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1.

Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation.

Cook, Deborah; Deane, Adam; Lauzier, François; Zytaruk, Nicole; Guyatt, Gordon; Saunders, Lois; Hardie, Miranda; Heels-Ansdell, Diane; Alhazzani, Waleed; Marshall, John; Muscedere, John; Myburgh, John; English, Shane; Arabi, Yaseen M; Ostermann, Marlies; Knowles, Serena; Hammond, Naomi; Byrne, Kathleen M; Chapman, Marianne; Venkatesh, Balasubramanian; Young, Paul; Rajbhandari, Dorrilyn; Poole, Alexis; Al-Fares, Abdulrahman; Reis, Gilmar; Johnson, Daniel; Iqbal, Mobeen; Hall, Richard; Meade, Maureen; Hand, Lori; Duan, Erick; Clarke, France; Dionne, Joanna C; Tsang, Jennifer L Y; Rochwerg, Bram; Karachi, Timothy; Lamontagne, Francois; D'Aragon, Frédérick; St Arnaud, Charles; Reeve, Brenda; Geagea, Anna; Niven, Daniel; Vazquez-Grande, Gloria; Zarychanski, Ryan; Ovakim, Daniel; Wood, Gordon; Burns, Karen E A; Goffi, Alberto; Wilcox, M Elizabeth; Henderson, William.

N Engl J Med ; 2024 Jun 14.

Article in English | MEDLINE | ID: mdl-38875111

2.

Early Treatment with Pegylated Interferon Lambda for Covid-19.

Reis, Gilmar; Moreira Silva, Eduardo A S; Medeiros Silva, Daniela C; Thabane, Lehana; Campos, Vitoria H S; Ferreira, Thiago S; Santos, Castilho V Q; Nogueira, Ana M R; Almeida, Ana P F G; Savassi, Leonardo C M; Figueiredo-Neto, Adhemar D; Dias, Ana C F; Freire Júnior, Adelino M; Bitarães, Carina; Milagres, Aline C; Callegari, Eduardo D; Simplicio, Maria I C; Ribeiro, Luciene B; Oliveira, Rosemary; Harari, Ofir; Wilson, Lindsay A; Forrest, Jamie I; Ruton, Hinda; Sprague, Sheila; McKay, Paula; Guo, Christina M; Limbrick-Oldfield, Eve H; Kanters, Steve; Guyatt, Gordon H; Rayner, Craig R; Kandel, Christopher; Biondi, Mia J; Kozak, Robert; Hansen, Bettina; Zahoor, M Atif; Arora, Paul; Hislop, Colin; Choong, Ingrid; Feld, Jordan J; Mills, Edward J; Glenn, Jeffrey S.

N Engl J Med ; 388(6): 518-528, 2023 02 09.

Article in English | MEDLINE | ID: mdl-36780676

3.

Effect of Early Treatment with Ivermectin among Patients with Covid-19.

Reis, Gilmar; Silva, Eduardo A S M; Silva, Daniela C M; Thabane, Lehana; Milagres, Aline C; Ferreira, Thiago S; Dos Santos, Castilho V Q; Campos, Vitoria H S; Nogueira, Ana M R; de Almeida, Ana P F G; Callegari, Eduardo D; Neto, Adhemar D F; Savassi, Leonardo C M; Simplicio, Maria I C; Ribeiro, Luciene B; Oliveira, Rosemary; Harari, Ofir; Forrest, Jamie I; Ruton, Hinda; Sprague, Sheila; McKay, Paula; Guo, Christina M; Rowland-Yeo, Karen; Guyatt, Gordon H; Boulware, David R; Rayner, Craig R; Mills, Edward J.

N Engl J Med ; 386(18): 1721-1731, 2022 05 05.

Article in English | MEDLINE | ID: mdl-35353979

4.

Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19 : A Randomized Platform Trial.

