[Small pelvis lipoma spreading to the gluteal region]. / Lipoma malogo taza i yagodichnoi oblasti.

We present a 36-year-old woman with small pelvis lipoma spreading to the gluteal region through the greater sciatic foramen. Resection of lipoma was performed via two accesses (lower median laparotomy and semilunar incision in the gluteal region). The tumor was the content of sciatic hernia that is extremely rare. Combination of surgical approaches can provide favorable outcomes in these patients.

[Pancreatic mucinous cystadenoma with atypical clinical presentation]. / Mutsinoznaya tsistadenoma podzheludochnoi zhelezy ­ netipichnyi variant techeniya zabolevaniya.

We present a 33-year-old patient with atypical clinical course of pancreatic mucinous cystadenoma. The tumor had connection with pancreatic ductal system and led to bleeding into cystic cavity. This contributed to incorrect preoperative diagnosis of post-necrotic cyst. The final diagnosis of mucinous cystadenoma was established after histological examination. Distal pancreatectomy excluded incorrect treatment.

[Pancreaticoduodenectomy - results and prospects (two-center study)]. / Pankreatoduodenal'naya rezektsiya ­ rezul'taty i perspektivy (dvukhtsentrovoe issledovanie).

OBJECTIVE: To summarize the results of pancreaticoduodenectomy (PD) for pancreatic tumors and complications of chronic pancreatitis regarding prediction and prevention of postoperative complications. MATERIAL AND METHODS: There were 336 PD procedures between 2016 and mid-2022 in two centers. We assessed the factors influencing specific postoperative complications (postoperative pancreatitis, pancreatic fistula, gastric stasis, arrosive bleeding). Several risk factors were distinguished: baseline pancreatic disease and tumor size, CT-signs of a «soft¼ gland, intraoperative assessment of the pancreas, number of functioning acinar structures. We assessed surgical prevention of pancreatic fistula via preserving adequate blood supply to the pancreatic stump. The last one is provided by extended pancreatic resection and reconstructive stage of surgery, i.e. Roux-en-Y hepatico- and duodenojejunostomy with isolation of pancreaticojejunostomy on the second loop. RESULTS: Postoperative pancreatitis underlies specific complications after PD. The risk of pancreatic fistula in case of postoperative pancreatitis increases by 5.3 times compared to patients without pancreatitis. Postoperative pancreatic fistula is more common in patients with T1 and T2 tumors. According to univariate analysis, only pancreatic fistula significantly affects the risk of gastric stasis. Among 336 people who underwent PD, pancreatic fistula occurred in 69 patients (20.5%), gastric stasis - in 61 (18.2%), pancreatic fistula complicated by arrosive bleeding - in 45 (13.4%) patients. Mortality rate was 3.6% (n=15). CONCLUSION: Modern prognostic criteria are valuable to predict specific complications after PD. A promising way to prevent postoperative pancreatitis can be extended pancreatic resection considering angioarchitectonics of the pancreatic stump. Roux-en-Y pancreaticojejunostomy is advisable to reduce aggressiveness of pancreatic fistula.

[A rare variant of pancreatic serous cystadenoma]. / Redkii variant seroznoi tsistadenomy podzheludochnoi zhelezy.

The authors present a patient with serous cystadenoma of the pancreatic head. Atypical symptoms and CT data did not allow excluding pancreatic cancer. Thus, pancreaticoduodenectomy was performed.

Large Shape Staggering in Neutron-Deficient Bi Isotopes.

The changes in the mean-square charge radius (relative to ^{209}Bi), magnetic dipole, and electric quadrupole moments of ^{187,188,189,191}Bi were measured using the in-source resonance-ionization spectroscopy technique at ISOLDE (CERN). A large staggering in radii was found in ^{187,188,189}Bi^{g}, manifested by a sharp radius increase for the ground state of ^{188}Bi relative to the neighboring ^{187,189}Bi^{g}. A large isomer shift was also observed for ^{188}Bi^{m}. Both effects happen at the same neutron number, N=105, where the shape staggering and a similar isomer shift were observed in the mercury isotopes. Experimental results are reproduced by mean-field calculations where the ground or isomeric states were identified by the blocked quasiparticle configuration compatible with the observed spin, parity, and magnetic moment.

