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1.
Rev Infirm ; 67(242): 18-20, 2018.
Article in French | MEDLINE | ID: mdl-29907171

ABSTRACT

Colourless and odourless, each year carbon monoxide is responsible for several thousand cases of poisoning. Often collective, their symptoms are non specific and can result in serious neurological sequelae or even death, if they are not detected in time. The (pre-) hospital emergency nurse plays an important role in the management of these patients, in terms of assessment, treatment and monitoring as well as the organisation of the admittance of victims, categorisation and medical triage. As part of a team, the nurse ensures that the patient enters an adapted, regulated pathway, with the most serious cases being directed towards a hospital equipped with a hyperbaric medicine facility.


Subject(s)
Carbon Monoxide Poisoning , Triage , Carbon Monoxide Poisoning/diagnosis , Carbon Monoxide Poisoning/nursing , Carbon Monoxide Poisoning/therapy , Emergencies/nursing , Emergency Nursing/methods , Emergency Nursing/organization & administration , Humans , Hyperbaric Oxygenation/statistics & numerical data , Triage/organization & administration , Workforce
2.
Rev Infirm ; 66(234): 37-40, 2017 Oct.
Article in French | MEDLINE | ID: mdl-28985782

ABSTRACT

Simple and non-invasive, the electrocardiogram is a basic examination for studying how the cardiac muscle functions. Very commonly used, it nonetheless requires great rigour when applying the electrodes to avoid false results that can be harmful to appropriate care for the patient. A reminder of good practices.


Subject(s)
Electrocardiography/methods , Electrodes , Electrocardiography/instrumentation , Humans
3.
Prehosp Emerg Care ; 20(5): 637-42, 2016.
Article in English | MEDLINE | ID: mdl-27018547

ABSTRACT

INTRODUCTION: During out-of-hospital cardiac arrest (OHCA), chest compression interruptions or hands-off time (HOT) affect the prognosis. Our aim was to measure HOT due to the application of an automated chest compression device (ACD) by an advanced life support team. MATERIALS AND METHODS: This was a prospective observational case series report since the introduction of a new method of installing the ACD. Inclusion criteria were patients over 18 years old with OHCA who were treated with an ACD (Lucas 2(TM), Physio-Control). The ACD application was indicated only for OHCA patients transported to a hospital for Extra Corporeal Life Support (ECLS). We recorded the HOT related to switching from manual to mechanical chest compressions. An ACD consists of dorsal and ventral components, which can be installed either in one or in two steps, separated from a chest compression sequence. HOT was expressed as a median number of seconds [interquartile range]. RESULTS: From January 1, 2012 to January 15, 2013, 30 patients were included. In the case of ACD application in one phase (n = 16), the median HOT was 25.3 s [19.8-30.5]. With regard to patients with an ACD application in two phases (n = 14), the median HOT was, respectively, 9.8 s [7.8-17] and 12.4 s [9.5-16.2], that is, a median global HOT of 23.6 s [19-27.6]. HOT was not different between ACD applications in one or two phases (p = 0.52). For a two phase application, the median chest compression time between the two manipulations was 14.2 s [6.4-18]. CONCLUSION: There was no significant difference between techniques in the application of the Lucas 2(TM) device in terms of HOT. The short time needed to apply the device lends itself well to use as a primary chest compression modality during cardiac arrest as well as a bridge to novel resuscitation strategies (ECLS). A further study is currently underway with a larger number of ECLS patients.


Subject(s)
Cardiopulmonary Resuscitation/methods , Heart Massage/methods , Out-of-Hospital Cardiac Arrest/therapy , Adult , Aged , Emergency Medical Services/methods , Female , Humans , Male , Middle Aged , Prospective Studies , Time Factors
4.
Prehosp Disaster Med ; 30(3): 316-9, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25868553

ABSTRACT

The majority of maxillofacial gunshot wounds are caused by suicide attempts. Young men are affected most often. When the lower one-third of the face is involved, airway patency (1.6% of the cases) and hemorrhage control (1.9% of the cases) are the two most urgent complications to monitor and prevent. Spinal fractures are observed with 10% of maxillary injuries and in 20% of orbital injuries. Actions to treat the facial gunshot victim need to be performed, keeping in mind spine immobilization until radiographic imaging is complete and any required spinal stabilization accomplished. Patients should be transported to a trauma center equipped to deal with maxillofacial and neurosurgery because 40% require emergency surgery. The mortality rate of maxillofacial injuries shortly after arrival at a hospital varies from 2.8% to 11.0%. Complications such as hemiparesis or cranial nerve paralysis occur in 20% of survivors. This case has been reported on a victim of four gunshot injuries. One of the gunshots was to the left mandibular ramus and became lodged in the C4 vertebral bone.