Reis, Gilmar; Dos Santos Moreira Silva, Eduardo Augusto; Medeiros Silva, Daniela Carla; Thabane, Lehana; de Souza Campos, Vitoria Helena; Ferreira, Thiago Santiago; Quirino Dos Santos, Castilho Vitor; Ribeiro Nogueira, Ana Maria; Figueiredo Guimaraes Almeida, Ana Paula; Cançado Monteiro Savassi, Leonardo; de Figueiredo Neto, Adhemar Dias; Bitarães, Carina; Cruz Milagres, Aline; Diniz Callegari, Eduardo; Campos Simplicio, Maria Izabel; Barra Ribeiro, Luciene; Oliveira, Rosemary; Harari, Ofir; Wilson, Lindsay A; Forrest, Jamie I; Ruton, Hinda; Sprague, Sheila; McKay, Paula; Guo, Christina M; Guyatt, Gordon H; Rayner, Craig R; Boulware, David R; Ezer, Nicole; Lee, Todd C; McDonald, Emily Gibson; Bafadhel, Mona; Butler, Christopher; Rodrigues Silva, Josue; Dybul, Mark; Mills, Edward J.

Ann Intern Med ; 176(5): 667-675, 2023 05.

Article in English | MEDLINE | ID: mdl-37068273

5.

Pegylated Interferon Lambda for Covid-19. Reply.

Reis, Gilmar; Mills, Edward J; Glenn, Jeffrey S.

N Engl J Med ; 388(22): 2108, 2023 Jun 01.

Article in English | MEDLINE | ID: mdl-37256990

6.

Ivermectin Treatment for Covid-19. Reply.

Reis, Gilmar; Mills, Edward J.

N Engl J Med ; 387(24): e66, 2022 12 15.

Article in English | MEDLINE | ID: mdl-36516104

7.

Evaluating COVID-19 vaccines in the real world.

Mills, Edward J; Reis, Gilmar.

Lancet ; 399(10331): 1205-1206, 2022 03 26.

Article in English | MEDLINE | ID: mdl-35303472

8.

A phase 3 randomized double-blind comparison of ceftobiprole medocaril versus ceftazidime plus linezolid for the treatment of hospital-acquired pneumonia.

Awad, Samir S; Rodriguez, Alejandro H; Chuang, Yin-Ching; Marjanek, Zsuszanna; Pareigis, Alex J; Reis, Gilmar; Scheeren, Thomas W L; Sánchez, Alejandro S; Zhou, Xin; Saulay, Mikaël; Engelhardt, Marc.

Clin Infect Dis ; 59(1): 51-61, 2014 Jul 01.

Article in English | MEDLINE | ID: mdl-24723282

9.

Matched vs Nonmatched Placebos in a Randomized Trial of COVID-19 Treatments.

Reis, Gilmar; Savassi, Leonardo Cançado Monteiro; Ferreira, Thiago Santiago; Reis, Luiza Lanna França; Simplicio, Maria Izabel Campos; Ribeiro, Luciene Barra; Silva, Eduardo Augusto Dos Santos Moreira; Lat, Prince Kumar; Harari, Ofir; Forrest, Jamie I; Dron, Louis; Park, Jay J H; Thorlund, Kristian; Mills, Edward J.

JAMA Netw Open ; 7(5): e2410335, 2024 May 01.

Article in English | MEDLINE | ID: mdl-38767921

10.

Early Treatment with Fluvoxamine among Patients with COVID-19: A Cost-Consequence Model.

Mills, Fergal P; Reis, Gilmar; Wilson, Lindsay A; Thorlund, Kristian; Forrest, Jamie I; Guo, Christina M; Boulware, David R; Mills, Edward J.

Am J Trop Med Hyg ; 108(1): 101-106, 2023 01 11.

Article in English | MEDLINE | ID: mdl-36379209

11.

Hydroxychloroquine for treatment of non-hospitalized adults with COVID-19: A meta-analysis of individual participant data of randomized trials.

