ABSTRACT
Mycosis fungoides (MF) is the most prevalent subtype of primary cutaneous T-cell lymphomas (CTCLs). Sézary syndrome (SS) is another entity defined by leukaemic involvement, lymphadenopathy and erythroderma. Pegylated liposomal doxorubicin (PEG-DOXO) is an anthracycline used in the management of advanced primary CTCL, particularly in induction strategies. However, there are limited data on its effectiveness and tolerability in real-life patients. We report 36 patients who received PEG-DOXO for MF or SS in our centre, describing the patients' characteristics, response rates and tolerance to the treatment. The best overall responses were observed for the skin, with lower response rates for nodal involvement and moderate responses for blood disease. The treatment was mainly well tolerated, without severe adverse events, and no cardiotoxicity was observed on cardiac function monitoring.
Subject(s)
Lymphoma, T-Cell, Cutaneous , Mycosis Fungoides , Sezary Syndrome , Skin Neoplasms , Doxorubicin/adverse effects , Doxorubicin/analogs & derivatives , Humans , Lymphoma, T-Cell, Cutaneous/pathology , Mycosis Fungoides/drug therapy , Mycosis Fungoides/pathology , Polyethylene Glycols , Sezary Syndrome/drug therapy , Sezary Syndrome/pathology , Skin Neoplasms/pathologySubject(s)
Larva , Strongyloides , Strongyloidiasis , Animals , Humans , Strongyloides stercoralis , Strongyloidiasis/complications , Strongyloidiasis/diagnosis , SyndromeSubject(s)
Syphilis , Humans , Syphilis/complications , Syphilis/diagnosis , Syphilis/drug therapy , GenitaliaSubject(s)
Acne Vulgaris , Hyperostosis , Osteitis , Synovitis , Acne Vulgaris/diagnosis , Acne Vulgaris/drug therapy , Humans , SyndromeSubject(s)
Cryoglobulinemia/pathology , Skin/pathology , Vasculitis/pathology , Aged , Cryoglobulinemia/diagnosis , Female , Humans , Vasculitis/diagnosisABSTRACT
OBJECTIVE: We present an unusual case of emphysematous cystitis with multiple septic embolisms to several organs. METHOD AND RESULTS: Case description and selection of related pictures. Review of the existing literature. CONCLUSIONS: Emphysematous cystitis is a rare condition but potentially severe. Prognosis depends on a rapid diagnosis and treatment.
Subject(s)
Cystitis/microbiology , Embolism, Air/microbiology , Emphysema/microbiology , Escherichia coli Infections , Aged , Escherichia coli Infections/diagnosis , Escherichia coli Infections/therapy , Female , HumansSubject(s)
Lentigo , Leukemia-Lymphoma, Adult T-Cell , Lymphoma, T-Cell, Cutaneous , Skin Neoplasms , Humans , Lymphoma, T-Cell, Cutaneous/chemically induced , Lymphoma, T-Cell, Cutaneous/diagnosis , Lymphoma, T-Cell, Cutaneous/drug therapy , Antibodies, Monoclonal, Humanized/adverse effects , Skin Neoplasms/chemically induced , Skin Neoplasms/diagnosis , Skin Neoplasms/drug therapy , Leukemia-Lymphoma, Adult T-Cell/pathologySubject(s)
Breast Neoplasms , Skin Neoplasms , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Dermoscopy , Female , Humans , Microscopy, ConfocalABSTRACT
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