Subject(s)
Maxillofacial Injuries/therapy , Spinal Injuries/therapy , Wounds, Gunshot/therapy , Adult , Emergency Medical Services , Humans , Injury Severity Score , Male
5.
Am J Emerg Med ; 32(5): 438-42, 2014 May.
Article in English | MEDLINE | ID: mdl-24612593

ABSTRACT

BACKGROUND: Improving access to thrombolytic therapy for patients with ischemic stroke is challenging. We assessed a prehospital process based on firemen rescuers under strict medical direction, aimed at facilitating thrombolysis of eligible patients. METHODS: This was a prospective observational study conducted over 4 months in Paris, France. Prehospital patients with suspected stroke were included after telephone consultation with a physician. If the time since the onset of symptoms was less than 6 hours, patients were transported directly to a neurovascular unit (NVU); if symptom onset was more than 6 hours ago, they were transported to an emergency department (ED). Confirmation of stroke diagnosis, the rate of thrombolysis, and the time intervals between the call and hospital arrival and imaging were assessed. Comparison used Fisher exact test. RESULTS: Of the 271 patients transported to an NVU, 218 were diagnosed with a stroke (166 with ischemic stroke), 69 received thrombolytic therapy, and the mean stroke-thrombolysis interval was 150 minutes. Of 64 patients admitted to the ED, 36 patients had a stroke (ischemic, 24). None were thrombolysed. Globally, 36% of ischemic strokes were thrombolysed (27% of all strokes diagnosed). The mean interval call-hospital was 65 minutes (ED vs NVU, P = .61). The interval call-imaging was 202 minutes (interquartile range, 105.5-254.5) for ED and 92 minutes (interquartile range, 77-116) for NVU (P < .001). CONCLUSIONS: The prehospital management of stroke by rescuers, under strict medical direction, seemed to be feasible and effective for selection of patients with stroke in an urban environment and may improve the access to thrombolysis.


Subject(s)
Emergency Medical Services/organization & administration , Stroke/drug therapy , Thrombolytic Therapy/methods , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Paris , Prospective Studies , Time Factors , Transportation of Patients , Treatment Outcome
6.
Air Med J ; 33(6): 283-5, 2014.
Article in English | MEDLINE | ID: mdl-25441521

ABSTRACT

OBJECTIVES: The aim of this study was to evaluate the capacity of a traditional stethoscope versus an electronically amplified one (expected to reduce background and ambient noise) to assess heart and respiratory sounds during medical transport. MATERIALS AND METHODS: It was a prospective, double-blinded, randomized performed study. One traditional stethoscope (Littmann Cardiology III; 3M, St Paul, MN) and 1 electronically amplified stethoscope (Littmann 3200, 3M) were used for our tests. Heart and lung auscultation during real medical evacuations aboard a medically configured Falcon 50 aircrafts were studied. The quality of auscultation was ranged using a numeric rating scale from 0 to 10 (0 corresponding to "I hear nothing" and 10 to "I hear perfectly"). Data collected were compared using a t-test for paired values. RESULTS: A total of 40 comparative evaluations were performed. For cardiac auscultation, the value of the rating scale was 4.53 ± 1.91 and 7.18 ± 1.88 for the traditional and amplified stethoscope, respectively (paired t-test: P < .0001). For respiratory sounds, quality of auscultation was estimated at 3.1 ± 1.95 for a traditional stethoscope and 5.10 ± 2.13 for the amplified one (paired t-test: P < .0001). CONCLUSIONS: This study showed that practitioners would be better helped in hearing cardiac and respiratory sounds with an electronically amplified stethoscope than with a traditional one during air medical transport in a medically configured Falcon 50 aircraft.


