Integrative clinical genomics of advanced prostate cancer.

Toward development of a precision medicine framework for metastatic, castration-resistant prostate cancer (mCRPC), we established a multi-institutional clinical sequencing infrastructure to conduct prospective whole-exome and transcriptome sequencing of bone or soft tissue tumor biopsies from a cohort of 150 mCRPC affected individuals. Aberrations of AR, ETS genes, TP53, and PTEN were frequent (40%-60% of cases), with TP53 and AR alterations enriched in mCRPC compared to primary prostate cancer. We identified new genomic alterations in PIK3CA/B, R-spondin, BRAF/RAF1, APC, ß-catenin, and ZBTB16/PLZF. Moreover, aberrations of BRCA2, BRCA1, and ATM were observed at substantially higher frequencies (19.3% overall) compared to those in primary prostate cancers. 89% of affected individuals harbored a clinically actionable aberration, including 62.7% with aberrations in AR, 65% in other cancer-related genes, and 8% with actionable pathogenic germline alterations. This cohort study provides clinically actionable information that could impact treatment decisions for these affected individuals.

Surgical techniques for management of acromioclavicular joint separations: review and update for radiologists.

Imaging plays a central role in the postoperative management of acromioclavicular (AC) joint separations. There are more than 150 described techniques for the surgical management of AC joint injuries. These procedures can be categorized as varying combinations of the following basic techniques: a) soft-tissue repair, b) trans-articular AC joint fixation, c) coracoclavicular (CC) fixation, d) non-anatomic reconstruction of the CC ligaments, e) anatomic reconstruction of the CC ligaments, f) distal clavicle resection, and g) dynamic muscle transfer. The goals of this article are to describe the basic techniques for the surgical management of AC joint separations with an emphasis on technique-specific complications and postoperative imaging assessment.

Prosthetic joint infections: diagnosis, management, and complications of the two-stage replacement arthroplasty.

Despite improved strategies to prevent prosthetic joint infection, as the total number of joint replacements increases, so does the absolute number of infections. Radiography serves as the first-line imaging modality for the assessment of a suspected prosthetic joint infection. Additionally, serial radiographs acquired after a surgery to eradicate a prosthetic joint infection are an important clinical tool. Prosthetic joint infections are often treated with a 2-stage replacement arthroplasty utilizing a prosthesis with antibiotic-loaded acrylic cement. While complications are uncommon with this procedure, imaging may demonstrate periprosthetic fractures, as well as spacer migration, joint dislocation, and spacer fracture. We describe the classification of prosthetic joint infections, the clinical and imaging diagnosis, and treatment strategies. Familiarity with the hardware utilized in the management of the prosthetic joint infection, and its potential complications is fundamental to accurate imaging interpretation.

The Relevance of Ulnar-Sided Contrast Extravasation During Radiocarpal Joint Wrist Arthrography.

OBJECTIVE: Contrast material often extends from the radiocarpal joint into the proximal soft tissues adjacent to the ulnar aspect of the ulnar styloid during single-compartment radiocarpal joint MR arthrography of the wrist. The hypothesis of this study was that this is a common finding unrelated to symptoms or examination technique. MATERIALS AND METHODS: Wrist MR arthrograms were retrospectively reviewed in consensus by two radiologists. The presence or absence of ulnar-sided contrast extravasation was documented, whether this extravasation appeared contained or dispersed, as was the overall degree of proximal extension of the extravasated contrast material. Patient age, sex, wrist sidedness, volume of contrast material administered, location of symptoms reported clinically, and aberrant contrast material also apparent within the midcarpal space or distal radioulnar joint on the MR images reviewed were documented to determine potential association with ulnar-sided contrast extravasation. RESULTS: Ninety-nine examinations met the inclusion criteria. Ulnar-sided contrast extravasation after single-compartment radiocarpal joint injection was present in 56 of the 99 wrists (57%). This finding was statistically more common in right versus left wrists. No other statistically significant associations were identified. CONCLUSION: Contrast extravasation along the ulnar aspect of the distal ulna after single-compartment radiocarpal joint injection is common. In this study it had no statistically significant association with the location of a patient's wrist pain or abnormal findings evaluated at MR arthrography.

Fragility fractures of the proximal femur: review and update for radiologists.

Proximal femoral fragility fractures are common and result in significant morbidity and mortality along with a considerable socioeconomic burden. The goals of this article are to review relevant proximal femoral anatomy together with imaging, classification, and management of proximal femoral fragility fractures, and their most common complications. Imaging plays an integral role in classification, management and follow-up of proximal femoral fragility fractures. Classification of proximal femoral fragility fractures is primarily based on anteroposterior hip radiographs. Pertinent imaging features for each category of proximal femoral fractures that would guide management are: differentiating nondisplaced from displaced femoral neck fractures, distinguishing stable from unstable intertrochanteric fractures, and determining the morphology and comminution of subtrochanteric fractures. Treatment of proximal femoral fragility fractures is primarily surgical with either arthroplasty or internal fixation. Intramedullary nailing is used in the treatment of some types of proximal femoral fragility fractures and may be associated with unique complications that become evident on postoperative follow-up radiographs.