Mitjà, Oriol; Reis, Gilmar; Boulware, David R; Spivak, Adam M; Sarwar, Ammar; Johnston, Christine; Webb, Brandon; Hill, Michael D; Smith, Davey; Kremsner, Peter; Curran, Marla; Carter, David; Alexander, Jim; Corbacho, Marc; Lee, Todd C; Hullsiek, Katherine Huppler; McDonald, Emily G; Hess, Rachel; Hughes, Michael; Baeten, Jared M; Schwartz, Ilan; Metz, Luanne; Richer, Lawrence; Chew, Kara W; Daar, Eric; Wohl, David; Dunne, Michael.

Clin Transl Sci ; 16(3): 524-535, 2023 03.

Article in English | MEDLINE | ID: mdl-36601684

12.

REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU: a randomised trial protocol.

Deane, Adam M; Alhazzani, Waleed; Guyatt, Gordon; Finfer, Simon; Marshall, John C; Myburgh, John; Zytaruk, Nicole; Hardie, Miranda; Saunders, Lois; Knowles, Serena; Lauzier, Francois; Chapman, Marianne J; English, Shane; Muscedere, John; Arabi, Yaseen; Ostermann, Marlies; Venkatesh, Balasubramanian; Young, Paul; Thabane, Lehana; Billot, Laurent; Heels-Ansdell, Diane; Al-Fares, Abdulrahman A; Hammond, Naomi E; Hall, R; Rajbhandari, Dorrilyn; Poole, Alexis; Johnson, Daniel; Iqbal, Mobeen; Reis, Gilmar; Xie, Feng; Cook, Deborah J.

BMJ Open ; 13(11): e075588, 2023 11 15.

Article in English | MEDLINE | ID: mdl-37968012

13.

Resilient Clinical Trial Infrastructure in Response to the COVID-19 Pandemic: Lessons Learned from the TOGETHER Randomized Platform Clinical Trial.

Forrest, Jamie I; Rawat, Angeli; Duailibe, Felipe; Guo, Christina M; Sprague, Sheila; McKay, Paula; Reis, Gilmar; Mills, Edward J.

Am J Trop Med Hyg ; 106(2): 389-393, 2022 01 07.

Article in English | MEDLINE | ID: mdl-34996047

14.

Toward a New Paradigm of North-South and South-South Partnerships for Pandemic Preparedness: Lessons Learned from COVID-19 and Other Outbreaks.

Nsanzimana, Sabin; Rawat, Angeli; Wilson, Lindsay A; Forrest, Jamie I; Reis, Gilmar; Ramagopalan, Sreeram; Muyembe-Tamfum, Jean-Jacques; Ntoumi, Francine; Zumla, Alimuddin; Sow, Papa Salif; Nachega, Jean B; Binagwaho, Agnes; Dybul, Mark; Mills, Edward J.

Am J Trop Med Hyg ; 107(6): 1162-1165, 2022 12 14.

Article in English | MEDLINE | ID: mdl-36375450

15.

Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial.

Reis, Gilmar; Dos Santos Moreira-Silva, Eduardo Augusto; Silva, Daniela Carla Medeiros; Thabane, Lehana; Milagres, Aline Cruz; Ferreira, Thiago Santiago; Dos Santos, Castilho Vitor Quirino; de Souza Campos, Vitoria Helena; Nogueira, Ana Maria Ribeiro; de Almeida, Ana Paula Figueiredo Guimaraes; Callegari, Eduardo Diniz; de Figueiredo Neto, Adhemar Dias; Savassi, Leonardo Cançado Monteiro; Simplicio, Maria Izabel Campos; Ribeiro, Luciene Barra; Oliveira, Rosemary; Harari, Ofir; Forrest, Jamie I; Ruton, Hinda; Sprague, Sheila; McKay, Paula; Glushchenko, Alla V; Rayner, Craig R; Lenze, Eric J; Reiersen, Angela M; Guyatt, Gordon H; Mills, Edward J.

