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1.
J Therm Biol ; 121: 103862, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38703597

ABSTRACT

Elevation gradients provide powerful study systems for examining the influence of environmental filters in shaping species assemblages. High-mountain habitats host specific high-elevation assemblages, often comprising specialist species adapted to endure pronounced abiotic stress, while such harsh conditions prevent lowland species from colonizing or establishing. While thermal tolerance may drive the altitudinal segregation of ectotherms, its role in structuring aquatic insect communities remains poorly explored. This study investigates the role of thermal physiology in shaping the current distribution of high-mountain diving beetles from the Sierra Nevada Iberian mountain range and closely related lowland species. Cold tolerance of five species from each altitudinal zone was measured estimating the supercooling point (SCP), lower lethal temperature (LLT) and tolerance to ice enclosure, while heat tolerance was assessed from the heat coma temperature (HCT). Alpine species exhibited wider fundamental thermal niches than lowland species, likely associated with the broader range of climatic conditions in high-mountain areas. Cold tolerance did not seem to prevent lowland species from colonizing higher elevations, as most studied species were moderately freeze-tolerant. Therefore, fundamental thermal niches seem not to fully explain species segregation along elevation gradients, suggesting that other thermal tolerance traits, environmental factors, and biotic interactions may also play important roles.


Subject(s)
Altitude , Thermotolerance , Animals , Coleoptera/physiology , Ecosystem , Acclimatization , Cold Temperature
2.
Clin Microbiol Rev ; 34(4): e0005019, 2021 12 15.
Article in English | MEDLINE | ID: mdl-34190572

ABSTRACT

Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have provided a wealth of information, but knowledge regarding "what happened" has precluded a deeper understanding of "how" evolution has proceeded, as in the case of antimicrobial resistance. The difficulty in answering the "how" question lies in the multihierarchical dimensions of evolutionary processes, nested in complex networks, encompassing all units of selection, from genes to communities and ecosystems. At the simplest ontological level (as resistance genes), evolution proceeds by random (mutation and drift) and directional (natural selection) processes; however, sequential pathways of adaptive variation can occasionally be observed, and under fixed circumstances (particular fitness landscapes), evolution is predictable. At the highest level (such as that of plasmids, clones, species, microbiotas), the systems' degrees of freedom increase dramatically, related to the variable dispersal, fragmentation, relatedness, or coalescence of bacterial populations, depending on heterogeneous and changing niches and selective gradients in complex environments. Evolutionary trajectories of antibiotic resistance find their way in these changing landscapes subjected to random variations, becoming highly entropic and therefore unpredictable. However, experimental, phylogenetic, and ecogenetic analyses reveal preferential frequented paths (highways) where antibiotic resistance flows and propagates, allowing some understanding of evolutionary dynamics, modeling and designing interventions. Studies on antibiotic resistance have an applied aspect in improving individual health, One Health, and Global Health, as well as an academic value for understanding evolution. Most importantly, they have a heuristic significance as a model to reduce the negative influence of anthropogenic effects on the environment.


Subject(s)
Ecosystem , Selection, Genetic , Anti-Bacterial Agents/pharmacology , Bacteria/genetics , Drug Resistance, Microbial , Mutation , Phylogeny
3.
Qual Life Res ; 31(8): 2519-2534, 2022 Aug.
Article in English | MEDLINE | ID: mdl-35229253

ABSTRACT

PURPOSE: Fibromyalgia (FM) is a chronic pain syndrome with a strong impact on quality of life (QoL). Treatment of this condition remains a challenge, due to the scarce evidence for the effectiveness of the therapeutic approaches available. Current attention is focused on transcranial direct current stimulation (tDCS), which has yielded promising results for pain treatment. Rather than focusing only on pain relief, in this study, we aimed to determine how active or sham tDCS (over three cortical targets -the primary motor cortex, the dorsolateral prefrontal cortex and the operculo-insular cortex-) affect QoL in patients with FM. METHODS: Using a double-blind, placebo-controlled design, we applied fifteen tDCS sessions of 20' to initial 130 participants (randomized to any of the four treatment groups). We evaluated the QoL (assessed by SF-36) and the symptoms' impact (assessed by FIQ-R) in baseline, after treatment and at 6 months follow-up. RESULTS: All groups were comparable as regards age, medication pattern and severity of symptoms before the treatment. We found that QoL and symptoms' impact improved in all treatment groups (including the sham) and this improvement lasted for up to 6 months. However, we did not observe any group effect nor group*treatment interaction. CONCLUSIONS: After the intervention, we observed a non-specific effect that may be due to placebo, favoured by the expectations of tDCS efficacy and psychosocial variables inherent to the intervention (daily relationship with therapists and other patients in the clinic). Therefore, active tDCS is not superior to sham stimulation in improving QoL in FM.