Subject(s)
Air Ambulances , Auscultation/instrumentation , Stethoscopes , Adult , Double-Blind Method , Female , Humans , Lung , Male , Prospective Studies , Young Adult
7.
J R Army Med Corps ; 160(3): 213-6, 2014 Sep.
Article in English | MEDLINE | ID: mdl-24109097

ABSTRACT

OBJECTIVES: Ultrasound has been used in the field and in emergency departments for more than two decades. In a military setting, its use has grown rapidly as it has gained widespread acceptance among emergency physicians and as the range of diagnostic and triage applications has continued to expand. Technological changes have enabled ultrasound devices to become accessible to general practitioners (GP), and it could be of particular interest for military GPs in isolated environments. We have investigated both the training of French military GPs in the area of ultrasonography and the use of ultrasound devices, in daily practice and abroad, in isolated military settings. METHODS: In 2011, a questionnaire was sent to all 147 in-the-field GPs of the French southeast regional military health service. The questionnaire evaluated the training of military GPs in ultrasonography, the use of ultrasound in France in daily practice, and during military operations in isolated environments abroad during 2010. RESULTS: The response rate was 52%. On the one hand, half the responding GPs had been specially trained in ultrasound, mainly (97%) in military institutes. On the other hand, only a quarter of doctors used ultrasound in daily practice. Among those GPs performing ultrasound examinations in France, 75% used it in 2010 during isolated operations abroad. Ultrasound examinations performed in such an austere environment were retrospectively declared useful to guide clinical reasoning (41% of examinations carried out), diagnosis (21%) and decision making as regards evacuation (11%). CONCLUSIONS: The challenge for the future is to make ultrasound courses mandatory for all military GPs going on overseas operations, to develop daily practice, and to investigate effective triage systems, combining both ultrasound imagery and physical examination.


Subject(s)
General Practitioners/education , Military Medicine/education , Military Personnel/education , Ultrasonography , Clinical Competence , France , General Practice , Humans , Practice Patterns, Physicians' , Surveys and Questionnaires
8.
JAMA Netw Open ; 5(7): e2223619, 2022 07 01.
Article in English | MEDLINE | ID: mdl-35881397

ABSTRACT

Importance: Blood transfusion is a mainstay of therapy for trauma-induced coagulopathy, but the optimal modalities for plasma transfusion in the prehospital setting remain to be defined. Objective: To determine whether lyophilized plasma transfusion can reduce the incidence of trauma-induced coagulopathy compared with standard care consisting of normal saline infusion. Design, Setting, and Participants: This randomized clinical trial was performed at multiple centers in France involving prehospital medical teams. Participants included 150 adults with trauma who were at risk for hemorrhagic shock and associated coagulopathy between April 1, 2016, and September 30, 2019, with a 28-day follow-up. Data were analyzed from November 1, 2019, to July 1, 2020. Intervention: Patients were randomized in a 1:1 ratio to receive either plasma or standard care with normal saline infusion (control). Main Outcomes and Measures: The primary outcome was the international normalized ratio (INR) on arrival at the hospital. Secondary outcomes included the need for massive transfusion and 30-day survival. As a safety outcome, prespecified adverse events included thrombosis, transfusion-related acute lung injury, and transfusion-associated circulatory overload. Results: Among 150 randomized patients, 134 were included in the analysis (median age, 34 [IQR, 26-49] years; 110 men [82.1%]), with 68 in the plasma group and 66 in the control group. Median INR values were 1.21 (IQR, 1.12-1.49) in the plasma group and 1.20 (IQR, 1.10-1.39) in the control group (median difference, -0.01 [IQR, -0.09 to 0.08]; P = .88). The groups did not differ significantly in the need for massive transfusion (7 [10.3%] vs 4 [6.1%]; relative risk, 1.78 [95% CI, 0.42-8.68]; P = .37) or 30-day survival (hazard ratio for death, 1.07 [95% CI, 0.44-2.61]; P = .89). In the full intention-to-treat population (n = 150), the groups did not differ in the rates of any of the prespecified adverse events. Conclusions and Relevance: In this randomized clinical trial including severely injured patients at risk for hemorrhagic shock and associated coagulopathy, prehospital transfusion of lyophilized plasma was not associated with significant differences in INR values vs standard care with normal saline infusion. Nevertheless, these findings show that lyophilized plasma transfusion is a feasible and safe procedure for this patient population. Trial Registration: ClinicalTrials.gov Identifier: NCT02736812.


