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1.
Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Nature
; 600(7887): 153-157, 2021 12.
Article
in English
| MEDLINE | ID: mdl-34819673
2.
Heparin is essential for optimal cell signaling by FGF21 and for regulation of ßKlotho cellular stability.
Proc Natl Acad Sci U S A
; 120(7): e2219128120, 2023 02 14.
Article
in English
| MEDLINE | ID: mdl-36745784
3.
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Proc Natl Acad Sci U S A
; 120(13): e2300054120, 2023 03 28.
Article
in English
| MEDLINE | ID: mdl-36943885
4.
Structures of ß-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature
; 553(7689): 501-505, 2018 01 25.
Article
in English
| MEDLINE | ID: mdl-29342135
5.
FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho.
Proc Natl Acad Sci U S A
; 117(50): 31800-31807, 2020 12 15.
Article
in English
| MEDLINE | ID: mdl-33257569
6.
Structures of ligand-occupied ß-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
Proc Natl Acad Sci U S A
; 116(16): 7819-7824, 2019 04 16.
Article
in English
| MEDLINE | ID: mdl-30944224
7.
Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).
Proc Natl Acad Sci U S A
; 115(33): 8340-8345, 2018 08 14.
Article
in English
| MEDLINE | ID: mdl-30061385
8.
Augmentor α and ß (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.
Proc Natl Acad Sci U S A
; 112(52): 15862-7, 2015 Dec 29.
Article
in English
| MEDLINE | ID: mdl-26630010
9.
Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein.
Cell Rep
; 41(4): 111545, 2022 10 25.
Article
in English
| MEDLINE | ID: mdl-36288716
10.
Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands.
J Med Chem
; 65(12): 8380-8400, 2022 06 23.
Article
in English
| MEDLINE | ID: mdl-35653642
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