ABSTRACT
Uterine tumors resembling ovarian sex cord tumors are rare neoplasms of unknown etiology that are classified as distinct from endometrial stromal tumors on the basis of their morphologic, molecular, and behavioral characteristics. These neoplasms have a variable immunophenotype, sometimes coexpressing epithelial, myoid, and sex cord markers. To date, only 2 cases of uterine tumors resembling ovarian sex cord tumors associated with tamoxifen use have been reported. Here, we report the case of a 49-year-old woman who had been using tamoxifen for 5 years to treat breast cancer. The tumor was initially diagnosed by hysteroscopy biopsy on the basis of morphologic and immunohistochemical features. Hysterectomy revealed a polypoid mass measuring 20 mm. After an 18-month follow-up, the patient remains disease free. Here, we review the clinical, pathologic, and immunohistochemical features of uterine tumors resembling ovarian sex cord tumors and endometrial stromal tumors with a sex cord component associated with tamoxifen treatment.
Subject(s)
Antineoplastic Agents, Hormonal/therapeutic use , Breast Neoplasms/drug therapy , Ovarian Neoplasms/pathology , Sex Cord-Gonadal Stromal Tumors/pathology , Tamoxifen/therapeutic use , Uterine Neoplasms/pathology , Breast Neoplasms/pathology , Female , Humans , Middle AgedABSTRACT
Los tumores carcinoides de mama son muy pocofrecuentes y pueden ser metastásicos o primarios.Sólo se puede considerar primario de mama trasdescartar las localizaciones más frecuentes.Reconocer esta diferencia es fundamental alplanificar el tratamiento, ya que requieren unmanejo terapéutico diferente
Carcinoid tumors of the breast are uncommon.These lesions may be either metastatic or primary.A primary breast lesion can only be diagnosedafter other, more frequent locations have beenexcluded. Recognizing this difference is essentialwhen planning treatment because the therapeuticmanagement differs between these types of lesions