ABSTRACT
Unlike bulk counterparts, two-dimensional (2D) superconductors are sensitive to disorder. Here, we investigated superconductivity of Pb atomic layers formed on vicinal substrates to reveal how surface steps with an interval shorter than the coherence length ξ affect it. Electrical transport showed reduced critical temperature and enhanced critical magnetic field. Scanning tunneling microscopy exhibited vortices elongated along the steps, that is, Abrikosov-Josephson vortices squeezed normal to the steps due to the reduced ξ. These results demonstrate that steps work as disorder and vicinal substrates provide a unique platform to manipulate the degree of disorder on 2D superconductors.
ABSTRACT
Glioblastoma (GBM) is the most common malignant tumor of the adult central nervous system. Aberrant regulation of cell death is an important feature of GBM, and investigating the regulatory mechanisms of cell death in GBM may provide insights into development of new therapeutic strategies. We demonstrated that myrislignan has ferroptosis-promoting activity. Myrislignan is a lignan isolated from Myristica fragrans Houtt and an inhibitor of NF-κB signaling pathway. Ferroptosis is an iron-dependent form of programmed cell death characterized by the accumulation of intracellular lipid peroxidation products. Interestingly, ferroptosis was associated with other biological processes in tumor cells such as autophagy and necroptosis. Recently, the crosstalk between epithelial-mesenchymal transition (EMT) and ferroptosis has also been reported, but the mechanisms underlying the crosstalk have not been identified. Our results indicated that myrislignan suppressed growth of GBM through EMT-mediated ferroptosis in a Slug-dependent manner. Myrislignan inhibited the activation of NF-κB signaling by blocking the phosphorylation of p65 protein and induced ferroptosis through the Slug-SLC7A11 signaling pathway in GBM cells. In addition, myrislignan suppressed the progression of GBM in xenograft mouse model. Hence, our findings contribute to the understanding of EMT-induced ferroptosis and provide targets for the development of targeted therapy against GBM.
Subject(s)
Ferroptosis , Glioblastoma , Lignans , Humans , Animals , Mice , Glioblastoma/pathology , NF-kappa B/metabolism , Epithelial-Mesenchymal Transition/physiology , Cell Line, Tumor , I-kappa B Proteins , Lignans/pharmacology , Lignans/therapeutic useABSTRACT
Electrocatalytic carbon dioxide reduction reaction (CO2RR) generates high value-added products and simultaneously reduces excess atmospheric CO2 concentrations, is regarded as a potential approach to achieve carbon neutrality. However, the kinetic process of the anode oxygen evolution reaction (OER) is slow, resulting in a poor electrochemical efficiency of CO2RR. It is a breakthrough to replace OER with methanol oxidation reaction (MOR), which has more advantageous reaction kinetics. Herein, this work proposed a bifunctional catalyst Bi2O3-SnO modified CuO nanowires (Bi2O3-SnO@CuO NWs) with excellent CO2RR and MOR performance. For CO2RR, Bi2O3-SnO@CuO NWs achieved more than 90% formate selectivity at wide potential windows from -0.88 to -1.08 V (vs. reversible hydrogen electrode (RHE)), peaking at 96.6%. Meanwhile, anodic Bi2O3-SnO@CuO NWs achieved 100 mA cm-2 at a low potential of 1.53 V (vs. RHE), possessing nearly 100% formate selectivity ranging from 1.6 to 1.8 V (vs. RHE). Impressively, by coupling cathodic CO2RR and anodic MOR, the integrated electrolytic cell realized co-production of formate (cathode: 94.7% and anode: 97.5%), minimizing the energy input by approximately 69%, compared with CO2RR. This work provided a meaningful perspective for the design of bifunctional catalysts and coupling reaction systems in CO2RR.