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1.

Trained Immunity: Reprogramming Innate Immunity in Health and Disease.

Bekkering, Siroon; Domínguez-Andrés, Jorge; Joosten, Leo A B; Riksen, Niels P; Netea, Mihai G.

Annu Rev Immunol ; 39: 667-693, 2021 04 26.

Article in English | MEDLINE | ID: mdl-33637018

2.

C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection.

Desai, Jigar V; Kumar, Dhaneshwar; Freiwald, Tilo; Chauss, Daniel; Johnson, Melissa D; Abers, Michael S; Steinbrink, Julie M; Perfect, John R; Alexander, Barbara; Matzaraki, Vasiliki; Snarr, Brendan D; Zarakas, Marissa A; Oikonomou, Vasileios; Silva, Lakmali M; Shivarathri, Raju; Beltran, Emily; Demontel, Luciana Negro; Wang, Luopin; Lim, Jean K; Launder, Dylan; Conti, Heather R; Swamydas, Muthulekha; McClain, Micah T; Moutsopoulos, Niki M; Kazemian, Majid; Netea, Mihai G; Kumar, Vinod; Köhl, Jörg; Kemper, Claudia; Afzali, Behdad; Lionakis, Michail S.

Cell ; 186(13): 2802-2822.e22, 2023 06 22.

Article in English | MEDLINE | ID: mdl-37220746

3.

Inflammasome-independent regulation of IL-1-family cytokines.

Netea, Mihai G; van de Veerdonk, Frank L; van der Meer, Jos W M; Dinarello, Charles A; Joosten, Leo A B.

Annu Rev Immunol ; 33: 49-77, 2015.

Article in English | MEDLINE | ID: mdl-25493334

4.

Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities.

Li, Xiaofei; Wang, Hui; Yu, Xiang; Saha, Gundappa; Kalafati, Lydia; Ioannidis, Charalampos; Mitroulis, Ioannis; Netea, Mihai G; Chavakis, Triantafyllos; Hajishengallis, George.

Cell ; 185(10): 1709-1727.e18, 2022 05 12.

Article in English | MEDLINE | ID: mdl-35483374

5.

The pathophysiology of sepsis and precision-medicine-based immunotherapy.

Giamarellos-Bourboulis, Evangelos J; Aschenbrenner, Anna C; Bauer, Michael; Bock, Christoph; Calandra, Thierry; Gat-Viks, Irit; Kyriazopoulou, Evdoxia; Lupse, Mihaela; Monneret, Guillaume; Pickkers, Peter; Schultze, Joachim L; van der Poll, Tom; van de Veerdonk, Frank L; Vlaar, Alexander P J; Weis, Sebastian; Wiersinga, W Joost; Netea, Mihai G.

Nat Immunol ; 25(1): 19-28, 2024 Jan.

Article in English | MEDLINE | ID: mdl-38168953

6.

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection.

Netea, Mihai G; Giamarellos-Bourboulis, Evangelos J; Domínguez-Andrés, Jorge; Curtis, Nigel; van Crevel, Reinout; van de Veerdonk, Frank L; Bonten, Marc.

Cell ; 181(5): 969-977, 2020 05 28.

Article in English | MEDLINE | ID: mdl-32437659

7.

Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly.

Giamarellos-Bourboulis, Evangelos J; Tsilika, Maria; Moorlag, Simone; Antonakos, Nikolaos; Kotsaki, Antigone; Domínguez-Andrés, Jorge; Kyriazopoulou, Evdoxia; Gkavogianni, Theologia; Adami, Maria-Evangelia; Damoraki, Georgia; Koufargyris, Panagiotis; Karageorgos, Athanassios; Bolanou, Amalia; Koenen, Hans; van Crevel, Reinout; Droggiti, Dionyssia-Irene; Renieris, George; Papadopoulos, Antonios; Netea, Mihai G.

Cell ; 183(2): 315-323.e9, 2020 10 15.

Article in English | MEDLINE | ID: mdl-32941801

8.

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity.

Kalafati, Lydia; Kourtzelis, Ioannis; Schulte-Schrepping, Jonas; Li, Xiaofei; Hatzioannou, Aikaterini; Grinenko, Tatyana; Hagag, Eman; Sinha, Anupam; Has, Canan; Dietz, Sevina; de Jesus Domingues, Antonio Miguel; Nati, Marina; Sormendi, Sundary; Neuwirth, Ales; Chatzigeorgiou, Antonios; Ziogas, Athanasios; Lesche, Mathias; Dahl, Andreas; Henry, Ian; Subramanian, Pallavi; Wielockx, Ben; Murray, Peter; Mirtschink, Peter; Chung, Kyoung-Jin; Schultze, Joachim L; Netea, Mihai G; Hajishengallis, George; Verginis, Panayotis; Mitroulis, Ioannis; Chavakis, Triantafyllos.

