1.
Br J Haematol
; 2024 Aug 05.
Article
in English
| MEDLINE
| ID: mdl-39099338
ABSTRACT
Rearrangement of NUTM1 gene (NUTM1r) is one of the most frequent aberrations occurring in infants (younger than 1 year at diagnosis) with B-cell precursor Acute Lymphoblastic Leukaemia (BCP-ALL). In this study we had the unique opportunity to analyze the umbilical cord blood (UCB) sample from one infant patient with NUTM1r BCP-ALL. Herein we reported for the first time that NUTM1r infant ALL arise prenatally, as both the patient-specific CUX1::NUTM1 fusion gene, as well as two IG/TR leukaemic markers were already present and detectable in the patient's UCB at birth. Our results clearly demonstrate the prenatal origin of NUTM1r infant BCP-ALL.
2.
Blood
; 137(14): 1980-1984, 2021 04 08.
Article
in English
| MEDLINE
| ID: mdl-33512459
Subject(s)
Histone-Lysine N-Methyltransferase/genetics , Myeloid-Lymphoid Leukemia Protein/genetics , Oncogene Fusion , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics , Female , Gene Rearrangement , Germ Cells/pathology , Humans , Infant , Male , Oncogene Proteins, Fusion/genetics , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/therapy , Retrospective Studies
3.