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1.

FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.

Cho, Sungyun; Chun, Yujin; He, Long; Ramirez, Cuauhtemoc B; Ganesh, Kripa S; Jeong, Kyungjo; Song, Junho; Cheong, Jin Gyu; Li, Zhongchi; Choi, Jungmin; Kim, Joohwan; Koundouros, Nikos; Ding, Fangyuan; Dephoure, Noah; Jang, Cholsoon; Blenis, John; Lee, Gina.

Mol Cell ; 83(16): 3010-3026.e8, 2023 08 17.

Article in English | MEDLINE | ID: mdl-37595559

2.

Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA).

Housden, Benjamin E; Li, Zhongchi; Kelley, Colleen; Wang, Yuanli; Hu, Yanhui; Valvezan, Alexander J; Manning, Brendan D; Perrimon, Norbert.

Proc Natl Acad Sci U S A ; 114(50): E10755-E10762, 2017 12 12.

Article in English | MEDLINE | ID: mdl-29183982

3.

Aging Biomarkers and Novel Targets for Anti-Aging Interventions.

Xu, Kang; Guo, Yannan; Li, Zhongchi; Wang, Zhao.

Adv Exp Med Biol ; 1178: 39-56, 2019.

Article in English | MEDLINE | ID: mdl-31493221

4.

Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling.

Li, Zhongchi; Xu, Kang; Zhang, Nannan; Amador, Gabriel; Wang, Yanying; Zhao, Sen; Li, Liyuan; Qiu, Ying; Wang, Zhao.

Kidney Int ; 93(4): 881-892, 2018 04.

Article in English | MEDLINE | ID: mdl-29373150

5.

Aging Kidney and Aging-Related Disease.

Li, Zhongchi; Wang, Zhao.

Adv Exp Med Biol ; 1086: 169-187, 2018.

Article in English | MEDLINE | ID: mdl-30232759

6.

Resveratrol Protects against High-Fat Diet Induced Renal Pathological Damage and Cell Senescence by Activating SIRT1.

Zhang, Nannan; Li, Zhongchi; Xu, Kang; Wang, Yanying; Wang, Zhao.

Biol Pharm Bull ; 39(9): 1448-54, 2016.

Article in English | MEDLINE | ID: mdl-27582325

7.

Decreased Enterobacteriaceae translocation due to gut microbiota remodeling mediates the alleviation of premature aging by a high-fat diet.

Xu, Kang; Guo, Yannan; Wang, Yida; Ren, Yu; Low, Vivien; Cho, Sungyun; Ping, Lu; Peng, Kezheng; Li, Xue; Qiu, Ying; Liu, Qingfei; Li, Zhongchi; Wang, Zhao.

Aging Cell ; 22(2): e13760, 2023 02.

Article in English | MEDLINE | ID: mdl-36567449

8.

Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment.

Low, Vivien; Li, Zhongchi; Blenis, John.

Sci Signal ; 15(759): eabj4220, 2022 11 08.

Article in English | MEDLINE | ID: mdl-36346837

9.

Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells.

He, Long; Endress, Jennifer; Cho, Sungyun; Li, Zhongchi; Zheng, Yuxiang; Asara, John M; Blenis, John.

Sci Adv ; 8(20): eabm8786, 2022 05 20.

Article in English | MEDLINE | ID: mdl-35594343

10.

Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.

Li, Zhongchi; Low, Vivien; Luga, Valbona; Sun, Janet; Earlie, Ethan; Parang, Bobak; Shobana Ganesh, Kripa; Cho, Sungyun; Endress, Jennifer; Schild, Tanya; Hu, Mengying; Lyden, David; Jin, Wenbing; Guo, Chunjun; Dephoure, Noah; Cantley, Lewis C; Laughney, Ashley M; Blenis, John.

Nat Commun ; 13(1): 6239, 2022 10 20.

Article in English | MEDLINE | ID: mdl-36266345

11.

SPATA4 improves aging-induced metabolic dysfunction through promotion of preadipocyte differentiation and adipose tissue expansion.

Li, Zhongchi; Xu, Kang; Zhao, Sen; Guo, Yannan; Chen, Huiling; Ni, Jianquan; Liu, Qingfei; Wang, Zhao.

Aging Cell ; 20(1): e13282, 2021 01.

Article in English | MEDLINE | ID: mdl-33314576

12.

Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice.

Xu, Kang; Guo, Yannan; Ping, Lu; Qiu, Ying; Liu, Qingfei; Li, Zhongchi; Wang, Zhao.

Cells ; 9(6)2020 06 22.

Article in English | MEDLINE | ID: mdl-32580272

13.

A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice.

Li, Zhongchi; Xu, Kang; Guo, Yannan; Ping, Lu; Gao, Yuqi; Qiu, Ying; Ni, Jianquan; Liu, Qingfei; Wang, Zhao.

Aging Cell ; 19(3): e13104, 2020 03.

Article in English | MEDLINE | ID: mdl-31967391

14.

Pooled CRISPR Screens in Drosophila Cells.

Viswanatha, Raghuvir; Brathwaite, Roderick; Hu, Yanhui; Li, Zhongchi; Rodiger, Jonathan; Merckaert, Pierre; Chung, Verena; Mohr, Stephanie E; Perrimon, Norbert.

Curr Protoc Mol Biol ; 129(1): e111, 2019 12.

Article in English | MEDLINE | ID: mdl-31763777

15.

Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells.

Viswanatha, Raghuvir; Li, Zhongchi; Hu, Yanhui; Perrimon, Norbert.

Elife ; 72018 07 27.

Article in English | MEDLINE | ID: mdl-30051818

16.

A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila.

Okamoto, Naoki; Viswanatha, Raghuvir; Bittar, Riyan; Li, Zhongchi; Haga-Yamanaka, Sachiko; Perrimon, Norbert; Yamanaka, Naoki.

Dev Cell ; 47(3): 294-305.e7, 2018 11 05.

Article in English | MEDLINE | ID: mdl-30293839

17.

Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling.

Zhang, Nannan; Li, Zhongchi; Mu, Wei; Li, Liyuan; Liang, Yaru; Lu, Maoyang; Wang, Zhuoran; Qiu, Ying; Wang, Zhao.

Cell Cycle ; 15(7): 1009-18, 2016.

Article in English | MEDLINE | ID: mdl-26940461

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