Search | VHL Search Portal

1.

CRISPR-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema.

Longhurst, Hilary J; Lindsay, Karen; Petersen, Remy S; Fijen, Lauré M; Gurugama, Padmalal; Maag, David; Butler, James S; Shah, Mrinal Y; Golden, Adele; Xu, Yuanxin; Boiselle, Carri; Vogel, Joseph D; Abdelhady, Ahmed M; Maitland, Michael L; McKee, Mark D; Seitzer, Jessica; Han, Bo W; Soukamneuth, Samantha; Leonard, John; Sepp-Lorenzino, Laura; Clark, Eliana D; Lebwohl, David; Cohn, Danny M.

N Engl J Med ; 390(5): 432-441, 2024 Feb 01.

Article in English | MEDLINE | ID: mdl-38294975

2.

Uncovering the true burden of hereditary angioedema due to C1-inhibitor deficiency: A focus on the Asia-Pacific region.

Honda, Daisuke; Li, Philip Hei; Jindal, Ankur Kumar; Katelaris, Constance H; Zhi, Yu-Xiang; Thong, Bernard Yu-Hor; Longhurst, Hilary J.

J Allergy Clin Immunol ; 153(1): 42-54, 2024 01.

Article in English | MEDLINE | ID: mdl-37898409

3.

An investigational oral plasma kallikrein inhibitor for on-demand treatment of hereditary angioedema: a two-part, randomised, double-blind, placebo-controlled, crossover phase 2 trial.

Aygören-Pürsün, Emel; Zanichelli, Andrea; Cohn, Danny M; Cancian, Mauro; Hakl, Roman; Kinaciyan, Tamar; Magerl, Markus; Martinez-Saguer, Inmaculada; Stobiecki, Marcin; Farkas, Henriette; Kiani-Alikhan, Sorena; Grivcheva-Panovska, Vesna; Bernstein, Jonathan A; Li, H Henry; Longhurst, Hilary J; Audhya, Paul K; Smith, Michael D; Yea, Christopher M; Maetzel, Andreas; Lee, Daniel K; Feener, Edward P; Gower, Richard; Lumry, William R; Banerji, Aleena; Riedl, Marc A; Maurer, Marcus.

Lancet ; 401(10375): 458-469, 2023 02 11.

Article in English | MEDLINE | ID: mdl-36774155

4.

New Therapies for Type 1 and Type 2 Hereditary Angioedema.

Ameratunga, Rohan; Longhurst, Hilary J.

N Engl J Med ; 2024 May 31.

Article in English | MEDLINE | ID: mdl-38819650

5.

The Icatibant Outcome Survey: 10 years of experience with icatibant for patients with hereditary angioedema.

Maurer, Marcus; Aberer, Werner; Caballero, Teresa; Bouillet, Laurence; Grumach, Anete S; Botha, Jaco; Andresen, Irmgard; Longhurst, Hilary J.

Clin Exp Allergy ; 52(9): 1048-1058, 2022 09.

Article in English | MEDLINE | ID: mdl-35861129

6.

Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema.

Aygören-Pürsün, Emel; Bygum, Anette; Grivcheva-Panovska, Vesna; Magerl, Markus; Graff, Jochen; Steiner, Urs C; Fain, Olivier; Huissoon, Aarnoud; Kinaciyan, Tamar; Farkas, Henriette; Lleonart, Ramon; Longhurst, Hilary J; Rae, William; Triggiani, Massimo; Aberer, Werner; Cancian, Mauro; Zanichelli, Andrea; Smith, William B; Baeza, Maria L; Du-Thanh, Aurelie; Gompels, Mark; Gonzalez-Quevedo, Teresa; Greve, Jens; Guilarte, Mar; Katelaris, Constance; Dobo, Sylvia; Cornpropst, Melanie; Clemons, Desiree; Fang, Lei; Collis, Phil; Sheridan, William; Maurer, Marcus; Cicardi, Marco.

N Engl J Med ; 379(4): 352-362, 2018 07 26.

Article in English | MEDLINE | ID: mdl-30044938

7.

