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1.

Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development.

Kim, Ji-Eun; Li, Bo; Fei, Lijiang; Horne, Rachael; Lee, Dorothy; Loe, Adrian Kwan; Miyake, Hiromu; Ayar, Eda; Kim, Dae-Kyum; Surette, Michael G; Philpott, Dana J; Sherman, Philip; Guo, Guoji; Pierro, Agostino; Kim, Tae-Hee.

Immunity ; 55(12): 2300-2317.e6, 2022 12 13.

Article in English | MEDLINE | ID: mdl-36473468

2.

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity.

Hezaveh, Kebria; Shinde, Rahul S; Klötgen, Andreas; Halaby, Marie Jo; Lamorte, Sara; Ciudad, M Teresa; Quevedo, Rene; Neufeld, Luke; Liu, Zhe Qi; Jin, Robbie; Grünwald, Barbara T; Foerster, Elisabeth G; Chaharlangi, Danica; Guo, Mengdi; Makhijani, Priya; Zhang, Xin; Pugh, Trevor J; Pinto, Devanand M; Co, Ileana L; McGuigan, Alison P; Jang, Gun Ho; Khokha, Rama; Ohashi, Pamela S; O'Kane, Grainne M; Gallinger, Steven; Navarre, William W; Maughan, Heather; Philpott, Dana J; Brooks, David G; McGaha, Tracy L.

Immunity ; 55(2): 324-340.e8, 2022 02 08.

Article in English | MEDLINE | ID: mdl-35139353

3.

Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1.

Killackey, Samuel A; Bi, Yuntian; Soares, Fraser; Hammi, Ikram; Winsor, Nathaniel J; Abdul-Sater, Ali A; Philpott, Dana J; Arnoult, Damien; Girardin, Stephen E.

Mol Cell ; 82(15): 2815-2831.e5, 2022 08 04.

Article in English | MEDLINE | ID: mdl-35752171

4.

Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.

Belcheva, Antoaneta; Irrazabal, Thergiory; Robertson, Susan J; Streutker, Catherine; Maughan, Heather; Rubino, Stephen; Moriyama, Eduardo H; Copeland, Julia K; Surendra, Anu; Kumar, Sachin; Green, Blerta; Geddes, Kaoru; Pezo, Rossanna C; Navarre, William W; Milosevic, Michael; Wilson, Brian C; Girardin, Stephen E; Wolever, Thomas M S; Edelmann, Winfried; Guttman, David S; Philpott, Dana J; Martin, Alberto.

Cell ; 158(2): 288-299, 2014 Jul 17.

Article in English | MEDLINE | ID: mdl-25036629

5.

Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development.

Kim, Ji-Eun; Li, Bo; Fei, Lijiang; Horne, Rachael; Lee, Dorothy; Loe, Adrian Kwan Ho; Miyake, Hiromu; Ayar, Eda; Gurma, Maria; Kim, Dae-Kyum; Surette, Michael G; Philpott, Dana J; Sherman, Philip; Guo, Guoji; Pierro, Agostino; Kim, Tae-Hee.

Immunity ; 56(9): 2175, 2023 Sep 12.

Article in English | MEDLINE | ID: mdl-37703832

6.

Recent Thymic Emigrants Require RBPJ-Dependent Notch Signaling to Transition into Functionally Mature Naive T Cells.

Teichman, Sintia; Wang, Helen; Lee, Christina R; Mohtashami, Mahmood; Foerster, Elisabeth; Han, Jianxun; Trotman-Grant, Ashton C; Winer, Shawn; Tsui, Hubert; Philpott, Dana J; Zúñiga-Pflücker, Juan Carlos.

J Immunol ; 211(1): 81-90, 2023 07 01.

Article in English | MEDLINE | ID: mdl-37154711

7.

gp130 blockade to NOD off Crohn's disease.

Mukherjee, Tapas; Philpott, Dana J.

Trends Immunol ; 42(7): 551-553, 2021 07.

Article in English | MEDLINE | ID: mdl-34103266

8.

Anti-CD40L therapy prevents the formation of precursor lesions to gastric B-cell MALT lymphoma in a mouse model.

