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1.

Replication and Transcription of Human Mitochondrial DNA.

Falkenberg, Maria; Larsson, Nils-Göran; Gustafsson, Claes M.

Annu Rev Biochem ; 2024 Apr 09.

Article in English | MEDLINE | ID: mdl-38594940

2.

SnapShot: Mitochondrial Nucleoid.

Bonekamp, Nina A; Larsson, Nils-Göran.

Cell ; 172(1-2): 388-388.e1, 2018 01 11.

Article in English | MEDLINE | ID: mdl-29328920

3.

Maintenance and Expression of Mammalian Mitochondrial DNA.

Gustafsson, Claes M; Falkenberg, Maria; Larsson, Nils-Göran.

Annu Rev Biochem ; 85: 133-60, 2016 Jun 02.

Article in English | MEDLINE | ID: mdl-27023847

4.

No role for nuclear transcription regulators in mammalian mitochondria?

Rubalcava-Gracia, Diana; García-Villegas, Rodolfo; Larsson, Nils-Göran.

Mol Cell ; 83(6): 832-842, 2023 03 16.

Article in English | MEDLINE | ID: mdl-36182692

5.

Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.

Nicholls, Thomas J; Spåhr, Henrik; Jiang, Shan; Siira, Stefan J; Koolmeister, Camilla; Sharma, Sushma; Kauppila, Johanna H K; Jiang, Min; Kaever, Volkhard; Rackham, Oliver; Chabes, Andrei; Falkenberg, Maria; Filipovska, Aleksandra; Larsson, Nils-Göran; Gustafsson, Claes M.

Mol Cell ; 76(5): 784-796.e6, 2019 12 05.

Article in English | MEDLINE | ID: mdl-31588022

6.

Small-molecule inhibitors of human mitochondrial DNA transcription.

Bonekamp, Nina A; Peter, Bradley; Hillen, Hauke S; Felser, Andrea; Bergbrede, Tim; Choidas, Axel; Horn, Moritz; Unger, Anke; Di Lucrezia, Raffaella; Atanassov, Ilian; Li, Xinping; Koch, Uwe; Menninger, Sascha; Boros, Joanna; Habenberger, Peter; Giavalisco, Patrick; Cramer, Patrick; Denzel, Martin S; Nussbaumer, Peter; Klebl, Bert; Falkenberg, Maria; Gustafsson, Claes M; Larsson, Nils-Göran.

Nature ; 588(7839): 712-716, 2020 12.

Article in English | MEDLINE | ID: mdl-33328633

7.

Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA.

Nicholls, Thomas J; Nadalutti, Cristina A; Motori, Elisa; Sommerville, Ewen W; Gorman, Gráinne S; Basu, Swaraj; Hoberg, Emily; Turnbull, Doug M; Chinnery, Patrick F; Larsson, Nils-Göran; Larsson, Erik; Falkenberg, Maria; Taylor, Robert W; Griffith, Jack D; Gustafsson, Claes M.

Mol Cell ; 69(1): 9-23.e6, 2018 01 04.

Article in English | MEDLINE | ID: mdl-29290614

8.

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.

Kremer, Laura S; Bozhilova, Lyuba V; Rubalcava-Gracia, Diana; Filograna, Roberta; Upadhyay, Mamta; Koolmeister, Camilla; Chinnery, Patrick F; Larsson, Nils-Göran.

PLoS Genet ; 19(1): e1010573, 2023 01.

Article in English | MEDLINE | ID: mdl-36608143

9.

Somatic mitochondrial DNA mutations in mammalian aging.

Larsson, Nils-Göran.

Annu Rev Biochem ; 79: 683-706, 2010.

Article in English | MEDLINE | ID: mdl-20350166

10.

Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction.

Milenkovic, Dusanka; Sanz-Moreno, Adrián; Calzada-Wack, Julia; Rathkolb, Birgit; Veronica Amarie, Oana; Gerlini, Raffaele; Aguilar-Pimentel, Antonio; Misic, Jelena; Simard, Marie-Lune; Wolf, Eckhard; Fuchs, Helmut; Gailus-Durner, Valerie; de Angelis, Martin Hrabe; Larsson, Nils-Göran.

PLoS Genet ; 18(5): e1010190, 2022 05.

Article in English | MEDLINE | ID: mdl-35533204

11.

Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen.

Mennuni, Mara; Filograna, Roberta; Felser, Andrea; Bonekamp, Nina A; Giavalisco, Patrick; Lytovchenko, Oleksandr; Larsson, Nils-Göran.

EMBO Rep ; 23(1): e53054, 2022 01 05.