Subject(s)
Emergency Medical Services , Shock, Hemorrhagic , Adult , Blood Component Transfusion , Blood Transfusion , Emergency Medical Services/methods , Humans , Male , Plasma , Saline Solution , Shock, Hemorrhagic/etiology , Shock, Hemorrhagic/therapy
9.
Arch Pediatr ; 28(8): 712-717, 2021 Nov.
Article in English | MEDLINE | ID: mdl-34625381

ABSTRACT

AIM: To assess the diagnostic performance of a simplified lung point-of-care ultrasound (POCUS) to confirm the correct positioning of an endotracheal tube (ETT) in a pediatric intensive care unit (PICU) used to chest radiography (CXR), and to compare the time to obtain the ETT position between POCUS and CXR. METHODS: We conducted a single-center prospective study in critically ill children requiring urgent endotracheal intubation. Esophageal tube malposition was first avoided using auscultation and end-tidal CO2. The ETT position was assessed with CXR and lung POCUS using the lung sliding sign on a pleural window. All of the investigators had to read guidelines and received 1-h training on the technical aspects of lung sliding. The primary objective was the accuracy of POCUS in confirming correct nonselective endotracheal intubation as compared with CXR. RESULTS: A total of 71 patients were included from December 2016 to November 2018. CXR identified proper nonselective ETT placement in 43 of 71 (61%) patients, while the rate for selective intubation was 39%. The sensitivity and specificity of POCUS as compared with CXR were 77% and 68%, respectively. Median time to POCUS was significantly shorter than CXR (2 min to perform POCUS, 10 min to obtain radiographs, p<10-4). CONCLUSION: Pleural ultrasound, although faster than CXR, appears to be inadequate for identifying selective ETT after urgent intubation in a PICU less accustomed to this kind of ultrasound. In this heterogeneous and fragile population, timely POCUS may remain useful at the bedside as compared with auscultation, aiming at guiding optimal ETT placement and reducing respiratory complications, provided by trained physicians.


Subject(s)
Intubation, Intratracheal/standards , Pleura/diagnostic imaging , Ultrasonography/standards , Adolescent , Child , Child, Preschool , Female , France , Humans , Infant , Infant, Newborn , Intensive Care Units, Pediatric/organization & administration , Intensive Care Units, Pediatric/statistics & numerical data , Intubation, Intratracheal/methods , Intubation, Intratracheal/statistics & numerical data , Male , Point-of-Care Systems , Prospective Studies , Sensitivity and Specificity , Ultrasonography/methods , Ultrasonography/statistics & numerical data
10.
Int J Hyg Environ Health ; 233: 113707, 2021 04.
Article in English | MEDLINE | ID: mdl-33631659

ABSTRACT

BACKGROUND: On 15th April 2019, the fire at Notre Dame Cathedral, Paris, resulted in the melting of 410 tons of lead. Four hundred fourteen Paris firefighters were involved. For the purpose of preventive medicine, the level of lead contamination among the firefighters was assessed. This study objectives' were to describe the blood lead levels (BLLs) in the firefighters, to study the influence of some parameters such as the function of firefighters and the decrease in BLLs during the follow-up investigations. METHODS: The emission of 138 kg of melted lead from the roof and spire of the Notre Dame Cathedral during the fire was estimated by the National Institute for Industrial Environment and Risks. Three categories were defined according to the estimated levels of external lead exposure and fire proximity: high (category 1, n = 170), medium (category 2, n = 151), and low (category 3, n = 93). Two to three weeks after the fire, blood samples to assess the BLLs were taken from firefighters in category 1 (N = 164) and from every female firefighter in category 1 and 2 (N = 4). When the BLL was above 50 µg/L (95th percentile of reference range concentrations for a sample of the French population), it was checked again at one month later (N = 31) and then, if still above 50 µg/L, at six months later (N = 10). RESULTS: The geometric mean of initial blood lead level was 31.5 µg/L (CI 95% [27.7-35.9]; Min-Max: 7.0-307.6 µg/L). Twenty-five percent (n = 42) of initial BLLs were above 50 µg/L, versus 10% (n = 16) at 1 month, and 2% (n = 3) at 6 months. The French binding biological BLL limit value (400 µg/L for men and 300 µg/L for women was never exceeded and all BLLs decreased over time. BLLs varied according to the function occupied during the extinguishing of the fire: operators', officers' and those of unknown function. BLLs were significantly higher compared to drivers reflecting their lower distance to fire and fume. CONCLUSIONS: The fire at Notre Dame Cathedral, Paris, resulted in moderate lead contamination among firefighters. Individual and collective protection measures probably helped to limit the contamination. Nevertheless, an effort could be made to improve the working conditions by rethinking the respiratory protection.