Subject(s)
Chronic Pain , Fibromyalgia , Transcranial Direct Current Stimulation , Chronic Pain/therapy , Double-Blind Method , Female , Fibromyalgia/psychology , Fibromyalgia/therapy , Humans , Pain Management/methods , Quality of Life/psychology , Transcranial Direct Current Stimulation/methods
4.
Plasmid ; 113: 102517, 2021 01.
Article in English | MEDLINE | ID: mdl-32535165

ABSTRACT

Multicopy plasmids play an important role in bacterial ecology and evolution by accelerating the rate of adaptation and providing a platform for rapid gene amplification and evolutionary rescue. Despite the relevance of plasmids in bacterial evolutionary dynamics, evaluating the population-level consequences of randomly segregating and replicating plasmids in individual cells remains a challenging problem, both in theory and experimentally. In recent years, technological advances in fluorescence microscopy and microfluidics have allowed studying temporal changes in gene expression by quantifying the fluorescent intensity of individual cells under controlled environmental conditions. In this paper, we will describe the manufacture, experimental setup, and data analysis pipeline of different microfluidic systems that can be used to study plasmid dynamics, both in single-cells and in populations. To illustrate the benefits and limitations of microfluidics to study multicopy plasmid dynamics, we will use an experimental model system consisting on Escherichia coli K12 carrying non-conjugative, multicopy plasmids (19 copies per cell, in average) encoding different fluorescent markers and ß-lactam resistance genes. First, we will use an image-based flow cytometer to estimate changes in the allele distribution of a heterogeneous population under different selection regimes. Then we will use a mothermachine microfluidic device to obtain time-series of fluorescent intensity of individual cells to argue that plasmid segregation and replication dynamics are inherently stochastic processes. Finally, using a microchemostat, we track thousands of cells in time to reconstruct bacterial lineages and evaluate the allele frequency distributions that emerge in response to a range of selective pressures.


Subject(s)
Computational Biology , Microfluidics , Bacteria , Plasmids/genetics , beta-Lactam Resistance
5.
Subst Use Misuse ; 56(4): 567-570, 2021.
Article in English | MEDLINE | ID: mdl-33627029

ABSTRACT

Objective: Substance use continues to pose threats to adolescent health and development in the United States (U.S.). Despite evidence of effectiveness, little is known about adolescent participation in self-help groups (e.g., Alcoholic Anonymous, Alateen) and individual/group counseling for coping with own and another family member's substance use. This study provides new information on the prevalence and trends of adolescent participation in self-help groups and counseling for substance use using a nationally-representative sample. Methods: Data was derived from the 2002-2017 National Survey on Drug Use and Health, which include cross-sectional samples of U.S. adolescents aged 12-17 (n=243,618). Specifically, year-by-year prevalence of program participation was estimated, and then the trends were tested using logistic regression analyses while controlling for sociodemographic factors. Results: We found that U.S. adolescents' participation in self-help groups and counseling for substance use decreased from 5.6% in 2002 to 3.4% in 2017, a 39 percent decline that was significant while controlling for sociodemographic confounds (AOR = 0.969, 95% CI = 0.963-0.974). The decreases were most notable among low-income (-39%) and Hispanic (-49%) adolescents. Conclusion: Findings suggest that barriers to therapeutic service use and potential unmet needs among U.S. adolescents, especially low-income and Hispanic adolescents affected by own and family member's substance use, need to be alleviated to promote healthy recovery.


