Search | VHL Search Portal

1.

Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations.

Salk, Jesse J; Schmitt, Michael W; Loeb, Lawrence A.

Nat Rev Genet ; 19(5): 269-285, 2018 05.

Article in English | MEDLINE | ID: mdl-29576615

2.

PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage.

Zhang, Yuezheng; Kohrn, Brendan F; Yang, Ming; Nachmanson, Daniela; Soong, T Rinda; Lee, I-Hsiu; Tao, Yong; Clevers, Hans; Swisher, Elizabeth M; Brentnall, Teresa A; Loeb, Lawrence A; Kennedy, Scott R; Salk, Jesse J; Naxerova, Kamila; Risques, Rosa Ana.

Proc Natl Acad Sci U S A ; 118(31)2021 08 03.

Article in English | MEDLINE | ID: mdl-34330826

3.

A high-resolution landscape of mutations in the BCL6 super-enhancer in normal human B cells.

Shen, Jiang-Cheng; Kamath-Loeb, Ashwini S; Kohrn, Brendan F; Loeb, Keith R; Preston, Bradley D; Loeb, Lawrence A.

Proc Natl Acad Sci U S A ; 116(49): 24779-24785, 2019 12 03.

Article in English | MEDLINE | ID: mdl-31748270

4.

Extensive subclonal mutational diversity in human colorectal cancer and its significance.

Loeb, Lawrence A; Kohrn, Brendan F; Loubet-Senear, Kaitlyn J; Dunn, Yasmin J; Ahn, Eun Hyun; O'Sullivan, Jacintha N; Salk, Jesse J; Bronner, Mary P; Beckman, Robert A.

Proc Natl Acad Sci U S A ; 116(52): 26863-26872, 2019 Dec 26.

Article in English | MEDLINE | ID: mdl-31806761

5.

Accurate RNA consensus sequencing for high-fidelity detection of transcriptional mutagenesis-induced epimutations.

Reid-Bayliss, Kate S; Loeb, Lawrence A.

Proc Natl Acad Sci U S A ; 114(35): 9415-9420, 2017 08 29.

Article in English | MEDLINE | ID: mdl-28798064

6.

Mutational spectra of aflatoxin B₁ in vivo establish biomarkers of exposure for human hepatocellular carcinoma.

Chawanthayatham, Supawadee; Valentine, Charles C; Fedeles, Bogdan I; Fox, Edward J; Loeb, Lawrence A; Levine, Stuart S; Slocum, Stephen L; Wogan, Gerald N; Croy, Robert G; Essigmann, John M.

Proc Natl Acad Sci U S A ; 114(15): E3101-E3109, 2017 04 11.

Article in English | MEDLINE | ID: mdl-28351974

7.

Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency.

Reid-Bayliss, Kate S; Arron, Sarah T; Loeb, Lawrence A; Bezrookove, Vladimir; Cleaver, James E.

Proc Natl Acad Sci U S A ; 113(36): 10151-6, 2016 09 06.

Article in English | MEDLINE | ID: mdl-27543334

8.

Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues.

Krimmel, Jeffrey D; Schmitt, Michael W; Harrell, Maria I; Agnew, Kathy J; Kennedy, Scott R; Emond, Mary J; Loeb, Lawrence A; Swisher, Elizabeth M; Risques, Rosa Ana.

Proc Natl Acad Sci U S A ; 113(21): 6005-10, 2016 May 24.

Article in English | MEDLINE | ID: mdl-27152024

9.

Sequencing small genomic targets with high efficiency and extreme accuracy.

Schmitt, Michael W; Fox, Edward J; Prindle, Marc J; Reid-Bayliss, Kate S; True, Lawrence D; Radich, Jerald P; Loeb, Lawrence A.

Nat Methods ; 12(5): 423-5, 2015 May.

Article in English | MEDLINE | ID: mdl-25849638

10.

Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase.

Klapacz, Joanna; Lingaraju, Gondichatnahalli M; Guo, Haiwei H; Shah, Dharini; Moar-Shoshani, Ayelet; Loeb, Lawrence A; Samson, Leona D.

Mol Cell ; 37(6): 843-53, 2010 Mar 26.

Article in English | MEDLINE | ID: mdl-20347426

11.

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage.

Kennedy, Scott R; Salk, Jesse J; Schmitt, Michael W; Loeb, Lawrence A.

PLoS Genet ; 9(9): e1003794, 2013.

Article in English | MEDLINE | ID: mdl-24086148

12.

Mitochondrial point mutations do not limit the natural lifespan of mice.

Vermulst, Marc; Bielas, Jason H; Kujoth, Gregory C; Ladiges, Warren C; Rabinovitch, Peter S; Prolla, Tomas A; Loeb, Lawrence A.

Nat Genet ; 39(4): 540-3, 2007 Apr.

Article in English | MEDLINE | ID: mdl-17334366

13.

Sphingosine, a modulator of human translesion DNA polymerase activity.

Kamath-Loeb, Ashwini S; Balakrishna, Sharath; Whittington, Dale; Shen, Jiang-Cheng; Emond, Mary J; Okabe, Takayoshi; Masutani, Chikahide; Hanaoka, Fumio; Nishimura, Susumu; Loeb, Lawrence A.

J Biol Chem ; 289(31): 21663-72, 2014 Aug 01.

Article in English | MEDLINE | ID: mdl-24928506

14.

Cancer: One cell at a time.

Fox, Edward J; Loeb, Lawrence A.

Nature ; 512(7513): 143-4, 2014 Aug 14.

Article in English | MEDLINE | ID: mdl-25079325

15.

Detection of ultra-rare mutations by next-generation sequencing.

Schmitt, Michael W; Kennedy, Scott R; Salk, Jesse J; Fox, Edward J; Hiatt, Joseph B; Loeb, Lawrence A.

Proc Natl Acad Sci U S A ; 109(36): 14508-13, 2012 Sep 04.

Article in English | MEDLINE | ID: mdl-22853953

16.

A substitution in the fingers domain of DNA polymerase Î´ reduces fidelity by altering nucleotide discrimination in the catalytic site.

Prindle, Marc J; Schmitt, Michael W; Parmeggiani, Fabio; Loeb, Lawrence A.

J Biol Chem ; 288(8): 5572-80, 2013 Feb 22.

Article in English | MEDLINE | ID: mdl-23283971

17.

Do mutator mutations fuel tumorigenesis?

Fox, Edward J; Prindle, Marc J; Loeb, Lawrence A.

Cancer Metastasis Rev ; 32(3-4): 353-61, 2013 Dec.

Article in English | MEDLINE | ID: mdl-23592419

18.

DNA polymerases and human disease.

Loeb, Lawrence A; Monnat, Raymond J.

Nat Rev Genet ; 9(8): 594-604, 2008 Aug.

Article in English | MEDLINE | ID: mdl-18626473

19.

The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase Î´.

Kamath-Loeb, Ashwini S; Shen, Jiang-Cheng; Schmitt, Michael W; Loeb, Lawrence A.

J Biol Chem ; 287(15): 12480-90, 2012 Apr 06.

Article in English | MEDLINE | ID: mdl-22351772

20.

A random mutation capture assay to detect genomic point mutations in mouse tissue.

Wright, Jocelyn H; Modjeski, Kristina L; Bielas, Jason H; Preston, Bradley D; Fausto, Nelson; Loeb, Lawrence A; Campbell, Jean S.

Nucleic Acids Res ; 39(11): e73, 2011 Jun.

Article in English | MEDLINE | ID: mdl-21459851

VHL Search Portal

Information and Knowledge for Health

Config filters

Your selection (0)

Export format:

Export: