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1.

High throughput screening identifies dasatinib as synergistic with trametinib in low grade serous ovarian carcinoma.

Hollis, Robert L; Elliott, Richard; Dawson, John C; Ilenkovan, Narthana; Matthews, Rosie M; Stillie, Lorna J; Oswald, Ailsa J; Kim, Hannah; Llaurado Fernandez, Marta; Churchman, Michael; Porter, Joanna M; Roxburgh, Patricia; Unciti-Broceta, Asier; Gershenson, David M; Herrington, C Simon; Carey, Mark S; Carragher, Neil O; Gourley, Charlie.

Gynecol Oncol ; 186: 42-52, 2024 Apr 05.

Article in English | MEDLINE | ID: mdl-38582027

2.

Incorporating patient centered benefits as endpoints in randomized trials of maintenance therapies in advanced ovarian cancer: A position paper from the GCIG symptom benefit committee.

Kurtz, Jean-Emmanuel; Gebski, Val; Sukhin, Vladyslav; Carey, Mark; Kong, Iwa; Glasspool, Rosalind M; Berek, Jonathan S; de Paiva Batista, Mariana; Hall, Marcia; Kim, Jae-Weon; Yeoshoua, Effi; Fujiwara, Noriko; Nam, Byung-Ho; Polleis, Sandra; Lee, Jung-Yun; Strojna, Aleksandra; Farrelly, Laura; Schwameis, Richard; Fossati, Roldano; Darlington, Anne-Sophie; Lai, Chyong-Huey; Wright, Alexi A; Rosenblat, Orgad; Harter, Phillip; Roxburgh, Patricia; Chowdhury, Rahul Roy; Chang, Ting-Chang; Paoletti, Xavier; Friedlander, Michael.

Gynecol Oncol ; 161(2): 502-507, 2021 05.

Article in English | MEDLINE | ID: mdl-33612336

3.

Metronomic oral cyclophosphamide in relapsed ovarian cancer.

Spiliopoulou, Pavlina; Hinsley, Samantha; McNeish, Iain A; Roxburgh, Patricia; Glasspool, Ros.

Int J Gynecol Cancer ; 31(7): 1037-1044, 2021 07.

Article in English | MEDLINE | ID: mdl-34016703

4.

A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours.

Wilson, Richard H; Evans, Tr Jeffry; Middleton, Mark R; Molife, L Rhoda; Spicer, James; Dieras, Veronique; Roxburgh, Patricia; Giordano, Heidi; Jaw-Tsai, Sarah; Goble, Sandra; Plummer, Ruth.

Br J Cancer ; 116(7): 884-892, 2017 Mar 28.

Article in English | MEDLINE | ID: mdl-28222073

5.

Squamous carcinoma of the ovary.

Roxburgh, Patricia; Glasspool, Rosalind.

Curr Oncol Rep ; 16(12): 413, 2014 Dec.

Article in English | MEDLINE | ID: mdl-25344339

6.

Olaparib plus Durvalumab, with or without Bevacizumab, as Treatment in PARP Inhibitor-Naïve Platinum-Sensitive Relapsed Ovarian Cancer: A Phase II Multi-Cohort Study.

Drew, Yvette; Kim, Jae-Weon; Penson, Richard T; O'Malley, David M; Parkinson, Christine; Roxburgh, Patricia; Plummer, Ruth; Im, Seock-Ah; Imbimbo, Martina; Ferguson, Michelle; Rosengarten, Ora; Steeghs, Neeltje; Kim, Min Hwan; Gal-Yam, Einav; Tsoref, Daliah; Kim, Jae-Hoon; You, Benoit; De Jonge, Maja; Lalisang, Roy; Gort, Eelke; Bastian, Sara; Meyer, Kassondra; Feeney, Laura; Baker, Nigel; Ah-See, Mei-Lin; Domchek, Susan M; Banerjee, Susana.

Clin Cancer Res ; 30(1): 50-62, 2024 01 05.

Article in English | MEDLINE | ID: mdl-37939124

7.

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2.

Dickens, Michael P; Roxburgh, Patricia; Hock, Andreas; Mezna, Mokdad; Kellam, Barrie; Vousden, Karen H; Fischer, Peter M.