Lancet Glob Health ; 10(1): e42-e51, 2022 01.

Article in English | MEDLINE | ID: mdl-34717820

16.

Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: The TOGETHER randomized platform clinical trial.

Reis, Gilmar; Dos Santos Moreira Silva, Eduardo Augusto; Medeiros Silva, Daniela Carla; Thabane, Lehana; Cruz Milagres, Aline; Ferreira, Thiago Santiago; Quirino Dos Santos, Castilho Vitor; de Figueiredo Neto, Adhemar Dias; Diniz Callegari, Eduardo; Monteiro Savassi, Leonardo Cançado; Campos Simplicio, Maria Izabel; Barra Ribeiro, Luciene; Oliveira, Rosemary; Harari, Ofir; Bailey, Holly; Forrest, Jamie I; Glushchenko, Alla; Sprague, Sheila; McKay, Paula; Rayner, Craig R; Ruton, Hinda; Guyatt, Gordon H; Mills, Edward J.

Lancet Reg Health Am ; 6: 100142, 2022 Feb.

Article in English | MEDLINE | ID: mdl-34927127

17.

How COVID-19 has fundamentally changed clinical research in global health.

Park, Jay J H; Mogg, Robin; Smith, Gerald E; Nakimuli-Mpungu, Etheldreda; Jehan, Fyezah; Rayner, Craig R; Condo, Jeanine; Decloedt, Eric H; Nachega, Jean B; Reis, Gilmar; Mills, Edward J.

Lancet Glob Health ; 9(5): e711-e720, 2021 05.

Article in English | MEDLINE | ID: mdl-33865476

18.

Three week compared to seven week run-in period length and the assessment of pre-randomization adherence: A study within a trial.

Collister, David; Mbuagbaw, Lawrence; Guyatt, Gordon; Devereaux, P J; Tennankore, Karthik K; Reis, Gilmar; Sola, Laura; Xavier, Denis; Jha, Vivekanand; Gallagher, Martin; Dans, Antonio L; Liu, Wen; de Zoysa, Janak; Félix, Camilo; Mark, Patrick B; Li, Zuo; Tyrwhitt, Jessica; Wilkinson, Joanne; Sheridan, Patrick; Yuan, Fei; Walsh, Michael.

Contemp Clin Trials ; 107: 106466, 2021 08.

Article in English | MEDLINE | ID: mdl-34098039

19.

Effect of Early Treatment With Hydroxychloroquine or Lopinavir and Ritonavir on Risk of Hospitalization Among Patients With COVID-19: The TOGETHER Randomized Clinical Trial.

Reis, Gilmar; Moreira Silva, Eduardo Augusto Dos Santos; Medeiros Silva, Daniela Carla; Thabane, Lehana; Singh, Gurmit; Park, Jay J H; Forrest, Jamie I; Harari, Ofir; Quirino Dos Santos, Castilho Vitor; Guimarães de Almeida, Ana Paula Figueiredo; Figueiredo Neto, Adhemar Dias de; Savassi, Leonardo Cançado Monteiro; Milagres, Aline Cruz; Teixeira, Mauro Martins; Simplicio, Maria Izabel Campos; Ribeiro, Luciene Barra; Oliveira, Rosemary; Mills, Edward J.

JAMA Netw Open ; 4(4): e216468, 2021 04 01.

Article in English | MEDLINE | ID: mdl-33885775

20.

Accelerating Clinical Evaluation of Repurposed Combination Therapies for COVID-19.

Rayner, Craig R; Dron, Louis; Park, Jay J H; Decloedt, Eric H; Cotton, Mark F; Niranjan, Vis; Smith, Patrick F; Dodds, Michael G; Brown, Fran; Reis, Gilmar; Wesche, David; Mills, Edward J.

Am J Trop Med Hyg ; 103(4): 1364-1366, 2020 10.

Article in English | MEDLINE | ID: mdl-32828137

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