Subject(s)
Firefighters , Occupational Exposure , Female , Humans , Lead , Male , Occupational Exposure/analysis , Paris , Reference Values
11.
Rev Prat ; 60(5): 669-82, 2010 May 20.
Article in French | MEDLINE | ID: mdl-20564852

ABSTRACT

Obstructive sleep apnea syndrome is a common disorder associated with potentially severe complications. Polysomnography is the gold standard diagnostic tool, while CPAP ventilation is recognized as the most efficient therapy. The numerous symptoms, even though little specific, should be rapidly detected to screen for the syndrome and transfer the patient to an adequate healthcare facility. The severity of the condition depends on the complications it causes.


Subject(s)
Sleep Apnea, Obstructive/diagnosis , Sleep Apnea, Obstructive/therapy , Continuous Positive Airway Pressure , Diagnosis, Differential , Humans , Polysomnography , Risk Factors , Sleep Apnea, Obstructive/complications , Sleep Apnea, Obstructive/economics
12.
Rev Prat ; 70(5): 527-531, 2020 May.
Article in French | MEDLINE | ID: mdl-33058642

ABSTRACT

Conductive hearing loss with a normal eardrum. Conductive hearing loss with a normal eardrum is defined by a hearing loss in in relation to a disturbance in the transmission of sound waves from a normal eardrum to an intact cochlear nerve. The interest in diagnosing these kinds of hearing loss is due on the one hand to their high frequency, on the other hand to the socio-professional repercussions that they can induce and finally to the fact that a large part of them are accessible to surgical treatment or, hearing aid. The CT-scan contributes to the diagnostic orientation and the preoperative assessment. If the pathologies of the middle ear dominate in frequency the possible causes of conductive hearing loss with a normal eardrum, especially otosclerosis, abnormalities of the inner ear, which can be responsible for conductive or mixed hearing loss, have recently listed thanks to advances in modern digital imaging. After a brief anatomical reminder of the tympano-ossicular system, we will deal with their positive, differential and etiological diagnosis.


Surdité de transmission à tympan normal. Les surdités de transmission à tympan normal sont définies par une diminution de la capacité auditive en relation avec une perturbation de transmission de l'onde sonore depuis un tympan normal jusqu'à un nerf cochléaire intègre. L'intérêt de diagnostiquer ces surdités tient d'une part à leur grande fréquence, d'autre part au retentissement socioprofessionnel qu'elles peuvent induire, et enfin au fait qu'une grande partie d'entre elles sont accessibles à un traitement chirurgical, ou à défaut prothétique. La tomodensitométrie contribue à l'orientation diagnostique et au bilan préopératoire. Si les pathologies de l'oreille moyenne dominent en fréquence les causes possibles de surdité de transmission à tympan normal, avec en tête l'otospongiose, des anomalies de l'oreille interne, pouvant être responsables de surdité de transmission ou de surdité mixte, ont été récemment répertoriées grâce aux progrès de l'imagerie numérique moderne.


Subject(s)
Deafness , Ear, Inner , Ear, Middle , Hearing Loss, Conductive/diagnosis , Humans , Tympanic Membrane
13.
Aerosp Med Hum Perform ; 91(5): 403-408, 2020 May 01.
Article in English | MEDLINE | ID: mdl-32327013