[Combination of intraductal papillary mucinous neoplasm with other cystic pancreatic tumors]. / Sochetanie vnutriprotokovoi papillyarnoi mutsinoznoi opukholi s drugimi kistoznymi opukholyami podzheludochnoi zhelezy.

Cystic tumors of the pancreas are uncommon entities. Synchronic occurrence of intraductal papillary mucinous neoplasm (IPMN) and other pancreatic tumors is extremely rare. Two patients with this diagnosis are reported in the manuscript. Cystic tumors of the pancreas can rarely occur in various combinations while malignancy potential of each neoplasm may be different. Surgery depends on localization and type of each tumor and must be determined individually.

[Endoscopic treatment of duodenal duplication cyst]. / Endoskopicheskoe lechenie duplikatsionnoi kisty dvenadtsatiperstnoi kishki.

Duodenal duplication cyst (DDC) is a rare form of intestinal malformation (2-12% of all gastrointestinal duplications). There are many difficulties in diagnosis and management of DDC. We present a case of successful endoscopic transluminal treatment of DDC in a 30-year-old female. She complained of epigastric pain, nausea and vomiting, weight loss of 5 kg over the past 3 months. Laparoscopic cholecystectomy for gallstone disease was performed 18 months prior to admission. Examination revealed a cyst 52×60?35 mm in descending part of duodenum. There was a calculus inside the cyst. Transluminal endoscopic cyst fenestration was performed. Histological examination confirmed DDC. According to control duodenoscopy data, cyst was collapsed. The patient remains asymptomatic three months after surgery. DDC is a rare disease of gastrointestinal tract, which should be differentiated first with choledochocele Todani type III and intraluminal duodenal diverticulum. Endoscopic treatment may be an adequate alternative to traditional interventions in some cases.

[Pancreatic proinsulinoma]. / Proinsulinoma podzheludochnoi zhelezy.

OBJECTIVE: To report own experience in the treatment of patients with proinsulinoma. MATERIAL AND METHODS: There were 10 patients with increased proinsulin production and normal insulin level since 2017. Most of them were young women. RESULTS: Fasting hypoglycemia in all patients was severe (up to 0.7 mmol/l). Clinical picture consisted of typical symptoms similar to those in insulinoma. The main difference in the course of proinsulinoma was the absence of weight gain in 7 patients and rapid weight loss (from 210 to 90 kg within 9 months) in 1 patient. All patients with proinsulinoma underwent surgery. In most cases, minimally aggressive surgery was performed. CONCLUSION: Proinsulinoma is an extremely rare endocrine-active neuroendocrine pancreatic tumor. Differential features of proinsulinoma are the absence of weight gain and normal insulin levels in the presence of hypoglycemia. Surgery is the only radical method of treatment.

[Diagnostic and treatment of the intraductal papillary mucinous tumor of pancreas]. / Diagnostika i lechenie vnutriprotokovoi papilliarnoi mutsinoznoi opukholi podzheludochnoi zhelezy.

