Ocular histiocytic sarcoma in a cat.

A 13-year-old male neutered British blue cat presented with uveitis, hyphema, and dyscoria in the right eye. Light microscopic examination revealed that the ciliary body, iris root, drainage angle, and adjacent choroid were infiltrated by sheets of large neoplastic mononuclear and multinucleate round to polygonal cells. Neoplastic cells stained immunopositive for CD18 and HLA-DR (MHC class II) and were immunonegative for CD3, CD79a, MUM-1, CD117 (c-Kit), and S100. These findings were consistent with a histiocytic sarcoma. The cat later developed multiple cutaneous masses composed of a similar neoplastic cell population to that seen in the eye. Eight months following enucleation, the cat developed respiratory distress and was euthanized. Postmortem examination revealed multiple pulmonary tumors associated with a pleural effusion.

Corneolimbal squamous cell carcinoma with intraocular invasion in two cats.

Unilateral corneolimbal squamous cell carcinoma associated with intraocular invasion is described in two unrelated cats. The diagnosis was made on histopathological examination of the enucleated globes in both cases. Findings revealed squamous cell carcinoma infiltrating the limbus, adjacent cornea, and sclera with associated intraocular invasion at the level of the limbus.