ABSTRACT

BACKGROUND: When a pilot is referred for presbycusis, his flight fitness may be questionable. The objective of this retrospective study was to describe a case series of presbycusis in a pilot population and to discuss the decisions about their flight waivers.METHODS: There were 19 pilots who were referred to the ENT-Head and Neck Surgery Department of the National Pilot Expertise Center. Their medical files were retrospectively examined.RESULTS: Of the 19 patients, 5 did not obtain flight fitness waivers. Among the 14 who received waivers, 7 had no restrictions on their flight fitness.DISCUSSION: Flight fitness was based on the maximum percentage of speech recognition and the slope of the curve for speech recognition in speech audiometry in noise and the follow-up of these findings. The results made it possible to determine a patient's fitness to fly with a waiver, which may be associated with restrictions. In our series, only 5 pilots out of 19 did not obtain a flight fitness waiver. The few published studies on the resumption of flight for patients who had presbycusis and our experience in France with similar waivers in commercial and military aviation suggest that under certain conditions and after relevant cochlear assessment, presbycusis may allow for a safe pursuit of aviation activity.Ballivet de Régloix S, Genestier L, Maurin O, Marty S, Crambert A, Pons Y. Presbycusis and fitness to fly. Aerosp Med Hum Perform. 2020; 91(5):403-408.


Subject(s)
Physical Fitness/physiology , Pilots , Presbycusis/physiopathology , Aerospace Medicine , Aged , Aged, 80 and over , Audiometry, Speech , Aviation , Female , Humans , Male , Middle Aged , Retrospective Studies
14.
Acad Emerg Med ; 27(10): 951-962, 2020 10.
Article in English | MEDLINE | ID: mdl-32445436

ABSTRACT

BACKGROUND: Out-of-hospital cardiac arrest (OHCA) remains associated with very high mortality. Accelerating the initiation of efficient cardiopulmonary resuscitation (CPR) is widely perceived as key to improving outcomes. The main goal was to determine whether identification and activation of nearby first responders through a smartphone application named Staying Alive (SA) can improve survival following OHCA in a large urban area (Paris). METHODS: We conducted a nonrandomized cohort study of all adults with OHCA managed by the Greater Paris Fire Brigade during 2018, irrespective of mobile application usage. We compared survival data in cases where SA did or did not lead to the activation of nearby first responders. During dispatch, calls for OHCA were managed with or without SA. The intervention group included all cases where nearby first responders were successfully identified by SA and actively contributed to CPR. The control group included all other cases. We compared survival at hospital discharge between the intervention and control groups. We analyzed patient data, CPR metrics, and first responders' characteristics. RESULTS: Approximately 4,107 OHCA cases were recorded in 2018. Among those, 320 patients were in the control group, whereas 46 patients, in the intervention group, received first responder-initiated CPR. After adjustment for confounders, survival at hospital discharge was significantly improved for patients in the intervention group (35% vs. 16%, adjusted odds ratio = 5.9, 95% confidence interval = 2.1 to 16.5, p < 0.001). All CPR metrics were improved in the intervention group. CONCLUSIONS: We report that mobile smartphone technology was associated with OHCA survival through accelerated initiation of efficient CPR by first responders in a large urban area.


Subject(s)
Cardiopulmonary Resuscitation/statistics & numerical data , Mobile Applications , Out-of-Hospital Cardiac Arrest/mortality , Smartphone , Adult , Aged , Case-Control Studies , Cohort Studies , Emergency Medical Services/statistics & numerical data , Female , Humans , Male , Middle Aged , Odds Ratio , Paris , Time-to-Treatment
15.
Trials ; 21(1): 106, 2020 Jan 22.
Article in English | MEDLINE | ID: mdl-31969168

ABSTRACT

BACKGROUND: Post-trauma bleeding induces an acute deficiency in clotting factors, which promotes bleeding and hemorrhagic shock. However, early plasma administration may reduce the severity of trauma-induced coagulopathy (TIC). Unlike fresh frozen plasma, which requires specific hospital logistics, French lyophilized plasma (FLYP) is storable at room temperature and compatible with all blood types, supporting its use in prehospital emergency care. We aim to test the hypothesis that by attenuating TIC, FLYP administered by prehospital emergency physicians would benefit the severely injured civilian patient at risk for hemorrhagic shock. METHODS/DESIGN: This multicenter randomized clinical trial will include adults severely injured and at risk for hemorrhagic shock, with a systolic blood pressure < 70 mmHg or a Shock Index > 1.1. Two parallel groups of 70 patients will receive either FLYP or normal saline in addition to usual treatment. The primary endpoint is the International Normalized Ratio (INR) at hospital admission. Secondary endpoints are transfusion requirement, length of stay in the intensive care unit, survival rate at day 30, usability and safety related to FLYP use, and other biological coagulation parameters. CONCLUSION: With this trial, we aim to confirm the efficacy of FLYP in TIC and its safety in civilian prehospital care. The study results will contribute to optimizing guidelines for treating hemorrhagic shock in civilian settings. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02736812. Registered on 13 April 2016. The trial protocol has been approved by the French ethics committee (CPP 3342) and the French Agency for the Safety of Medicines and Health Products (IDRCB 2015-A00866-43).


