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1.
A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
Neurobiol Dis
; 159: 105507, 2021 11.
Article
in English
| MEDLINE | ID: mdl-34509608
2.
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
Bioorg Med Chem Lett
; 25(3): 444-50, 2015 Feb 01.
Article
in English
| MEDLINE | ID: mdl-25577040
3.
Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
Bioorg Med Chem Lett
; 25(21): 4992-4999, 2015 Nov 01.
Article
in English
| MEDLINE | ID: mdl-25613676
4.
Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis.
Bioorg Med Chem Lett
; 24(9): 2079-85, 2014 May 01.
Article
in English
| MEDLINE | ID: mdl-24704030
5.
Benzimidazole CB2 agonists: design, synthesis and SAR.
Bioorg Med Chem Lett
; 24(4): 1218-21, 2014 Feb 15.
Article
in English
| MEDLINE | ID: mdl-24461289
6.
Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Bioorg Med Chem Lett
; 24(20): 4884-90, 2014 Oct 15.
Article
in English
| MEDLINE | ID: mdl-25248679
7.
Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.
ACS Med Chem Lett
; 15(1): 123-131, 2024 Jan 11.
Article
in English
| MEDLINE | ID: mdl-38229758
8.
Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).
Bioorg Med Chem Lett
; 23(24): 6620-4, 2013 Dec 15.
Article
in English
| MEDLINE | ID: mdl-24215892
9.
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
ACS Med Chem Lett
; 14(2): 146-155, 2023 Feb 09.
Article
in English
| MEDLINE | ID: mdl-36793422
10.
Decahydroquinoline amides as highly selective CB2 agonists: role of selectivity on in vivo efficacy in a rodent model of analgesia.
Bioorg Med Chem Lett
; 21(8): 2359-64, 2011 Apr 15.
Article
in English
| MEDLINE | ID: mdl-21420857
11.
Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.
Bioorg Med Chem Lett
; 21(8): 2354-8, 2011 Apr 15.
Article
in English
| MEDLINE | ID: mdl-21420860
12.
Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.
ACS Med Chem Lett
; 12(4): 540-547, 2021 Apr 08.
Article
in English
| MEDLINE | ID: mdl-33854701
13.
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.
Bioorg Med Chem Lett
; 19(5): 1488-91, 2009 Mar 01.
Article
in English
| MEDLINE | ID: mdl-19179073
14.
Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.
Bioorg Med Chem Lett
; 19(5): 1492-5, 2009 Mar 01.
Article
in English
| MEDLINE | ID: mdl-19181525
15.
A novel radioligand for glycine transporter 1: characterization and use in autoradiographic and in vivo brain occupancy studies.
Nucl Med Biol
; 35(3): 315-25, 2008 Apr.
Article
in English
| MEDLINE | ID: mdl-18355687
16.
Proline bis-amides as potent dual orexin receptor antagonists.
Bioorg Med Chem Lett
; 18(4): 1425-30, 2008 Feb 15.
Article
in English
| MEDLINE | ID: mdl-18207395
17.
Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists.
Bioorg Med Chem Lett
; 18(2): 716-20, 2008 Jan 15.
Article
in English
| MEDLINE | ID: mdl-18061443
18.
Kinetic Analysis of Membrane Potential Dye Response to NaV1.7 Channel Activation Identifies Antagonists with Pharmacological Selectivity against NaV1.5.
J Biomol Screen
; 21(5): 480-9, 2016 Jun.
Article
in English
| MEDLINE | ID: mdl-26861708
19.
The glycine transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior.
J Neurosci
; 23(20): 7586-91, 2003 Aug 20.
Article
in English
| MEDLINE | ID: mdl-12930797
20.
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
J Med Chem
; 47(24): 5825-8, 2004 Nov 18.
Article
in English
| MEDLINE | ID: mdl-15537338