Article in English | MEDLINE | ID: mdl-34779571

12.

Structure casts light on mtDNA replication.

Falkenberg, Maria; Larsson, Nils-Göran.

Cell ; 139(2): 231-3, 2009 Oct 16.

Article in English | MEDLINE | ID: mdl-19837028

13.

Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion.

Misic, Jelena; Milenkovic, Dusanka; Al-Behadili, Ali; Xie, Xie; Jiang, Min; Jiang, Shan; Filograna, Roberta; Koolmeister, Camilla; Siira, Stefan J; Jenninger, Louise; Filipovska, Aleksandra; Clausen, Anders R; Caporali, Leonardo; Valentino, Maria Lucia; La Morgia, Chiara; Carelli, Valerio; Nicholls, Thomas J; Wredenberg, Anna; Falkenberg, Maria; Larsson, Nils-Göran.

Nucleic Acids Res ; 50(15): 8749-8766, 2022 08 26.

Article in English | MEDLINE | ID: mdl-35947649

14.

Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response.

Filograna, Roberta; Lee, Seungmin; Tiklová, Katarína; Mennuni, Mara; Jonsson, Viktor; Ringnér, Markus; Gillberg, Linda; Sopova, Elena; Shupliakov, Oleg; Koolmeister, Camilla; Olson, Lars; Perlmann, Thomas; Larsson, Nils-Göran.

PLoS Genet ; 17(9): e1009822, 2021 09.

Article in English | MEDLINE | ID: mdl-34570766

15.

Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing.

Basu, Swaraj; Xie, Xie; Uhler, Jay P; Hedberg-Oldfors, Carola; Milenkovic, Dusanka; Baris, Olivier R; Kimoloi, Sammy; Matic, Stanka; Stewart, James B; Larsson, Nils-Göran; Wiesner, Rudolf J; Oldfors, Anders; Gustafsson, Claes M; Falkenberg, Maria; Larsson, Erik.

PLoS Genet ; 16(12): e1009242, 2020 12.

Article in English | MEDLINE | ID: mdl-33315859

16.

Mitochondrial fusion is required for regulation of mitochondrial DNA replication.

Silva Ramos, Eduardo; Motori, Elisa; Brüser, Christian; Kühl, Inge; Yeroslaviz, Assa; Ruzzenente, Benedetta; Kauppila, Johanna H K; Busch, Jakob D; Hultenby, Kjell; Habermann, Bianca H; Jakobs, Stefan; Larsson, Nils-Göran; Mourier, Arnaud.

PLoS Genet ; 15(6): e1008085, 2019 06.

Article in English | MEDLINE | ID: mdl-31170154

17.

TEFM regulates both transcription elongation and RNA processing in mitochondria.

Jiang, Shan; Koolmeister, Camilla; Misic, Jelena; Siira, Stefan; Kühl, Inge; Silva Ramos, Eduardo; Miranda, Maria; Jiang, Min; Posse, Viktor; Lytovchenko, Oleksandr; Atanassov, Ilian; Schober, Florian A; Wibom, Rolf; Hultenby, Kjell; Milenkovic, Dusanka; Gustafsson, Claes M; Filipovska, Aleksandra; Larsson, Nils-Göran.

EMBO Rep ; 20(6)2019 06.

Article in English | MEDLINE | ID: mdl-31036713

18.

Mutations of mitochondrial DNA are not major contributors to aging of fruit flies.

Kauppila, Timo E S; Bratic, Ana; Jensen, Martin Borch; Baggio, Francesca; Partridge, Linda; Jasper, Heinrich; Grönke, Sebastian; Larsson, Nils-Göran.

Proc Natl Acad Sci U S A ; 115(41): E9620-E9629, 2018 10 09.

Article in English | MEDLINE | ID: mdl-30249665

19.

Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice.

Kauppila, Johanna H K; Bonekamp, Nina A; Mourier, Arnaud; Isokallio, Marita A; Just, Alexandra; Kauppila, Timo E S; Stewart, James B; Larsson, Nils-Göran.

Nucleic Acids Res ; 46(13): 6642-6669, 2018 07 27.

Article in English | MEDLINE | ID: mdl-29860357

20.

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.

Ross, Jaime M; Stewart, James B; Hagström, Erik; Brené, Stefan; Mourier, Arnaud; Coppotelli, Giuseppe; Freyer, Christoph; Lagouge, Marie; Hoffer, Barry J; Olson, Lars; Larsson, Nils-Göran.

Nature ; 501(7467): 412-5, 2013 Sep 19.

Article in English | MEDLINE | ID: mdl-23965628

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