Subject(s)
Blood Coagulation Disorders/therapy , Blood Component Transfusion/methods , Emergency Medical Services/methods , Plasma , Shock, Hemorrhagic/therapy , Wounds and Injuries/therapy , Blood Coagulation Disorders/etiology , Freeze Drying , Humans , Wounds and Injuries/complications
16.
Presse Med ; 48(1 Pt 1): 29-33, 2019 Jan.
Article in French | MEDLINE | ID: mdl-30391270

ABSTRACT

Cervical congenital malformations are relatively common in children. They can also be found in adults. The embryological development of the cervical region is closely related to the branchial clefts. This must be a diagnosis made by elimination; a cervical tumor must evoke the diagnosis of cancer. A cutaneous fistula or a cervical tumor, chronic or recent appearance in an inflammatory context, are the clinical signs. The thyroglossal duct cysts and the second branchial clefts cysts are the most common causes of median and lateral cervical cysts, respectively. Imaging contributes greatly to the orientation and diagnostic evaluation of the extent of the lesions. Treatment is initially based on antibiotic therapy and then on complete surgical excision, away from an infectious episode, the sole guarantee for the absence of local recurrence.


Subject(s)
Branchioma/congenital , Cutaneous Fistula/congenital , Head and Neck Neoplasms/congenital , Thyroglossal Cyst/congenital , Adult , Anti-Bacterial Agents/therapeutic use , Branchioma/diagnostic imaging , Branchioma/drug therapy , Branchioma/surgery , Combined Modality Therapy , Cutaneous Fistula/diagnostic imaging , Cutaneous Fistula/drug therapy , Cutaneous Fistula/surgery , Head and Neck Neoplasms/diagnostic imaging , Head and Neck Neoplasms/drug therapy , Head and Neck Neoplasms/surgery , Humans , Inflammation , Thyroglossal Cyst/diagnostic imaging , Thyroglossal Cyst/drug therapy , Thyroglossal Cyst/surgery
17.
Resuscitation ; 135: 205-211, 2019 02.
Article in English | MEDLINE | ID: mdl-30562597

ABSTRACT

AIM: Out-of-hospital cardiac arrests (OHCAs) in pregnant women are rare events. In this study, we aimed to describe a cohort of pregnant women who experienced OHCAs in a large urban area, and received treatment by the prehospital teams in a two-tiered emergency response system. METHODS: This retrospective study included pregnant women over 18 years of age who experienced OHCAs. The analysed variables included maternal age, gestational age, variables specific to the rescue system, number of shocks delivered by an automatic external defibrillator, and rates of maternal and neonatal survival. RESULTS: Over the 5-year study period, 19,515 OHCAs occurred, 16 of which were in pregnant women. These 16 patients had a median age of 31 years [interquartile range (IQR): 28-35] and a median gestational age of 20 weeks [IQR: 10-33]. Three patients (18.8%) had an initial rhythm of ventricular fibrillation. Only one patient underwent thrombolysis. Of the 16 patients, 6 (38%) died after resuscitation on the scene. The remaining 10 were transported to the hospital, of whom 5 achieved circulation through a mechanical CPR device. Only 2 patients were alive 30days after OHCA. CONCLUSIONS: Over half of the pregnant women who experienced OHCA were at least 20 weeks pregnant. Analysis of the prehospital medical data suggests that the current recommendations are difficult to apply in an out-of-hospital environment. Specific recommendations for this situation must be developed.