Bioorg Med Chem ; 21(22): 6868-77, 2013 Nov 15.

Article in English | MEDLINE | ID: mdl-24113239

8.

How do we optimally use cetuximab in first-line treatment for metastatic colorectal cancer?

Lindsay, Colin R; Roxburgh, Patricia; Graham, Janet.

Future Oncol ; 9(6): 825-9, 2013 Jun.

Article in English | MEDLINE | ID: mdl-23718303

9.

A Phase I/II Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Low-Dose Gemcitabine in Patients with Advanced Cancer.

Jones, Robert; Plummer, Ruth; Moreno, Victor; Carter, Louise; Roda, Desamparados; Garralda, Elena; Kristeleit, Rebecca; Sarker, Debashis; Arkenau, Tobias; Roxburgh, Patricia; Walter, Harriet S; Blagden, Sarah; Anthoney, Alan; Klencke, Barbara J; Kowalski, Mark M; Banerji, Udai.

Clin Cancer Res ; 29(2): 331-340, 2023 01 17.

Article in English | MEDLINE | ID: mdl-36378548

10.

Description of a Retrospective Cohort of Epithelial Ovarian Cancer Patients with Brain Metastases: Evaluation of the Role of PARP Inhibitors in this Setting.

Alizzi, Zena; Roxburgh, Patricia; Cartwright, Douglas; McLaren, Alistair; Park, Sarah; Jones, Rachel; Greening, Semini; Hudson, Emma; Green, Clare; Gray, Simon; Khalique, Saira; Karteris, Emmanouil; Hall, Marcia.

J Clin Med ; 12(7)2023 Mar 25.

Article in English | MEDLINE | ID: mdl-37048581

11.

Small molecules that bind the Mdm2 RING stabilize and activate p53.

Roxburgh, Patricia; Hock, Andreas K; Dickens, Michael P; Mezna, Mokdad; Fischer, Peter M; Vousden, Karen H.

Carcinogenesis ; 33(4): 791-8, 2012 Apr.

Article in English | MEDLINE | ID: mdl-22301280

12.

Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma.

Spiliopoulou, Pavlina; Spear, Sarah; Mirza, Hasan; Garner, Ian; McGarry, Lynn; Grundland-Freile, Fabio; Cheng, Zhao; Ennis, Darren P; Iyer, Nayana; McNamara, Sophie; Natoli, Marina; Mason, Susan; Blyth, Karen; Adams, Peter D; Roxburgh, Patricia; Fuchter, Matthew J; Brown, Bob; McNeish, Iain A.

Mol Cancer Ther ; 21(4): 522-534, 2022 04 01.

Article in English | MEDLINE | ID: mdl-35131874

13.

Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification.

Hollis, Robert L; Meynert, Alison M; Michie, Caroline O; Rye, Tzyvia; Churchman, Michael; Hallas-Potts, Amelia; Croy, Ian; McCluggage, W Glenn; Williams, Alistair R W; Bartos, Clare; Iida, Yasushi; Okamoto, Aikou; Dougherty, Brian; Barrett, J Carl; March, Ruth; Matakidou, Athena; Roxburgh, Patricia; Semple, Colin A; Harkin, D Paul; Kennedy, Richard; Herrington, C Simon; Gourley, Charlie.

Clin Cancer Res ; 28(16): 3546-3556, 2022 08 15.

Article in English | MEDLINE | ID: mdl-35696721

14.

CA-125 Levels Are Predictive of Survival in Low-Grade Serous Ovarian Cancer-A Multicenter Analysis.

Wohlmuth, Christoph; Djedovic, Vladimir; Kjaer, Susanne K; Jensen, Allan; Glasspool, Rosalind; Roxburgh, Patricia; DeFazio, Anna; Johnatty, Sharon E; Webb, Penelope M; Modugno, Francesmary; Lambrechts, Diether; Schildkraut, Joellen M; Berchuck, Andrew; Thomsen, Liv Cecilie Vestrheim; Bjorge, Line; Høgdall, Estrid; Høgdall, Claus K; Goode, Ellen L; Winham, Stacey J; Matsuo, Keitaro; Karlan, Beth Y; Lester, Jenny; Goodman, Marc T; Thompson, Pamela J; Pejovic, Tanja; Riggan, Marjorie J; Lajkosz, Katherine; Tone, Alicia; May, Taymaa.