OBJECTIVE: Adjustment of diagnostics and management of the surgical treatment of patients with intraductal papillary mucinous tumor of pancreas. MATERIAL AND METHODS: From 2012 to 2018, 45 patients with intraductal papillary mucinous tumor were observed. During the observation the ultrasound examination, contrast-enhanced computed tomography and magnetic resonance tomography with contrast were used. In 29 cases radical surgery was performed, nonradical in 1 case; case follow-up is chosen for 15 patients. RESULTS: Intraductal papillary mucinous tumor was diagnosed and the definition of the type of tumor was made on the base of 2 types of imaging methods. Intraductal papillary mucinous tumor type 1 was founded in 5 (11%), whereas intraductal papillary mucinous tumor type 2 was founded in 20 (44,5%) and intraductal papillary mucinous tumor type 3 was observed in 20 (44,5%) cases. Intraductal papillary mucinous tumor associated with carcinoma was observed in 16 cases. Pancreaticoduodenal resection was performed in 20, distal exsection of pancreas was performed in 4 cases (2 in open manner access, 2 in robot-assisted manner), pancreatic head resection was performed in 3 cases (1 in open manner access, 2 in laparoscopic access) and in 2 cases the duodenopancreatectomy was performed. Explorative laparotomy was performed in case of intraductal papillary mucinous tumor type 2 associated with mucilaginous carcinoma and miliary metastasis in the liver. Early postoperative complications were observed in 5 cases (16, 6%): biliary fistula (n=2), postoperative wound infection (n=2), arrosive hemorrhage type B in ISGPS (n=1, was treated in an X-ray endovascular manner). Case follow-up was chosen in 15 cases of intraductal papillary mucinous tumor over the course of 6 to 74 months and disease progression was not observed. CONCLUSION: Intraductal papillary mucinous tumor is a condition associated with high risk of malignant change and demands early disease detection. The treatment should be provided in medical centers that specialize in the pancreas deceases, where a full patient examination as well as a clear-eyed understanding of diagnostic information with the execution of desirable type of surgical intervention with the guaranty of achievement R0 condition can be offered.

[Diagnosis and surgical treatment of duodenal tumors]. / Diagnostika i khirurgicheskoe lechenie opukholei dvenadtsatiperstnoi kishki.

AIM: To present the experience in diagnosis and surgical treatment of duodenal tumors. MATERIAL AND METHODS: The study included 27 patients with different duodenal tumors: adenocarcinoma (AC, n=8), gastrointestinal stromal tumor (GIST, n=13), neuroendocrine tumor (NET, n=6). The examination included computed tomography (in 27 patients), magnetic resonance imaging (12), transcutaneous ultrasound (14), endosonography (16), esophagogastroduodenoscopy (16). All patients were operated. Conventional (18), laparoscopic (4), robot-assisted (4), endoscopic endoluminal (1) surgical interventions were performed. 17 patients were followed up from 8 months to 10 years (median 26 months). RESULTS: According to the instrumental diagnostic methods, duodenal tumors were verified in 19 cases. Five patients with AC underwent pancreaticoduodenectomy (Whipple procedure), 2 - palliative operations (bypass gastroenteroanastomosis), 1 - explorative laparotomy. Patients with GIST underwent 3 pancreaticoduodenectomies and 10 duodenectomies: traditional (4), laparoscopic (4) and robot-assisted (2) approaches. In case of NET 3 interventions via traditional approach (pancreaticoduodenectomy, duodenal resection, tumor enucleation), 1 endoscopic endoluminal operation, 2 robot-assisted operations (duodenal resection and duodenopancreatectomy, splenectomy, distal gastrectomy) were performed. Postoperative complications occurred in 10 (37%) patients. Postoperative mortality was absent. Long-term results were analyzed in 17 patients. All patients with GIST and NET are alive without disease progression. Two AC patients are alive from those who are available. CONCLUSION: Duodenal tumors are relatively rare. Radical surgical intervention in accordance with oncological principles is preferred for these patients. Organ-preserving procedures may be applied depending on morphological type of tumor. Examination and treatment of patients with duodenal tumors should be carried out in specialized surgical departments.

[Intraductal papillary mucinous neoplasm of pancreas]. / Vnutriprotokovaia papilliarnaia mutsinoznaia opukhol' podzheludochnoi zhelezy.

Intraductal papillary mucinous neoplasm (IPMN) is the most common cystic pancreatic tumor. There are 3 ductal types of this tumor depending on localization. Several histological subtypes determine clinical course and prognosis. The problems of diagnosis, surgical treatment and follow-up are reviewed in several guidelines. Literature review devoted to pancreatic IPMN is presented in the article, the latest guidelines are compared.

