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1.
Meeting Report on the 2nd Chinese American Society for Mass Spectrometry Conference: Advancing Biological and Pharmaceutical Mass Spectrometry.
Mol Cell Proteomics
; 22(6): 100559, 2023 Jun.
Article
in English
| MEDLINE | ID: mdl-37105363
2.
Mass Balance, Metabolic Pathways, Absolute Bioavailability, And Pharmacokinetics of Giredestrant In Healthy Subjects.
Drug Metab Dispos
; 2024 Jun 04.
Article
in English
| MEDLINE | ID: mdl-38834357
3.
Meeting Report on the 3rd Chinese American Society for Mass Spectrometry Conference-Advancing Biological and Pharmaceutical Mass Spectrometry.
Biomed Chromatogr
; 38(3): e5795, 2024 Mar.
Article
in English
| MEDLINE | ID: mdl-38071756
4.
Absorption, Metabolism, and Excretion of Taselisib (GDC-0032), a Potent ß-Sparing PI3K Inhibitor in Rats, Dogs, and Humans.
Drug Metab Dispos
; 51(4): 436-450, 2023 04.
Article
in English
| MEDLINE | ID: mdl-36623882
5.
Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1-a]isoindole and Species Differences in Glucuronidation.
Drug Metab Dispos
; 51(7): 862-872, 2023 Jul.
Article
in English
| MEDLINE | ID: mdl-37059472
6.
The Absolute Bioavailability and Absorption, Metabolism, and Excretion of Ipatasertib, a Potent and Highly Selective Protein Kinase B (Akt) Inhibitor.
Drug Metab Dispos
; 51(10): 1332-1341, 2023 10.
Article
in English
| MEDLINE | ID: mdl-37524543
7.
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 59: 128576, 2022 03 01.
Article
in English
| MEDLINE | ID: mdl-35065235
8.
Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats.
Xenobiotica
; 52(3): 219-228, 2022 Mar.
Article
in English
| MEDLINE | ID: mdl-35379057
9.
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans.
Xenobiotica
; 51(7): 796-810, 2021 Jul.
Article
in English
| MEDLINE | ID: mdl-33938357
10.
Novel Homodimer Metabolites of GDC-0994 via Cytochrome P450-Catalyzed Radical Coupling.
Drug Metab Dispos
; 48(6): 521-527, 2020 06.
Article
in English
| MEDLINE | ID: mdl-32234735
11.
Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats.
Drug Metab Dispos
; 48(11): 1161-1168, 2020 11.
Article
in English
| MEDLINE | ID: mdl-32839277
12.
Strategies to Mitigate the Bioactivation of Aryl Amines.
Chem Res Toxicol
; 33(7): 1950-1959, 2020 07 20.
Article
in English
| MEDLINE | ID: mdl-32508087
13.
Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor.
Br J Clin Pharmacol
; 85(8): 1751-1760, 2019 08.
Article
in English
| MEDLINE | ID: mdl-30973970
14.
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Nat Chem Biol
; 12(10): 779-86, 2016 10.
Article
in English
| MEDLINE | ID: mdl-27479743
15.
CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339.
Drug Metab Dispos
; 45(10): 1084-1092, 2017 10.
Article
in English
| MEDLINE | ID: mdl-28790146
16.
Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450.
Drug Metab Dispos
; 45(5): 430-440, 2017 05.
Article
in English
| MEDLINE | ID: mdl-28188299
17.
Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs.
Xenobiotica
; 47(1): 50-65, 2017 Jan.
Article
in English
| MEDLINE | ID: mdl-27055783
18.
Non-cytochrome P450-mediated bioactivation and its toxicological relevance.
Drug Metab Rev
; 48(4): 473-501, 2016 11.
Article
in English
| MEDLINE | ID: mdl-27533622
19.
Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.
Drug Metab Dispos
; 44(1): 28-39, 2016 Jan.
Article
in English
| MEDLINE | ID: mdl-26451002
20.
Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450-Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor.
Drug Metab Dispos
; 43(12): 1929-33, 2015 Dec.
Article
in English
| MEDLINE | ID: mdl-26438627