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1.

Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid ß plaques.

Roy, Ethan R; Chiu, Gabriel; Li, Sanming; Propson, Nicholas E; Kanchi, Rupa; Wang, Baiping; Coarfa, Cristian; Zheng, Hui; Cao, Wei.

Immunity ; 55(5): 879-894.e6, 2022 05 10.

Article in English | MEDLINE | ID: mdl-35443157

2.

Epigenomic analysis of multilineage differentiation of human embryonic stem cells.

Xie, Wei; Schultz, Matthew D; Lister, Ryan; Hou, Zhonggang; Rajagopal, Nisha; Ray, Pradipta; Whitaker, John W; Tian, Shulan; Hawkins, R David; Leung, Danny; Yang, Hongbo; Wang, Tao; Lee, Ah Young; Swanson, Scott A; Zhang, Jiuchun; Zhu, Yun; Kim, Audrey; Nery, Joseph R; Urich, Mark A; Kuan, Samantha; Yen, Chia-an; Klugman, Sarit; Yu, Pengzhi; Suknuntha, Kran; Propson, Nicholas E; Chen, Huaming; Edsall, Lee E; Wagner, Ulrich; Li, Yan; Ye, Zhen; Kulkarni, Ashwinikumar; Xuan, Zhenyu; Chung, Wen-Yu; Chi, Neil C; Antosiewicz-Bourget, Jessica E; Slukvin, Igor; Stewart, Ron; Zhang, Michael Q; Wang, Wei; Thomson, James A; Ecker, Joseph R; Ren, Bing.

Cell ; 153(5): 1134-48, 2013 May 23.

Article in English | MEDLINE | ID: mdl-23664764

3.

Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading.

Xu, Yin; Propson, Nicholas E; Du, Shuqi; Xiong, Wen; Zheng, Hui.

Proc Natl Acad Sci U S A ; 118(27)2021 07 06.

Article in English | MEDLINE | ID: mdl-34187889

4.

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity.

Schwartz, Michael P; Hou, Zhonggang; Propson, Nicholas E; Zhang, Jue; Engstrom, Collin J; Santos Costa, Vitor; Jiang, Peng; Nguyen, Bao Kim; Bolin, Jennifer M; Daly, William; Wang, Yu; Stewart, Ron; Page, C David; Murphy, William L; Thomson, James A.

Proc Natl Acad Sci U S A ; 112(40): 12516-21, 2015 Oct 06.

Article in English | MEDLINE | ID: mdl-26392547

5.

Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis.

Hou, Zhonggang; Zhang, Yan; Propson, Nicholas E; Howden, Sara E; Chu, Li-Fang; Sontheimer, Erik J; Thomson, James A.

Proc Natl Acad Sci U S A ; 110(39): 15644-9, 2013 Sep 24.

Article in English | MEDLINE | ID: mdl-23940360

6.

MPBind: a Meta-motif-based statistical framework and pipeline to Predict Binding potential of SELEX-derived aptamers.

Jiang, Peng; Meyer, Susanne; Hou, Zhonggang; Propson, Nicholas E; Soh, H Tom; Thomson, James A; Stewart, Ron.

Bioinformatics ; 30(18): 2665-7, 2014 Sep 15.

Article in English | MEDLINE | ID: mdl-24872422

7.

Chemically defined conditions for human iPSC derivation and culture.

Chen, Guokai; Gulbranson, Daniel R; Hou, Zhonggang; Bolin, Jennifer M; Ruotti, Victor; Probasco, Mitchell D; Smuga-Otto, Kimberly; Howden, Sara E; Diol, Nicole R; Propson, Nicholas E; Wagner, Ryan; Lee, Garrett O; Antosiewicz-Bourget, Jessica; Teng, Joyce M C; Thomson, James A.

Nat Methods ; 8(5): 424-9, 2011 May.

Article in English | MEDLINE | ID: mdl-21478862

8.

Complement C3aR depletion reverses HIF-1α-induced metabolic impairment and enhances microglial response to Aß pathology.

Gedam, Manasee; Comerota, Michele M; Propson, Nicholas E; Chen, Tao; Jin, Feng; Wang, Meng C; Zheng, Hui.

J Clin Invest ; 133(12)2023 06 15.

Article in English | MEDLINE | ID: mdl-37317973

9.

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease.

