ABSTRACT
OBJECTIVE: To study the glycosides from Guangdong Liangcha Granules. METHODS: The chemical constituents were isolated by various chromatographic techniques and the structures of chemical constituents were identified by spectroscopic analysis and literature. RESULTS: Six compounds were isolated and identified as ilexoside B (1), asprellanosides B (2), asprellanoside A (3), 4', 5 ,7 -tri- hydroxyflavone-6-O-ß3-D-glucopyranosyl ester(4), isoviolanthin (5),3-O-methy-lellagic acid 4'-O-rhamnopyranoside (6). CONCLUSION: Compounds 1 - 5 are firstly obtained from Guangdong Liangcha Granules.
Subject(s)
Drugs, Chinese Herbal/chemistry , Glycosides/analysis , Saponins , TriterpenesABSTRACT
Six new triterpenoid saponins, psychotrianosides A-F (1-6), and two known triterpenoid saponins, psychotrianoside G (7) and ardisianoside D (8), were isolated from Psychotria sp. Their structures were determined mainly by spectroscopic methods. The cytotoxic activities of 1-8 against five human cancer cell lines (MDA-MB-231, MCF-7, MCF-7/ADM, HepG2, and HepG2/ADM) are reported for the first time. Psychotrianoside C (3) showed the most potent antiproliferative activity among these saponins, and the IC50 value of 3 against MDA-MB-231 was 2.391 ± 0.161 µM. Compound 3 was also found to induce apoptosis.
Subject(s)
Antineoplastic Agents, Phytogenic/pharmacology , Psychotria/chemistry , Saponins/pharmacology , Triterpenes/pharmacology , Antineoplastic Agents, Phytogenic/chemistry , Apoptosis , Cell Line, Tumor , Cell Proliferation/drug effects , Cell Survival , Drug Screening Assays, Antitumor , Humans , Inhibitory Concentration 50 , Magnetic Resonance Spectroscopy , Molecular Structure , Plant Stems/chemistry , Saponins/chemistry , Saponins/isolation & purification , Spectrum Analysis , Triterpenes/chemistry , Triterpenes/isolation & purificationABSTRACT
One new cyclic tetrapeptide cyclic-(Tyr-Ala-Leu-Ser) (1) along with four natural compounds firstly obtained 3H-imidazole-4-carboxylic acid (2), 2-methyl-3H-imidazole-4-carboxylic acid (3), 3-ethylidene-6-isopropyl-piperazine-2,5-dione (4), and 3-isobutylidene-6-methyl piperazine-2,5-dione (5) have been isolated from the coral derived endophytic bacteria Brevibacterium sp. L-4 collected from the South China Sea. Their structures were elucidated through spectroscopic techniques including NMR (1D and 2D), MS, and EA, and their relative configurations were also assigned by NMR analysis.
Subject(s)
Anthozoa/microbiology , Brevibacterium/chemistry , Peptides, Cyclic/chemistry , Animals , Endophytes/chemistry , Imidazoles/chemistry , Imidazoles/isolation & purification , Magnetic Resonance Spectroscopy , Molecular Structure , Oceans and Seas , Peptides, Cyclic/isolation & purification , Piperazines/chemistry , Piperazines/isolation & purificationABSTRACT
One new imidazole derivative alkaloid pelopuradazole (1), together with three known alkaloids as in 3H-imidazole-4-carboxylic acid (2), 1H-pyrrole-2-carboxylic acid (3) and 2-methyl-3H-imidazole-4-carboxylic acid (4) and two known cyclo-dipeptides pelopurin A (5) and pelopurin B (6), has been isolated from the marine bacterium Pelomonas puraquae sp. nov. Pelopuradazole (1) was a new imidazole derivative alkaloid, while compounds 2, 3, 5 and 6 were firstly obtained as natural products. Compounds 1-6 were isolated from P. puraquae sp. nov. for the first time.
Subject(s)
Alkaloids/isolation & purification , Comamonadaceae/chemistry , Imidazoles/isolation & purification , Alkaloids/chemistry , Imidazoles/chemistry , Marine Biology , Peptides, Cyclic/chemistry , Peptides, Cyclic/isolation & purification , Proline/analogs & derivatives , Proline/isolation & purificationABSTRACT
One new precursor of tetraterpenoids, Sarglaucol (1), along with eight known compounds have been isolated from the soft coral Sarcophyton glaucum collected from the Sanya Bay, Hainan Island, China. Their structures were elucidated through spectroscopic techniques including 1D- and 2D-NMR, and their relative configurations were also assigned by NMR and NOESY analysis. Compounds 1 showed weak antitumour activities.