ABSTRACT
Primary melanoma of the urinary bladder is rare. We report a case of a 58-year-old woman, who presented with a 4 month history of dysuria and hematuria. A biopsy indicated a diagnosis of invasive melanoma and a partial cystectomy was performed. The neoplasm had invaded the entire thickness of the bladder wall and the neoplastic cells were positive for Melan A and HMB-45. Four months later a urinary bladder measuring 13×7×5cm was sent for histopathology. Melanoma, melanosis and a melanocytic nevus were seen; the latter was confirmed by the positivity to melanocytic markers of non-atypical cells in both the urothelial basal layer and areas distant from the tumour. The patient died nine months later.
Subject(s)
Melanoma/pathology , Urinary Bladder Neoplasms/pathology , Biomarkers, Tumor/analysis , Cystectomy/methods , Fatal Outcome , Female , Humans , MART-1 Antigen/analysis , Melanocytes/pathology , Melanoma/chemistry , Melanoma/surgery , Melanoma-Specific Antigens/analysis , Melanosis/pathology , Middle Aged , Neoplasm Invasiveness , Nevus, Pigmented/pathology , Urinary Bladder Diseases/pathology , Urinary Bladder Neoplasms/chemistry , Urinary Bladder Neoplasms/surgery , gp100 Melanoma AntigenABSTRACT
Los melanomas de vejiga urinaria son poco frecuentes. Presentamos el caso de una paciente femenina de 58 años, quien consultó por disuria y hematuria de 4 meses de evolución. Se le realizó cistoscopia y biopsia, la cual fue interpretada como melanoma invasivo. Posteriormente se realizó cistectomía parcial, en la cual se diagnosticó melanoma, confirmado por positividad de las células neoplásicas para Melan-A y HMB-45 en estudio de inmunohistoquímica. Se demostró invasión neoplásica de todo el espesor de la capa muscular y de bordes quirúrgicos. Cuatro meses después se recibió vejiga urinaria de 13×7×5cm, en la cual se encontró, además del melanoma, melanosis y nevo melanocítico en vejiga urinaria. El nevo melanocítico se demostró mediante positividad a anticuerpos melanocíticos, de células no atípicas en capa basal de urotelio vecino y distante al tumor. La paciente sobrevivió 9 meses
Primary melanoma of the urinary bladder is rare. We report a case of a 58-year-old woman, who presented with a 4 month history of dysuria and hematuria. A biopsy indicated a diagnosis of invasive melanoma and a partial cystectomy was performed. The neoplasm had invaded the entire thickness of the bladder wall and the neoplastic cells were positive for Melan A and HMB-45. Four months later a urinary bladder measuring 13×7×5cm was sent for histopathology. Melanoma, melanosis and a melanocytic nevus were seen; the latter was confirmed by the positivity to melanocytic markers of non-atypical cells in both the urothelial basal layer and areas distant from the tumour. The patient died nine months later