Cell ; 183(3): 771-785.e12, 2020 10 29.

Article in English | MEDLINE | ID: mdl-33125892

9.

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.

Priem, Bram; van Leent, Mandy M T; Teunissen, Abraham J P; Sofias, Alexandros Marios; Mourits, Vera P; Willemsen, Lisa; Klein, Emma D; Oosterwijk, Roderick S; Meerwaldt, Anu E; Munitz, Jazz; Prévot, Geoffrey; Vera Verschuur, Anna; Nauta, Sheqouia A; van Leeuwen, Esther M; Fisher, Elizabeth L; de Jong, Karen A M; Zhao, Yiming; Toner, Yohana C; Soultanidis, Georgios; Calcagno, Claudia; Bomans, Paul H H; Friedrich, Heiner; Sommerdijk, Nico; Reiner, Thomas; Duivenvoorden, Raphaël; Zupancic, Eva; Di Martino, Julie S; Kluza, Ewelina; Rashidian, Mohammad; Ploegh, Hidde L; Dijkhuizen, Rick M; Hak, Sjoerd; Pérez-Medina, Carlos; Bravo-Cordero, Jose Javier; de Winther, Menno P J; Joosten, Leo A B; van Elsas, Andrea; Fayad, Zahi A; Rialdi, Alexander; Torre, Denis; Guccione, Ernesto; Ochando, Jordi; Netea, Mihai G; Griffioen, Arjan W; Mulder, Willem J M.

Cell ; 183(3): 786-801.e19, 2020 10 29.

Article in English | MEDLINE | ID: mdl-33125893

10.

Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes.

Temba, Godfrey S; Kullaya, Vesla; Pecht, Tal; Mmbaga, Blandina T; Aschenbrenner, Anna C; Ulas, Thomas; Kibiki, Gibson; Lyamuya, Furaha; Boahen, Collins K; Kumar, Vinod; Joosten, Leo A B; Schultze, Joachim L; van der Ven, Andre J; Netea, Mihai G; de Mast, Quirijn.

Nat Immunol ; 22(3): 287-300, 2021 03.

Article in English | MEDLINE | ID: mdl-33574617

11.

Transmission of trained immunity and heterologous resistance to infections across generations.

Katzmarski, Natalie; Domínguez-Andrés, Jorge; Cirovic, Branko; Renieris, Georgios; Ciarlo, Eleonora; Le Roy, Didier; Lepikhov, Konstantin; Kattler, Kathrin; Gasparoni, Gilles; Händler, Kristian; Theis, Heidi; Beyer, Marc; van der Meer, Jos W M; Joosten, Leo A B; Walter, Jörn; Schultze, Joachim L; Roger, Thierry; Giamarellos-Bourboulis, Evangelos J; Schlitzer, Andreas; Netea, Mihai G.

Nat Immunol ; 22(11): 1382-1390, 2021 11.

Article in English | MEDLINE | ID: mdl-34663978

12.

Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity.

Moorlag, Simone J C F M; Folkman, Lukas; Ter Horst, Rob; Krausgruber, Thomas; Barreca, Daniele; Schuster, Linda C; Fife, Victoria; Matzaraki, Vasiliki; Li, Wenchao; Reichl, Stephan; Mourits, Vera P; Koeken, Valerie A C M; de Bree, L Charlotte J; Dijkstra, Helga; Lemmers, Heidi; van Cranenbroek, Bram; van Rijssen, Esther; Koenen, Hans J P M; Joosten, Irma; Xu, Cheng-Jian; Li, Yang; Joosten, Leo A B; van Crevel, Reinout; Netea, Mihai G; Bock, Christoph.

Immunity ; 57(1): 171-187.e14, 2024 Jan 09.

Article in English | MEDLINE | ID: mdl-38198850

13.

Trained Immunity and Local Innate Immune Memory in the Lung.

Netea, Mihai G; Joosten, Leo A B.

Cell ; 175(6): 1463-1465, 2018 11 29.

Article in English | MEDLINE | ID: mdl-30500533

14.

Metabolic Induction of Trained Immunity through the Mevalonate Pathway.

Bekkering, Siroon; Arts, Rob J W; Novakovic, Boris; Kourtzelis, Ioannis; van der Heijden, Charlotte D C C; Li, Yang; Popa, Calin D; Ter Horst, Rob; van Tuijl, Julia; Netea-Maier, Romana T; van de Veerdonk, Frank L; Chavakis, Triantafyllos; Joosten, Leo A B; van der Meer, Jos W M; Stunnenberg, Henk; Riksen, Niels P; Netea, Mihai G.

