2%, p = 0.034), decreased significantly. In addition, the total anterior to posterior CoP displacement, and the time from peak anterior to peak posterior CoP displacement, both with eyes open (18.1%, p = 0.017 and 12.2%, p = 0.040) and eyes closed (16.3%, p = 0.023 and 11.7%, p = 0.044), also significantly decreased. However, after completing the resistance training, the parameters registered while standing on a stable platform, both with eyes open and closed, did not change significantly. The group that underwent an aerobic training also failed to show any significant changes in parameters of the load release balance test. CONCLUSION: Three months of resistance training in overweight and obese subjects improves reactive balance control in response to unexpected perturbations under unstable conditions, both with and without visual cues. Due to the fact that this unstable load release balance test was found to be sensitive in revealing post-training changes, it would be suitable for implementing in the functional diagnostic for this group, in addition to complementing existing testing methods.
Subject(s)
Obesity/physiopathology , Overweight/physiopathology , Postural Balance/physiology , Posture/physiology , Resistance Training/methods , Adult , Humans , MaleABSTRACT
BACKGROUND: This study evaluates the effect on power produced during a modified lifting task in the overweight and obese after three months of either resistance or aerobic training. METHODS: Seventeen male subjects divided randomly into two groups performed deadlift and deadlift high pull, both with increasing weights up to maximal power, prior to and after the training programs (three sessions per week). RESULTS: Their mean power increased significantly during the deadlift at 20 kg (14.3%, p = 0.026), 30 kg (17.7%, p = 0.008), 40 kg (16.5%, p = 0.011), 50 kg (14.5%, p = 0.020), and 60 kg (14.3%, p = 0.021) and during the deadlift high pull at 30 kg (9.9%, p = 0.037), 40 kg (10.1%, p = 0.035), and 50 kg (8.2%, p = 0.044) after the resistance training. However, the group that participated in the aerobic training failed to show any significant changes in power performance during either the deadlift or deadlift high pull. CONCLUSION: Three months of resistance training enhances power outputs during a lifting task with weights from 30 to 50 kg (~40%â»60% of 1-repetition maximum) in the overweight and obese. Because this test was sensitive in revealing pre-post training changes in lifting performance, it should be implemented in the functional diagnostics for overweight and obese individuals and also complement existing testing methods.
ABSTRACT
BACKGROUND: The aim of this project was to study changes in QRS amplitude in junior female athletes during the initial twenty-one months of competitive training programme in aerobic gymnastics. METHODS: Somatometric parameters, heart rate (HR), blood pressure (BP) and 12-lead ECGs were recorded in 12 female athletes, aged 13-17 years (average 13.8) at 3-month intervals over a period of 21 months. The Sokolow-Lyon index (SLI) and the maximum QRS spatial vector magnitude (QRSmax), approximated from RV5, RaVF and SV2 voltages, were analyzed. RESULTS: The mean values of QRSmax and SLI decreased gradually during the study period. The difference between the mean QRSmax values at the beginning and at the end of the study period was -0.8 mV (30.8%), p < 0.001, and between the initial and final values of SLI was -0.6 mV (24%), p < 0.001. The somatometric parameters changed only slightly, HR and systolic BP values did not change significantly. CONCLUSIONS: This study showed that 21 months of competitive aerobic gymnastics training led to a decrease in the QRSmax magnitude. This finding is in contrast with the classical hypothesis on the ECG diagnostics of LVH and is in agreement with an alternative hypothesis on the relative voltage deficit during the early stage of LVH development. (Cardiol J 2007; 14: 260-265).