ABSTRACT
Hair highlighting procedures are very common throughout the world. While rarely reported, potential adverse events to such procedures include allergic and irritant contact dermatitis, thermal burns, and chemical burns. Herein, we report two cases of female adolescents who underwent a hair highlighting procedure at local salons and sustained a chemical burn to the scalp. The burn etiology, clinical and histologic features, the expected sequelae, and a review of the literature are described.
Subject(s)
Alopecia/etiology , Alopecia/pathology , Burns, Chemical/etiology , Burns, Chemical/pathology , Hair Dyes/adverse effects , Adolescent , Biopsy , Child , Female , Humans , Scalp/injuries , Scalp/pathologyABSTRACT
Nijmegen breakage syndrome (NBS) is a chromosomal breakage disorder with characteristic physical features, chromosomal instability, and combined immunodeficiency. It is closely related to other chromosomal breakage disorders like ataxia telangiectasia. Noninfectious granulomatous inflammation refractory to treatment is a relatively common feature in ataxia telangiectasia. Herein we report a patient with NBS who developed chronic refractory necrotizing granulomatous ulcerations and review the pathophysiology of NBS and noninfectious granulomas in primary immunodeficiency syndromes.
Subject(s)
Granuloma/diagnosis , Nijmegen Breakage Syndrome/diagnosis , X-Linked Combined Immunodeficiency Diseases/diagnosis , Child , Chronic Disease , Female , Granuloma/drug therapy , Granuloma/genetics , Granuloma/pathology , Humans , Necrosis , Nijmegen Breakage Syndrome/drug therapy , Nijmegen Breakage Syndrome/genetics , Nijmegen Breakage Syndrome/pathology , X-Linked Combined Immunodeficiency Diseases/drug therapy , X-Linked Combined Immunodeficiency Diseases/genetics , X-Linked Combined Immunodeficiency Diseases/pathologyABSTRACT
Subcutaneous fat necrosis of the newborn (SFNN) is an uncommon self-limiting panniculitis. Lesions may be fluctuant and spontaneously drain. Here we report a technique to rapidly confirm the diagnosis of SFNN when fluctuance exists via a touch preparation that demonstrates the characteristic histologic features of this condition. The material can be collected by fine needle aspirate, from draining fluctuant lesions, or if biopsy if performed.
Subject(s)
Cytodiagnosis , Fat Necrosis/diagnosis , Subcutaneous Fat/pathology , Biopsy, Needle , Humans , Infant, Newborn , MaleABSTRACT
Sweet syndrome (SS) (Acute Febrile Neutrophilic Dermatosis) has been reported in association with autoimmune phenomena including relapsing polychondritis, drug-induced lupus, and the development of antineutrophil cytoplasmic antibodies (ANCAs). However, a combination of these autoimmune features has not been reported. Herein, we report a case of drug-induced bullous SS with ocular and mucosal involvement, glomerulonephritis, and multiple autoimmune features including clinical polychondritis with antitype II collagen antibodies, ANCAs, antinuclear (HEp-2), and antihistone antibodies in a patient on hydralazine and carbamazepine.