Cell ; 172(1-2): 135-146.e9, 2018 01 11.

Article in English | MEDLINE | ID: mdl-29328908

15.

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Mitroulis, Ioannis; Ruppova, Klara; Wang, Baomei; Chen, Lan-Sun; Grzybek, Michal; Grinenko, Tatyana; Eugster, Anne; Troullinaki, Maria; Palladini, Alessandra; Kourtzelis, Ioannis; Chatzigeorgiou, Antonios; Schlitzer, Andreas; Beyer, Marc; Joosten, Leo A B; Isermann, Berend; Lesche, Mathias; Petzold, Andreas; Simons, Kai; Henry, Ian; Dahl, Andreas; Schultze, Joachim L; Wielockx, Ben; Zamboni, Nicola; Mirtschink, Peter; Coskun, Ünal; Hajishengallis, George; Netea, Mihai G; Chavakis, Triantafyllos.

Cell ; 172(1-2): 147-161.e12, 2018 01 11.

Article in English | MEDLINE | ID: mdl-29328910

16.

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

Christ, Anette; Günther, Patrick; Lauterbach, Mario A R; Duewell, Peter; Biswas, Debjani; Pelka, Karin; Scholz, Claus J; Oosting, Marije; Haendler, Kristian; Baßler, Kevin; Klee, Kathrin; Schulte-Schrepping, Jonas; Ulas, Thomas; Moorlag, Simone J C F M; Kumar, Vinod; Park, Min Hi; Joosten, Leo A B; Groh, Laszlo A; Riksen, Niels P; Espevik, Terje; Schlitzer, Andreas; Li, Yang; Fitzgerald, Michael L; Netea, Mihai G; Schultze, Joachim L; Latz, Eicke.

Cell ; 172(1-2): 162-175.e14, 2018 01 11.

Article in English | MEDLINE | ID: mdl-29328911

17.

Physiological and Genetic Adaptations to Diving in Sea Nomads.

Ilardo, Melissa A; Moltke, Ida; Korneliussen, Thorfinn S; Cheng, Jade; Stern, Aaron J; Racimo, Fernando; de Barros Damgaard, Peter; Sikora, Martin; Seguin-Orlando, Andaine; Rasmussen, Simon; van den Munckhof, Inge C L; Ter Horst, Rob; Joosten, Leo A B; Netea, Mihai G; Salingkat, Suhartini; Nielsen, Rasmus; Willerslev, Eske.

Cell ; 173(3): 569-580.e15, 2018 04 19.

Article in English | MEDLINE | ID: mdl-29677510

18.

CRELD1 modulates homeostasis of the immune system in mice and humans.

Bonaguro, Lorenzo; Köhne, Maren; Schmidleithner, Lisa; Schulte-Schrepping, Jonas; Warnat-Herresthal, Stefanie; Horne, Arik; Kern, Paul; Günther, Patrick; Ter Horst, Rob; Jaeger, Martin; Rahmouni, Souad; Georges, Michel; Falk, Christine S; Li, Yang; Mass, Elvira; Beyer, Marc; Joosten, Leo A B; Netea, Mihai G; Ulas, Thomas; Schultze, Joachim L; Aschenbrenner, Anna C.

Nat Immunol ; 21(12): 1517-1527, 2020 12.

Article in English | MEDLINE | ID: mdl-33169013

19.

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.

Schirmer, Melanie; Smeekens, Sanne P; Vlamakis, Hera; Jaeger, Martin; Oosting, Marije; Franzosa, Eric A; Ter Horst, Rob; Jansen, Trees; Jacobs, Liesbeth; Bonder, Marc Jan; Kurilshikov, Alexander; Fu, Jingyuan; Joosten, Leo A B; Zhernakova, Alexandra; Huttenhower, Curtis; Wijmenga, Cisca; Netea, Mihai G; Xavier, Ramnik J.

Cell ; 167(4): 1125-1136.e8, 2016 11 03.

Article in English | MEDLINE | ID: mdl-27814509

20.

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

Li, Yang; Oosting, Marije; Smeekens, Sanne P; Jaeger, Martin; Aguirre-Gamboa, Raul; Le, Kieu T T; Deelen, Patrick; Ricaño-Ponce, Isis; Schoffelen, Teske; Jansen, Anne F M; Swertz, Morris A; Withoff, Sebo; van de Vosse, Esther; van Deuren, Marcel; van de Veerdonk, Frank; Zhernakova, Alexandra; van der Meer, Jos W M; Xavier, Ramnik J; Franke, Lude; Joosten, Leo A B; Wijmenga, Cisca; Kumar, Vinod; Netea, Mihai G.

Cell ; 167(4): 1099-1110.e14, 2016 11 03.

Article in English | MEDLINE | ID: mdl-27814507

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