The floating shoulder.

The floating shoulder refers to a subset of complex shoulder injuries that typically occur in the setting of high-energy trauma. Identification of the full extent of complex shoulder injuries with computed tomography may have critical implications in patient management. The goals of this article are to review the anatomy, definition, imaging evaluation, and treatment of floating shoulder injuries.

Update on the operative treatment of scapholunate instability for radiologists. II. Salvage procedures, total wrist arthrodesis, and total wrist arthroplasty.

Scapholunate (SL) instability is the most common form of carpal instability. Imaging (especially radiography) plays an important role in the staging, management, and postoperative follow-up of SL instability. In the final stage of SL instability, known as scapholunate advanced collapse, progressive degenerative changes occur at the carpal level. The goals of this article are to review the surgical options available for addressing the different stages of scapholunate advanced collapse, along with an emphasis on normal postoperative imaging and complications associated with each surgical option.

Update on operative treatment of scapholunate (SL) instability for radiologists: part 1-SL ligament repair, dorsal capsulodesis and SL ligament reconstruction.

Scapholunate instability is the most common form of carpal instability. Imaging (especially radiography) plays an important role in the staging, management and post-operative follow-up of scapholunate (SL) instability. The goals of this article are to review the pre-operative staging of SL instability, the surgical options for repair and reconstruction of the SL ligament, along with the normal postoperative imaging findings as well as complications associated with these surgical options.

Prevalence of burnout among musculoskeletal radiologists.

OBJECTIVE: Burnout is a job-related psychological syndrome with three aspects: emotional exhaustion, depersonalization, and perceived lack of personal accomplishment. Burnout is associated with deleterious effects on both workers and their work. When burnout affects physicians, their well-being, longevity, and care of patients are at risk. Recent studies concerning physician burnout treat specialists such as radiologists as one group. We studied burnout in musculoskeletal (MSK) subspecialist radiologists. MATERIALS AND METHODS: An institutional review board exemption was obtained. Society of Skeletal Radiology members received invitations to an anonymous survey that included questions from the Maslach Burnout Inventory ™ (MBI) measuring all three aspects of burnout. The response rate was 36.4% (433/1190). RESULTS: The prevalence of emotional exhaustion was 61.7% (255/413), of depersonalization 53.3% (219/411), and of perceived lack of personal accomplishment 39.6% (161/407). Only 19.5% (79/405) of MSK radiologists reported no burnout, while 80.5% (326/405) reported burnout along one or more dimensions. For all three dimensions, the prevalence was higher and the mean severity was worse for private practice compared with academic practice. The prevalence of burnout was affected more by practice setting than by gender. Burnout prevalence and severity also varied systematically with years since completion of training. CONCLUSION: Among MSK radiologists, we found a much higher prevalence and greater severity of burnout than has been previously reported for radiologists and other physicians. There were differences in prevalence and severity of burnout among practice settings, genders, and longevity cohorts.

Pathologies of the shoulder and elbow affecting the overhead throwing athlete.

The overhead-throwing athlete is susceptible to a variety of predictable disease entities affecting the shoulder and elbow. While the pathophysiology and nomenclature of these diseases are ubiquitous throughout the clinical literature, this information is sparse within the radiology domain. We provide a comprehensive review of these unique injuries with accompanying imaging features in an effort to enhance the role of the radiologist during the management of the overhead thrower. When appropriately recognized and described, the imaging features aid in establishing a diagnosis and ultimately the implementation of appropriate clinical management.

Case 228: Mueller-Weiss Disease.

History A 53-year-old woman presented to the hospital for evaluation of progressive long-standing left dorsomedial foot pain, which was made worse with weight bearing. There was no history of trauma. Prior assessments were performed at another facility, and she did not to respond to conservative therapy. History was negative for systemic disorders. Physical examination revealed tenderness over the left talonavicular joint and flattening of the medial arch of the left foot. Otherwise, the findings were unremarkable. A basic serum chemistry test and complete blood count revealed no abnormal findings. The patient underwent routine weight-bearing radiography of her left foot and weight-bearing computed tomography (CT) of both feet.

Understanding carpal instability: a radiographic perspective.

The wrist is disposed to a variety of instability patterns owing to its complex anatomical and biomechanical properties. Various classification schemes have been proposed to describe the different patterns of carpal instability, of which the Mayo classification is the most commonly used. Understanding the concepts and pertinent terminology of this classification scheme is important for the correct interpretation of images and optimal communication with referring physicians. Standard wrist radiographs are the first line of imaging in carpal instability. Additional information may be obtained with the use of stress radiographs and other imaging modalities.

Current Concepts in Total Ankle Replacement for Radiologists: Complications.