Impact of lanadelumab on health-related quality of life in patients with hereditary angioedema in the HELP study.

Lumry, William R; Weller, Karsten; Magerl, Markus; Banerji, Aleena; Longhurst, Hilary J; Riedl, Marc A; Lewis, Hannah B; Lu, Peng; Devercelli, Giovanna; Jain, Gagan; Maurer, Marcus.

Allergy ; 76(4): 1188-1198, 2021 04.

Article in English | MEDLINE | ID: mdl-33258114

8.

An Antisense Oligonucleotide for Hereditary Angioedema.

Longhurst, Hilary J; Ameratunga, Rohan.

N Engl J Med ; 386(11): 1083-1085, 2022 03 17.

Article in English | MEDLINE | ID: mdl-35294818

9.

Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks.

Riedl, Marc A; Maurer, Marcus; Bernstein, Jonathan A; Banerji, Aleena; Longhurst, Hilary J; Li, H Henry; Lu, Peng; Hao, James; Juethner, Salomé; Lumry, William R.

Allergy ; 75(11): 2879-2887, 2020 11.

Article in English | MEDLINE | ID: mdl-32452549

10.

Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans.

Tuijnenburg, Paul; Lango Allen, Hana; Burns, Siobhan O; Greene, Daniel; Jansen, Machiel H; Staples, Emily; Stephens, Jonathan; Carss, Keren J; Biasci, Daniele; Baxendale, Helen; Thomas, Moira; Chandra, Anita; Kiani-Alikhan, Sorena; Longhurst, Hilary J; Seneviratne, Suranjith L; Oksenhendler, Eric; Simeoni, Ilenia; de Bree, Godelieve J; Tool, Anton T J; van Leeuwen, Ester M M; Ebberink, Eduard H T M; Meijer, Alexander B; Tuna, Salih; Whitehorn, Deborah; Brown, Matthew; Turro, Ernest; Thrasher, Adrian J; Smith, Kenneth G C; Thaventhiran, James E; Kuijpers, Taco W.

J Allergy Clin Immunol ; 142(4): 1285-1296, 2018 10.

Article in English | MEDLINE | ID: mdl-29477724

11.

Clinical spectrum and features of activated phosphoinositide 3-kinase Î´ syndrome: A large patient cohort study.

Coulter, Tanya I; Chandra, Anita; Bacon, Chris M; Babar, Judith; Curtis, James; Screaton, Nick; Goodlad, John R; Farmer, George; Steele, Cathal Laurence; Leahy, Timothy Ronan; Doffinger, Rainer; Baxendale, Helen; Bernatoniene, Jolanta; Edgar, J David M; Longhurst, Hilary J; Ehl, Stephan; Speckmann, Carsten; Grimbacher, Bodo; Sediva, Anna; Milota, Tomas; Faust, Saul N; Williams, Anthony P; Hayman, Grant; Kucuk, Zeynep Yesim; Hague, Rosie; French, Paul; Brooker, Richard; Forsyth, Peter; Herriot, Richard; Cancrini, Caterina; Palma, Paolo; Ariganello, Paola; Conlon, Niall; Feighery, Conleth; Gavin, Patrick J; Jones, Alison; Imai, Kohsuke; Ibrahim, Mohammad A A; Markelj, Gasper; Abinun, Mario; Rieux-Laucat, Frédéric; Latour, Sylvain; Pellier, Isabelle; Fischer, Alain; Touzot, Fabien; Casanova, Jean-Laurent; Durandy, Anne; Burns, Siobhan O; Savic, Sinisa; Kumararatne, D S.

J Allergy Clin Immunol ; 139(2): 597-606.e4, 2017 02.

Article in English | MEDLINE | ID: mdl-27555459

12.

Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks: A Randomized Clinical Trial.

