Development of a Virtual Reality Tool for the Treatment of Pediatric Patients in the ICU.

Prolonged stays in the intensive care unit (ICU) cause difficulties in rehabilitation and other disorders for patients. This problem is exacerbated in the case of pediatric patients. The use of virtual reality can help with the lack of external stimuli and contribute as potential nonpharmacological therapies in some patient rehabilitation processes. To this end, we have developed a virtual reality application for use in the pediatric ICU as a tool for the treatment and rehabilitation of delirium. The tool consists of two applications: an immersive environment for a virtual reality headset used by the patient, and a web application managed by a therapist with which they can customize, control, adapt, and analyze in real time everything that happens in the patient's virtual world. Our application has been designed jointly with a university center and a hospital, and initial evaluations indicate the results to be promising.

Prognostic Value of the Neutrophil/Lymphocyte Ratio in Squamous Cell Carcinoma of the Penis.

INTRODUCTION: To determine the predictive role of the neutrophil/lymphocyte ratio (NLR) in the prognosis and survival of patients with squamous cell carcinoma of the penis. MATERIALS AND METHODS: A retrospective cohort study of 96 patients with squamous cell carcinoma of the penis (SCCP). Clinical and histological data, bloodwork and disease evolution information were collected. We determined neutrophil/lymphocyte ratios and analyzed their relationship to prognosis and survival. RESULTS: The mean age of patients was 72,1 years. The average follow-up time for the sample was 3,8 years (CI 95%: 3,0-4,6). Compared to patients with NLR <3, those with NLR >3 presented a higher proportion of cancers in stages cN1 (29.7% vs 6.8%; p = 0,004), stages pT3 and pT4 (24,3% vs 9,5%; p = 0,05), and stages TNM III and IV (32,4% vs 10,2%; p = 0,01); additionally, there were more cases of perineural invasion in the NLR >3 patients (29,7% vs 10,2%; p = 0,03). The mean overall survival (OS) was 7,9 years (CI 95%: 6,2-9,6) and the cancer-specific survival (CSS), 1,3 years (CI 95%: 0,7-1,9). There were no differences in OS, CSS or in progression-free survival (PFS) in patients with NLR >3 compared to those with NLR <3 . However, in the Cox regression analysis, a higher NLR was independently associated (along with metastasis and need for adjuvant treatment) with lower PFS, with an HR: 1,27 (CI 95%: 1,02-1,57; p = 0,02). CONCLUSIONS: The utilization of NLR in clinical practice can be considered an additional tool to aid in the diagnosis and prognosis of patients with squamous cell carcinoma of the penis.

Virtual Reality Application for Fostering Interest in Art.

There is concern within the cultural community about the decreasing number of people, especially young people, visiting museums and cultural institutions. To fight this trend, new ways of accessing art are needed. We believe that technologies like virtual reality can greatly foster the relationship between users and works of art. In this article, we present an elaborated virtual reality experience, ImmersArt, whose aim is to take users literally inside a work of art and the creative universe of its creator. The motivational impact of this tool was empirically analyzed and compared with other formats for experiencing art such as illustrated books and audiovisual presentations. The study suggests that young people are more motivated to study artwork when using virtual reality.

A Virtual Reality Training Application for Adults With Asperger's Syndrome.

Asperger's syndrome is a disorder that involves a qualitative impairment in social interactions. While most treatments are aimed at children or adolescents, in this paper we present the development of a virtual reality training application in which adults with Asperger's syndrome can train in an autonomous and controlled way how to present in public.

A comparative study between RadViz and Star Coordinates.

RadViz and star coordinates are two of the most popular projection-based multivariate visualization techniques that arrange variables in radial layouts. Formally, the main difference between them consists of a nonlinear normalization step inherent in RadViz. In this paper we show that, although RadViz can be useful when analyzing sparse data, in general this design choice limits its applicability and introduces several drawbacks for exploratory data analysis. In particular, we observe that the normalization step introduces nonlinear distortions, can encumber outlier detection, prevents associating the plots with useful linear mappings, and impedes estimating original data attributes accurately. In addition, users have greater flexibility when choosing different layouts and views of the data in star coordinates. Therefore, we suggest that analysts and researchers should carefully consider whether RadViz's normalization step is beneficial regarding the data sets' characteristics and analysis tasks.

A new user-adapted search haptic algorithm to navigate along filiform structures.

One of the mayor research challenges of this century is the understanding of the human brain. Regarding this field line, simulation based research is gaining importance. A large amount of money is being spent in huge international projects such as The Human Brain Project [1] and The Blue Brain [2]. The behavior of the brain and, therefore, the behavior of brain simulations depend to a large extend on the neural topology. Neural elements are organized in a connected, dense, complex network of thread-like (i.e., filiform) structures. The analysis of a computer-based simulation using just the visual modality is a highly complex task due to the complexity of the neural topology and the large amounts of multi-variable and multi-modal data generated by computer simulations. In this paper, we propose the use of haptic devices to aid in the navigation along these neural structures, helping neurobiologists in the analysis of neural network topologies. However, haptic navigation constrained to complex filiform networks entails problems when these structures have high frequency features, noise and/or complex branching nodes. We address these issues by presenting a new user-adapted search haptic method that uses the forces exerted by the users to infer their intentions. In addition, we propose a specific calibration technique to adapt the haptic navigation to the user's skills and to the data. We validate this approach through a perceptual study. Finally, we show in this paper the application of our method to the analysis of dense and complex filiform structures in the neurobiology context. Additionally, our technique could be applied to other problems such as electronic circuits and graph exploration.

Prognostic Value of the Neutrophil/Lymphocyte Ratio in Squamous Cell Carcinoma of the Penis

Introduction: To determine the predictive role of the neutrophil/lymphocyte ratio (NLR) in the prognosis and survival of patients with squamous cell carcinoma of the penis. Materials and Methods: A retrospective cohort study of 96 patients with squamous cell carcinoma of the penis (SCCP). Clinical and histological data, bloodwork and disease evolution information were collected. We determined neutrophil/lymphocyte ratios and analyzed their relationship to prognosis and survival. Results: The mean age of patients was 72,1 years. The average follow-up time for the sample was 3,8 years (CI 95%: 3,0–4,6). Compared to patients with NLR <3, those with NLR >3 presented a higher proportion of cancers in stages cN1 (29.7% vs 6.8%; p = 0,004), stages pT3 and pT4 (24,3% vs 9,5%; p = 0,05), and stages TNM III and IV (32,4% vs 10,2%; p = 0,01); additionally, there were more cases of perineural invasion in the NLR >3 patients (29,7% vs 10,2%; p = 0,03). The mean overall survival (OS) was 7,9 years (CI 95%: 6,2–9,6) and the cancer-specific survival (CSS), 1,3 years (CI 95%: 0,7–1,9). There were no differences in OS, CSS or in progression-free survival (PFS) in patients with NLR >3 compared to those with NLR <3 . However, in the Cox regression analysis, a higher NLR was independently associated (along with metastasis and need for adjuvant treatment) with lower PFS, with an HR: 1,27 (CI 95%: 1,02–1,57; p = 0,02). Conclusions: The utilization of NLR in clinical practice can be considered an additional tool to aid in the diagnosis and prognosis of patients with squamous cell carcinoma of the penis (AU)