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1.

GPCR-mediated ß-arrestin activation deconvoluted with single-molecule precision.

Asher, Wesley B; Terry, Daniel S; Gregorio, G Glenn A; Kahsai, Alem W; Borgia, Alessandro; Xie, Bing; Modak, Arnab; Zhu, Ying; Jang, Wonjo; Govindaraju, Alekhya; Huang, Li-Yin; Inoue, Asuka; Lambert, Nevin A; Gurevich, Vsevolod V; Shi, Lei; Lefkowitz, Robert J; Blanchard, Scott C; Javitch, Jonathan A.

Cell ; 185(10): 1661-1675.e16, 2022 05 12.

Article in English | MEDLINE | ID: mdl-35483373

2.

SnapShot: ß-Arrestin Functions.

Ahn, Seungkirl; Shenoy, Sudha K; Luttrell, Louis M; Lefkowitz, Robert J.

Cell ; 182(5): 1362-1362.e1, 2020 09 03.

Article in English | MEDLINE | ID: mdl-32888497

3.

Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody.

Wingler, Laura M; McMahon, Conor; Staus, Dean P; Lefkowitz, Robert J; Kruse, Andrew C.

Cell ; 176(3): 479-490.e12, 2019 01 24.

Article in English | MEDLINE | ID: mdl-30639100

4.

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.

Wingler, Laura M; Elgeti, Matthias; Hilger, Daniel; Latorraca, Naomi R; Lerch, Michael T; Staus, Dean P; Dror, Ron O; Kobilka, Brian K; Hubbell, Wayne L; Lefkowitz, Robert J.

Cell ; 176(3): 468-478.e11, 2019 01 24.

Article in English | MEDLINE | ID: mdl-30639099

5.

GPCR-G Protein-ß-Arrestin Super-Complex Mediates Sustained G Protein Signaling.

Thomsen, Alex R B; Plouffe, Bianca; Cahill, Thomas J; Shukla, Arun K; Tarrasch, Jeffrey T; Dosey, Annie M; Kahsai, Alem W; Strachan, Ryan T; Pani, Biswaranjan; Mahoney, Jacob P; Huang, Liyin; Breton, Billy; Heydenreich, Franziska M; Sunahara, Roger K; Skiniotis, Georgios; Bouvier, Michel; Lefkowitz, Robert J.

Cell ; 166(4): 907-919, 2016 Aug 11.

Article in English | MEDLINE | ID: mdl-27499021

6.

Structure of the M2 muscarinic receptor-ß-arrestin complex in a lipid nanodisc.

Staus, Dean P; Hu, Hongli; Robertson, Michael J; Kleinhenz, Alissa L W; Wingler, Laura M; Capel, William D; Latorraca, Naomi R; Lefkowitz, Robert J; Skiniotis, Georgios.

Nature ; 579(7798): 297-302, 2020 03.

Article in English | MEDLINE | ID: mdl-31945772

7.

Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by ß-arrestin.

Kahsai, Alem W; Shah, Kunal S; Shim, Paul J; Lee, Mason A; Shreiber, Bowie N; Schwalb, Allison M; Zhang, Xingdong; Kwon, Henry Y; Huang, Li-Yin; Soderblom, Erik J; Ahn, Seungkirl; Lefkowitz, Robert J.

Proc Natl Acad Sci U S A ; 120(43): e2303794120, 2023 10 24.

Article in English | MEDLINE | ID: mdl-37844230

8.

Mechanism of intracellular allosteric ß₂AR antagonist revealed by X-ray crystal structure.

Liu, Xiangyu; Ahn, Seungkirl; Kahsai, Alem W; Meng, Kai-Cheng; Latorraca, Naomi R; Pani, Biswaranjan; Venkatakrishnan, A J; Masoudi, Ali; Weis, William I; Dror, Ron O; Chen, Xin; Lefkowitz, Robert J; Kobilka, Brian K.

Nature ; 548(7668): 480-484, 2017 08 24.

Article in English | MEDLINE | ID: mdl-28813418

9.

The ß-arrestin-biased ß-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility.

Kim, Jihee; Grotegut, Chad A; Wisler, James W; Mao, Lan; Rosenberg, Paul B; Rockman, Howard A; Lefkowitz, Robert J.

Proc Natl Acad Sci U S A ; 117(22): 12435-12443, 2020 06 02.

Article in English | MEDLINE | ID: mdl-32414934

10.

Synthetic nanobodies as angiotensin receptor blockers.

McMahon, Conor; Staus, Dean P; Wingler, Laura M; Wang, Jialu; Skiba, Meredith A; Elgeti, Matthias; Hubbell, Wayne L; Rockman, Howard A; Kruse, Andrew C; Lefkowitz, Robert J.

Proc Natl Acad Sci U S A ; 117(33): 20284-20291, 2020 08 18.

Article in English | MEDLINE | ID: mdl-32753386

11.

The GPCR-ß-arrestin complex allosterically activates C-Raf by binding its amino terminus.

