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1.

NLRP3 inflammasome activation drives tau pathology.

Ising, Christina; Venegas, Carmen; Zhang, Shuangshuang; Scheiblich, Hannah; Schmidt, Susanne V; Vieira-Saecker, Ana; Schwartz, Stephanie; Albasset, Shadi; McManus, Róisín M; Tejera, Dario; Griep, Angelika; Santarelli, Francesco; Brosseron, Frederic; Opitz, Sabine; Stunden, James; Merten, Maximilian; Kayed, Rakez; Golenbock, Douglas T; Blum, David; Latz, Eicke; Buée, Luc; Heneka, Michael T.

Nature ; 575(7784): 669-673, 2019 11.

Article in English | MEDLINE | ID: mdl-31748742

2.

Author Correction: Inflammasome signalling in brain function and neurodegenerative disease.

Heneka, Michael T; McManus, Róisín M; Latz, Eicke.

Nat Rev Neurosci ; 20(3): 187, 2019 Mar.

Article in English | MEDLINE | ID: mdl-30742056

3.

NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro.

Braatz, Charlotte; Komes, Max P; Ravichandran, Kishore Aravind; de Fragas, Matheus Garcia; Griep, Angelika; Schwartz, Stephanie; McManus, Róisín M; Heneka, Michael T.

J Neurochem ; 2023 Feb 17.

Article in English | MEDLINE | ID: mdl-36799439

4.

Inflammasome signalling in brain function and neurodegenerative disease.

Heneka, Michael T; McManus, Róisín M; Latz, Eicke.

Nat Rev Neurosci ; 19(10): 610-621, 2018 10.

Article in English | MEDLINE | ID: mdl-30206330

5.

Soluble Aß oligomers and protofibrils induce NLRP3 inflammasome activation in microglia.

Luciunaite, Asta; McManus, Róisín M; Jankunec, Marija; Rácz, Ildikó; Dansokho, Cira; Dalgediene, Indre; Schwartz, Stephanie; Brosseron, Frederic; Heneka, Michael T.

J Neurochem ; 155(6): 650-661, 2020 12.

Article in English | MEDLINE | ID: mdl-31872431

6.

Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis.

Wilk, Mieszko M; Misiak, Alicja; McManus, Róisín M; Allen, Aideen C; Lynch, Marina A; Mills, Kingston H G.

J Immunol ; 199(1): 233-243, 2017 07 01.

Article in English | MEDLINE | ID: mdl-28533445

7.

IFN-Î³ Production by amyloid ß-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease.

Browne, Tara C; McQuillan, Keith; McManus, Róisín M; O'Reilly, Julie-Ann; Mills, Kingston H G; Lynch, Marina A.

J Immunol ; 190(5): 2241-51, 2013 Mar 01.

Article in English | MEDLINE | ID: mdl-23365075

8.

NLRP3 inflammasome signalling in Alzheimer's disease.

McManus, Róisín M; Latz, Eicke.

Neuropharmacology ; 252: 109941, 2024 Jul 01.

Article in English | MEDLINE | ID: mdl-38565393

9.

Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 2: Assessing Inflammasome Activation.

Lovotti, Marta; Mangan, Matthew S J; McManus, Róisín M; Shkarina, Kateryna; Vasconcelos, Matilde B; Latz, Eicke.

Methods Mol Biol ; 2713: 431-451, 2024.

Article in English | MEDLINE | ID: mdl-37639140

10.

Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 1: Cell Preparation and Inflammasome Stimulation.

Lovotti, Marta; Mangan, Matthew S J; McManus, Róisín M; Shkarina, Kateryna; Vasconcelos, Matilde B; Latz, Eicke.

Methods Mol Biol ; 2713: 407-429, 2024.

Article in English | MEDLINE | ID: mdl-37639139

11.

Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study.

Brosseron, Frederic; Maass, Anne; Kleineidam, Luca; Ravichandran, Kishore Aravind; Kolbe, Carl-Christian; Wolfsgruber, Steffen; Santarelli, Francesco; Häsler, Lisa M; McManus, Róisín; Ising, Christina; Röske, Sandra; Peters, Oliver; Cosma, Nicoleta-Carmen; Schneider, Luisa-Sophie; Wang, Xiao; Priller, Josef; Spruth, Eike J; Altenstein, Slawek; Schneider, Anja; Fliessbach, Klaus; Wiltfang, Jens; Schott, Björn H; Buerger, Katharina; Janowitz, Daniel; Dichgans, Martin; Perneczky, Robert; Rauchmann, Boris-Stephan; Teipel, Stefan; Kilimann, Ingo; Görß, Doreen; Laske, Christoph; Munk, Matthias H; Düzel, Emrah; Yakupow, Renat; Dobisch, Laura; Metzger, Coraline D; Glanz, Wenzel; Ewers, Michael; Dechent, Peter; Haynes, John Dylan; Scheffler, Klaus; Roy, Nina; Rostamzadeh, Ayda; Spottke, Annika; Ramirez, Alfredo; Mengel, David; Synofzik, Matthis; Jucker, Mathias; Latz, Eicke; Jessen, Frank.

