Subject(s)
Fibrin Fibrinogen Degradation Products/analysis , Thromboembolism/diagnosis , Humans , Hyperhomocysteinemia/complications , Hyperhomocysteinemia/diagnosis , Male , Middle Aged , Predictive Value of Tests , Smoking/adverse effects , Thromboembolism/blood , Venous Thrombosis/blood , Venous Thrombosis/diagnosisABSTRACT
Fentanyl (N-phenyl-N-(1-2-phenylethyl-4-piperidyl)propanamide) is a potent synthetic narcotic analgesic. He has an analgesic effect 100 times greater than that of morphine. The use of transdermal fentanyl delivrery systems has increased over recent years especially in patients with chronic pain who are already treated with high doses of morphine or it is derivate. However, many cases of fentanyl intoxication through a variety of transderrmal systems have been reported. This paper reports a fatality due to excessive administered Fentanyl Sandoz® Matrix 50 µg/h transdermal therapeutic systems.
Subject(s)
Analgesics, Opioid/poisoning , Fentanyl/poisoning , Neurotoxicity Syndromes/pathology , Administration, Cutaneous , Aged , Analgesics, Opioid/administration & dosage , Chronic Pain/drug therapy , Female , Fentanyl/administration & dosage , Humans , Prescription Drug Overuse/adverse effects , Rheumatic Diseases/drug therapySubject(s)
Anesthesia, General/methods , Anesthesia/methods , Arthroplasty, Replacement, Hip/methods , Osteoarthritis, Hip/surgery , Adult , Aged , Aged, 80 and over , Anesthesiology/methods , Female , Humans , Male , Middle Aged , Morocco , Operative Time , Postoperative Complications/epidemiology , Retrospective Studies , Young AdultABSTRACT
PURPOSE: To report a preliminary analysis of prospectively recorded data in 27 children in whom patient-controlled regional analgesia (PCRA) was used for postoperative pain control following lower limb surgery. METHODS: Under general anesthesia, perineural catheters (popliteal and fascia iliaca compartment block) were inserted and infused with ropivacaine 0.2% (0.02 mL.kg(-1).hr(-1)). Additional demand doses were left to the child's discretion (0.1 mL.kg(-1)and a 30-min lockout interval). RESULTS: The average total dose of ropivacaine administered was 4.9 +/- 2 mg.kg(-1)over 48 hr. Visual analogue scale and Children's Hospital of Eastern Ontario Pain Scale scores were always inferior to 5/10 and 6/13, respectively. Motor block was observed in two children and two children needed rescue analgesia. CONCLUSIONS: Our preliminary observations indicate that PCRA in children provides satisfactory postoperative pain relief following lower limb surgery.