Banerji, Aleena; Riedl, Marc A; Bernstein, Jonathan A; Cicardi, Marco; Longhurst, Hilary J; Zuraw, Bruce L; Busse, Paula J; Anderson, John; Magerl, Markus; Martinez-Saguer, Inmaculada; Davis-Lorton, Mark; Zanichelli, Andrea; Li, H Henry; Craig, Timothy; Jacobs, Joshua; Johnston, Douglas T; Shapiro, Ralph; Yang, William H; Lumry, William R; Manning, Michael E; Schwartz, Lawrence B; Shennak, Mustafa; Soteres, Daniel; Zaragoza-Urdaz, Rafael H; Gierer, Selina; Smith, Andrew M; Tachdjian, Raffi; Wedner, H James; Hebert, Jacques; Rehman, Syed M; Staubach, Petra; Schranz, Jennifer; Baptista, Jovanna; Nothaft, Wolfram; Maurer, Marcus.

JAMA ; 320(20): 2108-2121, 2018 11 27.

Article in English | MEDLINE | ID: mdl-30480729

13.

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid.

Hinz, Christine; Aldrovandi, Maceler; Uhlson, Charis; Marnett, Lawrence J; Longhurst, Hilary J; Warner, Timothy D; Alam, Saydul; Slatter, David A; Lauder, Sarah N; Allen-Redpath, Keith; Collins, Peter W; Murphy, Robert C; Thomas, Christopher P; O'Donnell, Valerie B.

J Biol Chem ; 291(26): 13448-64, 2016 Jun 24.

Article in English | MEDLINE | ID: mdl-27129261

14.

How Not to Be Misled by Disorders Mimicking Angioedema: A Review of Pseudoangioedema.

Andersen, Michelle Fog; Longhurst, Hilary J; Rasmussen, Eva Rye; Bygum, Anette.

Int Arch Allergy Immunol ; 169(3): 163-70, 2016.

Article in English | MEDLINE | ID: mdl-27100932

15.

Misdiagnosis trends in patients with hereditary angioedema from the real-world clinical setting.

Zanichelli, Andrea; Longhurst, Hilary J; Maurer, Marcus; Bouillet, Laurence; Aberer, Werner; Fabien, Vincent; Andresen, Irmgard; Caballero, Teresa.

Ann Allergy Asthma Immunol ; 117(4): 394-398, 2016 10.

Article in English | MEDLINE | ID: mdl-27742086

16.

Kallikrein Inhibition for Hereditary Angioedema.

Longhurst, Hilary J.

N Engl J Med ; 376(8): 788-789, 2017 02 23.

Article in English | MEDLINE | ID: mdl-28225685

17.

Analysis of characteristics associated with reinjection of icatibant: Results from the icatibant outcome survey.

Longhurst, Hilary J; Aberer, Werner; Bouillet, Laurence; Caballero, Teresa; Fabien, Vincent; Zanichelli, Andrea; Maurer, Marcus.

Allergy Asthma Proc ; 36(5): 399-406, 2015.

Article in English | MEDLINE | ID: mdl-26314822

18.

Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α.

Brooke, Matthew A; Longhurst, Hilary J; Plagnol, Vincent; Kirkby, Nicholas S; Mitchell, Jane A; Rüschendorf, Franz; Warner, Timothy D; Kelsell, David P; MacDonald, Thomas T.

Gut ; 63(1): 96-104, 2014 Jan.

Article in English | MEDLINE | ID: mdl-23268370

19.

Treatment of hereditary angioedema with icatibant: efficacy in clinical trials versus effectiveness in the real-world setting.

Maurer, Marcus; Longhurst, Hilary J; Fabien, Vincent; Li, H Henry; Lumry, William R.

Allergy Asthma Proc ; 35(5): 377-81, 2014.

Article in English | MEDLINE | ID: mdl-25198193

20.

The autoimmune rheumatological presentation of Common Variable Immunodeficiency Disorders with an overview of genetic testing.

Ameratunga, Rohan; Woon, See-Tarn; Leung, Euphemia; Lea, Edward; Chan, Lydia; Mehrtens, James; Longhurst, Hilary J; Steele, Richard; Lehnert, Klaus; Lindsay, Karen.

Semin Arthritis Rheum ; 65: 152387, 2024 Apr.

Article in English | MEDLINE | ID: mdl-38330740

VHL Search Portal

Information and Knowledge for Health

Config filters

Your selection (0)

Export format:

Export: