ABSTRACT
Objective: Femoral nerve palsy occurs after trauma, surgical procedures and tumors and leads to loss of quadriceps functions, disability and decreased quality of life. The aim of this report was to describe a successful restoration of knee extension by transferring the anterior branch of the obturator nerve to selective branches of the femoral nerve at the thigh level.Methods: We describe a 27-year-old male who had quadriceps femoris muscle paralysis after surgical evacuation for retroperitoneal hematoma five months ago. Since proximal stump of femoral nerve was not accessible, we transferred anterior branch of obturator nerve to selective branches of femoral nerve for reconstruction of quadriceps femoris muscle.Results: After four months, he regained quadriceps muscle strength M3 and began to walk. He achieved full muscle strength (M5) nine months after surgery and was able to walk up-stairs easily 14 months after surgery and atrophy of the quadriceps was improved.Conclusion: The anterior branch of the obturator nerve is an available donor nerve with an excellent functional recovery for the reconstruction of knee extension when proximal stump of femoral nerve is not reachable or the repair needs a long graft.
Subject(s)
Nerve Transfer , Obturator Nerve , Male , Humans , Adult , Obturator Nerve/transplantation , Quality of Life , Nerve Transfer/methods , Femoral Nerve/surgery , Lower ExtremityABSTRACT
Glioblastoma multiforme (GBM) is the commonest primary malignant brain tumor and has a remarkably weak prognosis. According to the aggressive form of GBM, understanding the accurate molecular mechanism associated with GBM pathogenesis is essential. Growth differentiation factor 15 (GDF-15) belongs to transforming growth factor-ß superfamily with important roles to control biological processes. It affects cancer growth and progression, drug resistance, and metastasis. It also can promote stemness in many cancers, and also can stress reactions control, bone generation, hematopoietic growth, adipose tissue performance, and body growth, and contributes to cardiovascular disorders. The role GDF-15 to develop and progress cancer is complicated and remains unclear. GDF-15 possesses tumor suppressor properties, as well as an oncogenic effect. GDF-15 antitumorigenic and protumorigenic impacts on tumor development are linked to the cancer type and stage. However, the GDF-15 signaling and mechanism have not yet been completely identified because of no recognized cognate receptor.
Subject(s)
Brain Neoplasms/drug therapy , Glioblastoma/drug therapy , Glioblastoma/pathology , Growth Differentiation Factor 15/metabolism , Brain Neoplasms/diagnosis , Brain Neoplasms/pathology , Cell Proliferation/drug effects , Cell Proliferation/physiology , Glioblastoma/diagnosis , Growth Differentiation Factor 15/drug effects , Humans , Signal Transduction/drug effects , Signal Transduction/physiology , Transforming Growth Factor beta/metabolismABSTRACT
Trichorrhexis invaginata and ichthyosiform erythroderma are pathognomic for Netherton Syndrome.