[Colonic metastases from carcinoma of the lung, an unusual presentation. Case report and literature review]. / Metástasis a colon de un carcinoma de pulmón, una presentación inusual. Reporte de un caso y revisión de la literatura.

The symptomatic metastasis of the colon from a pulmonary cancer is rare; however, the global incidence of pulmonary cancer is 12.9%. It is an infrequent site of metastasis, with a prevalence of less than 0.5% in patients with pulmonary cancer. One of the most common manifestation is intestinal obstruction. We present a case report of a patient with an acute lower intestinal bleeding from multiple metastasis lesion of the colon as the initial manifestation of a non-small cell lung carcinoma.

The first complete mitochondrial genome sequence of Cynopterusbrachyotis (Chiroptera, Pteropodidae) from the Philippines.

The technical limitations of capillary sequencing in providing insights on phylogeny have been greatly aided in recent years by the implementation of next generation sequencing platforms which can generate whole mitochondrial genome (mitogenome) sequences. In this study, enriched mitochondrial DNA of Cynopterusbrachyotis from Mindanao, Philippines was sequenced using the Illumina MiSeq platform. A total of 653,967 clean paired-end reads was assembled using a MIRA-MITObim pipeline, resulting in a consensus mitogenome sequence length of 17,382 bases and a GC content of 41.48%, which is consistent with other published mitogenomes in fruit bats. The assembled C.brachyotis mitogenome was annotated using the MITOS online server and was able to resolve all mitochondrial genes, except for one transfer RNA gene (trnT) which may be further resolved by additional capillary sequencing of the region. Sequence analysis showed that the Philippine C.brachyotis is only 90%-91% homologous with other Cynopterus spp., based on its full mitogenome sequence. Phylogenetic analysis of fruit bat mitogenomes, deposited in online repositories, revealed that the Philippine C.brachyotis in this study has diverged from Asian Cynopterus, namely Cynopterusbrachyotis and Cynopterussphinx from other parts of Asia (100% bootstrap support) with the latter two forming a separate clade. This divergence at the species level was consistent with phylogentic inference using cytochrome oxidase 1 (CO1) and cytochrome B (cytb) gene markers. Our results strengthen the previously reported hypothesis that the Cynopteruscf.brachyotis in the Philippines is distinct from its Asian counterparts and should be, therefore, treated as a new species.

Genome-based local dynamics of canine rabies virus epidemiology, transmission, and evolution in Davao City, Philippines, 2018-2019.

Rabies is a fatal zoonotic and neglected tropical disease caused by the rabies virus (RABV) and is associated with neuronal dysfunction and death, with dogs as the predominant carrier. The Philippines plans to eradicate rabies by 2022, but this is challenged with sub-optimal coverage of vaccination programs coupled with sustained transmission chains, making it unable to eradicate the disease. We investigated the dynamics of canine rabies in the highly urbanized Davao City of the Philippines and its neighboring localities by assessing genetic relationships, transmission patterns, selection pressure, and recombination events using the whole genome sequence of 49 RABV cases from June 2018 to May 2019, majority of which (46%) were from the district of Talomo, Davao City. Although phylogeographic clustering was observed, local variants also exhibited genetic sub-lineages. Phylogenetic and spatial transmission analysis provided evidence for intra- and inter-city transmission predominantly through the Talomo district of Davao City. Around 84% of the cases were owned dogs, but the genetic similiarity of RABVs from stray and owned dogs further alluded to the role of the former as transmission vectors. The high rate of improper vaccination among the affected dogs (80%) was also a likely contributor to transmission. The RABV population under Investigation is generally under strong purifying selection with no evidence of vaccine evasion due to the genetic homogeneity of viruses from vaccinated and improperly vaccinated dogs. However, some homologous recombination (HR) events were identified along the G and L genes, also predominantly associated with viruses from Talomo. The complementary findings on epidemiology, transmission, and recombination for Talomo suggest that high incidence areas can be seeds for virus dispersal and evolution. We recommend further Investigations on the possibility of HR in future large-scale genome studies. Finally, districts associated with these phenomena can be targeted for evidence-based local strategies that can help break RABV transmission chains and prevent emergence of novel strains in Davao City.