OBJECTIVE: The purpose of this article is to review current concepts of total ankle replacement from an imaging perspective. The emphasis is on the reported complications and their imaging features in relation to current understanding of how and why these failures occur. CONCLUSION: Total ankle replacement has become mainstream surgical treatment of disabling ankle arthritis. With the many types of prostheses available for sale in the United States, rapid growth in the number of procedures can be expected with concomitant growth in the number of complications. Knowledge gained through experience with the more common hip and knee prostheses can generally be applied to ankle prostheses. Some complications are unique to the ankle, and some are unique to specific ankle prostheses.

Current Concepts in Total Ankle Replacement for Radiologists: Features and Imaging Assessment.

OBJECTIVE: This article reviews the current concepts of total ankle replacement (TAR). The features of traditional and new prosthetic designs, materials, and surgical techniques are discussed. Normal postoperative imaging findings are illustrated. CONCLUSION: TAR is becoming a mainstream treatment of end-stage ankle arthritis. Although the results after TAR have not reached the same level as those for hip arthroplasty and knee arthroplasty, the revision rates show that this form of therapy is rational and promising. For this reason, assessment of postoperative imaging is important. The foundation of the radiologic interpretation of TAR is knowledge of the physiologic purpose, orthopedic trends, imaging findings, and complications.

The anterolateral ligament of the knee: MRI appearance, association with the Segond fracture, and historical perspective.

OBJECTIVE. A recent publication has drawn attention to the anterolateral ligament, a structure of the knee with which most radiologists are unfamiliar. We evaluate this structure on MRI; clarify its origin, insertion, meniscal relationship, and morphologic appearance; and identify its relationship with the Segond fracture. MATERIALS AND METHODS. A total of 53 routine knee MRI studies interpreted as normal were reviewed to characterize the anterolateral ligament. A further 20 knee MRI studies with a Segond fracture were assessed to determine a relationship between the fracture and the anterolateral ligament. RESULTS. In all 53 cases, a structure was present along the lateral knee connecting the distal femur to the proximal tibia, with meniscofemoral and meniscotibial components. This structure was somewhat ill defined and sheetlike, inseparable from the adjacent fibular collateral ligament proximally and iliotibial band distally. Aside from one case limited by anatomic distortion, all cases with a Segond fracture exhibited attachment of this structure to the fracture fragment (19/20 cases). CONCLUSION. An ill-defined sheetlike structure along the lateral knee exists attaching the distal femur, body of lateral meniscus, and proximal tibia. This structure has been referenced in the literature dating back to Paul Segond's original description of the Segond fracture in 1879. The structure is identifiable on MRI and appears to be attached to the Segond fracture fragment. For the radiologist, it may be best to forgo an attempt to separate this structure into discrete divisions, such as the anterolateral ligament, because these individual components are inseparable on routine MRI.

Disruption of the proximal tibiofibular joint in the setting of multi-ligament knee injury.

Instability of the proximal tibiofibular joint is a relatively uncommon condition when in isolation; however, instability of the proximal tibiofibular joint is far more frequent in those presenting with a severe multi-ligament injury of the knee. If this joint is left unstable, repair of a co-existent injury of the posterolateral corner may fail, regardless of the proficiency of the technique. We present two patients with disruption of the proximal tibiofibular joint, including the MRI appearance, who initially presented to our hospital for management of significant polytrauma, as well as multi-ligament injury of the ipsilateral knee.

Current concepts in knee replacement: complications.

OBJECTIVE: The purposes of this article are to review current concepts of knee replacement, including features of traditional and newer prosthetic designs, materials, and surgical techniques; illustrate normal and abnormal postoperative imaging findings; and to relate the complications to current understanding of how and why these failures occur. CONCLUSION: Complications after knee replacement may be asymptomatic. For this reason, assessment with postoperative imaging is important. The foundation of radiologic interpretation of knee replacement is knowledge of the physiologic purpose, orthopedic trends, imaging findings, and complications.

Fractures of the distal radius: postmanagement radiographic characterization.

OBJECTIVE: The purpose of this article is to describe the management options available for the treatment of the distal radius fracture as well as potential associated complications. CONCLUSION: There are a wide variety of currently accepted and used treatment options for fractures of the distal radius, ranging from closed reduction with casting to various forms of invasive surgical management. The radiologist must be familiar with these various forms of management to recognize complications when present on follow-up radiographs.

Fracture of the distal radius: epidemiology and premanagement radiographic characterization.

OBJECTIVE: Fractures of the distal radius are common and frequently encountered by the radiologist. We review the epidemiology, classification, as well as the concept of instability. Salient qualitative and quantitative features of the distal radius fracture identifiable on the routine radiography series are highlighted. We conclude with a synopsis of descriptors that are of greatest utility to the clinician for treatment planning and that should be addressed in the radiology report. CONCLUSION: A detailed understanding of the intricacies of the distal radius fracture is necessary for the radiologist to provide a clinically relevant description.