Ying, Le; Liu, Phoebe; Ding, Zhoujie; Wray-McCann, Georgie; Emery, Jack; Colon, Nina; Le, Lena Hm; Tran, Le Son; Xu, Ping; Yu, Liang; Philpott, Dana J; Tu, Yugang; Cheah, Daryl Mz; Cheng, Chee L; Lim, Soon T; Ong, Choon K; Ferrero, Richard L.

J Pathol ; 259(4): 402-414, 2023 04.

Article in English | MEDLINE | ID: mdl-36640261

9.

Effect of faecal microbial transplant via colonoscopy in patients with severe obesity and insulin resistance: A randomized double-blind, placebo-controlled Phase 2 trial.

Ghorbani, Yasaman; Schwenger, Katherine J P; Sharma, Divya; Jung, Hyejung; Yadav, Jitender; Xu, Wei; Lou, Wendy; Poutanen, Susan; Hota, Susy S; Comelli, Elena M; Philpott, Dana; Jackson, Timothy D; Okrainec, Allan; Gaisano, Herbert Y; Allard, Johane P.

Diabetes Obes Metab ; 25(2): 479-490, 2023 02.

Article in English | MEDLINE | ID: mdl-36239189

10.

NOD2 modulates immune tolerance via the GM-CSF-dependent generation of CD103⁺ dendritic cells.

Prescott, David; Maisonneuve, Charles; Yadav, Jitender; Rubino, Stephen J; Girardin, Stephen E; Philpott, Dana J.

Proc Natl Acad Sci U S A ; 117(20): 10946-10957, 2020 05 19.

Article in English | MEDLINE | ID: mdl-32350141

11.

The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates.

Mukherjee, Tapas; Ramaglia, Valeria; Abdel-Nour, Mena; Bianchi, Athanasia A; Tsalikis, Jessica; Chau, Hien N; Kalia, Suneil K; Kalia, Lorraine V; Chen, Jane-Jane; Arnoult, Damien; Gommerman, Jennifer L; Philpott, Dana J; Girardin, Stephen E.

J Biol Chem ; 296: 100050, 2021.

Article in English | MEDLINE | ID: mdl-33168630

12.

NOD-like receptors: versatile cytosolic sentinels.

Motta, Vinicius; Soares, Fraser; Sun, Tian; Philpott, Dana J.

Physiol Rev ; 95(1): 149-78, 2015 Jan.

Article in English | MEDLINE | ID: mdl-25540141

13.

LRRK2 and Nod2 promote lysozyme sorting in Paneth cells.

Rocha, Juliana D B; Schlossmacher, Michael G; Philpott, Dana J.

Nat Immunol ; 16(9): 898-900, 2015 Sep.

Article in English | MEDLINE | ID: mdl-26287588

14.

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.

Travassos, Leonardo H; Carneiro, Leticia A M; Ramjeet, Mahendrasingh; Hussey, Seamus; Kim, Yun-Gi; Magalhães, João G; Yuan, Linda; Soares, Fraser; Chea, Evelyn; Le Bourhis, Lionel; Boneca, Ivo G; Allaoui, Abdelmounaaim; Jones, Nicola L; Nuñez, Gabriel; Girardin, Stephen E; Philpott, Dana J.

Nat Immunol ; 11(1): 55-62, 2010 Jan.

Article in English | MEDLINE | ID: mdl-19898471

15.

Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia.

Bruce, Jessica K; Burns, Grace L; Sinn Soh, Wai; Nair, Prema M; Sherwin, Simonne; Fan, KeNing; Dowling, Laura R; Goggins, Bridie J; Koloski, Natasha; Potter, Michael; Bollipo, Steven; Foster, Robert; Gan, Lay T; Veysey, Martin; Philpott, Dana J; Girardin, Stephen E; Holtmann, Gerald; Kaiko, Gerard E; Walker, Marjorie M; Talley, Nicholas J; Keely, Simon.

Brain Behav Immun ; 101: 335-345, 2022 03.

Article in English | MEDLINE | ID: mdl-35093492

16.

The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.