Subject(s)
Substance-Related Disorders , Adolescent , Counseling , Cross-Sectional Studies , Hispanic or Latino , Humans , Prevalence , Substance-Related Disorders/epidemiology , Substance-Related Disorders/therapy , United States/epidemiology
6.
Prev Med ; 126: 105753, 2019 09.
Article in English | MEDLINE | ID: mdl-31220508

ABSTRACT

Programs designed to help youth prevent early/unwanted pregnancy and sexually transmitted infection (STI) have been shown to yield a positive impact on youth behavior and key outcomes. However, recent evidence suggests that youth participation in prevention programming for health-risk behavior may be declining. The aim of the present study is to provide up-to-date information on the national trends in adolescent participation in prevention programming targeting early pregnancy and STI in the United States. We examined fifteen years of cross-sectional data (2002-2016, N = 234,803) from the National Survey on Drug Use and Health. Our main outcome was youth self-reported (no/yes) past-year participation in a pregnancy or STI prevention program. Survey adjusted prevalence estimates and logistic regression analysis were used to examine trends in participation. Youth participation in pregnancy and STI prevention programming decreased significantly from a high of 15% in 2003 to a low of 7% in 2016. Representing a 53% proportional decline in youth participation, this downward trend was significant even when controlling for age, gender, race/ethnicity, household income, and urbanicity (AOR: 0.947, 95% CI: 0.943-0.951). The downward trend in participation was observed across racial/ethnic subgroups. A consistent pattern of differences in prevalence was observed with African-American youth reporting the highest levels of participation followed by Hispanic, and then White youth. It is incumbent upon concerned citizens, scientists, and policymakers to push for change that can shift the trend line in adolescent participation in teen pregnancy and STI prevention programming to an upward tilt.


Subject(s)
Health Risk Behaviors , Pregnancy in Adolescence/prevention & control , Sexually Transmitted Diseases/epidemiology , Sexually Transmitted Diseases/prevention & control , Adolescent , Black or African American/statistics & numerical data , Cross-Sectional Studies , Female , Hispanic or Latino/statistics & numerical data , Humans , Male , Pregnancy , Sexual Behavior , Socioeconomic Factors , Surveys and Questionnaires , United States/epidemiology , White People/statistics & numerical data
7.
J Nanosci Nanotechnol ; 19(5): 2950-2962, 2019 05 01.
Article in English | MEDLINE | ID: mdl-30501805

ABSTRACT

An increasing awareness about novel medical applications of smaller, inorganic-based nanoparticles, possessing unique properties at the nanoscale, has led to a burst of research activities in the development of "nanoprobes" for diagnostic medicine and agents for novel, externally activated therapies. In this research field magnetic nanoparticles are prominent due to fundamental peculiar properties particularly appealing for their use in materials and biomedical applications. Aiming to study the relationship between the topology of the magnetic nanoparticles and their efficacy as MRI contrast agents (relaxometric properties), we prepared three different stable colloidal suspension (ferrofluid) of magnetic nanobeads (MNBs) constituted by a discrete number of maghemite nanoparticles, arranged in disordered clusters or ordered in a polymeric matrix. An accurate morpho-dimensional and magnetic characterization displays the close correlation between the magnetic fundamental properties and the topology of our spin systems. The NMR relaxometry profiles confirmed the nature of the physical mechanisms inducing the increase of nuclear relaxation rates at low (magnetic anisotropy) and high (Curie relaxation) magnetic fields. Moreover the transverse relaxivity (r2) values for all the MNBs are higher than those of common contrast agents and the differences between the three MNBs are suggested to be due to the spin topology effect.

8.
J Prim Prev ; 40(4): 483-490, 2019 08.
Article in English | MEDLINE | ID: mdl-31377924

ABSTRACT

Parental engagement is critical to adolescent substance use prevention. However, our understanding of the degree to which parents are actually talking to their children about tobacco, alcohol, and drugs remains limited. The present study provides new evidence on the prevalence and trends of parental substance use communication (PSC) in the United States between 2002 and 2016. Trend analyses were conducted using 15 years of cross-sectional survey data from non-Hispanic White (n = 153,087), Black/African American (n = 35,216), and Hispanic (n = 45,780) adolescents aged 12-17 from the National Survey on Drug Use and Health. Since the early-to-mid 2000s, the rate of past-year PSC declined significantly, even when accounting for sociodemographic factors. We observed particularly noteworthy declines among adolescents residing in households earning less than $20,000 per year, declining by 19% (in relative terms) from a high of 58% PSC in 2003 and 2008 to a low of 47% in 2016. Teens reporting PSC reported higher levels of perceived parental warmth/engagement and consistent discipline/limit setting. Findings underscore the importance of engaging parents, particularly those less likely to talk to their children about substance use, and providing caregivers instruction and encouragement to talk to teens about the very real dangers of substance use.