[Duodenopancreatectomy for pancreatic tumors - pros and cons]. / Duodenopankreatéktomiia pri opukholiakh podzheludochnoi zhelezy - PRO ET CONTRA.

AIM: To optimize surgical treatment of multiple and advanced pancreatic tumors. MATERIAL AND METHODS: There were 852 patients with various pancreatic tumors for the period 2011 - September 2019. Duodenopancreatectomy (DPE) was performed in 18 patients. Locally advanced ductal adenocarcinoma was diagnosed in 10 patients, acinar cell carcinoma - in 1 patient, multiple neuroendocrine tumors - in 4 cases, intraductal papillary mucinous tumor - in 2 patients, multiple metastases of renal cell carcinoma - in 1 patient. This procedure was avoided in 9 patients who underwent alternative operations: pancreatoduodenectomy (PDE) with pancreatic body resection for intraductal papillary mucinous tumor - 5 cases, two-stage (2) and one-stage (1) distal pancreatectomy and PDE for multiple neuroendocrine tumors - 2 patients, simultaneous pancreatic head resection and distal pancreatectomy for multiple metastases of renal cell carcinoma - 1 patient. RESULTS: Postoperative complications occurred in 14 patients after DPE (77.8%) and in 5 patients after alternative operations (55.5%). Alternative procedures in patients with neuroendocrine tumors, intraductal papillary mucinous tumors and metastases of renal cell carcinoma ensured radical surgical treatment. These patients did not need for insulin replacement therapy and enzyme drugs. CONCLUSION: Strict adherence to oncological canons and differentiated approach in patients with multiple neuroendocrine tumors, metastases of renal cell carcinoma and intraductal papillary mucinous tumors are essential to avoid DPE in some cases in favor of alternative operations.

[Microbiological aspects of zirconia orthopedic structures].

The article gives a detailed analysis of oral cavity microbiological aspects of 23 patients before and after prosthetic treatment with zirconia structures. Microbiocenoses of oral cavity in patients with defects of the dentition can be described as disbiotic. It was found that the incidence of lactobacilli and bifidobacteria was increased and frequency of occurrence of pathogens, including Staphylococcus aureus, was decreased under the influence of temporary plastic prosthesis as an intermediate step prosthetics. After applying prosthetic zirconia an increase of the normal biotopes number was seen, as well as reduce in the number of Staphylococcus aureus and the yeast fungus Candida to less than 4 lg CFU/ml. Such amounts do not cause inflammation in the oral cavity.

[Psychological status assessment in patients with TMJ malfunctions].

This article describes the assessment of psychological status and quality of life in 41 patients with temporomandibular joint (TMJ) dysfunction as well as the importance of the disease for patients. The study revealed a number of personal characteristics and emotional problems in TMJ dysfunction patients, such as increased anxiety and low level of psychological stability.

[Diagnostics of mandibular articulation disorders in TMJ dysfunction patients].

Diagnostics of disorders of mandibular articulation of 95 patients with TMJ dysfunction were described. Collecting the data from transcranial x-ray examination, CT, MRT and computerized axijgraphy of TMJ typical disorders of articulation of the mandibular at 4 base clinio-roentgenogical forms of TMJ dysfunction were found.

Robotic surgery in treatment of retroperitoneal tumors. Comparative single center study.