Alzheimers Res Ther ; 15(1): 13, 2023 01 12.

Article in English | MEDLINE | ID: mdl-36631909

12.

The Role of Immunity in Alzheimer's Disease.

McManus, Róisín M.

Adv Biol (Weinh) ; 6(5): e2101166, 2022 05.

Article in English | MEDLINE | ID: mdl-35254006

13.

How location and cellular signaling combine to activate the NLRP3 inflammasome.

Akbal, Anil; Dernst, Alesja; Lovotti, Marta; Mangan, Matthew S J; McManus, Róisín M; Latz, Eicke.

Cell Mol Immunol ; 19(11): 1201-1214, 2022 11.

Article in English | MEDLINE | ID: mdl-36127465

14.

p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function.

Perea, Juan R; Bolós, Marta; Cuadros, Raquel; García, Esther; García-Escudero, Vega; Hernández, Félix; McManus, Róisín M; Heneka, Michael T; Avila, Jesús.

Mol Neurobiol ; 59(3): 1632-1648, 2022 Mar.

Article in English | MEDLINE | ID: mdl-35006531

15.

Psychedelic perceptions: mental health service user attitudes to psilocybin therapy.

Corrigan, Kate; Haran, Maeve; McCandliss, Conor; McManus, Roisin; Cleary, Shannon; Trant, Rebecca; Kelly, Yazeed; Ledden, Kathryn; Rush, Gavin; O'Keane, Veronica; Kelly, John R.

Ir J Med Sci ; 191(3): 1385-1397, 2022 Jun.

Article in English | MEDLINE | ID: mdl-34131812

16.

Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease.

Brosseron, Frederic; Maass, Anne; Kleineidam, Luca; Ravichandran, Kishore Aravind; González, Pablo García; McManus, Róisín M; Ising, Christina; Santarelli, Francesco; Kolbe, Carl-Christian; Häsler, Lisa M; Wolfsgruber, Steffen; Marquié, Marta; Boada, Mercè; Orellana, Adelina; de Rojas, Itziar; Röske, Sandra; Peters, Oliver; Cosma, Nicoleta-Carmen; Cetindag, Arda; Wang, Xiao; Priller, Josef; Spruth, Eike J; Altenstein, Slawek; Schneider, Anja; Fliessbach, Klaus; Wiltfang, Jens; Schott, Björn H; Bürger, Katharina; Janowitz, Daniel; Dichgans, Martin; Perneczky, Robert; Rauchmann, Boris-Stephan; Teipel, Stefan; Kilimann, Ingo; Goerss, Doreen; Laske, Christoph; Munk, Matthias H; Düzel, Emrah; Yakupov, Renat; Dobisch, Laura; Metzger, Coraline D; Glanz, Wenzel; Ewers, Michael; Dechent, Peter; Haynes, John Dylan; Scheffler, Klaus; Roy, Nina; Rostamzadeh, Ayda; Teunissen, Charlotte E; Marchant, Natalie L.

Neuron ; 110(6): 1009-1022.e4, 2022 03 16.

Article in English | MEDLINE | ID: mdl-34995486

17.

Impact of the COVID-19 pandemic on persons experiencing an eating disorder in the Republic of Ireland.

Khan, Jahan Zeb; McManus, Roisin; Mcloughlin, Declan M; O'Toole, Clare.

Ir J Psychol Med ; : 1-2, 2024 Apr 29.

Article in English | MEDLINE | ID: mdl-38682678

18.

Role of neuroinflammation in neurodegeneration: new insights.

McManus, Róisín M; Heneka, Michael T.

Alzheimers Res Ther ; 9(1): 14, 2017 Mar 04.

Article in English | MEDLINE | ID: mdl-28259169

19.

FTY720 Attenuates Infection-Induced Enhancement of Aß Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation.

McManus, Róisín M; Finucane, Orla M; Wilk, Mieszko M; Mills, Kingston H G; Lynch, Marina A.

J Neuroimmune Pharmacol ; 12(4): 670-681, 2017 12.

Article in English | MEDLINE | ID: mdl-28620801

20.

The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function.

Costello, Derek A; Keenan, Kathryn; McManus, Róisín M; Falvey, Aidan; Lynch, Marina A.

Neurobiol Aging ; 43: 140-8, 2016 07.

Article in English | MEDLINE | ID: mdl-27255823

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