Subject(s)
Parent-Child Relations , Substance-Related Disorders/prevention & control , Adolescent , Child , Communication , Cross-Sectional Studies , Female , Humans , Male , Racial Groups/psychology , Racial Groups/statistics & numerical data , Socioeconomic Factors , Substance-Related Disorders/psychology , United States
10.
Enferm Intensiva ; 28(3): 125-134, 2017.
Article in English, Spanish | MEDLINE | ID: mdl-28602752

ABSTRACT

INTRODUCTION: The monitoring system based on standards of quality allows clinicians to evaluate and improve the patient's care. According to the quality indicators recommended by Sociedad Española de Medicina Intensiva Crítica y Unidades Coronarias, and due to the importance of prone position (PP) as a treatment in patients with acute respiratory distress syndrome, it is fundamental to keep accurate record of serious adverse events occurring during the prone position procedure and its posterior analysis. OBJECTIVES: To establish fulfilment of the Sociedad Española de Medicina Intensiva Crítica y Unidades Coronarias standards of quality according to the register of serious complications. To identify the incidence of serious complications registered as well as to identify possible factors related to these complications. METHOD: Retrospective, cross-sectionsl descriptive study, polyvalent ICU (16 beds). Study population Patients with acute respiratory distress syndrome treated with PP (January 2012-December 2013). Study variables PP recording, accidental extubation, removal of catheters, decubitus ulcers (DU), ETT obstruction, urgency of the procedure, hours in PP, nutritional intake, type of feeding tube, food regurgitation/retention and use of prokinetics/muscle relaxant. RESULTS: The study sample comprised 38 cases, with an adequate record of complications in 92.1% of the cases. DU were the only serious complication recorded, with a 25.7% incidence. Possible factors related to DU: more hours in PP in patients developing DU (p= .067). Less incidence of DU in well-nourished patients (p= .577). 82.9% of patients were not appropriately nourished. CONCLUSIONS: The percentage of records duly completed is very high. The presence of DU (grade 1-2 mostly) is to be noted. There is no stastistical significance, although a trend is obversed, between DU and hours in PP.


Subject(s)
Guideline Adherence/statistics & numerical data , Patient Positioning/adverse effects , Prone Position , Respiratory Distress Syndrome/therapy , Adult , Aged , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Retrospective Studies
11.
Phys Rev Lett ; 112(11): 117202, 2014 Mar 21.
Article in English | MEDLINE | ID: mdl-24702408

ABSTRACT

A single-molecule magnet placed in a magnetic field perpendicular to its anisotropy axis can be truncated to an effective two-level system, with easily tunable energy splitting. The quantum coherence of the molecular spin is largely determined by the dynamics of the surrounding nuclear spin bath. Here we report the measurement of the nuclear spin-lattice relaxation rate 1/T1n in a single crystal of the single-molecule magnet Mn12-ac, at T ≈ 30 mK in perpendicular fields B⊥ up to 9 T. The relaxation channel at B ≈ 0 is dominated by incoherent quantum tunneling of the Mn12-ac spin S, aided by the nuclear bath itself. However for B⊥>5 T we observe an increase of 1/T1n by several orders of magnitude up to the highest field, despite the fact that the molecular spin is in its quantum mechanical ground state. This striking observation is a consequence of the zero-point quantum fluctuations of S, which allow it to mediate the transfer of energy from the excited nuclear spin bath to the crystal lattice at much higher rates. Our experiment highlights the importance of quantum fluctuations in the interaction between an "effective two-level system" and its surrounding spin bath.

12.
Sci Rep ; 14(1): 7798, 2024 04 02.
Article in English | MEDLINE | ID: mdl-38565572

ABSTRACT

Fibromyalgia (FM) is a widespread chronic pain syndrome, possibly associated with the presence of central dysfunction in descending pain inhibition pathways. Conditioned Pain Modulation (CPM) has been proposed as a biomarker of FM. Nonetheless, the wide variety of methods used to measure CPM has hampered robust conclusions being reached. To clarify the validity of CPM as a biomarker of FM, we tested two CPM paradigms (parallel and sequential) in a sample of 23 female patients and 23 healthy women by applying test (mechanical) stimuli and conditioning (pressure cuff) stimuli. We evaluated whether CPM indices could correctly classify patients and controls, and we also determined the correlations between the indices and clinical variables such as symptomatology, disease impact, depression, quality of life, pain intensity, pain interference, fatigue and numbness. In addition, we compared the clinical status of CPM responders (efficient pain inhibitory mechanism) and non-responders. We observed that only parallel CPM testing correctly classified about 70% of patients with FM. In addition, more than 80% of healthy participants were found to be responders, while the rate was about 50% in the FM patients. The sequential CPM test was not as sensitive, with a decrease of up to 40% in the response rate for both groups. On the other hand, we did not observe any correlation between CPM measures and clinical symptoms. In summary, our findings demonstrate the influence of the CPM paradigm used and confirm that CPM may be a useful marker to complement FM diagnosis. However, the findings also cast doubts on the sensitivity of CPM as a marker of pain severity in FM.


