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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA-A*3303 and HLA-DPB1*0501.

Shu, Yaqing; Huang, Renliang; Li, Qihui; Lu, Yi; Yin, Junping; Li, Huilu; Lan, Zhike; Zheng, Xiujun; Ye, Jinlong; Long, Youming; Wang, Zhanhang; Xiao, Li; Zhou, Qiaomiao; Liu, Xu; Fu, Ying; Chen, Hao; Chen, Juanjuan; Zhou, Yanxia; Zhou, Juan; Zhang, Liting; Zhou, Jing; Jiang, Ying; Peng, Fuhua; Lu, Zhengqi; Petersen, Frank; Qiu, Wei; Yu, Xinhua.

Ann Neurol ; 95(5): 901-906, 2024 May.

Article in English | MEDLINE | ID: mdl-38400794

ABSTRACT

We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that autoimmune GFAP astrocytopathy was associated with HLA-A*3303 (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.32-3.06, p = 0.00072, padj. = 0.046) and HLA-DBP1*0501 (OR = 0.51, 95% CI = 0.36-0.71, p = 0.000048, padj. = 0.0062). Moreover, HLA-A*3303 carriers with the disease had a longer hospital stay (p = 0.0005) than non-carriers. This study for the first time provides evidence for a role of genetic factor in the development of autoimmune GFAP astrocytopathy. ANN NEUROL 2024;95:901-906.

Subject(s)

Astrocytes , Glial Fibrillary Acidic Protein , HLA-A Antigens , HLA-DP beta-Chains , Humans , Glial Fibrillary Acidic Protein/genetics , Male , Female , Middle Aged , HLA-DP beta-Chains/genetics , Adult , HLA-A Antigens/genetics , Astrocytes/metabolism , Astrocytes/pathology , Aged

ABSTRACT

Subject(s)

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