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1.
A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety.
Bioorg Med Chem Lett
; 25(3): 602-6, 2015 Feb 01.
Article
in English
| MEDLINE | ID: mdl-25556095
2.
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study.
Lancet Oncol
; 13(11): 1133-40, 2012 Nov.
Article
in English
| MEDLINE | ID: mdl-23084521
3.
Acute myeloid leukemia patients' clinical response to idasanutlin (RG7388) is associated with pre-treatment MDM2 protein expression in leukemic blasts.
Haematologica
; 101(5): e185-8, 2016 05.
Article
in English
| MEDLINE | ID: mdl-26869629
4.
MDM2 antagonist clinical response association with a gene expression signature in acute myeloid leukaemia.
Br J Haematol
; 171(3): 432-5, 2015 Nov.
Article
in English
| MEDLINE | ID: mdl-25855517
5.
Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 19(8): 2333-7, 2009 Apr 15.
Article
in English
| MEDLINE | ID: mdl-19286381
6.
Synthesis, in vitro activities of (2-cyclopropoxyphenyl)piperidine derivatives for alpha 1a and alpha 1d adrenergic receptor inhibitors.
Med Chem
; 5(1): 15-22, 2009 Jan.
Article
in English
| MEDLINE | ID: mdl-19149646
7.
Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors.
Mol Pharmacol
; 73(2): 338-48, 2008 Feb.
Article
in English
| MEDLINE | ID: mdl-17975007
8.
(Phenylpiperazinyl)cyclohexylureas: discovery of alpha1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS).
Bioorg Med Chem Lett
; 18(2): 640-4, 2008 Jan 15.
Article
in English
| MEDLINE | ID: mdl-18055202
9.
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: design, synthesis, and biological activity.
Bioorg Med Chem Lett
; 18(18): 5130-3, 2008 Sep 15.
Article
in English
| MEDLINE | ID: mdl-18718756
10.
4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors.
Bioorg Med Chem Lett
; 18(16): 4615-9, 2008 Aug 15.
Article
in English
| MEDLINE | ID: mdl-18653333
11.
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: design, synthesis, and biological activity.
Bioorg Med Chem Lett
; 18(17): 4896-9, 2008 Sep 01.
Article
in English
| MEDLINE | ID: mdl-18678484
12.
Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases.
Bioorg Med Chem Lett
; 18(12): 3495-9, 2008 Jun 15.
Article
in English
| MEDLINE | ID: mdl-18508264
13.
Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening.
J Med Chem
; 50(3): 462-71, 2007 Feb 08.
Article
in English
| MEDLINE | ID: mdl-17266198
14.
The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases.
Cancer Res
; 65(19): 9038-46, 2005 Oct 01.
Article
in English
| MEDLINE | ID: mdl-16204078
15.
Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor.
Mol Cancer Ther
; 5(10): 2459-67, 2006 Oct.
Article
in English
| MEDLINE | ID: mdl-17041089
16.
Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors.
J Med Chem
; 48(6): 1886-900, 2005 Mar 24.
Article
in English
| MEDLINE | ID: mdl-15771433
17.
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.
J Med Chem
; 48(13): 4208-11, 2005 Jun 30.
Article
in English
| MEDLINE | ID: mdl-15974571
18.
Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors.
J Med Chem
; 48(14): 4535-46, 2005 Jul 14.
Article
in English
| MEDLINE | ID: mdl-15999992
19.
Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
J Med Chem
; 48(15): 4892-909, 2005 Jul 28.
Article
in English
| MEDLINE | ID: mdl-16033269
20.
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
J Med Chem
; 48(26): 8163-73, 2005 Dec 29.
Article
in English
| MEDLINE | ID: mdl-16366598