Subject(s)
Chronic Pain , Fibromyalgia , Humans , Female , Quality of Life , Chronic Pain/diagnosis , Chronic Pain/complications , Pain Measurement/methods , Biomarkers , Pain Threshold/physiology
13.
J Fam Violence ; : 1-10, 2023 Apr 06.
Article in English | MEDLINE | ID: mdl-37358977

ABSTRACT

Purpose: Intimate partner violence (IPV) victim advocates are exposed daily to the traumas of their clients, including the potential exposure to an intimate partner homicide (IPH). While research has examined the effects of daily secondary exposure to IPV on victim advocates, little is known about the specific effect of IPH. This study examined how the IPH of a client affected advocates' perception of and approach to their work. Methods: Nine advocates were recruited from the northeastern U.S. and interviewed about their experience of the IPH of a client. Advocate interviews were analyzed using The Listening Guide Analysis which systematically isolates and listens to the different, and often contradictory, voices that a participant uses. Results: Exposure to IPH changed participants' perception of their role, how they defined client, and how they interacted with future clients. At a macro-level, the IPH of a client motivated advocates to advance changes in agency protocol, multisector responses, and state policy based on what they had learned from the IPH. Opportunities to translate shifts in their worldview into tangible changes to protocol and policy were critical to advocate adjustment after the IPH. Conclusions: In order to support advocates after IPH, organizations should acknowledge the potentially transformative effect of IPH and create opportunities for meaning making to assist in advocate adjustment. It is imperative for advocacy organizations to support their employees to prevent advocate burnout and the loss of experienced staff, and to continue to provide effective services to vulnerable members of their communities after IPH.

14.
J Fam Violence ; : 1-12, 2023 Jan 12.
Article in English | MEDLINE | ID: mdl-36685752

ABSTRACT

Purpose: Among homicides in the United States, intimate partners kill almost 50% of female and 10% of male victims. Intimate partner violence (IPV) also contributes to an estimated 6% of suicides. These trends suggest that opportunities for IPV interventions prior to the fatalities may have been missed. Thus, researchers must investigate the context and circumstances of IPV-related fatalities to inform effective prevention strategy development. There are two primary national fatality databases that can be used to examine such factors: the National Violent Death Reporting System (NVDRS, homicide and suicides); and the Uniform Crime Reporting-Supplementary Homicide Reports (UCR-SHR, homicides). These datasets include data on many IPV-related violent deaths but are limited by variations in data quality. Method: This critical review summarizes opportunities and challenges when examining IPV-related fatalities using these national datasets. To document how the current literature is conceptualizing IPV, a rapid review on IPV-related homicide and suicide articles was performed (2019-2022). Missingness analyses were conducted to describe limitations in key dataset variables. Results: These datasets enable tracking IPV-related fatalities nationally over time. However, issues with the operationalization of variables that record IPV circumstances, particularly in the UCR-SHR, and high levels of missingness represent significant barriers to research. Novel methodologies can optimize the use of these datasets. Conclusion: National-level datasets enable researchers to examine IPV-related fatalities, evaluate policy differences between states, and monitor trends and disparities. This research can inform key recommendations for interventions to prevent IPV-related fatalities. Supplementary Information: The online version contains supplementary material available at 10.1007/s10896-022-00487-2.