Metástasis a colon de un carcinoma de pulmón, una presentación inusual: Reporte de un caso y revisión de la literatura / Colonic metastases from carcinoma of the lung, an unusual presentation: Case report and literature review

Las metástasis sintomáticas al colon de un carcinoma de pulmón son raras, a pesar de ser una neoplasia que representa el 12,9% de la incidencia mundial de cáncer. El colon es un sitio infrecuente de metástasis, con una prevalencia reportada menor al 0,5% en pacientes con carcinomas de pulmón, existiendo en la literatura mundial pocos casos. Es inusual que sea la forma de presentación de este tipo de neoplasia. Con respecto a las manifestaciones clínicas que se reportan pueden cursar con obstrucción intestinal como síntoma cardinal. Se presenta el caso de un paciente que curso con hemorragia de vías digestivas bajas como manifestación inicial de múltiples lesiones metastásicas a colon de un carcinoma de pulmón de célula no pequeña.

The symptomatic metastasis of the colon from a pulmonary cancer is rare; however, the global incidence of pulmonary cancer is 12.9%. It is an infrequent site of metastasis, with a prevalence of less than 0.5% in patients with pulmonary cancer. One of the most common manifestation is intestinal obstruction. We present a case report of a patient with an acute lower intestinal bleeding from multiple metastasis lesion of the colon as the initial manifestation of a non-small cell lung carcinoma.

Medio familiar y entorno escolar: detonantes y antídotos de las conductas agresivas en niños en edad escolar / Medio familiar y entorno escolar: detonantes y antídotos de las conductas agresivas en niños en edad escolar

Se realizó una investigación-acción participativa en 32 niños en edad escolar, con conductas agresivas, del Colegio General Santander de Chía, para observar cómo influye el medio familiar y escolar en las conductas agresivas de los niños, y plantear alternativas para modular dichas conductas. El estudio indagó, en niños y padres de familia, factores determinantes de las conductas agresivas. Se evaluaron el tipo de estructura familiar, las personas responsables del cuidado de los niños, las condiciones de vivienda, el hacinamiento, el nivel de escolaridad, la situación laboral, los métodos correctivos y el consumo de alcohol por parte de los padres o cuidadores, como variables determinantes del medio familiar. Se encontró que los determinantes que influyeron en las manifestaciones agresivas de los niños, en este caso, fueron: el tipo de estructura familiar, el bajo nivel de escolaridad de los padres, y las personas responsables de la educación y cuidado de los niños; y en relación con el medio escolar, la fuente de imitación de conductas agresivas.

Medio familiar y entorno escolar: detoantes y antídotos de las conductas agresivas en niños en edad escolar / Average relative and scholastic surroundings: detonating and antidotes of the aggressive conducts in children in scholastic age

Se realizó una investigación-acción participativa en 32 niños en edad escolar, con conductas agresivas, del Colegio General Santander de Chía, para observar cómo influye el medio familiar y escolar en las conductas agresivas de los niños, y plantear alternativas para modular dichas conductas. El estudio indagó, en niños y padres de familia, factores determinantes de las conductas agresivas. Se evaluaron el tipo de estructura familiar, las personas responsables del cuidado de los niños, las condiciones de vivienda, el hacinamiento, el nivel de escolaridad, la situación laboral, los métodos correctivos y el consumo de alcohol por parte de los padres o cuidadores, como variables determinantes del medio familiar. Se encontró que los determinantes que influyeron en las manifestaciones agresivas de los niños, en este caso, fueron: el tipo de estructura familiar, el bajo nivel de escolaridad de los padres, y las personas responsables de la educación y cuidado de los niños; y en relación con el medio escolar, la fuente de imitación de conductas agresivas