Sorbara, Matthew T; Ellison, Lisa K; Ramjeet, Mahendrasingh; Travassos, Leonardo H; Jones, Nicola L; Girardin, Stephen E; Philpott, Dana J.

Immunity ; 39(5): 858-73, 2013 Nov 14.

Article in English | MEDLINE | ID: mdl-24238340

17.

The multifaceted role of the intestinal microbiota in colon cancer.

Irrazábal, Thergiory; Belcheva, Antoaneta; Girardin, Stephen E; Martin, Alberto; Philpott, Dana J.

Mol Cell ; 54(2): 309-20, 2014 Apr 24.

Article in English | MEDLINE | ID: mdl-24766895

18.

Innate Immune Nod1/RIP2 Signaling Is Essential for Cardiac Hypertrophy but Requires Mitochondrial Antiviral Signaling Protein for Signal Transductions and Energy Balance.

Lin, Han-Bin; Naito, Kotaro; Oh, Yena; Farber, Gedaliah; Kanaan, Georges; Valaperti, Alan; Dawood, Fayez; Zhang, Liyong; Li, Guo Hua; Smyth, David; Moon, Mark; Liu, Youan; Liang, Wenbin; Rotstein, Benjamin; Philpott, Dana J; Kim, Kyoung-Han; Harper, Mary-Ellen; Liu, Peter P.

Circulation ; 142(23): 2240-2258, 2020 12 08.

Article in English | MEDLINE | ID: mdl-33070627

19.

Vitamin D deficiency enhances expression of autophagy-regulating miR-142-3p in mouse and "involved" IBD patient intestinal tissues.

McGillis, Laurel; Bronte-Tinkew, Dana M; Dang, Frances; Capurro, Mariana; Prashar, Akriti; Ricciuto, Amanda; Greenfield, Laura; Lozano-Ruf, Ana; Siddiqui, Iram; Hsieh, Adam; Church, Peter; Walters, Thomas; Roth, Daniel E; Griffiths, Anne; Philpott, Dana; Jones, Nicola L.

Am J Physiol Gastrointest Liver Physiol ; 321(2): G171-G184, 2021 08 01.

Article in English | MEDLINE | ID: mdl-34159811

20.

Innate Immune Molecule NLRC5 Protects Mice From Helicobacter-induced Formation of Gastric Lymphoid Tissue.

Chonwerawong, Michelle; Ferrand, Jonathan; Chaudhry, Hassan Mohammad; Higgins, Chloe; Tran, Le Son; Lim, San Sui; Walker, Marjorie M; Bhathal, Prithi S; Dev, Anouk; Moore, Gregory T; Sievert, William; Jenkins, Brendan J; D'Elios, Mario M; Philpott, Dana J; Kufer, Thomas A; Ferrero, Richard L.

Gastroenterology ; 159(1): 169-182.e8, 2020 07.

Article in English | MEDLINE | ID: mdl-32169428

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Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development.

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity.

Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1.

Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.

Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development.

Recent Thymic Emigrants Require RBPJ-Dependent Notch Signaling to Transition into Functionally Mature Naive T Cells.

gp130 blockade to NOD off Crohn's disease.

Anti-CD40L therapy prevents the formation of precursor lesions to gastric B-cell MALT lymphoma in a mouse model.

Effect of faecal microbial transplant via colonoscopy in patients with severe obesity and insulin resistance: A randomized double-blind, placebo-controlled Phase 2 trial.

NOD2 modulates immune tolerance via the GM-CSF-dependent generation of CD103⁺ dendritic cells.

The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates.

NOD-like receptors: versatile cytosolic sentinels.

LRRK2 and Nod2 promote lysozyme sorting in Paneth cells.

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.

Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia.

The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.

The multifaceted role of the intestinal microbiota in colon cancer.

Innate Immune Nod1/RIP2 Signaling Is Essential for Cardiac Hypertrophy but Requires Mitochondrial Antiviral Signaling Protein for Signal Transductions and Energy Balance.

Vitamin D deficiency enhances expression of autophagy-regulating miR-142-3p in mouse and "involved" IBD patient intestinal tissues.

Innate Immune Molecule NLRC5 Protects Mice From Helicobacter-induced Formation of Gastric Lymphoid Tissue.