15.
Cir Pediatr ; 25(1): 20-3, 2012 Jan.
Article in Spanish | MEDLINE | ID: mdl-23113408

ABSTRACT

UNLABELLED: Testicular absence may cause psychological trauma in children. It can be avoided by placing testicular prosthesis (TP). However there is no consensus on the optimal age of implantation. We evaluate the results of TP implantation and their complications, as well as patient and family satisfaction. MATERIAL AND METHODS: This is a retrospective study of TP implanted between 2004-2010 in our center. Variables analyzed are: age, size and side, indication, surgical technique, complications and comorbidity. Telephone survey was done by a single interviewer to 50 families. DATA COLLECTED: general family satisfaction, characteristics of the prosthesis (size, shape, location and consistency), body image and psychological situation of the child, duration of analgesia after surgery, reoperation rate, and family advice to other parents. Statistical analysis with SPSS-18.0. RESULTS: 107 prostheses were placed (4 bilateral, 64 left and 35 rights) at a mean age of 70,10 +/- 58,6 months. The most common indication was cryptorchidism (48.2%). Initial inguinal approach in 69%, and simultaneous contralateral orchidopexy in 29.9%. Only one patient refused the prostheses. In 71% the mother was interviewed. Parents consider size, shape and position appropriate in 55.6%, 66.7% and 82.22% respectively. Hard consistency of TP was considered in 82.3% of the patients. Psychological problems were absent in 86.7%. Nighty five percent would be willing to replace when it was necessary. Parents would recommend the intervention to parents in the same situation in 86.7%. CONCLUSION: Testicular prosthesis avoids psychological trauma. The lack of satisfaction regarding to the small size and hardness makes necessary to replace the TP in adulthood. An open question remains whether we should consider the placement of TP in early ages, or if we should establish some indications based on a more rational communication with the family.


Subject(s)
Patient Satisfaction , Prosthesis Implantation , Testis/surgery , Child, Preschool , Humans , Male , Retrospective Studies , Surveys and Questionnaires
16.
Cir Pediatr ; 25(1): 53-5, 2012 Jan.
Article in Spanish | MEDLINE | ID: mdl-23113414

ABSTRACT

INTRODUCTION: Resection of bronchial tumors usually needs resection of the lung parenchyma ventilated by the ill bronchus. Surgery over a developing child must preserve the biggest amount of lung parenchyma as possible. We show a complete resection of a benign tumor from the left main-stem bronchus, without pneumonectomy. MATERIALS AND METHODS: Case report RESULTS: A 5 month girl presented with left hypoventilation. No significant previous dates. After bronchoscopy (with negative biopsy), chest radiograph and CT, she was diagnosed of a tumor in the mainstem left bronchus (20 x 15 mm) without metastatic extension. A sleeve resection of the tumor, with carinal reconstruction was performed. It was done under unipulmonary ventilation, with selective bronchial intubation. The patient was extubated in the operating room and the hospital stay was of 5 days. Follow up bronchoscopies shows no anastomotic stricture neither leakage. The patient is doing well 2 years after surgery. CONCLUSIONS: With this report and others in literature we can say that is possible to resect bronchial tumors in infancy without parenchymal resections.


Subject(s)
Bronchi/surgery , Bronchial Neoplasms/pathology , Bronchial Neoplasms/surgery , Bronchoscopy , Neoplasms, Muscle Tissue/pathology , Neoplasms, Muscle Tissue/surgery , Female , Humans , Infant
17.
J Interpers Violence ; 37(1-2): 764-781, 2022 01.
Article in English | MEDLINE | ID: mdl-32306830

ABSTRACT

Studies on criminal behaviors largely focus on youth and younger adults. While criminal engagement declines with age, the aging population and significant costs associated with older offenders warrant their increased clinical and research attention. The present study utilizes data from the 2002 to 2017 National Survey on Drug Use and Health to estimate the prevalence and explore the sociodemographic and psychosocial correlates of criminal behavior in adults aged 50 years and older. The overall prevalence of older adults engaging in criminal behaviors during this time was approximately 1.20%. There was no significant difference in crime involvement between adults aged 50 to 64 years and 65 years and older. Older individuals who committed crimes were more likely to be male and Black and earning low income. Criminality was also associated with use of illicit substances and depression as well as receipt of mental health treatment.