Cancers (Basel) ; 14(8)2022 Apr 13.

Article in English | MEDLINE | ID: mdl-35454861

15.

Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.

Ho, Gwo Yaw; Kyran, Elizabeth L; Bedo, Justin; Wakefield, Matthew J; Ennis, Darren P; Mirza, Hasan B; Vandenberg, Cassandra J; Lieschke, Elizabeth; Farrell, Andrew; Hadla, Anthony; Lim, Ratana; Dall, Genevieve; Vince, James E; Chua, Ngee Kiat; Kondrashova, Olga; Upstill-Goddard, Rosanna; Bailey, Ulla-Maja; Dowson, Suzanne; Roxburgh, Patricia; Glasspool, Rosalind M; Bryson, Gareth; Biankin, Andrew V; Cooke, Susanna L; Ratnayake, Gayanie; McNally, Orla; Traficante, Nadia; DeFazio, Anna; Weroha, S John; Bowtell, David D; McNeish, Iain A; Papenfuss, Anthony T; Scott, Clare L; Barker, Holly E.

Cancer Res ; 82(23): 4457-4473, 2022 12 02.

Article in English | MEDLINE | ID: mdl-36206301

16.

First-Line PARP Inhibitors-Emerging Side Effects Require Caution: A Case of PARPi-Induced Pneumonitis.

McLaren, Alistair; Cartwright, Douglas; Ross, Ewen; Roxburgh, Patricia.

J Immunother Precis Oncol ; 4(3): 171-174, 2021 08.

Article in English | MEDLINE | ID: mdl-35663102

17.

Safety and efficacy of the tumor-selective adenovirus enadenotucirev with or without paclitaxel in platinum-resistant ovarian cancer: a phase 1 clinical trial.

Moreno, Victor; Barretina-Ginesta, Maria-Pilar; García-Donas, Jesús; Jayson, Gordon C; Roxburgh, Patricia; Vázquez, Raúl Márquez; Michael, Agnieszka; Antón-Torres, Antonio; Brown, Richard; Krige, David; Champion, Brian; McNeish, Iain.

J Immunother Cancer ; 9(12)2021 12.

Article in English | MEDLINE | ID: mdl-34893524

18.

Structural Variants at the BRCA1/2 Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma.

Ewing, Ailith; Meynert, Alison; Churchman, Michael; Grimes, Graeme R; Hollis, Robert L; Herrington, C Simon; Rye, Tzyvia; Bartos, Clare; Croy, Ian; Ferguson, Michelle; Lennie, Mairi; McGoldrick, Trevor; McPhail, Neil; Siddiqui, Nadeem; Dowson, Suzanne; Glasspool, Rosalind; Mackean, Melanie; Nussey, Fiona; McDade, Brian; Ennis, Darren; McMahon, Lynn; Matakidou, Athena; Dougherty, Brian; March, Ruth; Barrett, J Carl; McNeish, Iain A; Biankin, Andrew V; Roxburgh, Patricia; Gourley, Charlie; Semple, Colin A.

Clin Cancer Res ; 27(11): 3201-3214, 2021 06 01.

Article in English | MEDLINE | ID: mdl-33741650

19.

Effect of food on the pharmacokinetics of the WEE1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors.

Någård, Mats; Ah-See, Mei-Lin; So, Karen; Vermunt, Marit; Thistlethwaite, Fiona; Labots, Mariette; Roxburgh, Patricia; Ravaud, Alain; Campone, Mario; Valkenburg-van Iersel, Liselot; Ottesen, Lone; Li, Yan; Mugundu, Ganesh.

Cancer Chemother Pharmacol ; 86(1): 97-108, 2020 07.

Article in English | MEDLINE | ID: mdl-32556602

20.

Concerning the feasibility of obtaining biopsies for research in relapsed ovarian cancer.

Roxburgh, Patricia; Cowell, Gordon W; Glasspool, Rosalind M.

Int J Gynecol Cancer ; 24(1): 2-3, 2014 Jan.

Article in English | MEDLINE | ID: mdl-24356410

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