Search details
1.
The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022.
Int J Mol Sci
; 24(6)2023 Mar 14.
Article
in English
| MEDLINE | ID: mdl-36982624
2.
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.
Nature
; 539(7629): 443-447, 2016 11 17.
Article
in English
| MEDLINE | ID: mdl-27828943
3.
PI3Kγ is a molecular switch that controls immune suppression.
Nature
; 539(7629): 437-442, 2016 11 17.
Article
in English
| MEDLINE | ID: mdl-27642729
4.
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer.
Proc Natl Acad Sci U S A
; 116(2): 631-640, 2019 01 08.
Article
in English
| MEDLINE | ID: mdl-30578319
5.
Corrigendum: PI3Kγ is a molecular switch that controls immune suppression.
Nature
; 542(7639): 124, 2017 02 02.
Article
in English
| MEDLINE | ID: mdl-27974794
6.
Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model.
Proc Natl Acad Sci U S A
; 109(20): 7859-64, 2012 May 15.
Article
in English
| MEDLINE | ID: mdl-22550175
7.
Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma.
Cancer
; 120(4): 537-47, 2014 Feb 15.
Article
in English
| MEDLINE | ID: mdl-24151134
8.
The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway.
Xenobiotica
; 43(10): 875-85, 2013 Oct.
Article
in English
| MEDLINE | ID: mdl-23527529
9.
Discovery and Characterization of a Novel Aryl Hydrocarbon Receptor Inhibitor, IK-175, and Its Inhibitory Activity on Tumor Immune Suppression.
Mol Cancer Ther
; 21(8): 1261-1272, 2022 08 02.
Article
in English
| MEDLINE | ID: mdl-35666806
10.
Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme.
Nat Catal
; 5(10): 952-967, 2022 Oct.
Article
in English
| MEDLINE | ID: mdl-36465553
11.
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.
Nat Commun
; 11(1): 4011, 2020 08 11.
Article
in English
| MEDLINE | ID: mdl-32782249
12.
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.
Mol Cancer Ther
; 7(9): 2725-35, 2008 Sep.
Article
in English
| MEDLINE | ID: mdl-18790753
13.
The phosphoinositide-3 kinase (PI3K)-δ,γ inhibitor, duvelisib shows preclinical synergy with multiple targeted therapies in hematologic malignancies.
PLoS One
; 13(8): e0200725, 2018.
Article
in English
| MEDLINE | ID: mdl-30067771
14.
Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.
Nat Biotechnol
; 36(8): 758-764, 2018 09.
Article
in English
| MEDLINE | ID: mdl-30010674
15.
The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation.
Front Immunol
; 8: 747, 2017.
Article
in English
| MEDLINE | ID: mdl-28713374
16.
Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia.
Sci Transl Med
; 7(291): 291ra96, 2015 Jun 10.
Article
in English
| MEDLINE | ID: mdl-26062848
17.
HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer.
PLoS One
; 9(12): e115228, 2014.
Article
in English
| MEDLINE | ID: mdl-25542032
18.
Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.
PLoS One
; 9(3): e90534, 2014.
Article
in English
| MEDLINE | ID: mdl-24608250
19.
Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.
Mol Cancer Ther
; 13(5): 1259-69, 2014 May.
Article
in English
| MEDLINE | ID: mdl-24634412
20.
Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors.
J Med Chem
; 55(20): 8859-78, 2012 Oct 25.
Article
in English
| MEDLINE | ID: mdl-23025805