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[ESR1 gene allelic polymorphism analysis in population of Ukraine].
Livshyts', G B; Kucherenko, A M; Podliesna, S S; Kravchenko, S A; Livshyts', L A.
Tsitol Genet ; 46(4): 31-9, 2012.
Article in Ukrainian | MEDLINE | ID: mdl-23074960

ABSTRACT

In this study analysis of single nucleotide polymorhisms A351G, C397T and number of TA-repeats in ESR1 gene among 199 healthy volunteers from Ukraine was performed. Data concerning genotypes and particular alleles of polymorphic variants distribution were obtained. Possible mechanisms of these polymorphic variants role in ESR1 gene transcription and estrogen receptor expression changes are being discussed.


Subject(s)
Estrogen Receptor alpha/genetics , Polymorphism, Genetic , Adult , Alleles , Base Sequence , Dinucleotide Repeats , Female , Gene Expression , Gene Frequency , Genetics, Population , Genotype , Humans , Introns , Male , Molecular Sequence Data , Promoter Regions, Genetic , Transcription, Genetic , Ukraine
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