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1.
Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site.
J Biol Chem
; 299(3): 102999, 2023 03.
Article
in English
| MEDLINE | ID: mdl-36773804
2.
Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.
Biochemistry
; 56(17): 2282-2293, 2017 05 02.
Article
in English
| MEDLINE | ID: mdl-28355486
3.
Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production.
Biochemistry
; 55(31): 4356-65, 2016 08 09.
Article
in English
| MEDLINE | ID: mdl-27426448
4.
Catalytically relevant electrostatic interactions of cytochrome P450c17 (CYP17A1) and cytochrome b5.
J Biol Chem
; 289(49): 33838-49, 2014 Dec 05.
Article
in English
| MEDLINE | ID: mdl-25315771
5.
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.
Nat Chem Biol
; 9(2): 112-8, 2013 Feb.
Article
in English
| MEDLINE | ID: mdl-23222885
6.
Epoxidation activities of human cytochromes P450c17 and P450c21.
Biochemistry
; 53(48): 7531-40, 2014 Dec 09.
Article
in English
| MEDLINE | ID: mdl-25386927
7.
Two surfaces of cytochrome b5 with major and minor contributions to CYP3A4-catalyzed steroid and nifedipine oxygenation chemistries.
Arch Biochem Biophys
; 541: 53-60, 2014 Jan 01.
Article
in English
| MEDLINE | ID: mdl-24256945
8.
The action of cytochrome b(5) on CYP2E1 and CYP2C19 activities requires anionic residues D58 and D65.
Biochemistry
; 52(1): 210-20, 2013 Jan 08.
Article
in English
| MEDLINE | ID: mdl-23193974
9.
Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination.
J Biol Chem
; 287(2): 1556-65, 2012 Jan 06.
Article
in English
| MEDLINE | ID: mdl-22128174
10.
Ubiquitination of neuronal nitric-oxide synthase in the calmodulin-binding site triggers proteasomal degradation of the protein.
J Biol Chem
; 287(51): 42601-10, 2012 Dec 14.
Article
in English
| MEDLINE | ID: mdl-23109339
11.
Bacterial expression, purification, and reconstitution of human steroid 5α-reductases in phospholipid liposomes and nanodiscs.
Methods Enzymol
; 689: 263-276, 2023.
Article
in English
| MEDLINE | ID: mdl-37802573
12.
Selectivity of osilodrostat as an inhibitor of human steroidogenic cytochromes P450.
J Steroid Biochem Mol Biol
; 231: 106316, 2023 07.
Article
in English
| MEDLINE | ID: mdl-37098354
13.
Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates.
Biochemistry
; 51(36): 7064-77, 2012 Sep 11.
Article
in English
| MEDLINE | ID: mdl-22873692
14.
Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.
Biochemistry
; 50(33): 7146-56, 2011 Aug 23.
Article
in English
| MEDLINE | ID: mdl-21755988
15.
C331A mutant of neuronal nitric-oxide synthase is labilized for Hsp70/CHIP (C terminus of HSC70-interacting protein)-dependent ubiquitination.
J Biol Chem
; 285(44): 33642-51, 2010 Oct 29.
Article
in English
| MEDLINE | ID: mdl-20729196
16.
Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.
J Biol Chem
; 285(21): 15714-23, 2010 May 21.
Article
in English
| MEDLINE | ID: mdl-20348093
17.
Expression in Escherichia Coli, Purification, and Functional Reconstitution of Human Steroid 5α-Reductases.
Endocrinology
; 161(8)2020 08 01.
Article
in English
| MEDLINE | ID: mdl-32716491
18.
Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination.
Biochemistry
; 48(35): 8483-90, 2009 Sep 08.
Article
in English
| MEDLINE | ID: mdl-19642705
19.
Predicted Benign and Synonymous Variants in CYP11A1 Cause Primary Adrenal Insufficiency Through Missplicing.
J Endocr Soc
; 3(1): 201-221, 2019 Jan 01.
Article
in English
| MEDLINE | ID: mdl-30620006
20.
Catalytic modulation of human cytochromes P450 17A1 and P450 11B2 by phospholipid.
J Steroid Biochem Mol Biol
; 181: 63-72, 2018 07.
Article
in English
| MEDLINE | ID: mdl-29548669