Jennings, Danna; Huntwork-Rodriguez, Sarah; Henry, Anastasia G; Sasaki, Jennifer C; Meisner, René; Diaz, Dolores; Solanoy, Hilda; Wang, Xiang; Negrou, Elvira; Bondar, Vitaliy V; Ghosh, Rajarshi; Maloney, Michael T; Propson, Nicholas E; Zhu, Yuda; Maciuca, Romeo D; Harris, Laura; Kay, Angela; LeWitt, Peter; King, T Alex; Kern, Drew; Ellenbogen, Aaron; Goodman, Ira; Siderowf, Andrew; Aldred, Jason; Omidvar, Omid; Masoud, Shababa T; Davis, Sonnet S; Arguello, Annie; Estrada, Anthony A; de Vicente, Javier; Sweeney, Zachary K; Astarita, Giuseppe; Borin, Marie T; Wong, Bradley K; Wong, Harvey; Nguyen, Hoang; Scearce-Levie, Kimberly; Ho, Carole; Troyer, Matthew D.

Sci Transl Med ; 14(648): eabj2658, 2022 06 08.

Article in English | MEDLINE | ID: mdl-35675433

10.

Complement in Neurologic Disease.

Propson, Nicholas E; Gedam, Manasee; Zheng, Hui.

Annu Rev Pathol ; 16: 277-298, 2021 01 24.

Article in English | MEDLINE | ID: mdl-33234021

11.

Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging.

Propson, Nicholas E; Roy, Ethan R; Litvinchuk, Alexandra; Köhl, Jörg; Zheng, Hui.

J Clin Invest ; 131(1)2021 01 04.

Article in English | MEDLINE | ID: mdl-32990682

12.

An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease.

Ghosh, Anamitra; Comerota, Michele M; Wan, Debin; Chen, Fading; Propson, Nicholas E; Hwang, Sung Hee; Hammock, Bruce D; Zheng, Hui.

Sci Transl Med ; 12(573)2020 12 09.

Article in English | MEDLINE | ID: mdl-33298560

13.

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease.

Roy, Ethan R; Wang, Baiping; Wan, Ying-Wooi; Chiu, Gabriel; Cole, Allysa; Yin, Zhuoran; Propson, Nicholas E; Xu, Yin; Jankowsky, Joanna L; Liu, Zhandong; Lee, Virginia M-Y; Trojanowski, John Q; Ginsberg, Stephen D; Butovsky, Oleg; Zheng, Hui; Cao, Wei.

J Clin Invest ; 130(4): 1912-1930, 2020 04 01.

Article in English | MEDLINE | ID: mdl-31917687

14.

Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease.

Swartzlander, Dan B; Propson, Nicholas E; Roy, Ethan R; Saito, Takashi; Saido, Takaomi; Wang, Baiping; Zheng, Hui.

JCI Insight ; 3(13)2018 07 12.

Article in English | MEDLINE | ID: mdl-29997299

15.

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease.

Litvinchuk, Alexandra; Wan, Ying-Wooi; Swartzlander, Dan B; Chen, Fading; Cole, Allysa; Propson, Nicholas E; Wang, Qian; Zhang, Bin; Liu, Zhandong; Zheng, Hui.

Neuron ; 100(6): 1337-1353.e5, 2018 12 19.

Article in English | MEDLINE | ID: mdl-30415998

16.

Uniform neural tissue models produced on synthetic hydrogels using standard culture techniques.

Barry, Christopher; Schmitz, Matthew T; Propson, Nicholas E; Hou, Zhonggang; Zhang, Jue; Nguyen, Bao K; Bolin, Jennifer M; Jiang, Peng; McIntosh, Brian E; Probasco, Mitchell D; Swanson, Scott; Stewart, Ron; Thomson, James A; Schwartz, Michael P; Murphy, William L.

Exp Biol Med (Maywood) ; 242(17): 1679-1689, 2017 11.

Article in English | MEDLINE | ID: mdl-28599598

17.

Embryonic Stem Cell Growth Factors Regulate eIF2α Phosphorylation.

Friend, Kyle; Brooks, Hunter A; Propson, Nicholas E; Thomson, James A; Kimble, Judith.

PLoS One ; 10(9): e0139076, 2015.

Article in English | MEDLINE | ID: mdl-26406898

18.

Characterization and target identification of a DNA aptamer that labels pluripotent stem cells.

Hou, Zhonggang; Meyer, Susanne; Propson, Nicholas E; Nie, Jeff; Jiang, Peng; Stewart, Ron; Thomson, James A.

Cell Res ; 25(3): 390-3, 2015 Mar.

Article in English | MEDLINE | ID: mdl-25591927

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