ABSTRACT
The aim of this study is to evaluate the association between changes in routinely prescribed laboratory tests and tracheostomy-free survival in amyotrophic lateral sclerosis (ALS). Two hundred seventy-five ALS patients were retrospectively studied. BMI, forced vital capacity, hemoglobin, hematocrit, lymphocytes, cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, proteins, albumin, creatine-phosphokinase, iron, ferritin, transferrin, glucose, urea, uric acid, and creatinine were measured every 6 months from baseline to 24 months, death or study end, together with the probability of death or tracheostomy. Missing data were handled using multiple imputation chained equations. Hemoglobin (OR = 1.71, 95%CI 1.24-2.36 for IQR increase), hematocrit (OR = 1.87, 95%CI 1.34-2.63 for IQR increase), urea (OR = 1.51, 95%CI 1.21-1.89 for IQR increase), and uric acid (OR = 1.98, 95%CI 1.23-3.20 for IQR increase) were directly associated, while triglycerides (OR = 0.69, 0.51 to 0.93 for IQR increase) were inversely associated with the odds of death or tracheostomy. In our cohort, an increase of hemoglobin, hematocrit, urea, and uric acid was directly associated, and an increase of triglycerides was inversely associated with the odds of death or tracheostomy. Should these findings be replicated in an external cohort, they might help to discriminate ALS progression and patients' decisions about procedures and end of life.
Subject(s)
Amyotrophic Lateral Sclerosis/diagnosis , Amyotrophic Lateral Sclerosis/mortality , Clinical Laboratory Techniques , Aged , Amyotrophic Lateral Sclerosis/physiopathology , Amyotrophic Lateral Sclerosis/surgery , Biomarkers/blood , Body Mass Index , Disease Progression , Female , Humans , Incidence , Logistic Models , Male , Middle Aged , Multivariate Analysis , Odds Ratio , Retrospective Studies , Tracheostomy , Vital CapacityABSTRACT
We have investigated age, sex, nationality, origin, diagnosis and treatment types in ambulatory patients of the External Clinics of the Division Health Mental of the General Hospital for Acute Patients "Dr. Teodoro Alvarez", of 600 Clinical Histories obtained in the years 1980, 1990 and 2000. These data have been extracted with the purpose of studying probable changes in the social and psychopathologic conformation of the patients, in the last two decades.
Subject(s)
Health Services Needs and Demand , Mental Health Services/statistics & numerical data , Argentina , Epidemiologic Studies , Hospitals, General/statistics & numerical data , Humans , Mental Health Services/standards , Mental Health Services/trendsABSTRACT
Se han investigado los diagnósticos y los distintos tipos de tratamientos de 600 historias clínicas, de pacientes ambulatorios de los consultorios externos de la división salud mental del Hospital general de agudos Dr. Teodoro Alvarez, obtenidas en los años 1980, 1990 y 2000. Se ha comprobado el incremento y la importancia que han adquirido los tratamientos psicoterapéuticos, en las últimas dos décadas, en relación a los distintos abordajes terapéuticos
Subject(s)
Mental Health , Research , Diagnosis , Treatment OutcomeABSTRACT
Se han investigado los diagnósticos y los distintos tipos de tratamientos de 600 historias clínicas, de pacientes ambulatorios de los consultorios externos de la división salud mental del Hospital general de agudos Dr. Teodoro Alvarez, obtenidas en los años 1980, 1990 y 2000. Se ha comprobado el incremento y la importancia que han adquirido los tratamientos psicoterapéuticos, en las últimas dos décadas, en relación a los distintos abordajes terapéuticos
Subject(s)
Research , Mental Health , Diagnosis , Treatment OutcomeABSTRACT
We have investigated age, sex, nationality, origin, diagnosis and treatment types in ambulatory patients of the External Clinics of the Division Health Mental of the General Hospital for Acute Patients [quot ]Dr. Teodoro Alvarez[quot ], of 600 Clinical Histories obtained in the years 1980, 1990 and 2000. These data have been extracted with the purpose of studying probable changes in the social and psychopathologic conformation of the patients, in the last two decades.
ABSTRACT
We have investigated age, sex, nationality, origin, diagnosis and treatment types in ambulatory patients of the External Clinics of the Division Health Mental of the General Hospital for Acute Patients [quot ]Dr. Teodoro Alvarez[quot ], of 600 Clinical Histories obtained in the years 1980, 1990 and 2000. These data have been extracted with the purpose of studying probable changes in the social and psychopathologic conformation of the patients, in the last two decades.