Retroperitoneal tumors (RT)-group of benign and malignant mesenchymal tumors without any specific organ affiliation. Surgery is the only effective treatment. Robotic surgery is becoming popular and an effective approach in abdominal surgery. There is insufficient data about robotic treatment of retroperitoneal tumors. The comparative retrospective study of the results of surgical treatment of RTs between 2009 and 2019 was performed. 88 patients were surgically treated. The average age of patients was 58 (21;85). Clinical manifestations of RT were presented in 59 (67.1%) cases. RTs were asymptomatic in 29 patients (32.9%). The preoperative diagnosis was based on radiological diagnostic methods. Depending on the surgical approach, patients were divided into 3 groups. 35 patients were operated with robot-assisted (RA) method, 14 with laparoscopic (L), and 39 with traditional (TA) open approach. TA had the least operation time, but the most amount of blood loss. The median duration of postoperative drainage, morbidity rate, and postoperative length of stat were less after robotic approaches. The conversion rate was significantly less in robotic group in comparison with laparoscopy. There were no postoperative mortalities after each approach. The robot-assisted surgery could be successfully used in cases of retroperitoneal tumors. It's feasible, safe, and comfortable for patients. The RA significantly reduces risks in cases when the tumor is located in hard-to-reach small spaces and/or attached to the main vessels and the size of the tumor is less than 10 cm.

Virulence Polymorphism of Puccinia recondita f. sp. tritici and Effectiveness of Lr Genes for Leaf Rust Resistance of Wheat in Ukraine.

In 2002 and 2003, 1,300 isolates of Puccinia recondita f. sp. tritici were obtained from six commercial cultivars of wheat at three locations in the eastern forest-steppe region of Ukraine. All isolates were tested for virulence on an international set of eight differential cultivars. Seventeen known wheat leaf rust races and several new, unnamed races were identified. The most common races in each year were races 61, 149, and 192. In 2003, up to 20 isolates each of the seven most common leaf rust races plus 8 to 10 isolates of unnamed races were tested for virulence to 35 near-isogenic wheat lines with different single Lr genes for leaf rust resistance. Isolates were polymorphic for virulence on Lr1, Lr2a, Lr2b, Lr2c, Lr9, Lr19, Lr23, Lr26, and the combination Lr27 + Lr31. No isolates were found virulent on Lr24, Lr25, or Lr28, and few isolates were virulent on Lr9. Few isolates of known races but most isolates of the new, unnamed races were virulent on Lr19. The 35 Lr gene lines also were exposed to mixed-race inoculum in field plots to tests effectiveness of their resistance. Lines with Lr24, Lr25, and Lr28 suffered no leaf rust damage in the field, and lines with Lr9, Lr18, Lr35, Lr36, and the combination Lr27 + Lr31 showed less than 10% severity.

[Correlation between the probability and dosage characteristics of safety in the processing of radioactive liquids].

The authors show it possible and expedient to use the probability characteristics for evaluation of the safe operation of radiation-dangerous plants. The calculated values of doses that might be following an accident at these plants fail to give an adequate account of reality since the doses are largely variates. To divide accidents into classes or levels, it is necessary to use the principle of non-excess of accident probability of the given class or level rather than the threshold principle of non-excess of doses.

[Processing of liquid radioactive waste by RADON Industrial Research Association].

The authors present experience accumulated by "RADON" Industrial Research Association in treating liquid radioactive waste. According to the presentation, activities of "R ADON" Industrial Research Association develop in three directions--evolving technical means to purify radioactive waters in "RADON" Industrial Research Association, advancing mobile plants to purify radioactive waters in other institutions, elaborating new technologies for liquid radioactive waste purifications within numerous national and international projects and agreements with various organizations (including those associated with nuclear power stations and nuclear submarines).

The radioisotope complex project "RIC-80" at the Petersburg Nuclear Physics Institute.

The high current cyclotron C-80 capable of producing 40-80 MeV proton beams with a current of up to 200 µA has been constructed at Petersburg Nuclear Physics Institute. One of the main goals of the C-80 is the production of a wide spectrum of medical radionuclides for diagnostics and therapy. The project development of the radioisotope complex RIC-80 (radioisotopes at the cyclotron C-80) at the beam of C-80 has been completed. The RIC-80 complex is briefly discussed in this paper. The combination of the mass-separator with the target-ion source device, available at one of the new target stations for on-line or semi on-line production of a high purity separated radioisotopes, is explored in greater detail. The results of target and ion source tests for a mass-separator method for the production of high purity radioisotopes (82)Sr and (223,224)Ra are also presented.