ASSESSMENT OF TYPES OF MYOCARDIAL DIASTOLIC DYSFUNCTION DEPENDING ON THE DEGREE OF CORONARY ARTERY LESION IN PATIENTS WITH NSTEMI.

OBJECTIVE: The aim: To evaluate the types of myocardial diastolic dysfunction depending on the degree of coronary artery lesion in patients with NSTEMI. PATIENTS AND METHODS: Materials and methods: We examined 200 patients with NSTEMI aged 38 to 80 years, who were urgently hospitalized in the Vinnytsya Regional Clinical Center of Cardiovascular Pathology. All patients underwent echocardiography examination from 3 to 5 day of hospitalization after coronary angiography. RESULTS: Results: We established that there were no significant gender and age differences in the types of diastolic dysfunction. However, we found that with an increase in the degree of damage to the coronary arteries and an increase in the number of affected arteries, the degree of severity of myocardial diastolic dysfunction increases and the probability of occurrence of more unfavorable types of dysfunction increases. CONCLUSION: Conclusions: Determining the types of myocardial diastolic dysfunction in the early period of NSTEMI makes it possible to predict unfavorable variants of the course of the disease and prevent possible complications.

THE LEVEL OF GROWTH STIMULATING FACTOR EXPRESSED BY GENE 2 AND TROPONIN I IN THE BLOOD PLASMA OF NSTEMI PATIENTS DEPENDING ON DIFFERENT CLINICAL CHARACTERISTICS.

OBJECTIVE: The aim of the study is to evaluate the relationship between ST2 and Troponin I with various clinical and instrumental parameters. PATIENTS AND METHODS: Materials and methods: We examined 200 patients with NSTEMI aged 38 to 80 years, who were urgently hospitalized in the Vinnytsya Regional Clinical Center of Cardiovascular Pathology. All patients underwent laboratory testing of ST2 and Troponin I levels in plasma by enzyme-linked immunosorbent assay on the first day of hospitalization before coronary angiography. RESULTS: Results: Elevations in ST2 levels were significantly higher in patients with acute heart failure (Killip III) and the presence of acute arrhythmias, diabetes mellitus, and smoking. The increase in Troponin I was associated primarily with the nature of changes in the ECG, stratification on the GRACE score and the presence of concomitant arterial hypertension. CONCLUSION: Conclusions: Determination of ST2 and Troponin I before coronary angiography makes it possible to predict the course of NSTEMI and make appropriate therapeutic corrections to prevent complications.