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1.
Arthroscopy ; 35(7): 2003-2011, 2019 07.
Article in English | MEDLINE | ID: mdl-31147110

ABSTRACT

PURPOSE: To evaluate clinical and radiological outcomes of knotless suture bridge repair after a minimum of 5 years of follow-up. METHODS: A prospective consecutive series of full-thickness supraspinatus atraumatic chronic tears was evaluated in the study. Tears were medium or large. Further inclusion criteria were minimum clinical follow-up of 5 years with magnetic resonance imaging (MRI) at 24 months and fatty infiltration <2. Patients with shoulder stiffness, arthritis, or rotator cuff tear involving the subscapularis tendon were excluded. An arthroscopic cuff repair was performed using a knotless double-row suture bridge technique with braided suture tapes. Clinical outcomes were evaluated using the Constant score, the American Shoulder and Elbow Surgeons score, strength score, and a visual analog scale. Tendon healing was analyzed according to Sugaya MRI classification at 24 months. A Sugaya score of 1 or 2 was considered as tendon healing. Statistical analysis was performed with the Student's t-test. P = .05 were considered statistically significant. RESULTS: Sixty-eight patients were included in this series. Mean follow-up was equal to 68.8 ± 7 months. At last follow-up, the mean visual analog scale, American Shoulder and Elbow Surgeons score, and Constant scores improved significantly from 5.5 ± 1.6, 48.2 ± 13.1, 37.8 ± 8.3, to 2.1 ± 2.1 (P = 5.43 E-14), 87.4 ± 15.8 (P = 7.15 E-27), and 82.8 ± 14.7 (P = 1.01 E-33), respectively. Anteflexion improved from 99.3° ± 13.4° preoperatively to 136.6° ± 15.9° at last follow-up (P = 3.08 E-21). Strength score was significantly higher postoperatively (18.4 ± 6.7 vs 8.3 ± 3.5). MRI showed 88% (n = 57) of Sugaya 1-2 repairs. Patients with unhealed rotator cuffs showed significantly lower functional results than the Sugaya 1-2 group. No correlation between degree of retraction and rate of healing was observed. Four symptomatic patients (6%) required revision for failed rotator cuff repair. CONCLUSIONS: Despite potential confounding factors, arthroscopic knotless suture bridge repair of rotator cuff tears with acromioplasty demonstrated excellent long-term results of tendon healing, pain relief, and improvement of shoulder function. LEVEL OF EVIDENCE: Level IV, therapeutic case series.


Subject(s)
Arthroscopy , Rotator Cuff Injuries/surgery , Rotator Cuff/diagnostic imaging , Shoulder Joint/physiopathology , Suture Techniques , Adult , Aged , Female , Follow-Up Studies , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Muscle Strength/physiology , Prospective Studies , Visual Analog Scale
2.
Arch Phys Med Rehabil ; 98(12): 2558-2565.e10, 2017 12.
Article in English | MEDLINE | ID: mdl-28465221

ABSTRACT

OBJECTIVE: To describe the dose components and choice justifications in exercise interventions in a convenient sample of randomized controlled trials (RCTs). DATA SOURCES: We searched the following databases: PubMed and Cochrane Central Register of Controlled Trials in 2014. STUDY SELECTION: We included published RCTs evaluating preventive or therapeutic interventions in people with clinical conditions or at risk to develop health problems. DATA EXTRACTION: Two reviewers independently extracted data and evaluated the adequacy of the justifications. We contacted and invited the trials authors to complete an online survey to ask for additional information on dose justifications and dose-effect relation. DATA SYNTHESIS: We included 187 published RCTs. Of these, 68 (36%) reported a justification for the dose choice, and 135 (72%) reported 3 doses components. Most reported components were duration (96%) and frequency (93%). Sixty-six survey responders (response rate, 35%) provided additional information. When combining the publications and survey responses, 104 (56%) trials had a justification for the dose choice. We judged justifications adequate in 45 (43%) articles. From the survey responders, 39% indicated that intensity was the dose component that can have the greatest effect on their study results. CONCLUSIONS: Most of the published RCTs adequately reported the dose components of their exercise interventions but only a small number provided sufficient justifications for dosage choices. Further studies are recommended to justify the exercise intervention dose choices.