Subject(s)
Pharmaceutical Preparations , Substance-Related Disorders , Adolescent , Aged , Crime , Criminal Behavior , Female , Humans , Male , Middle Aged , Substance-Related Disorders/epidemiology , Violence
18.
Am J Prev Med ; 62(4): 529-537, 2022 04.
Article in English | MEDLINE | ID: mdl-34876319

ABSTRACT

INTRODUCTION: Little is known about intimate partner violence-related fatalities among young people. This study comprehensively identifies and describes intimate partner violence-related homicides, homicide-suicides, legal intervention deaths, and suicides among young people. METHODS: Data from the 2014-2018 National Violent Death Reporting System were analyzed for all decedents aged 0-24 years in 38 states, the District of Columbia, and Puerto Rico with known circumstances of death (n=29,702). Intimate partner violence-related deaths were identified using National Violent Death Reporting System variables across all manners of death and supplementary narrative review for suicides. This article reports the proportion of intimate partner violence versus non-intimate partner violence-related deaths by manner of death, descriptive statistics, and rate of intimate partner violence-related death per 100,000 person years. To examine disparities in intimate partner violence-related deaths, generalized estimating equations were used with robust standard errors to account for clustering of deaths within states and fixed effects for years. Statistical analyses were conducted May and August 2021. RESULTS: A total of 1,927 intimate partner violence-related deaths were identified, which represents 6.5% of violent deaths with known circumstances, at a rate of 0.35 per 100,000 person years. Supplementary narrative review identified 44.7% of all intimate partner violence-related deaths. There were significant differences by race/ethnicity and whether a firearm inflicted the fatal injury for male and female decedents by manner of death. CONCLUSIONS: If the National Violent Death Reporting System does not assess whether intimate partner violence was a precipitating factor across all death manners, the true magnitude of intimate partner violence's contribution to violent death will be underestimated. Future research that identifies factors associated with all manners of intimate partner violence-related deaths among young people will help inform intervention and prevention strategies to save young lives.


Subject(s)
Intimate Partner Violence , Suicide , Adolescent , Adult , Age Distribution , Cause of Death , Child , Child, Preschool , Female , Homicide , Humans , Infant , Infant, Newborn , Male , Population Surveillance , Sex Distribution , United States/epidemiology , Violence , Young Adult
19.
Neurocirugia (Astur) ; 22(6): 558-61; discussion 561, 2011 Dec.
Article in Spanish | MEDLINE | ID: mdl-22167286

ABSTRACT

Treatment of patients with prolactinomas consists primarily of dopamine agonists (DA). When these drugs reduce the size of invasive prolactinomas, the intra- and extra-cranial spaces may be communicated. Pneumocephalus and cerebrospinal fluid leakage have been reported. A 56 year old male was admitted to the emergency unit with an intracranial hypertension syndrome. He had been treated for 2 weeks with cabergoline after an invasive prolactinoma was discovered. Brain CT showed frontal interhemispheric pneumocephalus on the previous tumor cavity, and bony defect on the sellar floor. Evacuation of pneumocephalus, reparation of cranial and meningeal defects and subtotal tumor removal were performed. The literature is reviewed looking for possible pathophysiological mechanism, prevention and treatment.


Subject(s)
Antineoplastic Agents/adverse effects , Antineoplastic Agents/therapeutic use , Ergolines/adverse effects , Ergolines/therapeutic use , Pituitary Neoplasms/drug therapy , Pneumocephalus/chemically induced , Prolactinoma/drug therapy , Cabergoline , Humans , Male , Middle Aged , Pituitary Neoplasms/pathology , Prolactinoma/pathology , Tomography, X-Ray Computed
20.
Rev Sci Instrum ; 92(5): 054905, 2021 May 01.
Article in English | MEDLINE | ID: mdl-34243261

ABSTRACT

Magnetic heating, namely, the use of heat released by magnetic nanoparticles (MNPs) excited with a high-frequency magnetic field, has so far been mainly used for biological applications. More recently, it has been shown that this heat can be used to catalyze chemical reactions, some of them occurring at temperatures up to 700 °C. The full exploitation of MNP heating properties requires the knowledge of the temperature dependence of their heating power up to high temperatures. Here, a setup to perform such measurements is described based on the use of a pyrometer for high-temperature measurements and on a protocol based on the acquisition of cooling curves, which allows us to take into account calorimeter losses. We demonstrate that the setup permits to perform measurements under a controlled atmosphere on solid state samples up to 550 °C. It should in principle be able to perform measurements up to 900 °C. The method, uncertainties, and possible artifacts are described and analyzed in detail. The influence on losses of putting under vacuum different parts of the calorimeter is measured. To illustrate the setup possibilities, the temperature dependence of heating power is measured on four samples displaying very different behaviors. Their heating power increases or decreases with temperature, displaying temperature sensibilities ranging from -2.5 to +4.4% K-1. This setup is useful to characterize the MNPs for magnetically heated catalysis applications and to produce data that will be used to test models permitting to predict the temperature dependence of MNP heating power.

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