Zang, Yunxiang; Kahsai, Alem W; Pakharukova, Natalia; Huang, Li-Yin; Lefkowitz, Robert J.

J Biol Chem ; 297(6): 101369, 2021 12.

Article in English | MEDLINE | ID: mdl-34757127

12.

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.

Staus, Dean P; Strachan, Ryan T; Manglik, Aashish; Pani, Biswaranjan; Kahsai, Alem W; Kim, Tae Hun; Wingler, Laura M; Ahn, Seungkirl; Chatterjee, Arnab; Masoudi, Ali; Kruse, Andrew C; Pardon, Els; Steyaert, Jan; Weis, William I; Prosser, R Scott; Kobilka, Brian K; Costa, Tommaso; Lefkowitz, Robert J.

Nature ; 535(7612): 448-52, 2016 07 21.

Article in English | MEDLINE | ID: mdl-27409812

13.

ß-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-Stimulated ß Adrenergic Receptor Cardioprotection.

Wang, Jialu; Pani, Biswaranjan; Gokhan, Ilhan; Xiong, Xinyu; Kahsai, Alem W; Jiang, Haoran; Ahn, Seungkirl; Lefkowitz, Robert J; Rockman, Howard A.

Mol Pharmacol ; 100(6): 568-579, 2021 12.

Article in English | MEDLINE | ID: mdl-34561298

14.

Unique Positive Cooperativity Between the ß-Arrestin-Biased ß-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the ß2-Adrenergic Receptor.

Pani, Biswaranjan; Ahn, Seungkirl; Rambarat, Paula K; Vege, Shashank; Kahsai, Alem W; Liu, Andrew; Valan, Bruno N; Staus, Dean P; Costa, Tommaso; Lefkowitz, Robert J.

Mol Pharmacol ; 100(5): 513-525, 2021 11.

Article in English | MEDLINE | ID: mdl-34580163

15.

Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes.

Pakharukova, Natalia; Masoudi, Ali; Pani, Biswaranjan; Staus, Dean P; Lefkowitz, Robert J.

J Biol Chem ; 295(49): 16773-16784, 2020 12 04.

Article in English | MEDLINE | ID: mdl-32978252

16.

A Serendipitous Scientist.

Lefkowitz, Robert J.

Annu Rev Pharmacol Toxicol ; 58: 17-32, 2018 01 06.

Article in English | MEDLINE | ID: mdl-28715979

17.

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in ß-arrestin coupling.

Staus, Dean P; Wingler, Laura M; Choi, Minjung; Pani, Biswaranjan; Manglik, Aashish; Kruse, Andrew C; Lefkowitz, Robert J.

Proc Natl Acad Sci U S A ; 115(15): 3834-3839, 2018 04 10.

Article in English | MEDLINE | ID: mdl-29581292

18.

Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein-coupled receptors.

Staus, Dean P; Wingler, Laura M; Pichugin, Dmitry; Prosser, Robert Scott; Lefkowitz, Robert J.

J Biol Chem ; 294(36): 13218-13223, 2019 09 06.

Article in English | MEDLINE | ID: mdl-31362983

19.

Visualization of arrestin recruitment by a G-protein-coupled receptor.

Shukla, Arun K; Westfield, Gerwin H; Xiao, Kunhong; Reis, Rosana I; Huang, Li-Yin; Tripathi-Shukla, Prachi; Qian, Jiang; Li, Sheng; Blanc, Adi; Oleskie, Austin N; Dosey, Anne M; Su, Min; Liang, Cui-Rong; Gu, Ling-Ling; Shan, Jin-Ming; Chen, Xin; Hanna, Rachel; Choi, Minjung; Yao, Xiao Jie; Klink, Bjoern U; Kahsai, Alem W; Sidhu, Sachdev S; Koide, Shohei; Penczek, Pawel A; Kossiakoff, Anthony A; Woods, Virgil L; Kobilka, Brian K; Skiniotis, Georgios; Lefkowitz, Robert J.

Nature ; 512(7513): 218-222, 2014 08 14.

Article in English | MEDLINE | ID: mdl-25043026

20.

Distinct conformations of GPCR-ß-arrestin complexes mediate desensitization, signaling, and endocytosis.

Cahill, Thomas J; Thomsen, Alex R B; Tarrasch, Jeffrey T; Plouffe, Bianca; Nguyen, Anthony H; Yang, Fan; Huang, Li-Yin; Kahsai, Alem W; Bassoni, Daniel L; Gavino, Bryant J; Lamerdin, Jane E; Triest, Sarah; Shukla, Arun K; Berger, Benjamin; Little, John; Antar, Albert; Blanc, Adi; Qu, Chang-Xiu; Chen, Xin; Kawakami, Kouki; Inoue, Asuka; Aoki, Junken; Steyaert, Jan; Sun, Jin-Peng; Bouvier, Michel; Skiniotis, Georgios; Lefkowitz, Robert J.

Proc Natl Acad Sci U S A ; 114(10): 2562-2567, 2017 03 07.

Article in English | MEDLINE | ID: mdl-28223524

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