Subject(s)
Exercise Therapy/methods , Humans , Randomized Controlled Trials as Topic
3.
Lung ; 193(6): 965-73, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26411589

ABSTRACT

AIM: Despite the increasing adoption of parenchymal-sparing procedures, pneumonectomy is still necessary in several pleural and pulmonary (benign or malignant) diseases. We reviewed clinical data of a large cohort of patients treated by pneumonectomy with the aim of better define its impact on early and long-term results. METHODS: Clinical and pathological characteristics of all consecutive patients treated by pneumonectomy between January 2005 and May 2012 were retrospectively reviewed. Thirty- and 90-day mortality, as well as long-term survival was assessed. Factors associated to long-term survival were analyzed by univariate and multivariate analyses. Evaluation of quality of life was carried out by a standard questionnaire (SF-12) administrated by phone to patients surviving beyond 1 year. RESULTS: A total of 398 patients (293 men; mean age 61 ± 10.9 years) were operated on in the study period. Indication was malignancy in 380 patients (350 primary lung cancers). Thirty-day mortality was 9 % (right: 12.6 % vs. left: 6.3 %, p = 0.013), significantly correlating with age (p = 0.021), comorbidities (p = 0.034), PS > 1 (p = 0.018), preoperative dyspnea (p = 0.0013), and FEV1 (p = 0.0071). Overall 1-, 3-, 5-, and 7-year survival rates were 76.6, 46.6, 34.4, and 29.2 %. In case of primary lung cancer, these figures were 76.8, 46.4, 34.5, and 29.7 %. At univariate analysis, a less favorable survival was associated to PS > 1 (p = 0.0078), right side (p = 0.044), occurrence of postoperative complications (p = 0.00079), and T3-4 status (p = 0.013). At multivariate analysis, PS > 1, right side, and occurrence of postoperative complications were identified as independent worse prognostic factors. SF12 physical score was 39.1 ± 9.0 and was correlated to the presence of preoperative symptoms (p = 0.013). Mental score was 50.68 ± 9.63 and was correlated to preoperative FEV1/FVC ratio (p = 0.023) and side of disease (p = 0.023). CONCLUSION: In current practice, pneumonectomy is still performed for malignancy, sometimes after induction treatment. High postoperative morbidity and mortality are observed; however, at a farer interval time point, long-term survival with preserved quality of life can be observed.


Subject(s)
Adenocarcinoma/surgery , Bronchiectasis/surgery , Carcinoma, Large Cell/surgery , Carcinoma, Non-Small-Cell Lung/surgery , Carcinoma, Squamous Cell/surgery , Lung Neoplasms/surgery , Mesothelioma/surgery , Tuberculosis, Pulmonary/surgery , Adenocarcinoma/mortality , Adenocarcinoma/physiopathology , Age Factors , Aged , Bronchiectasis/mortality , Bronchiectasis/physiopathology , Carcinoma, Large Cell/mortality , Carcinoma, Large Cell/physiopathology , Carcinoma, Non-Small-Cell Lung/mortality , Carcinoma, Non-Small-Cell Lung/physiopathology , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/physiopathology , Comorbidity , Dyspnea/epidemiology , Dyspnea/physiopathology , Female , Forced Expiratory Volume , Humans , Lung Neoplasms/mortality , Lung Neoplasms/physiopathology , Male , Mesothelioma/mortality , Mesothelioma/physiopathology , Mesothelioma, Malignant , Middle Aged , Multivariate Analysis , Organ Sparing Treatments , Pneumonectomy , Proportional Hazards Models , Quality of Life , Retrospective Studies , Severity of Illness Index , Survival Rate , Tuberculosis, Pulmonary/mortality , Tuberculosis, Pulmonary/physiopathology , Vital Capacity
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