Subject(s)
Cardiopulmonary Resuscitation , Emergency Medical Services , Out-of-Hospital Cardiac Arrest , Pregnancy Complications , Ventricular Fibrillation , Adult , Cardiopulmonary Resuscitation/methods , Cardiopulmonary Resuscitation/statistics & numerical data , Emergency Medical Services/methods , Emergency Medical Services/statistics & numerical data , Female , France/epidemiology , Gestational Age , Humans , Infant, Newborn , Male , Maternal Age , Out-of-Hospital Cardiac Arrest/etiology , Out-of-Hospital Cardiac Arrest/mortality , Out-of-Hospital Cardiac Arrest/therapy , Outcome and Process Assessment, Health Care , Pregnancy , Pregnancy Complications/diagnosis , Pregnancy Complications/mortality , Pregnancy Complications/therapy , Retrospective Studies , Survival Analysis , Ventricular Fibrillation/complications , Ventricular Fibrillation/diagnosis , Ventricular Fibrillation/mortality , Ventricular Fibrillation/therapy
19.
Mil Med ; 183(11-12): e624-e627, 2018 11 01.
Article in English | MEDLINE | ID: mdl-29635523

ABSTRACT

Introduction: Blast injuries in modern warfare are common, and tympanic perforation is often found. Spontaneous closures of large perforations that encompass greater than 80% of the tympanic surface are rare. Early closure of the tympanic membrane avoids the immediate infectious risk, which potentially complicates the initial management of these war-wounded patients, and allows for safe and early recovery of military activity. This study compared the outcomes of spontaneous closures and early biomembrane myringoplasty in subjects with large blast injury-induced tympanic perforation following a massive explosion. Materials and Methods: This is a retrospective, observational, cohort study military troops with large barotraumatic tympanic membrane perforation. The study investigates early surgical tympanoplasty versus observation for spontaneous closure. The hearing loss, tympanic perforation closure rate, and closure time were noted. Results: Fourteen patients (19 ears) were referred from May 2008 to April 2017, and 6 patients (9 ears) underwent early myringoplasty. A total of 89% (n = 8) and 100% (n = 9) of the ears exhibited successful sealing of the perforation at one and 6 mo, respectively. In contrast, 60% (n = 6) of the 10 ears (8 patients) without initial myringoplasty did not heal spontaneously at 6 mo, and these ears underwent a delayed tympanoplasty procedure. Notably, patients with early myringoplasty suffered lower conductive hearing loss and fewer functional signs remotely. Conclusion: Early myringoplasty using a biomembrane for blast injury-induced large tympanic perforation is a fast and minimally invasive method to achieve earlier tympanic closure and a higher closure rate for safe recovery of activity. It can be performed under general anesthesia concurrently with surgery for additional body-wide trauma. The deployment of ENT surgeons on the battlefield in the French Army has enabled early management of these patients.


Subject(s)
Biological Dressings/standards , Tympanic Membrane Perforation/surgery , Tympanoplasty/instrumentation , Adult , Biological Dressings/adverse effects , Blast Injuries/complications , Blast Injuries/surgery , Cohort Studies , Female , France , Humans , Male , Middle Aged , Military Personnel/statistics & numerical data , Retrospective Studies , Statistics, Nonparametric , Treatment Outcome , Tympanic Membrane Perforation/etiology , Tympanoplasty/methods , Warfare
20.
Iran J Otorhinolaryngol ; 29(93): 215-219, 2017 Jul.
Article in English | MEDLINE | ID: mdl-28819620

ABSTRACT

INTRODUCTION: We present a retrospective study series and discussion of the current literature to discuss the management of fishbones in the upper aerodigestive tract. MATERIALS AND METHODS: From January 2013 to July 2016, all patients referred to our referral center because of a fishbone in the upper aerodigestive tract were analysed. RESULTS: Of the 24 patients, 95% of them reported discomfort in the throat. It was noted that 58% of physical examinations and nasofibroscopy results were normal. Ten fishbones were found in the upper aerodigestive tract. They were removed by foreign body forceps or by endoscopy depending on the location. Foreign body-related complications were not observed. Ten patients with no identifiable fishbone had no symptoms after 48 hours. Other patients, including the 10 patients with the fishbone removed, were asymptomatic after 10 days. CONCLUSION: From our experience, we recommend a systematic nasofibroscopy. If it is normal, the patient is assessed at 48h. The complementary investigation by CT scan and/or oesophagoscopy must be reserved in cases of suspicion of oesophageal localization or complication. Otherwise, rigid or flexible endoscopy may be performed when laryngoscopy is unsuccessful or for the treatment of foreign bodies lodged below this area.

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